Functional Diversification of Motor Neuron-specific Enhancers during Evolution

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During evolution, motor neurons became specialized to control movements of different body parts including head, trunk and limbs. Here we report that two enhancers of Isl1, E1 and E2, are active together with transcription factors in motor neurons. Surprisingly, E1 and its response to transcription factors has been conserved in evolution from the lamprey to man, whereas E2 is only found in animals with limbs. Our study provides an evolutionary example of how functional diversification of motor neurons is achieved by a dynamic interplay between enhancers and transcription factors.

Vyšlo v časopise: Functional Diversification of Motor Neuron-specific Enhancers during Evolution. PLoS Genet 11(10): e32767. doi:10.1371/journal.pgen.1005560
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005560

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