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Inter-population Differences in Retrogene Loss and Expression in Humans


Many retrogenes, long considered to be genomic “junk”, were recently revealed as vitally important. Retroposition plays an important role in shaping differences between species, populations and individuals. Variation may result either from new retroposition events and/or retrocopy loss, as well as from differences in retrocopy expression. Genome analysis of 1092 individuals from various populations and transcriptomes from 50 individuals, revealed differences between populations in the frequency of transcriptionally active ancient retrocopy loss, as well as differences in retrocopy expression levels. Overall, these results provide new insights into the genomic events of inter-population variation, which has not been evaluated much with respect to gene loss.


Vyšlo v časopise: Inter-population Differences in Retrogene Loss and Expression in Humans. PLoS Genet 11(10): e32767. doi:10.1371/journal.pgen.1005579
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005579

Souhrn

Many retrogenes, long considered to be genomic “junk”, were recently revealed as vitally important. Retroposition plays an important role in shaping differences between species, populations and individuals. Variation may result either from new retroposition events and/or retrocopy loss, as well as from differences in retrocopy expression. Genome analysis of 1092 individuals from various populations and transcriptomes from 50 individuals, revealed differences between populations in the frequency of transcriptionally active ancient retrocopy loss, as well as differences in retrocopy expression levels. Overall, these results provide new insights into the genomic events of inter-population variation, which has not been evaluated much with respect to gene loss.


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