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preLekára.sk / Odborné časopisy / PLOS Genetics / 2015 - 10

The Genomic Aftermath of Hybridization in the Opportunistic Pathogen

English version České info

Human pathogens belong to different phylogenetic clades and it is clear that the ability to infect humans emerged several times independently. The sequencing and comparison of genomes from pathogenic and non-pathogenic species and strains paves the way to identify what genomic changes underlie the emergence of virulence. In this study we sequenced 11 globally-distributed clinical isolates of Candida metapsilosis, an emerging fungal pathogen of growing concern. We found that all isolates were the result of a single hybridization between two unidentified species, which points to hybridization as a mechanism for the origin of a virulent lineage. We found that the hybrids likely originated by sexual reproduction as they were diploids and retained genomic regions of opposite mating types. We reconstructed the aftermath of the genome merging by identifying where recombination led to the removal of one of the parental subgenomes. We finally compare the newly-sequenced genome with those of other pathogens from the Candida clade and establish global trends, such an enriched repertoire in cell-wall proteins in more virulent species. Our results provide insight into how hybridization may play a key role in the emergence of novel pathogenic lineages.

Vyšlo v časopise: The Genomic Aftermath of Hybridization in the Opportunistic Pathogen. PLoS Genet 11(10): e32767. doi:10.1371/journal.pgen.1005626
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005626

Souhrn

Human pathogens belong to different phylogenetic clades and it is clear that the ability to infect humans emerged several times independently. The sequencing and comparison of genomes from pathogenic and non-pathogenic species and strains paves the way to identify what genomic changes underlie the emergence of virulence. In this study we sequenced 11 globally-distributed clinical isolates of Candida metapsilosis, an emerging fungal pathogen of growing concern. We found that all isolates were the result of a single hybridization between two unidentified species, which points to hybridization as a mechanism for the origin of a virulent lineage. We found that the hybrids likely originated by sexual reproduction as they were diploids and retained genomic regions of opposite mating types. We reconstructed the aftermath of the genome merging by identifying where recombination led to the removal of one of the parental subgenomes. We finally compare the newly-sequenced genome with those of other pathogens from the Candida clade and establish global trends, such an enriched repertoire in cell-wall proteins in more virulent species. Our results provide insight into how hybridization may play a key role in the emergence of novel pathogenic lineages.

Zdroje

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Článek Quantitative Differences in Nuclear β-catenin and TCF Pattern Embryonic Cells in .
Článek HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse
Článek Axon Regeneration Is Regulated by Ets–C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca Signaling Pathways
Článek A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers
Článek The Roles of CDF2 in Transcriptional and Posttranscriptional Regulation of Primary MicroRNAs
Článek A Genetic Cascade of Modulates Nucleolar Size and rRNA Pool in
Článek Inter-population Differences in Retrogene Loss and Expression in Humans
Článek Cationic Peptides Facilitate Iron-induced Mutagenesis in Bacteria
Článek EP4 Receptor–Associated Protein in Macrophages Ameliorates Colitis and Colitis-Associated Tumorigenesis
Článek Fungal Infection Induces Sex-Specific Transcriptional Changes and Alters Sexual Dimorphism in the Dioecious Plant
Článek FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores
Článek MET18 Connects the Cytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation in
Článek Sex Bias and Maternal Contribution to Gene Expression Divergence in Blastoderm Embryos
Článek Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection
Článek Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient
Článek Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross
Článek Identification of a Single Strand Origin of Replication in the Integrative and Conjugative Element ICE of
Článek The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization
Článek The Dynamic Genome and Transcriptome of the Human Fungal Pathogen and Close Relative
Článek Secondary Structure across the Bacterial Transcriptome Reveals Versatile Roles in mRNA Regulation and Function
Článek ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Regeneration
Článek Pelle Modulates dFoxO-Mediated Cell Death in
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PLOS Genetics

2015 Číslo 10
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Autori: doc. MUDr. David Zemánek, Ph.D., MUDr. Anna Chaloupka, Ph.D.
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