Measuring affect-related cognitive bias: Do mice in opposite affective states react differently to negative and positive stimuli?

Autoři: Anna C. Trevarthen aff001;  Sarah Kappel aff002;  Claire Roberts aff001;  Emily M. Finnegan aff001;  Elizabeth S. Paul aff001;  Isaac Planas-Sitjà aff003;  Michael T. Mendl aff001;  Carole Fureix aff002
Působiště autorů: Bristol Veterinary School, University of Bristol, Bristol, United Kingdom aff001;  School of Biological & Marine Science, University of Plymouth, Plymouth, Devon, United Kingdom aff002;  Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, Tokyo, Japan aff003
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
prolekare.web.journal.doi_sk: 10.1371/journal.pone.0226438


Affect-driven cognitive biases can be used as an indicator of affective (emotional) state. Since humans in negative affective states demonstrate greater responses to negatively-valenced stimuli, we investigated putative affect-related bias in mice by monitoring their response to unexpected, task-irrelevant stimuli of different valence. Thirty-one C57BL/6J and 31 DBA/2J females were individually trained to return to their home-cage in a runway. Mice then underwent an affective manipulation acutely inducing a negative (NegAff) or a comparatively less negative (CompLessNeg) affective state before immediately being tested in the runway with either an ‘attractive’ (familiar food) or ‘threatening’ (flashing light) stimulus. Mice were subsequently trained and tested again (same affective manipulation) with the alternative stimulus. As predicted, mice were slower to approach the light and spent more time with the food. DBA/2J mice were slower than C57BL/6J overall. Contrary to predictions, NegAff mice tended to approach both stimuli more readily than CompLessNeg mice, especially the light, and even more so for DBA/2Js. Although the stimuli successfully differentiated the response of mice to unexpected, task-irrelevant stimuli, further refinement may be required to disentangle the effects of affect manipulation and arousal on the response to valenced stimuli. The results also highlight the significant importance of considering strain differences when developing cognitive tasks.

Klíčová slova:

Animal behavior – Animal cognition – Animal welfare – Attention – Behavior – Emotions – Food consumption – Mice


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