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Modulation of Ambient Temperature-Dependent Flowering in by Natural Variation of
Plants control their flowering time in response to the temperatures of their environment, e.g. in response to the experience of winter or in response to cold and warm ambient temperatures experienced during spring. The knowledge about the evolutionary adaptation of plants to changing ambient temperatures is at present very limited. Understanding the latter is, however, becoming increasingly important due to the temperature changes associated with global warming and the anticipated changes in flowering time in ecosystems and agricultural systems. Here, we uncover an evolutionarily conserved molecular mechanism employed by Arabidopsis thaliana ecotypes for the adaptation of flowering time to cool temperatures. This structural change in the architecture of the gene FLOWERING LOCUS M can be found in multiple A. thaliana natural accessions and the knowledge gained in our study may be used to predict or modify flowering time in plants related to A. thaliana in the future.
Vyšlo v časopise: Modulation of Ambient Temperature-Dependent Flowering in by Natural Variation of. PLoS Genet 11(10): e32767. doi:10.1371/journal.pgen.1005588
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005588Souhrn
Plants control their flowering time in response to the temperatures of their environment, e.g. in response to the experience of winter or in response to cold and warm ambient temperatures experienced during spring. The knowledge about the evolutionary adaptation of plants to changing ambient temperatures is at present very limited. Understanding the latter is, however, becoming increasingly important due to the temperature changes associated with global warming and the anticipated changes in flowering time in ecosystems and agricultural systems. Here, we uncover an evolutionarily conserved molecular mechanism employed by Arabidopsis thaliana ecotypes for the adaptation of flowering time to cool temperatures. This structural change in the architecture of the gene FLOWERING LOCUS M can be found in multiple A. thaliana natural accessions and the knowledge gained in our study may be used to predict or modify flowering time in plants related to A. thaliana in the future.
Zdroje
1. Andres F, Coupland G. The genetic basis of flowering responses to seasonal cues. Nat Rev Genet. 2012;13(9):627–39. Epub 2012/08/18. doi: 10.1038/nrg3291 22898651
2. Song J, Irwin J, Dean C. Remembering the prolonged cold of winter. Curr Biol. 2013;23(17):R807–11. Epub 2013/09/14. doi: 10.1016/j.cub.2013.07.027 24028964
3. Kumar SV, Wigge PA. H2A.Z-containing nucleosomes mediate the thermosensory response in Arabidopsis. Cell. 2010;140(1):136–47. Epub 2010/01/19. doi: 10.1016/j.cell.2009.11.006 20079334
4. Balasubramanian S, Weigel D. Temperature Induced Flowering in Arabidopsis thaliana. Plant Signal Behav. 2006;1(5):227–8. Epub 2006/09/01. 19704664
5. Wigge PA. Ambient temperature signalling in plants. Curr Opin Plant Biol. 2013;16(5):661–6. Epub 2013/09/12. doi: 10.1016/j.pbi.2013.08.004 24021869
6. Michaels SD, Amasino RM. FLOWERING LOCUS C encodes a novel MADS domain protein that acts as a repressor of flowering. Plant Cell. 1999;11(5):949–56. Epub 1999/05/20. 10330478
7. Michaels SD, Amasino RM. Loss of FLOWERING LOCUS C activity eliminates the late-flowering phenotype of FRIGIDA and autonomous pathway mutations but not responsiveness to vernalization. Plant Cell. 2001;13(4):935–41. Epub 2001/04/03. 11283346
8. Johanson U, West J, Lister C, Michaels S, Amasino R, Dean C. Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering time. Science. 2000;290(5490):344–7. Epub 2000/10/13. 11030654
9. Song J, Angel A, Howard M, Dean C. Vernalization—a cold-induced epigenetic switch. J Cell Sci. 2012;125(Pt 16):3723–31. Epub 2012/09/01.
10. Distelfeld A, Li C, Dubcovsky J. Regulation of flowering in temperate cereals. Curr Opin Plant Biol. 2009;12(2):178–84. Epub 2009/02/07. doi: 10.1016/j.pbi.2008.12.010 19195924
11. Trevaskis B, Hemming MN, Dennis ES, Peacock WJ. The molecular basis of vernalization-induced flowering in cereals. Trends in plant science. 2007;12(8):352–7. Epub 2007/07/17. 17629542
12. Lempe J, Balasubramanian S, Sureshkumar S, Singh A, Schmid M, Weigel D. Diversity of flowering responses in wild Arabidopsis thaliana strains. PLoS Genet. 2005;1(1):109–18. Epub 2005/08/17. 16103920
13. Strange A, Li P, Lister C, Anderson J, Warthmann N, Shindo C, et al. Major-effect alleles at relatively few loci underlie distinct vernalization and flowering variation in Arabidopsis accessions. PLoS One. 2011;6(5):e19949. Epub 2011/06/01. doi: 10.1371/journal.pone.0019949 21625501
14. Verhage L, Angenent GC, Immink RG. Research on floral timing by ambient temperature comes into blossom. Trends in plant science. 2014;19(9):583–91. Epub 2014/05/02. doi: 10.1016/j.tplants.2014.03.009 24780095
15. Capovilla G, Schmid M, Pose D. Control of flowering by ambient temperature. J Exp Bot. 2015;66(1):59–69. Epub 2014/10/19. doi: 10.1093/jxb/eru416 25326628
16. Werner JD, Borevitz JO, Warthmann N, Trainer GT, Ecker JR, Chory J, et al. Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for natural flowering-time variation. Proc Natl Acad Sci U S A. 2005;102(7):2460–5. Epub 2005/02/08. 15695584
17. Balasubramanian S, Sureshkumar S, Lempe J, Weigel D. Potent induction of Arabidopsis thaliana flowering by elevated growth temperature. PLoS Genet. 2006;2(7):e106. Epub 2006/07/15. 16839183
18. Scortecci KC, Michaels SD, Amasino RM. Identification of a MADS-box gene, FLOWERING LOCUS M, that represses flowering. Plant J. 2001;26(2):229–36. Epub 2001/06/08. 11389763
19. Pose D, Verhage L, Ott F, Yant L, Mathieu J, Angenent GC, et al. Temperature-dependent regulation of flowering by antagonistic FLM variants. Nature. 2013;503(7476):414–7. Epub 2013/09/27. doi: 10.1038/nature12633 24067612
20. Lee JH, Ryu HS, Chung KS, Pose D, Kim S, Schmid M, et al. Regulation of temperature-responsive flowering by MADS-box transcription factor repressors. Science. 2013;342(6158):628–32. Epub 2013/09/14. doi: 10.1126/science.1241097 24030492
21. Gu X, Le C, Wang Y, Li Z, Jiang D, He Y. Arabidopsis FLC clade members form flowering-repressor complexes coordinating responses to endogenous and environmental cues. Nat Commun. 2013;4 : 1947. Epub 2013/06/19. doi: 10.1038/ncomms2947 23770815
22. Wheeler T, von Braun J. Climate change impacts on global food security. Science. 2013;341(6145):508–13. Epub 2013/08/03. doi: 10.1126/science.1239402 23908229
23. Moore FC, Lobell DB. The fingerprint of climate trends on European crop yields. Proc Natl Acad Sci U S A. 2015;112(9):2670–5. Epub 2015/02/19. doi: 10.1073/pnas.1409606112 25691735
24. Mora C, Caldwell IR, Caldwell JM, Fisher MR, Genco BM, Running SW. Suitable Days for Plant Growth Disappear under Projected Climate Change: Potential Human and Biotic Vulnerability. PLoS Biol. 2015;13(6):e1002167. Epub 2015/06/11. doi: 10.1371/journal.pbio.1002167 26061091
25. Thuiller W, Lavorel S, Araujo MB, Sykes MT, Prentice IC. Climate change threats to plant diversity in Europe. Proc Natl Acad Sci U S A. 2005;102(23):8245–50. Epub 2005/05/28. 15919825
26. Werner JD, Borevitz JO, Uhlenhaut NH, Ecker JR, Chory J, Weigel D. FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. Genetics. 2005;170(3):1197–207. Epub 2005/05/25. 15911588
27. Weigel D. Natural variation in Arabidopsis: from molecular genetics to ecological genomics. Plant Physiol. 2012;158(1):2–22. Epub 2011/12/08. doi: 10.1104/pp.111.189845 22147517
28. Tsuchiya T, Eulgem T. An alternative polyadenylation mechanism coopted to the Arabidopsis RPP7 gene through intronic retrotransposon domestication. Proc Natl Acad Sci U S A. 2013;110(37):E3535–43. Epub 2013/08/14. doi: 10.1073/pnas.1312545110 23940361
29. Wu X, Liu M, Downie B, Liang C, Ji G, Li QQ, et al. Genome-wide landscape of polyadenylation in Arabidopsis provides evidence for extensive alternative polyadenylation. Proc Natl Acad Sci U S A. 2011;108(30):12533–8. Epub 2011/07/13. doi: 10.1073/pnas.1019732108 21746925
30. Duc C, Sherstnev A, Cole C, Barton GJ, Simpson GG. Transcription termination and chimeric RNA formation controlled by Arabidopsis thaliana FPA. PLoS Genet. 2013;9(10):e1003867. Epub 2013/11/10. doi: 10.1371/journal.pgen.1003867 24204292
31. Lewis BP, Green RE, Brenner SE. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc Natl Acad Sci U S A. 2003;100(1):189–92. Epub 2002/12/28. 12502788
32. Kalyna M, Simpson CG, Syed NH, Lewandowska D, Marquez Y, Kusenda B, et al. Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis. Nucleic Acids Res. 2012;40(6):2454–69. Epub 2011/12/01. doi: 10.1093/nar/gkr932 22127866
33. Hori K, Watanabe Y. UPF3 suppresses aberrant spliced mRNA in Arabidopsis. Plant J. 2005;43(4):530–40. Epub 2005/08/16. 16098107
34. Li Y, Huang Y, Bergelson J, Nordborg M, Borevitz JO. Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2010;107(49):21199–204. Epub 2010/11/17. doi: 10.1073/pnas.1007431107 21078970
35. Ossowski S, Schneeberger K, Lucas-Lledo JI, Warthmann N, Clark RM, Shaw RG, et al. The rate and molecular spectrum of spontaneous mutations in Arabidopsis thaliana. Science. 2010;327(5961):92–4. Epub 2010/01/02. doi: 10.1126/science.1180677 20044577
36. Schultz ST, Lynch M, Willis JH. Spontaneous deleterious mutation in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 1999;96(20):11393–8. Epub 1999/09/29. 10500187
37. Atwell S, Huang YS, Vilhjalmsson BJ, Willems G, Horton M, Li Y, et al. Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature. 2010;465(7298):627–31. Epub 2010/03/26. doi: 10.1038/nature08800 20336072
38. Hong RL, Hamaguchi L, Busch MA, Weigel D. Regulatory elements of the floral homeotic gene AGAMOUS identified by phylogenetic footprinting and shadowing. Plant Cell. 2003;15(6):1296–309. Epub 2003/06/05. 12782724
39. Schauer SE, Schluter PM, Baskar R, Gheyselinck J, Bolanos A, Curtis MD, et al. Intronic regulatory elements determine the divergent expression patterns of AGAMOUS-LIKE6 subfamily members in Arabidopsis. Plant J. 2009;59(6):987–1000. Epub 2009/05/29. doi: 10.1111/j.1365-313X.2009.03928.x 19473325
40. Yoo SK, Wu X, Lee JS, Ahn JH. AGAMOUS-LIKE 6 is a floral promoter that negatively regulates the FLC/MAF clade genes and positively regulates FT in Arabidopsis. Plant J. 2011;65(1):62–76. Epub 2010/12/24. doi: 10.1111/j.1365-313X.2010.04402.x 21175890
41. Coustham V, Li P, Strange A, Lister C, Song J, Dean C. Quantitative modulation of polycomb silencing underlies natural variation in vernalization. Science. 2012;337(6094):584–7. Epub 2012/07/17. doi: 10.1126/science.1221881 22798408
42. Kleinboelting N, Huep G, Kloetgen A, Viehoever P, Weisshaar B. GABI-Kat SimpleSearch: new features of the Arabidopsis thaliana T-DNA mutant database. Nucleic Acids Res. 2012;40(Database issue):D1211–5. Epub 2011/11/15. doi: 10.1093/nar/gkr1047 22080561
43. Alonso JM, Stepanova AN, Leisse TJ, Kim CJ, Chen H, Shinn P, et al. Genome-wide insertional mutagenesis of Arabidopsis thaliana. Science. 2003;301(5633):653–7. Epub 2003/08/02. doi: 10.1126/science.1086391 12893945.
44. Kuromori T, Hirayama T, Kiyosue Y, Takabe H, Mizukado S, Sakurai T, et al. A collection of 11 800 single-copy Ds transposon insertion lines in Arabidopsis. Plant J. 2004;37(6):897–905. Epub 2004/03/05. 14996221
45. Lisch D. Epigenetic regulation of transposable elements in plants. Annu Rev Plant Biol. 2009;60 : 43–66. Epub 2008/11/15. doi: 10.1146/annurev.arplant.59.032607.092744 19007329
46. McCue AD, Slotkin RK. Transposable element small RNAs as regulators of gene expression. Trends Genet. 2012;28(12):616–23. Epub 2012/10/09. doi: 10.1016/j.tig.2012.09.001 23040327
47. Kinoshita T, Miura A, Choi Y, Kinoshita Y, Cao X, Jacobsen SE, et al. One-way control of FWA imprinting in Arabidopsis endosperm by DNA methylation. Science. 2004;303(5657):521–3. Epub 2003/11/25. 14631047
48. Lippman Z, Gendrel AV, Black M, Vaughn MW, Dedhia N, McCombie WR, et al. Role of transposable elements in heterochromatin and epigenetic control. Nature. 2004;430(6998):471–6. Epub 2004/07/23. 15269773
49. Michaels SD, He Y, Scortecci KC, Amasino RM. Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of summer-annual flowering behavior in Arabidopsis. Proc Natl Acad Sci U S A. 2003;100(17):10102–7. Epub 2003/08/09. 12904584
50. Caicedo AL, Stinchcombe JR, Olsen KM, Schmitt J, Purugganan MD. Epistatic interaction between Arabidopsis FRI and FLC flowering time genes generates a latitudinal cline in a life history trait. Proc Natl Acad Sci U S A. 2004;101(44):15670–5. Epub 2004/10/27. 15505218
51. He Y, Doyle MR, Amasino RM. PAF1-complex-mediated histone methylation of FLOWERING LOCUS C chromatin is required for the vernalization-responsive, winter-annual habit in Arabidopsis. Genes Dev. 2004;18(22):2774–84. Epub 2004/11/03. 15520273
52. Angel A, Song J, Dean C, Howard M. A Polycomb-based switch underlying quantitative epigenetic memory. Nature. 2011;476(7358):105–8. Epub 2011/07/26. doi: 10.1038/nature10241 21785438
53. Castaings L, Bergonzi S, Albani MC, Kemi U, Savolainen O, Coupland G. Evolutionary conservation of cold-induced antisense RNAs of FLOWERING LOCUS C in Arabidopsis thaliana perennial relatives. Nat Commun. 2014;5 : 4457. Epub 2014/07/18. doi: 10.1038/ncomms5457 25030056
54. Zhang X, Clarenz O, Cokus S, Bernatavichute YV, Pellegrini M, Goodrich J, et al. Whole-genome analysis of histone H3 lysine 27 trimethylation in Arabidopsis. PLoS Biol. 2007;5(5):e129. Epub 2007/04/19. 17439305
55. Mascarenhas D, Mettler IJ, Pierce DA, Lowe HW. Intron-mediated enhancement of heterologous gene expression in maize. Plant Mol Biol. 1990;15(6):913–20. Epub 1990/12/01. 2103480
56. Rose AB. Intron-mediated regulation of gene expression. Curr Top Microbiol Immunol. 2008;326 : 277–90. Epub 2008/07/18. 18630758
57. Sieburth LE, Meyerowitz EM. Molecular dissection of the AGAMOUS control region shows that cis elements for spatial regulation are located intragenically. Plant Cell. 1997;9(3):355–65. Epub 1997/03/01. 9090880
58. Sanchez-Bermajo E, Zhu W, Tasset C, Eimer H, Sureshkumar S, Singh R, et al. Genetic architecture of natural variation in thermal responses of Arabidopsis thaliana. Plant Physiol. 2015. Epub 2015/07/22.
59. Koornneef M, Alonso-Blanco C, Vreugdenhil D. Naturally occurring genetic variation in Arabidopsis thaliana. Annu Rev Plant Biol. 2004;55 : 141–72. Epub 2004/09/21.: doi: 10.1146/annurev.arplant.55.031903.141605 15377217.
60. Alonso-Blanco C, Aarts MG, Bentsink L, Keurentjes JJ, Reymond M, Vreugdenhil D, et al. What has natural variation taught us about plant development, physiology, and adaptation? Plant Cell. 2009;21(7):1877–96. Epub 2009/07/04. doi: 10.1105/tpc.109.068114 19574434
61. Gazzani S, Gendall AR, Lister C, Dean C. Analysis of the molecular basis of flowering time variation in Arabidopsis accessions. Plant Physiol. 2003;132(2):1107–14. Epub 2003/06/14. 12805638
62. Pacurar DI, Pacurar ML, Street N, Bussell JD, Pop TI, Gutierrez L, et al. A collection of INDEL markers for map-based cloning in seven Arabidopsis accessions. J Exp Bot. 2012;63(7):2491–501. Epub 2012/01/28. doi: 10.1093/jxb/err422 22282537
63. Untergasser A, Nijveen H, Rao X, Bisseling T, Geurts R, Leunissen JA. Primer3Plus, an enhanced web interface to Primer3. Nucleic Acids Res. 2007;35(Web Server issue):W71–4. Epub 2007/05/09. 17485472
64. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29(9):e45. Epub 2001/05/09. 11328886
65. Trapnell C, Salzberg SL. How to map billions of short reads onto genomes. Nat Biotechnol. 2009;27(5):455–7. doi: 10.1038/nbt0509-455 19430453
66. Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 2013;14(4):R36. doi: 10.1186/gb-2013-14-4-r36 23618408
67. Anders S, Pyl PT, Huber W. HTSeq—a Python framework to work with high-throughput sequencing data. Bioinformatics. 2015;31(2):166–9. Epub 2014/09/28. doi: 10.1093/bioinformatics/btu638 25260700
68. Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. Epub 2014/12/18. 25516281
69. Anders S, Reyes A, Huber W. Detecting differential usage of exons from RNA-seq data. Genome Res. 2012;22(10):2008–17. Epub 2012/06/23. doi: 10.1101/gr.133744.111 22722343
70. Hellens RP, Edwards EA, Leyland NR, Bean S, Mullineaux PM. pGreen: a versatile and flexible binary Ti vector for Agrobacterium-mediated plant transformation. Plant Mol Biol. 2000;42(6):819–32. Epub 2000/07/13. 10890530
71. Sawano A, Miyawaki A. Directed evolution of green fluorescent protein by a new versatile PCR strategy for site-directed and semi-random mutagenesis. Nucleic Acids Res. 2000;28(16):E78. Epub 2000/08/10. 10931937
72. Clough SJ, Bent AF. Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. Plant J. 1998;16(6):735–43. Epub 1999/03/09. 10069079
73. Schneeberger K, Ossowski S, Lanz C, Juul T, Petersen AH, Nielsen KL, et al. SHOREmap: simultaneous mapping and mutation identification by deep sequencing. Nat Methods. 2009;6(8):550–1. Epub 2009/08/01. doi: 10.1038/nmeth0809-550 19644454
74. Ossowski S, Schneeberger K, Clark RM, Lanz C, Warthmann N, Weigel D. Sequencing of natural strains of Arabidopsis thaliana with short reads. Genome Res. 2008;18(12):2024–33. Epub 2008/09/27. doi: 10.1101/gr.080200.108 18818371
75. Finn RD, Clements J, Eddy SR. HMMER web server: interactive sequence similarity searching. Nucleic Acids Res. 2011;39(Web Server issue):W29–37. Epub 2011/05/20. doi: 10.1093/nar/gkr367 21593126
76. Finn RD, Bateman A, Clements J, Coggill P, Eberhardt RY, Eddy SR, et al. Pfam: the protein families database. Nucleic Acids Res. 2014;42(Database issue):D222–30. Epub 2013/11/30. doi: 10.1093/nar/gkt1223 24288371
77. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol. 2011;28(10):2731–9. Epub 2011/05/07. doi: 10.1093/molbev/msr121 21546353
78. Scotto-Lavino E, Du G, Frohman MA. 3' end cDNA amplification using classic RACE. Nat Protoc. 2006;1(6):2742–5. Epub 2007/04/05. 17406530
79. Kaufmann K, Muino JM, Osteras M, Farinelli L, Krajewski P, Angenent GC. Chromatin immunoprecipitation (ChIP) of plant transcription factors followed by sequencing (ChIP-SEQ) or hybridization to whole genome arrays (ChIP-CHIP). Nat Protoc. 2010;5(3):457–72. Epub 2010/03/06. doi: 10.1038/nprot.2009.244 20203663
80. Box MS, Coustham V, Dean C, Mylne JS. Protocol: A simple phenol-based method for 96-well extraction of high quality RNA from Arabidopsis. Plant Methods. 2011;7 : 7. Epub 2011/03/15. doi: 10.1186/1746-4811-7-7 21396125
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