Stratification by Smoking Status Reveals an Association of Genotype with Body Mass Index in Never Smokers


We found that a single nucleotide polymorphism in the CHRNA5-A3-B4 gene cluster, which is known to influence smoking heaviness, is associated with lower body mass index (BMI) in current smokers, but higher BMI in never smokers. This difference in effects suggests that the variant influences BMI both via pathways other than smoking, and via the weight-reducing effects of smoking, in opposite directions. The overall effect on BMI would therefore be undetectable in an unstratified genome-wide association study, indicating that novel associations may be obscured by hidden population sub-structure.


Vyšlo v časopise: Stratification by Smoking Status Reveals an Association of Genotype with Body Mass Index in Never Smokers. PLoS Genet 10(12): e32767. doi:10.1371/journal.pgen.1004799
Kategorie: Research Article
prolekare.web.journal.doi_sk: 10.1371/journal.pgen.1004799

Souhrn

We found that a single nucleotide polymorphism in the CHRNA5-A3-B4 gene cluster, which is known to influence smoking heaviness, is associated with lower body mass index (BMI) in current smokers, but higher BMI in never smokers. This difference in effects suggests that the variant influences BMI both via pathways other than smoking, and via the weight-reducing effects of smoking, in opposite directions. The overall effect on BMI would therefore be undetectable in an unstratified genome-wide association study, indicating that novel associations may be obscured by hidden population sub-structure.


Zdroje

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Genetika Reprodukčná medicína

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PLOS Genetics


2014 Číslo 12
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