GC-Content Evolution in Bacterial Genomes: The Biased Gene Conversion Hypothesis Expands

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Classical population genetics models indicate that the efficiency of selection, and hence adaptation, depends on a number of non-selective factors, such as the size of a population or the intensity of recombination. In the last 10 years, evidence has accumulated that another mechanism called GC-Biased Gene Conversion (gBGC) can interfere with selection and even mimic its effects. This phenomenon, which arises from a particularity of the recombination machinery, was first thought to be restricted to sexual eukaryotic organisms. Here, we show that this mechanism probably exists in Bacteria and has a strong impact on their genome evolution. This discovery not only explains many previously unconnected features of bacterial genome evolution, but also highlights the importance of non-adaptive evolutionary processes in Bacteria.

Vyšlo v časopise: GC-Content Evolution in Bacterial Genomes: The Biased Gene Conversion Hypothesis Expands. PLoS Genet 11(2): e32767. doi:10.1371/journal.pgen.1004941
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004941

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