Candida albicans is an important cause of human disease that occurs if the fungus proliferates strongly on skin surfaces or in several internal organs causing superficial and systemic mycosis. Remarkably, at low cell numbers, C. albicans is also a normal inhabitant of mucosal surfaces and the gut and it is believed that its transition from the commensal to the virulent, highly proliferative state is a key event that initiates fungal disease. In the gut and other body niches, C. albicans adapts to an oxygen-poor environment, which downregulates its virulence traits including the ability to form hyphae. We report on a set of four transcription factors in C. albicans that form an interdependent regulatory circuit, which downregulates filamentation specifically under hypoxia at slightly lowered body temperatures (≤ 35°C). Disturbance of this circuit is expected to initiate the fungal virulence and proliferation in predisposed patients.
Vyšlo v časopise: Hypoxia and Temperature Regulated Morphogenesis in. PLoS Genet 11(8): e32767. doi:10.1371/journal.pgen.1005447 Kategorie: Research Article prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005447
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