Octopamine Neuromodulation Regulates Gr32a-Linked Aggression and Courtship Pathways in Males

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To mate or fight? When meeting other members of their species, male fruit flies must determine whether a second fly is male or female and proceed with the appropriate behavioral patterns. The taste receptor, Gr32a, has been reported to respond to chemical messages (pheromones) that are important for gender recognition, as eliminating Gr32a function impairs both male courtship and aggressive behavior. Here we demonstrate that different subsets of Gr32a-expressing neuron populations mediate these mutually exclusive behaviors and the male Gr32a-mediated behavioral response is amplified through neurons that contain the neuromodulator octopamine (OA, an invertebrate equivalent of norepinephrine). Gr32a-expressing neurons connect functionally and synaptically with distinct OA neurons indicating these amine neurons may function as early as a second-order step in a chemosensory-driven circuit. Our results contribute to understanding how an organism selects an appropriate behavioral response upon receiving external sensory signals.

Vyšlo v časopise: Octopamine Neuromodulation Regulates Gr32a-Linked Aggression and Courtship Pathways in Males. PLoS Genet 10(5): e32767. doi:10.1371/journal.pgen.1004356
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004356

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