Non-synonymous FGD3 Variant as Positional Candidate for Disproportional Tall Stature Accounting for a Carcass Weight QTL () and Skeletal Dysplasia in Japanese Black Cattle


Livestock are typically subjected to intensive artificial selection for traits of economic value to producers. In spite of this strong selection, some major quantitative trait loci (QTLs) for an economically important trait never reach fixation in the population. Several studies have revealed that such QTLs are accompanied with an unfavorable effect on other traits of economic importance, including heritable disease phenotypes. The carcass weight QTL, named CW-3, was previously identified as one of three major QTL in Japanese Black cattle, and it was found to originate from a specific line that had been maintained in a regional subpopulation. Recent efforts to maintain genetic diversity of the Japanese Black breed have resulted in the widespread use of this line throughout Japan. Half-sib QTL analyses of the elite sires repeatedly detected the CW-3 QTL, while skeletal dysplasia has been found in the descendants. Genomic analyses revealed that skeletal dysplasia is inseparably linked with CW-3 and a functional variant of FGD3 was identified as a positional candidate QTN. Further studies such as creating a genetically modified mouse model will be useful to understand a molecular mechanism of FGD3 to modulate bone development.


Vyšlo v časopise: Non-synonymous FGD3 Variant as Positional Candidate for Disproportional Tall Stature Accounting for a Carcass Weight QTL () and Skeletal Dysplasia in Japanese Black Cattle. PLoS Genet 11(8): e32767. doi:10.1371/journal.pgen.1005433
Kategorie: Research Article
prolekare.web.journal.doi_sk: 10.1371/journal.pgen.1005433

Souhrn

Livestock are typically subjected to intensive artificial selection for traits of economic value to producers. In spite of this strong selection, some major quantitative trait loci (QTLs) for an economically important trait never reach fixation in the population. Several studies have revealed that such QTLs are accompanied with an unfavorable effect on other traits of economic importance, including heritable disease phenotypes. The carcass weight QTL, named CW-3, was previously identified as one of three major QTL in Japanese Black cattle, and it was found to originate from a specific line that had been maintained in a regional subpopulation. Recent efforts to maintain genetic diversity of the Japanese Black breed have resulted in the widespread use of this line throughout Japan. Half-sib QTL analyses of the elite sires repeatedly detected the CW-3 QTL, while skeletal dysplasia has been found in the descendants. Genomic analyses revealed that skeletal dysplasia is inseparably linked with CW-3 and a functional variant of FGD3 was identified as a positional candidate QTN. Further studies such as creating a genetically modified mouse model will be useful to understand a molecular mechanism of FGD3 to modulate bone development.


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