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Dengue Virus Infection of Requires a Putative Cysteine Rich Venom Protein


Dengue virus (DENV) is responsible for serious human disease worldwide and the World Health Organization estimates that over 2 billion people are at risk for disease. There are no vaccines or specific antiviral medications currently available for DENV infection. DENV is transmitted to humans by infected mosquitoes during feeding and probing. By examining the effects of virus infection on gene expression, and interactions between virus and vector, we may be able to find new targets for prevention and treatment. Here we look at a mosquito protein, CRVP379, whose gene expression was highly increased during DENV infection in mosquitoes. We show a requirement for CRVP379 during DENV infection in the mosquito and a correlation between the levels of CRVP379 and levels of infection. Our results indicate that the protein may be acting with a putative DENV receptor in the mosquito, prohibitin protein. These data also suggest that blocking CRVP379 function may be used to block DENV infection in the mosquito.


Vyšlo v časopise: Dengue Virus Infection of Requires a Putative Cysteine Rich Venom Protein. PLoS Pathog 11(10): e32767. doi:10.1371/journal.ppat.1005202
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1005202

Souhrn

Dengue virus (DENV) is responsible for serious human disease worldwide and the World Health Organization estimates that over 2 billion people are at risk for disease. There are no vaccines or specific antiviral medications currently available for DENV infection. DENV is transmitted to humans by infected mosquitoes during feeding and probing. By examining the effects of virus infection on gene expression, and interactions between virus and vector, we may be able to find new targets for prevention and treatment. Here we look at a mosquito protein, CRVP379, whose gene expression was highly increased during DENV infection in mosquitoes. We show a requirement for CRVP379 during DENV infection in the mosquito and a correlation between the levels of CRVP379 and levels of infection. Our results indicate that the protein may be acting with a putative DENV receptor in the mosquito, prohibitin protein. These data also suggest that blocking CRVP379 function may be used to block DENV infection in the mosquito.


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