Intraocular pressure elevation after subtenon triamcinolone acetonide injection; Multicentre retrospective cohort study in Japan


Autoři: Yuki Maeda aff001;  Hiroto Ishikawa aff001;  Hiroki Nishikawa aff003;  Miho Shimizu aff001;  Takamasa Kinoshita aff001;  Rie Ogihara aff001;  Shigehiko Kitano aff001;  Chihiro Yamanaka aff001;  Yoshinori Mitamura aff001;  Masahiko Sugimoto aff001;  Mineo Kondo aff001;  Yoshihiro Takamura aff001;  Nahoko Ogata aff001;  Tomohiro Ikeda aff001;  Fumi Gomi aff001
Působiště autorů: J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan aff001;  Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan aff002;  Center for Clinical Research and Education, Hyogo College of Medicine, Nishinomiya, Japan aff003;  Department of Ophthalmology, Sapporo City General Hospital, Sapporo, Japan aff004;  Department of Ophthalmology, Diabetes Center, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Japan aff005;  Department of Ophthalmology, Tokushima University, Tokushima, Japan aff006;  Department of Ophthalmology, Mie University, Tsu, Japan aff007;  Department of Ophthalmology, Fukui University, Yoshida, Japan aff008;  Department of Ophthalmology, Nara Medical University School of Medicine, Kashihara, Japan aff009
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
prolekare.web.journal.doi_sk: 10.1371/journal.pone.0226118

Souhrn

Purpose

To evaluate real-world evidence for intraocular pressure (IOP) elevation after subtenon triamcinolone acetonide injection (STTA) in 1252 Japanese patients (1406 eyes) in the Japan Clinical REtina STudy group (J-CREST).

Methods

This was a multicentre retrospective study of the medical records of 1252 patients (676 men (758 eyes); mean age: 63.8 ± 12.9 years) who received STTA in participating centres between April 2013 and July 2017.

Results

IOP elevation was observed in 206 eyes (14.7%) and IOP increase ≥ 6 mmHg was found in 328 eyes (23.3%). In total, 106 eyes (7.5%) needed medication and two eyes (0.14%) needed surgical procedures. Younger age, higher baseline IOP, and steroid dose were risk factors associated with IOP elevation. Risk factors associated with IOP increase ≥ 6 mmHg were younger age, lower baseline IOP, steroid dose, and higher incidences of diabetic macular oedema (DME) and uveitis. In contrast, with steroid dose fixed at 20 mg, a lower incidence of DME was a risk factor for increased IOP, suggesting that STTA had dose-dependent effects on IOP increase, especially in patients with DME.

Conclusion

Our real-world evidence from a large sample of Japanese patients who received STTA showed that the incidence of IOP elevation after STTA was 14.7%, and was associated with younger age, higher baseline IOP, and steroid dose. Thus, IOP should be monitored, especially in patients with younger age, higher baseline IOP, and higher incidences of DME and uveitis.

Klíčová slova:

Eye diseases – Eyes – Glaucoma – Medical risk factors – Ophthalmic procedures – Steroids – Surgical and invasive medical procedures – Uveitis


Zdroje

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