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It's All in Your Mind: Determining Germ Cell Fate by Neuronal IRE-1 in


Cells in the C.
elegans germline undergo programmed cell death as part of the normal developmental program and in response to various stresses. Here, we discovered that more germ cells undergo programmed cell death under stress conditions associated with the accumulation of misfolded proteins in the endoplasmic reticulum, a cellular organelle responsible for protein folding and trafficking. Surprisingly, we found that germ cell death is a consequence of stress in neurons rather than in the germ cells themselves. This implies that germ cell death under ER stress conditions is regulated at the organismal level and implicates signaling between tissues.


Vyšlo v časopise: It's All in Your Mind: Determining Germ Cell Fate by Neuronal IRE-1 in. PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004747
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004747

Souhrn

Cells in the C.
elegans germline undergo programmed cell death as part of the normal developmental program and in response to various stresses. Here, we discovered that more germ cells undergo programmed cell death under stress conditions associated with the accumulation of misfolded proteins in the endoplasmic reticulum, a cellular organelle responsible for protein folding and trafficking. Surprisingly, we found that germ cell death is a consequence of stress in neurons rather than in the germ cells themselves. This implies that germ cell death under ER stress conditions is regulated at the organismal level and implicates signaling between tissues.


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