Contribution of the Two Genes Encoding Histone Variant H3.3 to Viability and Fertility in Mice

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Histones package DNA and regulate chromosome activity. Histone H3 is particularly important in this regard. The H3.3 isoform is unique, among H3 histones, in being able to incorporate into chromosomes independent of DNA replication. Thus, in slowly -⁠ or non-dividing somatic cells, H3.3 histone can take on the bulk of H3 functions. The developing germ line is very slowly dividing, and undergoes large-scale changes in chromosome activity. H3.3 is therefore likely to be very important in regulating these processes. Here, we have studied the effects of null mutations in each of the two genes encoding H3.3. We demonstrate that H3.3 is very important in germ cell development, regulating oogenesis, spermatogenesis, and fertilization. Also, we reveal H3.3 to be important in somatic growth. Each of the two genes is required to varying extents in regulating these processes.

Vyšlo v časopise: Contribution of the Two Genes Encoding Histone Variant H3.3 to Viability and Fertility in Mice. PLoS Genet 11(2): e32767. doi:10.1371/journal.pgen.1004964
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004964

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