Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells


Autoři: Qingtai Su aff001;  Aurélie Bouteau aff001;  Jacob Cardenas aff003;  Balaji Uthra aff003;  Yuanyaun Wang aff003;  Cynthia Smitherman aff003;  Jinghua Gu aff003;  Botond Z. Igyártó aff001
Působiště autorů: Baylor Scott & White Research Institute, Baylor Institute for Immunology Research, Dallas, Texas, United States of America aff001;  Baylor University, Institute of Biomedical Studies, Waco, Texas, United States of America aff002;  Baylor Scott & White Research Institute, Dallas, Texas, United States of America aff003;  Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, Pennsylvania, United States of America aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
prolekare.web.journal.doi_sk: 10.1371/journal.pone.0223397

Souhrn

Tissue-resident and infiltrating immune cells are continuously exposed to molecules derived from the local cells that often come in form of secreted factors, such as cytokines. These factors are known to impact the immune cells’ biology. However, very little is known about whether the tissue resident immune cells in return also affect the local environment. In this study, with the help of RNA-sequencing, we show for the first time that long-term absence of epidermal resident Langerhans cells led to significant gene expression changes in the local keratinocytes and resident dendritic epidermal T cells. Thus, immune cells might play an active role in maintaining tissue homeostasis, which should be taken in consideration at data interpretation.

Klíčová slova:

Cytokines – Gene expression – Gene ontologies – Homeostasis – Immune cells – Principal component analysis – RNA sequencing – Sequence alignment


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