Viral load testing among women on ‘option B+’ in Mazowe, Zimbabwe: How well are we doing?

Autoři: Justice Nyakura aff001;  Hemant Deepak Shewade aff002;  Serge Ade aff002;  Angela Mushavi aff001;  Solomon Huruva Mukungunugwa aff001;  Anesu Chimwaza aff001;  Philip Owiti aff002;  Mbazi Senkoro aff007;  Owen Mugurungi aff001
Působiště autorů: AIDS and TB Unit, Ministry of Health and Child Care, Harare, Zimbabwe aff001;  International Union Against Tuberculosis and Lung Disease (The Union), Paris, France aff002;  The Union South-East Asia, New Delhi, India aff003;  Karuna Trust, Bengaluru, Karnataka, India aff004;  Faculté de Médecine, Université de Parakou, Parakou, Benin aff005;  National Tuberculosis, Leprosy and Lung Disease Programme, Nairobi, Kenya aff006;  National Institute for Medical Research- Muhimbili Medical Research Centre, Dar es Salaam, Tanzania aff007
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
prolekare.web.journal.doi_sk: 10.1371/journal.pone.0225476



Globally, ten percent of new HIV infections are among children and most of these children acquire infection through mother-to-child transmission. To prevent this, lifelong ART among pregnant and breast feeding (PBF) women living with HIV, irrespective of the WHO clinical stage, was adopted (option B+). There is limited cohort-wise assessment of VL testing among women on ‘option B+’.


Among a pregnancy cohort on antiretroviral therapy in public hospitals and clinics of Mazowe district, Zimbabwe (2017), to determine the i) proportion undergoing VL testing anytime up to six months post child birth and associated factors; ii) turnaround time (TAT) from sending the specimen to results receipt and VL suppression among those undergoing VL testing.


This was a cohort study involving secondary programme data. Modified Poisson regression using robust variance estimates was used to determine the independent predictors of VL testing.


Of 1112 women, 354 (31.8%, 95% CI: 29.2–34.6) underwent VL testing: 113 (31.9%) during pregnancy, 124 (35%) within six months of child birth and for 117 (33.1%), testing period was unknown. Of 354, VL suppression was seen in 334 (94.4%) and 13 out of 20 with VL non-suppression underwent repeat VL testing. Among those with available dates (125/354), the median TAT was 93 days (IQR 19.3–255). Of 1112, VL results were available between 32 weeks and child birth in 31 (2.8%) women. When compared to hospitals, women registered for antenatal care in clinics were 36% less likely to undergo VL testing [aRR: 0.64 (95% CI: 0.53, 0.76)].


Among women on option B+, the uptake of HIV VL testing was low with unacceptably long TAT. VL suppression among those tested was satisfactory. There is an urgent need to prioritize VL testing among PBF women and to consider use of point of care machines. There is a critical need to strengthen the recording and local utilisation of routine clinic data in order to successfully monitor progress of healthcare services provided.

Klíčová slova:

anémia – Antenatal care – Pregnancy – Viral load – Zimbabwe


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Článok vyšiel v časopise


2019 Číslo 12