A Novel CH Transcription Factor that Regulates Expression Interdependently with GliZ in

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Fungal infections cause severe problems for immune-compromised individuals. Current antifungal treatment is problematic, as some therapies are toxic to humans and others are not highly effective. These fungal infections also burden hospitals, as costs to treat and prevent such disease runs high. Aspergillus fumigatus is the most common cause of fungal infections worldwide. A. fumigatus produces a variety of toxins that aid the fungus in survival both in the environment and within host systems. Genes involved in producing such toxins are often found in clusters within the genome, being almost exclusively dependent on transcription factors located within the clusters. Gliotoxin, one such toxin, is known to negatively affect immune cell function. Although gliotoxin has been studied extensively, information is still lacking with regards to regulation of gliotoxin biosynthesis. Our lab has discovered a novel C2H2 transcription factor, GipA, which plays an important role in gliotoxin production. Not only does GipA enhance gliotoxin production when over-expressed, but loss of GipA causes a significant reduction in gliotoxin production. As this gene is not located within the gliotoxin cluster, understanding its mode of action and upstream partners could shed light on toxin production in general and lead to better, more effective antifungal therapies.

Vyšlo v časopise: A Novel CH Transcription Factor that Regulates Expression Interdependently with GliZ in. PLoS Genet 10(5): e32767. doi:10.1371/journal.pgen.1004336
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004336

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