The rarity of genetic mutations limits the likelihood of adaptation. However, transcriptional and translational errors, so-called phenotypic mutations, are >105-fold more frequent, thus generating protein mutants from unmodified genes. We provide the first evidence that phenotypic mutations paved the path to what later, after gene duplication, became newly compartmentalized enzymes. Thus, gene duplication followed rather than initiated the divergence of this new trait. Our findings also show that translational infidelity and phenotypic variability comprise the origins of evolutionary innovations, and how selection for enhanced phenotypic variability also promotes the appearance of genetic mutations that lead to the very same outcome.
Vyšlo v časopise: The Evolutionary Potential of Phenotypic Mutations. PLoS Genet 11(8): e32767. doi:10.1371/journal.pgen.1005445 Kategorie: Research Article prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005445
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