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Germline Mutations in Are Associated with Familial Gastric Cancer
The underlying genetic mutations involved in 60% of inherited gastric cancer cases remain unknown. Here we present a large, extended pedigree with familial gastric cancer and an association in part of the family with a mutation in MAP3K6. The conservation, predicted pathogenicity of the variant, tissue distribution, and known function of MAP3K6 made this a strong candidate that warranted further investigation. Examination of an additional 115 unrelated probands identified additional mutations in MAP3K6, including a truncating mutation.
Vyšlo v časopise: Germline Mutations in Are Associated with Familial Gastric Cancer. PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004669
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004669Souhrn
The underlying genetic mutations involved in 60% of inherited gastric cancer cases remain unknown. Here we present a large, extended pedigree with familial gastric cancer and an association in part of the family with a mutation in MAP3K6. The conservation, predicted pathogenicity of the variant, tissue distribution, and known function of MAP3K6 made this a strong candidate that warranted further investigation. Examination of an additional 115 unrelated probands identified additional mutations in MAP3K6, including a truncating mutation.
Zdroje
1. FerlayJ, ShinH-R, BrayF, FormanD, MathersC, et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. 127 : 2893–2917 doi:10.1002/ijc.25516
2. WadhwaR, SongS, LeeJ-S, YaoY, WeiQ, et al. (2013) Gastric cancer-molecular and clinical dimensions. Nat Rev Clin Oncol 10 : 643–655 doi:10.1038/nrclinonc.2013.170
3. LaurenP (1965) The two histological main types of gastric carcinoma, an attempt at a histoclinical classification. Acta Pathol Microbiol Scand 64 : 31–49.
4. ParkinDM (2006) The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118 : 3030–3044 doi:10.1002/ijc.21731
5. OliveiraC, SerucaR, CarneiroF (2009) Hereditary gastric cancer. 23 : 147–157 doi:10.1016/j.bpg.2009.02.003
6. GuilfordP, HopkinsJ, HarrawayJ, McLeodM, McLeodN, et al. (1998) E-cadherin germline mutations in familial gastric cancer. Nature 392 : 402–405 doi:10.1038/32918
7. FitzgeraldRC, HardwickR, HuntsmanD, CarneiroF, GuilfordP, et al. (2010) Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. J Med Genet 47 : 436–444 doi:10.1136/jmg.2009.074237
8. ParkJ-G, YangH-K, KimWH, CaldasC, YokotaJ, et al. (2000) Report on the first meeting of the International Collaborative Group on Hereditary Gastric Cancer. J Natl Cancer Inst 92 : 1781–1782 doi:10.1093/jnci/92.21.1781
9. OliveiraC, SenzJ, KaurahP, PinheiroH, SangesR, et al. (2009) Germline CDH1 deletions in hereditary diffuse gastric cancer families. Hum Mol Genet 18 : 1545–1555 doi:10.1093/hmg/ddp046
10. IriyamaT, TakedaK, NakamuraH, MorimotoY, KuroiwaT, et al. (2009) ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. The EMBO Journal 28 : 843–853 doi:10.1038/emboj.2009.32
11. ZangZJ, OngCK, CutcutacheI, YuW, ZhangSL, et al. (2011) Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. Cancer Res 71 : 29–39 doi:10.1158/0008-5472.CAN-10-1749
12. AbecasisGR, ChernySS, CooksonWO, CardonLR (2002) Merlin–rapid analysis of dense genetic maps using sparse gene flow trees. Nature Genetics 30 : 97–101 doi:10.1038/ng786
13. ForbesSA, BindalN, BamfordS, ColeC, KokCY, et al. (2011) COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res 39: D945–D950 doi:10.1093/nar/gkq929
14. TakedaK, ShimozonoR, NoguchiT, UmedaT, MorimotoY, et al. (2007) Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. Journal of Biological Chemistry 282 : 7522–7531 doi:10.1074/jbc.M607177200
15. EtoN, MiyagishiM, InagiR, FujitaT, NangakuM (2009) Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. Am J Pathol 174 : 1553–1563 doi:10.2353/ajpath.2009.080190
16. BaylinSB, EstellerM, RountreeMR, BachmanKE, SchuebelK, et al. (2001) Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genet 10 : 687–692 doi:10.1093/hmg/10.7.687
17. ChoiMR, InY-H, ParkJ, ParkT, JungKH, et al. (2012) Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture. Exp Mol Med 44 : 503 doi:10.3858/emm.2012.44.8.057
18. TakaiD, JonesPA (2003) The CpG island searcher: a new WWW resource. In silico biology 3 : 235–240.
19. KumarS, SanderfordM, GrayVE, YeJ, LiuL (2012) Evolutionary diagnosis method for variants in personal exomes. Nat Methods 9 : 855–856 doi:10.1038/nmeth.2147
20. AdzhubeiIA, SchmidtS, PeshkinL, RamenskyVE, GerasimovaA, et al. (2010) A method and server for predicting damaging missense mutations. Nat Methods 7 : 248–249 doi:10.1038/nmeth0410-248
21. NgPC, HenikoffS (2003) SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res 31 : 3812–3814 doi:10.1093/nar/gkg509
22. KulisM, QueirósAC, BeekmanR, Martín-SuberoJI (2013) Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829 : 1161–1174 doi:10.1016/j.bbagrm.2013.08.001
23. HayakawaY, HirataY, NakagawaH (2011) Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer Vol. 108. 780–785 doi:10.1073/pnas.1011418108/-/DCSupplemental
24. GreenmanC, StephensP, SmithR, DalglieshGL, HunterC, et al. (2007) Patterns of somatic mutation in human cancer genomes. Nature 446 : 153–158 doi:10.1038/nature05610
25. SjöblomT, JonesS, WoodLD, ParsonsDW, LinJ, et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314 : 268–274 doi:10.1126/science.1133427
26. LubbeSJ, Di BernardoMC, ChandlerIP, HoulstonRS (2009) Clinical implications of the colorectal cancer risk associated with MUTYH mutation. Journal of Clinical Oncology 27 : 3975–3980 doi:10.1200/JCO.2008.21.6853
27. ClearySP, CotterchioM, JenkinsMA, KimH, BristowR, et al. (2009) Germline MutY Human Homologue Mutations and Colorectal Cancer: A Multisite Case-Control Study. Gastroenterology 136 : 1251–1260 doi:10.1053/j.gastro.2008.12.050
28. TheodoratouE, CampbellH, TenesaA, HoulstonR, WebbE, et al. (2010) A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants. Br J Cancer 103 : 1875–1884 doi:10.1038/sj.bjc.6605966
29. SiemiatkowskaAM, Schuurs-HoeijmakersJHM, BoschDGM, BoonstraFN, RiemslagFCC, et al. (2014) Nonpenetrance of the Most Frequent Autosomal Recessive Leber Congenital Amaurosis Mutation in NMNAT1. JAMA Ophthalmol 132 : 1002–4 doi:10.1001/jamaophthalmol.2014.983
30. Baradaran-HeraviA, ChoKS, TolhuisB, SanyalM, MorozovaO, et al. (2012) Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. Hum Mol Genet 21 : 2572–2587 doi:10.1093/hmg/dds083
31. Estrada-CuzcanoA, KoenekoopRK, SenechalA, De BaereEBW, de RavelT, et al. (2012) BBS1 Mutations in a Wide Spectrum of Phenotypes Ranging From Nonsyndromic Retinitis Pigmentosa to Bardet-Biedl Syndrome. Arch Ophthalmol 130 : 1425–1432 doi:10.1001/archophthalmol.2012.2434
32. BealesPL, BadanoJL, RossAJ, AnsleySJ (2003) Genetic Interaction of BBS1 Mutations with Alleles at Other BBS Loci Can Result in Non-Mendelian Bardet-Biedl Syndrome. Am J Hum Gen doi:10.1086/375178
33. OrtnerE, MoellingK (2007) Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced signaling. Biochemical and Biophysical Research Communications 362 : 454–459 doi:10.1016/j.bbrc.2007.08.006
34. van ZantenSJOV, PollakPT, BestLM, BezansonGS, MarrieT (1994) Increasing Prevalence of Helicobacter pylori Infection with Age: Continuous Risk of Infection in Adults Rather than Cohort Effect. J Infect Dis 169 : 434–437 doi:10.1093/infdis/169.2.434
35. GoodmanKJ, JacobsonK, Veldhuyzen van ZantenS (2008) Helicobacter pylori infection in Canadian and related Arctic Aboriginal populations. Can J Gastroenterol 22 : 289–295.
36. SinghO, ShillingsA, CraggsP, WallI, RowlandP, et al. (2013) Crystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug design. Protein Science 22 : 1071–1077 doi:10.1002/pro.2298
37. JinL, LiD, LeeJS, ElfS, AlesiGN, et al. (2013) p90 RSK2 Mediates Antianoikis Signals by both Transcription-Dependent and-Independent Mechanisms. … and cellular biology. doi:10.1128/MCB.01677-12
38. CaiD-T, JinH, XiongQ-X, LiuW-G, GaoZ-G, et al. (2013) ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells. Mol Cell Biochem 379 : 161–169 doi:10.1007/s11010-013-1638-2
39. HayakawaR, HayakawaT, TakedaK (2012) Therapeutic targets in the ASK1-dependent stress signaling pathways Vol. 88. 434–453 doi:10.2183/pjab.88.434
40. HuangQ, SheteS, AmosCI (2004) Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis. Am J Hum Gen 75 : 1106–1112 doi:10.1086/426000
41. PurcellS, NealeB, Todd-BrownK, ThomasL, FerreiraMAR, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Gen 81 : 559–575 doi:10.1086/519795
42. WhittemoreAS, HalpernJ (1994) A class of tests for linkage using affected pedigree members. Biometrics 50 : 118–127.
43. KongA, CoxNJ (1997) Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Gen 61 : 1179–1188 doi:10.1086/301592
44. International HapMap 3 Consortium (2010) AltshulerDM, GibbsRA, PeltonenL, DermitzakisE, et al. (2010) Integrating common and rare genetic variation in diverse human populations. Nature 467 : 52–58 doi:10.1038/nature09298
45. AlfaresA, NunezLD, Al-ThihliK, MitchellJ, MelançonS, et al. (2011) Combined malonic and methylmalonic aciduria: exome sequencing reveals mutations in the ACSF3 gene in patients with a non-classic phenotype. 48 : 602–605 doi:10.1136/jmedgenet-2011-100230
46. LiH, DurbinR (2009) Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25 : 1754–1760 doi:10.1093/bioinformatics/btp324
47. McKennaA, HannaM, BanksE, SivachenkoA, CibulskisK, et al. (2010) The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Research 20 : 1297–1303 doi:10.1101/gr.107524.110
48. CingolaniP, PlattsA, WangLL, CoonM, NguyenT, et al. (2012) A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin) 6 : 80–92 doi:10.4161/fly.19695
49. PailaU, KirchnerR, ChapmanBA, QuinlanAR (2013) GEMINI: integrative exploration of genetic variation and genome annotations. PLoS Comput Biol 9: e1003153 doi:10.1371/journal.pcbi.1003153
50. SherryST, WardMH, KholodovM, BakerJ, PhanL, et al. (2001) dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 29 : 308–311 doi:10.1093/nar/29.1.308
51. The 1000 Genomes Project Consortium (2010) A map of human genome variation from population-scale sequencing. Nature 467 : 1061–1073 doi:10.1038/nature09534
52. Ferrer-CostaC, GelpíJL, ZamakolaL, ParragaI, la Cruz deX, et al. (2005) PMUT: a web-based tool for the annotation of pathological mutations on proteins. Bioinformatics 21 : 3176–3178 doi:10.1093/bioinformatics/bti486
53. AdzhubeiI, JordanDM, SunyaevSR (2013) Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protoc Hum Genet Chapter 7: Unit7.20–7.20.41 doi:10.1002/0471142905.hg0720s76
54. ChoiY, SimsGE, MurphyS, MillerJR, ChanAP (2012) Predicting the functional effect of amino acid substitutions and indels. 7: e46688 doi:10.1371/journal.pone.0046688
55. SchwarzJM, RödelspergerC, SchuelkeM, SeelowD (2010) MutationTaster evaluates disease-causing potential of sequence alterations. Nat Methods 7 : 575–576 doi:10.1038/nmeth0810-575
56. ShihabHA, GoughJ, CooperDN, StensonPD, BarkerGLA, et al. (2013) Predicting the Functional, Molecular, and Phenotypic Consequences of Amino Acid Substitutions using Hidden Markov Models. Hum Mutat 34 : 57–65 doi:10.1002/humu.22225
57. ShihabHA, GoughJ, CooperDN, DayINM, GauntTR (2013) Predicting the functional consequences of cancer-associated amino acid substitutions. Bioinformatics 29 : 1504–1510 doi:10.1093/bioinformatics/btt182
Štítky
Genetika Reprodukčná medicína
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