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Sex Bias and Maternal Contribution to Gene Expression Divergence in Blastoderm Embryos

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The early embryonic stage of development is unique as this stage begins under the genetic control of the mother and transitions to genetic control of the zygote. In order to investigate how these developmental specificities have shaped gene expression evolution, we studied the contribution of maternal gene expression to the pool of transcripts in the early embryo and how gene expression differs in early female and male embryos. We find extensive female-bias in gene expression, something not observed in adults. This is largely due to the delay in the establishment of a mechanism that balances gene expression from the differing number of X chromosomes in females and males. The maternal contribution to the transcript pool in the embryo is largely conserved over species, with some exceptions. However, there may also be some species-specific differences in the degradation rate of maternal transcripts, an often-overlooked contributor to variation in transcript level.

Vyšlo v časopise: Sex Bias and Maternal Contribution to Gene Expression Divergence in Blastoderm Embryos. PLoS Genet 11(10): e32767. doi:10.1371/journal.pgen.1005592
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005592

Souhrn

The early embryonic stage of development is unique as this stage begins under the genetic control of the mother and transitions to genetic control of the zygote. In order to investigate how these developmental specificities have shaped gene expression evolution, we studied the contribution of maternal gene expression to the pool of transcripts in the early embryo and how gene expression differs in early female and male embryos. We find extensive female-bias in gene expression, something not observed in adults. This is largely due to the delay in the establishment of a mechanism that balances gene expression from the differing number of X chromosomes in females and males. The maternal contribution to the transcript pool in the embryo is largely conserved over species, with some exceptions. However, there may also be some species-specific differences in the degradation rate of maternal transcripts, an often-overlooked contributor to variation in transcript level.

Zdroje

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