CDP-Diacylglycerol Synthetase Coordinates Cell Growth and Fat Storage through Phosphatidylinositol Metabolism and the Insulin Pathway

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During development, animals undergo a rapid increase in cell size and number, which requires large amounts of lipids, in the form of phospholipids, for the expansion of cell membranes. Once the growth phase ends, excess lipids are usually stored as body fat, in the form of triacylglycerol (TAG), for use when nutrients are limited. How cells coordinate growth and fat storage is not fully understood. By screening for genes that affect lipid storage in the fruitfly Drosophila we discovered that the enzyme CDP-diacylglycerol synthetase (CdsA) coordinates cell growth and fat storage. Phospholipids and TAG have a common precursor, phosphatidic acid, which is diverted by CdsA from TAG synthesis to synthesis of the phospholipid phosphatidylinositol (PI). We also uncovered a link between CdsA and the insulin signaling pathway, which plays a major role in regulating cell and tissue growth. CdsA regulates the level of PI, which modulates insulin pathway activity; insulin pathway activity, in turn, influences the level of CdsA. The lipid metabolism pathways and the insulin signaling pathway are conserved in other animals including humans. Our findings may therefore provide further insights into clinically important imbalances in fat storage such as obesity.

Vyšlo v časopise: CDP-Diacylglycerol Synthetase Coordinates Cell Growth and Fat Storage through Phosphatidylinositol Metabolism and the Insulin Pathway. PLoS Genet 10(3): e32767. doi:10.1371/journal.pgen.1004172
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004172

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