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Putting the Brakes on Huntington Disease in a Mouse Experimental Model

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Vyšlo v časopise: Putting the Brakes on Huntington Disease in a Mouse Experimental Model. PLoS Genet 11(8): e32767. doi:10.1371/journal.pgen.1005409
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005409

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Zdroje

1. The Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72 : 971–983. 8458085

2. Andrew SE, Goldberg YP, Kremer B, Telenius H, Theilmann J, et al. (1993) The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nat Genet 4 : 398–403. 8401589

3. Zoghbi HY, Orr HT (2000) Glutamine repeats and neurodegeneration. Annu Rev Neurosci 23 : 217–247. 10845064

4. Mirkin SM (2007) Expandable DNA repeats and human disease. Nature 447 : 932–940. 17581576

5. Usdin K, House NC, Freudenreich CH (2015) Repeat instability during DNA repair: Insights from model systems. Crit Rev Biochem Mol Biol 50 : 142–167. doi: 10.3109/10409238.2014.999192 25608779

6. Manley K, Shirley TL, Flaherty L, Messer A (1999) Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. Nat Genet 23 : 471–473. 10581038

7. Kovtun IV, McMurray CT (2001) Trinucleotide expansion in haploid germ cells by gap repair. Nat Genet 27 : 407–411. 11279522

8. Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, et al. (2007) OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature 447 : 447–452. 17450122

9. Kim JC, Mirkin SM (2013) The balancing act of DNA repeat expansions. Curr Opin Genet Dev 23 : 280–288. doi: 10.1016/j.gde.2013.04.009 23725800

10. Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Pena S, McMurray CT. (2015) Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington's disease. PLoS Genet 11(8): e1005267.

11. Xun Z, Rivera-Sanchez S, Ayala-Pena S, Lim J, Budworth H, et al. (2012) Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep 2 : 1137–1142. doi: 10.1016/j.celrep.2012.10.001 23122961

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Článok vyšiel v časopise

PLOS Genetics

2015 Číslo 8

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Autori: MUDr. Petr Výborný, CSc., FEBO

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