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preLekára.sk / Odborné časopisy / PLOS Genetics / 2014 - 5

Genes That Bias Mendelian Segregation

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Chromosome segregation during meiosis ensures that paternal and maternal chromosomes are equally transmitted to the progeny. Meiotic Drive Elements (MDs) are known to distort this 1∶1 ratio in many animal, plant, and fungal species by killing the gametes not carrying them. Most of the known MDs are complex genetic loci with separate genes for the killing activity and the resistance to said killing. Here, we report in a model fungus on two genes endowed with MD properties previously unreported. Both genes produce a single polypeptide and confer both killing and resistance. They exert their effect irrespective of their position in the genome. They can cross species barriers and promote bias in segregation in other species. As related genes are frequently observed in fungal genomes, we propose that they are representative of a novel kind of selfish genes that propagate by distorting the Mendel laws of segregation.

Vyšlo v časopise: Genes That Bias Mendelian Segregation. PLoS Genet 10(5): e32767. doi:10.1371/journal.pgen.1004387
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004387

Souhrn

Chromosome segregation during meiosis ensures that paternal and maternal chromosomes are equally transmitted to the progeny. Meiotic Drive Elements (MDs) are known to distort this 1∶1 ratio in many animal, plant, and fungal species by killing the gametes not carrying them. Most of the known MDs are complex genetic loci with separate genes for the killing activity and the resistance to said killing. Here, we report in a model fungus on two genes endowed with MD properties previously unreported. Both genes produce a single polypeptide and confer both killing and resistance. They exert their effect irrespective of their position in the genome. They can cross species barriers and promote bias in segregation in other species. As related genes are frequently observed in fungal genomes, we propose that they are representative of a novel kind of selfish genes that propagate by distorting the Mendel laws of segregation.

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