Influenza Virus Reassortment Is Enhanced by Semi-infectious Particles but Can Be Suppressed by Defective Interfering Particles

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Since the genome of an influenza A virus has eight non-contiguous segments, two influenza A viruses can exchange genes readily when they infect the same cell. This process of reassortment is important to the evolution of the virus and is one reason why this pathogen is constantly changing. It has long been known that a large proportion of the virus particles that influenza and many other RNA viruses produce are not fully infectious, but the biological significance of these particles has remained unclear. Here we show that virus particles that deliver incomplete genomes to the cell enhance the rate of reassortment. Thus, despite their limited potential to produce progeny viruses, these incomplete particles may play an important role in viral evolution.

Vyšlo v časopise: Influenza Virus Reassortment Is Enhanced by Semi-infectious Particles but Can Be Suppressed by Defective Interfering Particles. PLoS Pathog 11(10): e32767. doi:10.1371/journal.ppat.1005204
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1005204

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