The Formation of Endoderm-Derived Taste Sensory Organs Requires a -Dependent Expansion of Embryonic Taste Bud Progenitor Cells

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Gustatory perception is an evolutionary ancient sense, and the ability to discriminate toxic and digestible substances is vitally important for all organisms. In mammals, taste perception occurs in taste buds, groups of sensory cells that are housed in various types of taste papillae in the oral cavity. Little is known about the genetic and developmental programs that underlie the different architectures of these papillae. Using mouse models, we identified the transcription factor Pax9 as a major determinant for the development of endoderm-derived taste papillae, which develop in different locations in the back of the oral cavity. In these papillae, Pax9 regulates the expansion of the taste progenitor field, maintains the competence of these progenitors to interact with afferent nerve fibers of the glossopharyngeal nerve, and prevents their differentiation towards epidermal-like epithelial cells. In contrast, Pax9 is not required for the development of ectoderm-derived taste papillae that are distributed over the dorsum of the tongue. Our data reveal that mammals have evolved a specific developmental program to generate taste buds and associated papilla structures in different parts of the oral cavity.

Vyšlo v časopise: The Formation of Endoderm-Derived Taste Sensory Organs Requires a -Dependent Expansion of Embryonic Taste Bud Progenitor Cells. PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004709
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004709

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