Reactive oxygen species are essential signaling molecules within the cell. However, when levels of these reactive intermediates become too high (oxidative stress), they cause significant damage to proteins and DNA. It is therefore vitally important to understand how cells regulate genes required to limit oxidative stress. Here we describe a new role for the transcription co-factor KDM5 as an activator of genes that prevent oxidative stress. KDM5 activates these genes by interacting with the transcription factor Foxo and affecting its ability to be recruited to target promoters. Our data provide new insights into the mechanisms by which redox state is regulated, and into the multiple means by which KDM5 regulates gene expression.
Vyšlo v časopise: KDM5 Interacts with Foxo to Modulate Cellular Levels of Oxidative Stress. PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004676 Kategorie: Research Article prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004676
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