Drosophila Casein Kinase I Alpha Regulates Homolog Pairing and Genome Organization by Modulating Condensin II Subunit Cap-H2 Levels

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The Cap-H2 condensin II subunit is required for interphase condensin II activity. Previous work has shown that low levels of Cap-H2 protein in interphase is achieved by SCFSlimb mediated protein turnover and limits chromatin-bound protein levels. Here we show that Casein Kinase I alpha (CK1α) is also a negative regulator of interphase condensin II activity by promoting Cap-H2 destruction and limiting chromatin-bound Cap-H2 levels. Loss of CK1α function leads to aberrant chromosome structures that are suppressed by mutation or depletion of Cap-H2 or other condensin subunits. These observations suggest that normally, interphase condensin II levels must be kept low in order to maintain proper interphase chromosome organization, and this low activity is maintained by targeted destruction of Cap-H2.

Vyšlo v časopise: Drosophila Casein Kinase I Alpha Regulates Homolog Pairing and Genome Organization by Modulating Condensin II Subunit Cap-H2 Levels. PLoS Genet 11(2): e32767. doi:10.1371/journal.pgen.1005014
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005014

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