Unisexual Reproduction Drives Meiotic Recombination and Phenotypic and Karyotypic Plasticity in

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Unisexual reproduction has been reported in several fungal species that have been traditionally thought to undergo bisexual reproduction, including major human fungal pathogens such as Cryptococcus neoformans and Candida albicans. While it has been well characterized qualitatively, quantitative description of unisexual reproduction, and detailed comparisons between unisexual and bisexual reproduction, are lacking. Here, by analyzing meiotic progeny generated from both α-α unisexual and a-α bisexual reproduction in C. neoformans, we find that the progeny collected from the two modes of sexual reproduction show similar phenotypic segregation, with transgressive segregation of several phenotypes being observed in both. Additionally, the two modes of sexual reproduction are similar in all the aspects of meiotic recombination that we have examined, providing definitive evidence that α-α unisexual reproduction is a meiotic process that operates similarly as in a-α bisexual reproduction. The ability to undergo both unisexual and bisexual reproduction may provide evolutionary advantages in environments where suitable mating partners are scarce, or where sexual reproduction is favored over asexual reproduction by mixing genetic materials and producing spores that are more tolerant of harsh environments. We discuss the implications of these findings in the context of the evolution of pathogenesis, mating types, and mating systems.

Vyšlo v časopise: Unisexual Reproduction Drives Meiotic Recombination and Phenotypic and Karyotypic Plasticity in. PLoS Genet 10(12): e32767. doi:10.1371/journal.pgen.1004849
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004849

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