1. VidalM, CaganRL (2006) Drosophila models for cancer research. Curr Opin Genet Dev 16: 10–16.
2. TenenbaumD (2003) What's All the Buzz? Fruit Flies Provide Unique Model for Cancer Research. J Natl Cancer Inst 95: 1742–1744.
3. EdgarBA (2006) From cell structure to transcription: Hippo forges a new path. Cell 124: 267–273.
4. KarimFD, ChangHC, TherrienM, WassarmanDA, LavertyT, et al. (1996) A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics 143: 315–329.
5. DicksonBJ, van der StratenA, DominguezM, HafenE (1996) Mutations Modulating Raf signaling in Drosophila eye development. Genetics 142: 163–171.
6. TherrienM, MorrisonDK, WongAM, RubinGM (2000) A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila. Genetics 156: 1231–1242.
7. RebayI, ChenF, HsiaoF, KolodziejPA, KuangBH, et al. (2000) A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein. Genetics 154: 695–712.
8. ParsonsJT (2003) Focal adhesion kinase: the first ten years. J Cell Sci 116: 1409–1416.
9. GelmanIH (2003) Pyk 2 FAKs, any two FAKs. Cell Biol Int 27: 507–510.
10. SiesserPM, HanksSK (2006) The signaling and biological implications of FAK overexpression in cancer. Clin Cancer Res 12: 3233–3237.
11. ZhaoJ, GuanJL (2009) Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev 28: 35–49.
12. FujimotoJ, SawamotoK, OkabeM, TakagiY, TezukaT, et al. (1999) Cloning and characterization of Dfak56, a homolog of focal adhesion kinase, in Drosophila melanogaster. J Biol Chem 274: 29196–29201.
13. PalmerRH, FesslerLI, EdeenPT, MadiganSJ, McKeownM, et al. (1999) DFak56 is a novel Drosophila melanogaster focal adhesion kinase. J Biol Chem 274: 35621–35629.
14. FoxGL, RebayI, HynesRO (1999) Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo. Proc Natl Acad Sci USA 96: 14978–14983.
15. MurakamiS, UmetsuD, MaeyamaY, SatoM, YoshidaS, et al. (2007) Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk. Development 134: 1539–1548.
16. TsaiP-I, KaoH-H, GrabbeC, LeeY-T, GhoseA, et al. (2008) Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth. Neural development 3: 26.
17. GrabbeC, ZervasCG, HunterT, BrownNH, PalmerRH (2004) Focal adhesion kinase is not required for integrin function or viability in Drosophila. Development 131: 5795–5805.
18. UedaA, GrabbeC, LeeJ, LeeJ, PalmerRH, et al. (2008) Mutation of Drosophila focal adhesion kinase induces bang-sensitive behavior and disrupts glial function, axonal conduction and synaptic transmission. Eur J Neurosci 27: 2860–2870.
19. ReadRD, GoodfellowPJ, MardisER, NovakN, ArmstrongJR, et al. (2005) A Drosophila model of multiple endocrine neoplasia type 2. Genetics 171: 1057–1081.
20. VidalM, WellsS, RyanA, CaganR (2005) ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma. Cancer Res 65: 3538–3541.
21. DasT, CaganR (2010) Drosophila as a novel therapeutic discovery tool for thyroid cancer. Thyroid 20: 689–695.
22. JhiangSM (2000) The RET proto-oncogene in human cancers. Oncogene 19: 5590–5597.
23. LeboulleuxS, BaudinE, TravagliJP, SchlumbergerM (2004) Medullary thyroid carcinoma. Clin Endocrinol (Oxf) 61: 299–310.
24. GriecoM, SantoroM, BerlingieriMT, MelilloRM, DonghiR, et al. (1990) PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60: 557–563.
25. BongarzoneI, ButtiMG, CoronelliS, BorrelloMG, SantoroM, et al. (1994) Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. Cancer Res 54: 2979–2985.
26. SantoroM, RosatiR, GriecoM, BerlingieriMT, D'AmatoGL, et al. (1990) The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas. Oncogene 5: 1595–1598.
27. BoulayA, BreuleuxM, StephanC, FuxC, BriskenC, et al. (2008) The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer. Cancer Res 68: 3743–3751.
28. ChenSY, ChenHC (2006) Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol Cell Biol 26: 5155–5167.
29. SiegDJ, HauckCR, IlicD, KlingbeilCK, SchaeferE, et al. (2000) FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2: 249–256.
30. Plaza-MenachoI, MorandiA, MologniL, BoenderP, Gambacorti-PasseriniC, et al. (2011) Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. J Biol Chem 286: 17292–17302.
31. SandilandsE, SerrelsB, WilkinsonS, FrameMC (2012) Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells. EMBO Rep 13: 733–740.
32. CorderoJ, JassimO, BaoS, CaganR (2004) A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye. Mech Dev 121: 1523–1530.
33. DarAC, DasTK, ShokatKM, CaganRL (2012) Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature 486: 80–84.
34. SpeicherSA, ThomasU, HinzU, KnustE (1994) The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation. Development 120: 535–544.
35. GleichaufR (1936) Anatomie und Variabilitat des Geschlechtapparates von Drosophila melanogaster (Meigen).. ZWissZool 148: 1–66.
36. AdamG, PerrimonN, NoselliS (2003) The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila. Development 130: 2397–2406.
37. FrameMC, PatelH, SerrelsB, LiethaD, EckMJ (2010) The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol 11: 802–814.
38. ZhaoX, PengX, SunS, ParkAY, GuanJL (2010) Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol 189: 955–965.
39. SawamotoK, TaguchiA, HirotaY, YamadaC, JinMH, et al. (1998) Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway. Cell Death Differ 5: 262–270.
40. BergmannA, AgapiteJ, McCallK, StellerH (1998) The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95: 331–341.
41. KuradaP, WhiteK (1998) Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95: 319–329.
42. GretherME, AbramsJM, AgapiteJ, WhiteK, StellerH (1995) The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev 9: 1694–1708.
43. BlochlingerK, JanLY, JanYN (1993) Postembryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila. Development 117: 441–450.
44. VerduJ, BuratovichMA, WilderEL, BirnbaumMJ (1999) Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat Cell Biol 1: 500–506.
45. LongW, YiP, AmazitL, LamarcaHL, AshcroftF, et al. (2010) SRC-3Delta4 Mediates the Interaction of EGFR with FAK to Promote Cell Migration. Molecular cell 37: 321–332.
46. Diaz-BenjumeaFJ, HafenE (1994) The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120: 569–578.
47. CorkeryB, CrownJ, ClynesM, O'DonovanN (2009) Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer. Ann Oncol 20: 862–867.
48. PriceJT, TiganisT, AgarwalA, DjakiewD, ThompsonEW (1999) Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism. Cancer Res 59: 5475–5478.
49. OwensLV, XuL, CravenRJ, DentGA, WeinerTM, et al. (1995) Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 55: 2752–2755.
50. AgochiyaM, BruntonVG, OwensDW, ParkinsonEK, ParaskevaC, et al. (1999) Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene 18: 5646–5653.
51. SigismundS, ArgenzioE, TosoniD, CavallaroE, PoloS, et al. (2008) Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev Cell 15: 209–219.
52. MiaczynskaM, ChristoforidisS, GinerA, ShevchenkoA, Uttenweiler-JosephS, et al. (2004) APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell 116: 445–456.
53. SadowskiL, PileckaI, MiaczynskaM (2009) Signaling from endosomes: location makes a difference. Exp Cell Res 315: 1601–1609.
54. MarshallCJ (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179–185.
55. IrwinME, MuellerKL, BohinN, GeY, BoernerJL (2011) Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. J Cell Physiol 226: 2316–2328.
56. MaciaE, EhrlichM, MassolR, BoucrotE, BrunnerC, et al. (2006) Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell 10: 839–850.
57. MesakiK, TanabeK, ObayashiM, OeN, TakeiK (2011) Fission of tubular endosomes triggers endosomal acidification and movement. PLoS One 6: e19764.
58. HenriksenL, GrandalMV, KnudsenSL, van DeursB, GrovdalLM (2013) Internalization mechanisms of the epidermal growth factor receptor after activation with different ligands. PLoS One 8: e58148.
59. RizzolioS, RabinowiczN, RaineroE, LanzettiL, SeriniG, et al. (2012) Neuropilin-1-dependent regulation of EGF-receptor signaling. Cancer Res 72: 5801–5811.
60. RaineroE, NormanJC (2013) Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion: cell matrix receptors are trafficked through the late endosomal pathway in a way that dictates how cells migrate. Bioessays 35: 523–532.
61. RobertsM, BarryS, WoodsA, van der SluijsP, NormanJ (2001) PDGF-regulated rab4-dependent recycling of alphavbeta3 integrin from early endosomes is necessary for cell adhesion and spreading. Curr Biol 11: 1392–1402.
62. ChenT-H, ChanP-C, ChenC-L, ChenH-C (2011) Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition. Oncogene 30: 153–166.
63. HalfarK, RommelC, StockerH, HafenE (2001) Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity. Development 128: 1687–1696.
64. MatsuoT, TakahashiK, KondoS, KaibuchiK, YamamotoD (1997) Regulation of cone cell formation by Canoe and Ras in the developing Drosophila eye. Development 124: 2671–2680.
65. SandilandsE, SerrelsB, McEwanDG, MortonJP, MacagnoJP, et al. (2012) Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol 14: 51–60.
66. SchlaepferDD, HanksSK, HunterT, van der GeerP (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372: 786–791.
67. CanceWG, KurenovaE, MarloweT, GolubovskayaV (2013) Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics. Sci Signal 6: pe10.
68. InfanteJR, CamidgeDR, MileshkinLR, ChenEX, HicksRJ, et al. (2012) Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors. J Clin Oncol 30: 1527–1533.
69. GabrielB, zur HausenA, StickelerE, DietzC, GitschG, et al. (2006) Weak expression of focal adhesion kinase (pp125FAK) in patients with cervical cancer is associated with poor disease outcome. Clin Cancer Res 12: 2476–2483.
70. AyakiM, KomatsuK, MukaiM, MurataK, KameyamaM, et al. (2001) Reduced expression of focal adhesion kinase in liver metastases compared with matched primary human colorectal adenocarcinomas. Clin Cancer Res 7: 3106–3112.
71. OhtaR, YamashitaY, TaketomiA, KitagawaD, KurodaY, et al. (2006) Reduced expression of focal adhesion kinase in intrahepatic cholangiocarcinoma is associated with poor tumor differentiation. Oncology 71: 417–422.
72. LuZ, JiangG, Blume-JensenP, HunterT (2001) Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol 21: 4016–4031.
73. ZhengY, LuZ (2009) Paradoxical roles of FAK in tumor cell migration and metastasis. Cell Cycle 8: 3474–3479.
74. HayBA, MaileR, RubinGM (1997) P element insertion-dependent gene activation in the Drosophila eye. Proc Natl Acad Sci U S A 94: 5195–5200.
75. FreemanM (1996) Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87: 651–660.
76. BradfordMM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248–254.
77. RaineroE, CaswellPT, MullerPA, GrindlayJ, McCaffreyMW, et al. (2012) Diacylglycerol kinase alpha controls RCP-dependent integrin trafficking to promote invasive migration. J Cell Biol 196: 277–295.