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Governing Tripolye: Integrative architecture in Tripolye settlements
Authors: Robert Hofmann aff001; Johannes Müller aff001; Liudmyla Shatilo aff001; Mykhailo Videiko aff003; René Ohlrau aff001; Vitalii Rud aff004; Nataliia Burdo aff004; Marta Dal Corso aff001; Stefan Dreibrodt aff002; Wiebke Kirleis aff001
Authors place of work: Institute for Pre- and Protohistory, Kiel University, Kiel, Schleswig-Holstein, Germany aff001; Collaborative Research Centre 1266: "Scales of Transformation—Human-Environmental Interaction in Prehistoric and Archaic Societies", Kiel University, Kiel, Schleswig-Holstein, Germany aff002; Laboratory of Archaeology, Borys Grinchenko Kyiv University, Kyiv, Ukraine aff003; Institute of Archaeology, National Academy of Sciences of Ukraine, Kyiv, Ukraine aff004; Institute for Ecosystem Research, Kiel University, Kiel, Schleswig-Holstein, Germany aff005
Published in the journal: PLoS ONE 14(9)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0222243Summary
Recently, high-resolution magnetometry surveys have led to the discovery of a special category of buildings–so-called ‘mega-structures’–situated in highly visible positions in the public space of Tripolye giant-settlements of the late 5th and first half of the 4th millennium BCE. In this paper we explore what these buildings actually are and how they can contribute to the understanding of the development of social space in Tripolye giant-settlements. For this investigation, we linked newly obtained excavation data from the giant-settlement Maidanetske, Ukraine, with a much larger sample of such buildings from magnetic plans obtained in the region between the Carpathian foothills and the Dnieper River. Accordingly, Tripolye mega-structures represent a particular kind of integrative building documented in many non-ranked ethnographic contexts. Based on our results we are interpreting that these buildings were used for various ritual and non-ritual activities, joint decision-making, and the storage and consumption of surplus. In Tripolye giant-settlements at least three different categories of mega-structures could be identified which most likely represent different levels of socio-political integration and decision-making. The emergence of this hierarchical system of high-level integrative buildings for the whole community and different low-level integrative architectures for certain segments of local communities was related to the rise of Tripolye mega-sites. The presence of different integrative levels most likely reflects the fusion of different previously independent communities in the giant-settlements. Later in the mega-site development, we observe how low-level integrative buildings increasingly lose their importance indicated by shrinking size and, finally, their disappearance. This observation might indicate that the power which was previously distributed across the community was transferred to a central institution. It is argued that the non-acceptance of this concentration of power and the decline of lower decision-making levels might be a crucial factor for the disintegration of Tripolye giant-settlements around 3600 BCE.
Keywords:
Food consumption – Decision making – Archaeology – Archaeological dating – Radioactive carbon dating – ceramics – Timber – Specimen grinding
Introduction
Between ca. 4100–3600 BCE ‘giant-settlements’ or ‘mega-sites’ with thousands of houses arranged in a very specific centripetal layout emerged in a concentrated area of the Southern Bug-Dnieper Interfluve in the eastern part of the Tripolye distribution area (Fig 1). Currently, these unique settlements are the focus of different international projects [1–6]. Interpretations of their nature span between two extremes, from early urban phenomenon with complex social stratification to seasonally used pilgrimage sites. Thus, the question of their social organisation is newly under discussion [7–14].
Fig. 1. Maidanetske. Empirical anthropological research suggests that additional political institutions become necessary with rising population sizes in order to manage increased social complexity and scalar stress in large population agglomerations [15, 16]. Thus, the question arises how might these large Chalcolithic settlements have been organised in socio-political terms? While evolutionary-thinking authors assume a strong correlation between population sizes, organisational complexity, and social stratification [17], other authors stress that group size alone represents an insufficient criterion to predict social organisation. Rather, different modes of human cooperation have to be considered [18, 19]. Both archaeologists [20] and ethnographers [21, 22] have described the many possibilities of social organization from non-stratified to stratified societies existing independently from demographic, economic, and technological preconditions.
In Tripolye societies, no clear indicators of pronounced wealth inequality, social stratification, or hierarchies have been identified so far, neither at the local level of large sites nor at the regional level between neighbouring villages [14, 23–25]. Consistent with that is the high degree of standardization of the houses and their furnishing. Thus, we assume [16] a rather balanced, non-hierarchical, corporative and negotiation-based mode of social organisation [12].
According to ethnographic sources, such non-stratified societies are frequently associated with integrative architecture or other integrative facilities (e.g. public squares); within these spaces, integrative activities and joint decision-making take place as mechanisms to maintain the social balance [26–28]. In many societies different levels of integration–for some part of the local community, for the whole local community, or even at a regional level–can be identified. The architecture mirrors the differentiated social organisation of these societies and low - and high-level social integration mechanisms.
The suggestion that in Tripolye mega-sites a hierarchy of public buildings existed was supposed first in 1987 by Mycola Shmaglij and Mykhailo Videiko [29] based on the comparison of different buildings in Maidanetske. A completely new category of large buildings characterised by their highly visible positioning in public spaces was discovered through high-resolution magnetic surveys over the last decade [7–10, 30, 31]. Since these so called ‘mega-structures’ might represent examples of such ‘integrative architecture’, their importance for the understanding of Tripolye societies can hardly be overestimated.
There is a broad consensus that mega-structures represent some kind of public buildings [2, 8, 10, 31] and that they reflect the social organisation and the fused character of Tripolye giant-settlements [8, 10, 11, 32]. However, there is disagreement regarding the actual activities which were performed in such buildings [30]. Partly, this is due to the still very limited evidence related to the function of these buildings from excavations. So far questions concerning the temporal development of such buildings in relation to the formation of mega-sites and their spatial variations within in the large Tripolye distribution area remain unanswered.
The main aim of this paper is to clarify what the mega-structures actually are and how these buildings can contribute to the reconstruction of the social organization in Tripolye settlements and the understanding of the mega-site phenomenon. Before we will discuss these questions in the last section of this article, different aspects need to be explored:
In order to understand the nature of mega-structures, it is necessary to reconstruct their setup and define what differentiates them from domestic dwellings.
In order to identify different decision-making levels, categories of mega-structures recognizable in the archaeological record must be established as well as the extent to which they represent similar or different phenomena.
In order to identify different scales of integration, the number of people potentially using mega-structures in relation to the total population of Tripolye settlements must be determined.
In order to identify social processes and their spatial conditioning it is necessary to investigate how the mega-structures developed over time and vary within sites, between sites and across larger geographic spaces.
When these different aspects are synthesized, mega-structures represent a key-element for social-historical reconstructions of Tripolye societies.
Data and methods
Analytical steps
In order to answer the outlined research questions, data from different excavations and magnetic surveys were included into our analyses. The data was analysed on multiple scales:
At the local level of the giant-settlement Maidanetske, mega-structure 3 (Fig 1) was excavated and analysed in detail as an example of the architectural design, the construction method, and activity areas within such a building.
The results from this detailed investigation were linked with information about twelve other mega-structures across the site in order to test the scope and validity of the results obtained.
Also at the level of the site, in order to evaluate to what extent mega-structures are different from domestic dwellings, the architecture and find inventory of mega-structure 3 was compared qualitatively and quantitatively with that of normal dwellings.
On a meso-regional and macro-regional level, 104 mega-structures from high resolution magnetic maps of 19 settlements and excavations were analysed with regard to their frequency, location, dimensions, and architectural characteristics in order to detect their architectural variability and to identify different categories of mega-structures.
In conjunction with other information extracted from the analysed magnetic plans, estimations of the ‘use group size’ of mega-structures were performed to identify the groups of people in terms of population size who potentially used the buildings. The term ‘use group’ was introduced by Michael Adler [26] for an cross-cultural ethnographic sample and refers to the population of the local group most intimately associated with the use of an integrative building.
This regional data set was further analysed so as to draw basic development lines of mega-structures and to detect their regional variability.
The synthesis of the different aspects finally allows a general statement on mega-structures in the discussion section of this article.
Terminology and criteria for the identification of mega-structures
The first Tripolye mega-structures were identified in 2009 during high-resolution magnetic surveys [33]. The application of improved survey techniques led to the discovery of rectangular constructions bigger than normal houses located mainly in non-built spaces of the domestic sites that were not detectable in former magnetic surveys because of their lower resolution.
The term ‘mega-structure’ was introduced by Mykhailo Videiko and John Chapman for a large construction that was investigated in Nebelivka in 2012 [33]. Within our research at Maidanetske, the term was adopted and used for all large buildings in highly visible positions. They could be identified mainly in otherwise unbuilt concentric ring-corridors of the giant-settlement, which we interpret as public areas in-between residential domestic zones [7, 8]. In addition to this first, most important criterion, two other criteria are hierarchically used in the identification of mega-structures in magnetic site plans. Namely, these buildings display specific architecture in comparison to domestic dwellings and they often have extraordinary dimensions. Due to the hierarchy of our three criteria, in some cases very small buildings are classified as ‘mega-structures’ if they are located in certain prominent positions. The number of mega-structures is many times lower than that of residential houses.
According to René Ohlrau, a distinction need to be made between ‘giant mega-structures’ which occur only once per settlement and the more frequent ‘ring - or pathway mega-structures’ [34]. Giant mega-structures are buildings up to 70 m in length and 24 m in width located in very specific rectangular unbuilt ‘plazas’ situated at the northern, north-eastern or eastern side of settlements close to their main entrance. A further terminological distinction is necessary between a ‘primary plaza’ located at the main entrance to the site and occurring once per settlement, and ‘secondary plazas’, which can be found repeatedly at different locations in the settlement. In contrast, multiple ring - or pathway-mega-structures were found in the public spaces of settlements of the Southern Bug-Dnieper interfluve. For this paper, we continue to use the relatively general phrase ‘mega-structure’ as an umbrella term so as to include both types of mega-structures in our analyses.
Materials
Local data base: Maidanetske
With a size of ca. 200 ha, Maidanetske is one of the largest Tripolye sites in the Southern Bug-Dnieper interfluve (Fig 1). Excavations at the site took place in the 1970s and 1980s and again from 2011–2016 [35–37]. According to a large series of 14C dates, the settlement was occupied over period of 350 years ca. 3990–3640 BCE [25, 34]. Based on the dominating pottery style, Maidanetske belongs to the Tomashovka local group of Tripolye C1. The site is characterised by concentric rings of about 3000 houses with associated pits around a large unbuilt space. An unbuilt concentric ring-corridor ca. 100 m wide in-between the house-ring areas and pathways, which are leading radially into the site crossing the house-rings, are also present. Beside houses and associated pits, other features have been detected, namely an enclosure made up of segmented elongated pits and pottery kilns. Like the plazas, the central space empty of houses, the radial paths, and the concentric ring-corridor are interpreted as public areas and communication paths.
In Maidanetske, thirteen magnetic features distributed across the entire settlement were identified as mega-structures according to the above mentioned three criteria (Fig 1). Mega-structure 3 was chosen for excavation in 2016 to investigate a representative mega-structure within the ring-corridor of the settlement. For comparison of mega-structures with domestic houses, the dwellings 44 and 59 from Maidanetske were used, which were excavated in the same manner [34, 37].
Regional data: Mega-structures from magnetic surveys and excavations
High resolution magnetic plans provide detailed information on a large sample of 104 mega-structures from 19 settlements (Tables 1 and 2). Geographically this sample covers three regions: the Southern Bug-Dnieper interfluve, the Southern Bug-Dniester interfluve, and the Middle Dniester region (Fig 2). Chronologically, the sample includes sites from the periods Tripolye A to Tripolye C1–C2, i.e. from ca. 4600–3600 BCE. The regional dataset allows an investigation of general characteristics of mega-structures. The sample include three other excavated mega-structures in Baia [38], Nebelivka [30, 31], and Dobrovody [39] which provide more detailed information regarding architecture and furnishing and helps to evaluate the validity of the data obtained in Maidanetske.
Fig. 2. Map of sites with mega-structures analysed in this article and Tripolye periods. Tab. 1. List of sites with mega-structures analysed in this article with information regarding location (latitude/longitude), dating, size, number of houses, average house size, number of mega-structures, estimations of use group sizes, and references. Column ‘phase’: PC = Precucuteni, T = Tripolye, C = Cucuteni. Column ‘reference’: u = unpublished. * rounded. Tab. 2. List of mega-structures analysed in this article containing information regarding floor area, dimensions, type affiliation, interior division, furnishing, and position in the settlement. Methods
Reconstructing the appearance of a mega-structure
The evaluation of the architectural remains, distribution patterns of daub, and negative imprints of timbers allows the reconstruction of the general building design of the investigated mega-structure 3. This evaluation was based on the field documentation which included excavations plans, photos, and the recording of location and masses of daub and movable finds either with point coordinates or in a grid of 1 x 1 m cell size. During excavation, daub was systematically documented to reconstruct both architectural attributes and wood resources [37, 45, 46]. This documentation included the mapping of daub fragments and a typological classification of daub pieces based on their material attributes and on the direction and dimension of imprints of structural (wooden) elements. To determine the architectural construction, the location of wood imprints was mapped differentiated according to the diameter of logs and the width of split wood planks.
Mapping of artefact distributions was performed in order to identify activity zones within the excavated mega-structure 3. Refitting of ceramic vessels and mapping of pottery fragmentation were used for the consideration of taphonomic formation processes and interpretations of primary and secondary artefact distributions.
Comparison of artefact and botanical macro-remain assemblages of mega-structures and dwellings
Qualities and quantities of objects which were associated with the mega-structure and two normal dwellings provide an estimate for reconstructing activities performed related to these different objects. Generally, similar formation processes of find assemblages are assumed for the compared different types of buildings. Specifically, we assume that possible behavioural differences during abandonment of the houses and the mega-structures are balanced through the inclusion of materials from probably waste disposal areas in the surrounding of the buildings. Additionally, the degree of fragmentation of pottery is used to evaluate the questions if vessels were found in primary or secondary waste disposal contexts.
The inventory comparisons take into account the absolute amount of objects and partly the density of objects per cubic metre of excavated soil. Thus, e.g. the frequency of particular vessel classes allows conclusions about certain functional aspects of a particular find context. This is especially the case for vessels associated with storage purposes and for food consumption.
Vessels were quantified as follows: After intensive processing and refitting of vessel units, the identification and counting of individual vessels units took place in consideration of typological differences concerning size, morphology, and decorations. A minimal number of vessel units (MNI) was determined by recording the preserved percentages of rims, bellies, and bottoms and setting a complete vessel as 100%. An alternative quantification of vessel classes is based on the count of recorded vessel units, reflected in the number of data sets in the project database. The percentage of sherds with engobe on their inner surface provides a relative measure for the percentage of bowls in an assemblage.
For botanical macro-remains 214 samples of sediment of 10 litres each were taken in the trench 111 (198 of these samples come from the stratigraphy of the mega-structure 3). Systematic sampling was carried out grid-wise and intensified for every second quadrant (1 m2) for the ancient soil surface. Flotation has been carried out on these samples, using a metal sieve of 300 μm, as previously done for the other samples from the site [45, 47]. Overall 414 charred botanical finds have been retrieved from trench 111, but preservation conditions allowed the taxonomic identification of only 305 of those. The carbonised remains found in trench 111 (S1 Table) include cereal grains (Triticum sp., Hordeum sp., mostly cereals indet.), pulses (Fabaceae) and feather-grass awns (Stipa sp.).
Calculation of the use group size
The use group sizes of mega-structures were quantified based on the numerical ratio between mega-structures and dwellings. Therefore, the key-value of the estimates is the determination of the number of dwellings that belonged in purely arithmetical terms to a single mega-structure. Within settlements, we assume the rough contemporaneity all low-level mega-structures visible in the magnetic plans, since this is clearly indicated by the uniform distribution of the buildings. The population estimates are based on the average floor space of 7 m2 per person determined using a cross-cultural ethnographic data-set [48]. For each site the average size of residential buildings was taken into account. We are aware that the values calculated in this schematic way of quantification provide only maximum use group sizes since the contemporaneity of the houses is assumed in the most cases. Nevertheless, the calculations are suitable for identifying regional and chronological trends regarding the size of use groups.
Detecting temporal and regional variability
Key parameters of the regional sample of mega-structures such as frequency, architectural design, positioning in settlements, and dimensions were analysed with regard to their variability in space and time. For mega-structure 3 from Maidanetske, the basis for the chronological investigations are 14C data calibrated and analysed using the software OxCal v. 4.3.2 [49, 50]. In the case of the regional data set, 14C calibrations of already established Tripolye periodization schemes were used [51, 52].
Results
What do mega-structures look like and differentiates them from domestic dwellings?
In the following section, the architectural design and the internal organization of an average mega-structure in Maidanetske will be evaluated. The extent to which the architecture and spatial organization of this building differs from normal houses is then examined by comparison with houses 44 and 59 from Maidanetske [34, 36, 37]. The extent to which the findings made for Maidanetske mega-structure 3 are representative is finally evaluated on the basis of comparisons with mega-structures in magnetic plans and other archaeologically examined buildings.
Investigating a mega-structure: The case of Maidanetske mega-structure 3
Mega-structure 3 in trench 111 was chosen for excavation because the magnetic plan displayed both highly magnetised and low magnetised sections within a clearly demarcated area. The different parts were hypothetically interpreted as roofed and not-roofed areas for different activities. During the excavation it turned out that the area was used for settlement activities already before the construction of the mega-structure.
In order to determine the absolute chronology, eleven bone-samples were 14C dated by accelerator mass spectroscopy at the Poznan Radiocarbon Laboratory from different stratigraphic contexts of trench 111 (Table 3). Pre-mega-structure activities are dated through the dates Poz-87599–Poz-87605 deriving from pits and a levelling layer below the floor of the mega-structure. The phase of use of mega-structure 3 is represented by two dates from disarticulated bones which were found in-between the wall debris of the mega-structure (Poz-87598, Poz-87610). Post-mega-structure activities are represented by two dates from the layer directly above the wall debris (Poz-87609, Poz-87721).
Tab. 3. Maidanetske, list of 14C dates from trench 111. Overall, the dates fall into a plateau of the calibration curve and the following steep section, covering a long range of about 300 years between 3950 and 3650 BCE. Through application of Bayesian modelling and the use of the function boundary with the assumption of two successive occupation phases and several events, the range of the dates becomes significantly narrowed, roughly into the 38th century BCE (Fig 3 and S1 File). However, the overall probability of this model amounts to only 40% (Amodel = 33.8) due to widely identical dates from the different phases. Higher overall probabilities of more than 100% can only be obtained through exclusion of the potential (too old) outliers Poz-87605, Poz-87609, and Poz-87610. The dating results imply that mega-structure 3 was constructed during phase 3 of the site chronology suggested by Ohlrau [31]. Consequently, mega-structure3 from Maidanetske was build related to the rapid population increase of the 38th century and abandoned at the beginning of phase 4, related to the starting population decrease.
Fig. 3. Maidanetske. Bayesian models of 14C dates from trench 111 plotted on the calibration curve. In the magnetic plan of the Maidanetske settlement, the architectural remains of mega-structure 3 appeared as a northwest-southeast aligned anomaly with a floor size of approximately 190 m2 (dimensions 19 x 10 m) (Fig 4). Trench 111, opened over this anomaly, measured 23 x 15 m and the daub package of mega-structure 3 was encountered buried under a Chernozem 0.5 m thick.
Fig. 4. Maidanetske, trench 111, section of the magnetic plans with anomalies of mega-structure 3. Mega-structure 3 was built in an area in which stratigraphic evidence indicates an earlier settlement phase. To this pre-mega-structure occupation belong the pit 111/1, perhaps the pits 111/2–111/5, and a massive levelling layer with numerous pottery finds (Figs 5 and 6). The pits were probably located in the back area of a northwest-southeast running row of houses whose position can be reconstructed based on remaining buildings in the magnetic plan. As the massive filling of pit 111/1 with daub located directly below the central fireplace of the mega-structure shows, the houses of the earlier phase were obviously burnt down and levelled to prepare the ground for the construction of the mega-structure.
Fig. 5. Maidanetske, features of the first building phase in trench 111 below mega-structure 3 with location of pits and a row of dwellings. Fig. 6. Within the mega-structure, daub was not equally distributed, corresponding with the high and low magnetised areas visible in the magnetic plan (Figs 7 and 8) [46]. In some parts of the exterior walls and in the north-western half of the building, concentrations in quantities of between 10 and 50 kg/m2 were found. In contrast, a particularly low amount of daub in the range of up to 1 kg/m2 was documented in the southern quarter of the structure and the surrounding open space. In consequence, an internal division into northwestern and southeastern parts is clearly apparent.
Fig. 7. Maidanetske, mega-structure 3 in trench 111, drawing of daub from collapsed walls, floor, and pottery. Fig. 8. Maidanetske, weight of daub belonging to mega-structure 3 in trench 111. The mega-structure was outlined by a lightweight outer wall made of clay-covered split wood and log timbers. Due to various post-depositional processes, this construction was preserved in different qualities. Based on analysis of negative imprints and the measurements of the burnt daub cover, the width of the wall is estimated to have been about 15–20 cm thick. As building timber, ash (Fraxinus 75%, n = 44) and oak (Quercus 19%, n = 11) were used whose dimensions generally fall below 10 cm [45]. Taking the wood imprints into account, both narrow sides and parts of the southwestern longitudinal part of the wall were constructed with log timbers, while the other parts of the wall were constructed mainly with split wood (Fig 9).
Fig. 9. Maidanetske, kind, dimension, and direction of timber imprints from mega-structure 3. At the southern ends of the longitudinal walls daub-free areas about 1.4 m wide are interpreted as possible entrances. The southeastern narrow side of the mega-structure was particular massive, indicated by the largest diameters of log timbers. A daub concentration 7 m south of the northwestern narrow end might indicate the remains of an interior wall dividing the mega-structure in two parts. The internal wall probably reached 4 m across the house, but 3.50 m remained daub-free, perhaps as a passageway between the two parts of the structure. A small entrance about 1 m wide might also have existed directly north of the interior wall on the northeastern longitudinal side.
The orientation of the negative imprints in the split-wood suggests the timbers were aligned horizontally in the walls of the southeastern part and vertically in the walls of the northwestern part of the mega-structure. The lack of postholes could indicate a construction with horizontal beams as wall foundations. In the northwestern corner the daub remains with vertically oriented negative imprints might be remains of a gable wall which collapsed into the internal space of the mega-structure. The height of the original external wall can be reconstructed to about 3.5 m. Also daub remains of the internal wall suggest an original height of 3–3.5 m.
Below small-sized and chaff-tempered debris of the walls, remains of a burnt rammed earth floor were found in the entire area of the mega-structure (Fig 7). Since this mostly only poorly burnt and partly only 1 cm thick floor layer was preserved exclusively in those places which were also covered by wall debris, it was particularly badly preserved (due to low firing intensity) in the southeastern part of the structure. The floor under the debris of the exterior walls was in best condition and the floor layer was up to several centimetres thick. At the outer edge of the wall debris, even in the locations with better preservation, the floor layer suddenly stopped. Here, the floor layer was slightly raised upwards where it would have originally met the outer walls if they had been preserved in place. In consequence, it is suggested that all 190 m2 of the mega-structure’s interior were originally covered with a rammed earth floor. The outer edge of this rammed earth floor marked the position of the not preserved exterior walls.
In the northwestern part of the building different installations existed. Within the interior space only few remains of furnishings were recovered. However, spatial concentrations of a specific yellowish kind of daub in the northwestern part of the building might indicate destroyed furnishing elements. In normal dwellings such as house 44 similar material was used for the construction of bins and podiums [37].
An oval area 2.2 x 1.3 m, situated within the mega-structure three to five meters away from the northwestern narrow end along the longitudinal axis, marks a fireplace which was raised above the rest of the floor by several extra layers of tamped and burnt earth (I–J/8–10; Figs 7 and 10). Corresponding installations are a standard element of Tripolye houses [53]. Since they are sometimes decorated, they are frequently interpreted as altars [31, 53]. In the installation of mega-structure 3 from Maidanetske at least three successive screed layers lay one above another and testify to a longer-lasting use of the building. In contrast, no signs of floor renewals were determined in the remaining parts of the mega-structure.
Fig. 10. Maidanetske, profile sections through the fireplace of mega-structure 3. The southeastern part of the mega-structure has a size of 10 x 7 m, measuring from the base of the interior wall, which collapsed probably in a southeastern direction. No archaeological features could be detected. In this respect, the southeastern part of the mega-structure is empty, but artefact distributions describe different activity zones.
Artefact distribution patterns provide information about the depositional processes and activities which took place within the mega-structure 3. In the case of certain artefact categories such as querns, bones, and remains of textile production a distinction can be made between activities performed repeatedly over a longer period of time and actions done just before the abandonment of the mega-structure. On the other hand, due to the probable deliberate burning of the mega-structure usual abandonment processes such as the disposal of foreign waste occurred perhaps not or in lower scale. The find distributions of pottery are most likely determined by both, long and short term depositional processes. The overall low degree of fragmentation seems to indicate that pottery was fragmented during a primary context of use (Fig 11).
Fig. 11. Maidanetske, find distributions in mega-structure 3. (A) Ceramic fragmentation. (B) Ceramics. (C) Bowls. (D) Closed/half-closed shapes. (E) Kitchen ware. (F) Ground stone artefacts. (G) Cereal Grains. (H) Animal bones. (I) Flint artefacts. (J) Remains of textile production. (K) Stipa seeds. Pottery is distributed all over the mega-structure (Fig 11). For example, bowls, which are generally associated with consumption activities, are evenly distributed across the whole interior space of the mega-structure (Figs 11 and 12). Nevertheless, concentrations are visible in the northwestern and the southeastern parts. This might indicate different activity areas whose character might be detectable by functional differences of the involved morphological vessel types:
Half-closed and closed vessels, which probably had storage functions, are concentrated in both already described zones (Figs 11–13). In the northwestern part of the mega-structure they are situated in the northeastern area east of the fire place. In the southeastern part they are concentrated in the southern corner beside the postulated entrance.
Kitchen wares, which are associated with food processing activities, occur frequently in the southeastern part but have an additional distribution focus in the northwestern part of the building, mainly southwest of the fireplace (Figs 11 and 14).
Fig. 12. Maidanetske, ceramic inventory of mega-structure 3: Cup (1), bowls (3–5, 7, 8), miniature vessel (2), and goblet (6). Fig. 13. Maidanetske, ceramic inventory of mega-structure 3: Biconical vessel (1), crater (3), biconical/sphero-conical vessels (4, 5), and sphero-conical vessel (2). Fig. 14. Maidanetske, ceramic inventory of mega-structure 3: Amphorae (1–3), pear-shaped vessel (4), pots made of kitchen ware (5–7), and pots made of table ware (8). In summary, the patterns of pottery distribution indicate food consumption in all parts of the mega-structure (bowls), food processing southwest of the fire place and along the southern walls of the southeastern part (kitchen ware), and food storage northeast of the fireplace and in the southern corner of the southeastern part. The lower fragmentation rate in the indicated zones supports our view that the named activities primarily took place in these parts of the mega-structure (Fig 11).
Remains of querns are again mainly concentrated in two zones of the mega-structure (Fig 11). Several fragments were found at the northwestern end of the building partly inside and partly outside of the external walls. Another concentration was observed in the central area of the southeastern part of the mega-structure, where the only complete quern was found.
In consequence, the different artefact distribution patterns seem to reflect the already discovered dual distribution pattern of the ceramics. We would particularly like to stress the contrast between the only partly preserved querns in the northwestern part and at least one complete and several fragmented querns in the central southeastern part. This might indicate that cereal processing only took place in the southeastern part of the mega-structure where also slightly more cereal remains were found (Fig 11). We interpret the fragmented querns as secondarily appropriated construction material, as also might hold true for a larger number of quarry stones, a boulder, and two unworked stone slabs (Fig 11). They are distributed in certain accumulations along the external walls and along the central axis of the mega-structure.
The spatial distribution of bones clearly reveals another focused activity area in the northwestern half of the mega-structure (Fig 11). In fact, the detailed bone distribution displays a half-circular density at some distance from the fireplace along the walls. This could indicate that the consumption of meat was restricted to the northwestern part of the mega-structure. Since heavily used areas within buildings are typically kept free from perishable waste, it is reasonable to assume that the bones within the building are from a meal just before the building was abandoned.
Other ground-stone artefacts include a polishing stone and a whetstone; both of which were found in the northwestern end of the building. With these artefacts, further activities are identified as taking place in the northwestern part, i.e. the polishing and the sharpening of tools (Fig 11). The distribution of the few flint artefacts (three pieces of debris and one flake) mirrors perhaps again the two larger activity zones in the northwest and southeast of the structure (Fig 11). This also holds true for remnants of textile production (Fig 11). In one concentration six fragments and one complete loom weight were found in the southern corner of the building. The second concentration consisting of a loom weight fragment and a spindle whorl was found in the western corner. The one fragment (foot and calf) of a large anthropomorphic figurine was deposited outside of the building along its northwestern narrow end and may indicate a certain kind of non-utilitarian practice linked to the northwestern part of the mega-structure.
In consequence, multiple domestic activities could be detected and localised. In the northwestern part of the mega-structure in addition to pyrotechnical activities at the fireplace, short-term storage, food preparation, meat consumption, textile production, and tool sharpening and polishing are identified. In the southeastern part of the mega-structure cereal processing, short-term storage, food preparation, and textile production took place. Food consumption is evident in both parts.
Comparing the architectural remains and the artefact distribution patterns, the ‘dichotomy’ between the northwestern and the southeastern part of the building is evident and crucial for the reconstruction of mega-structure 3 (Fig 15):
The ca. 60 m2 of the northeastern part were constructed as a more or less closed space with walls up to 3.50 m in height and possible entrances from the outside, and a passageway to the southeastern part of the structure. The fireplace holds a central position within this roofed section. The main activities are linked to the consumption of cattle and pork meat, the sharpening of tools, and storage.
The ca. 70 m2 of the southeastern part were constructed as an enclosed but unroofed space with lower walls up to 1.5 m in height in which cereal processing, but also food preparation, food consumption, short-term storage, and textile production took place.
Fig. 15. Maidanetske, reconstructed ground plan of mega-structure 3 with activity zones. In principle, our interpretation focuses on the difference between a roofed building in which meat consumption and pyrotechnic activities took place, and an appended unroofed enclosure in which activities including cereal processing were performed. Probably the spatial distribution of vessels (except bowls) with their concentration along the exterior walls indicates their original alignment. The difference between the roofed and the unroofed part of the mega-structure is reflected in the presence of charred Stipa awns in the southeastern part (Fig 11). Feather-grass is a plant of the steppe and might have entered the archaeological record due to its deliberate collection e.g. for matting [54] or attached to the fur of animals that visited spring-summer grasslands [55–57]. The presence of the tiny, charred, Stipa awns could be due to a taphonomical bias such as percolation from upper layers, but a direct radiocarbon date from another context in Maidanetske revealed to be contemporaneous to the site occupation (3969–3794 cal. BCE) [45].
In consequence, the differences in daub quantities between the northwestern and the southeastern part of the mega-structure have definitely architectural reasons and are not due to different degrees of burning. This interpretation is also supported by significant differences in activities between the two parts of the mega-structure. Whether this building was permanently inhabited or sporadically used will now be explored by comparison with other excavated dwellings.
Comparison with residential buildings
The architecture of mega-structure 3 (covering ca. 190 m2) differs substantially from that of dwellings 44 (77.5 m2) and 59 (42 m2). While the latter are characterized by massive platforms and indications of two storeys, the former is a one-storey construction. Consequently, much smaller amounts of daub were used for the construction of the mega-structure (house 44 : 1–100 kg/m2 to mega-structure 3: <1–50 kg/m2) [46]. The remains of the internal architecture also differ. While in the mega-structure only a fireplace is documented, in each dwelling both a fireplace and an oven are present. Additionally, within the dwellings a podium and a bin were documented, which were missing in the mega-structure. While the division of the mega-structure into two parts could be seen as a reflection of the division of the main dwelling into two rooms, the aspect of roofing indicates clear differences: an open activity space which is much larger in size cannot be compared to a roofed and much smaller anteroom of a dwelling.
For the comparison of find inventories in Table 4 the objects are listed which were found within or in the direct vicinity of the excavated mega-structure 3. They are compared with the inventories of the two domestic houses 44 and 59. Additionally displayed are possible activities from which these finds might derive.
Tab. 4. Maidanetske, comparison of inventories of mega-structures 3 and dwellings 44 and 56. Compared to the dwellings, mega-structure 3 contained overall a clearly lower amount (38 kg) and density (0.1–2 kg/m3) of pottery remains. The comparison of three buildings based on the percentage of engobe on the insides of sherds shows that bowl fragments are consistently ca. 8–12% of the ceramic assemblage (Fig 16). The counts of vessel categories for the dwellings show more or less similar percentages of vessel classes with relatively high amounts of both bowls/lids and cups (Fig 16). In contrast, in the mega-structure clearly higher percentages of half-closed and closed storage vessels were counted while cups for consumption are missing. A similar trend was detected also through summation of rim, belly and bottom percentages and the calculation of minimum individual vessel numbers (Fig 16). Accordingly, a minimum of 27 vessel units were associated with mega-structure 3 in contrast to 38 in house 44 and 68 in house 56.
Fig. 16. Maidanetske, comparison of pottery characteristics in dwellings 44 and 59 and mega-structure 3. (A) Location of engobe, (B) Frequency of morphological vessel classes according to the count of vessel units, (C) Frequency of vessel classes according to summed rim percentages. Comparing the inventory of the mega-structure and residential houses, some possible differences concern, among other things, artefacts related to the textile production. While such finds in the mega-structure are represented by at least nine objects, they are very rare in both compared dwellings. In contrast, anthropomorphic figurines are rather less represented in the mega-structure than in residential buildings (the one piece that was found moreover was located outside the external walls).
Summing up, there are striking differences between dwellings and the investigated mega-structure concerning architectural design, internal organisation, and to a lesser extent also the kind and intensity of performed activities. Next, we will examine how representative the results achieved are by comparing mega-structure 3 with other mega-structures in Maidanetske and mega-structures from other settlements.
Comparison with mega-structures in magnetic plans
In Maidanetske, 82% of the total settlement area has been surveyed by high resolution magnetometry, and thirteen mega-structures have been identified (Figs 1 and 17 and Table 2). Including mega-structure 3, seven of these buildings are located within the ring corridor of the settlement. In another five cases they were placed within radial trackways. Lastly, one construction was situated on a rectangular square in the east-northeast part of the settlement, of which, however, only a very small section could be recorded.
Fig. 17. Maidanetske, magnetic anomalies of mega-structures 1–13. In addition to this positioning, the buildings show considerable size differences between 120 and 580 m2 and also a certain degree of architectural variability. Within the settlement of Maidanetske eleven of thirteen special buildings show an at least partially empty interior surface. Only in the case of mega-structure 5 is the laminar deposition of daub the case. In mega-structures 1, 3, 6, and 9 remains of internal partitions are visible. In eight cases point or point-like anomalies are visible along the central axis of the structure which most likely represent fireplaces. Thus, in Maidanetske, mega-structures show a considerable variability. Beside of partly roofed buildings like the investigated mega-structure 3 we may also need to consider that some of the mega-structures were completely unroofed and others completely roofed.
Also in magnetic plans of other Tripolye settlements, many mega-structures are characterised by low or no magnetisation of the interior space in contrast to the majority of residential buildings (Tables 1 and 2). Exterior, and in some cases also interior, walls are visible as linear (stripe-shaped) or spot-like magnetic anomalies. This characteristic is (at least partly) observed in 69 cases and raises again the question of completely unroofed mega-structures. In at least six cases, mega-structures with open interior space show internal subdivisions. Most frequent are structures with a smaller anteroom and a larger main room. A centrally located subdivision as reconstructed in the case of Maidanetske mega-structure 3 seems to be rare. According to the consistent evidence of the excavated cases from Dobrovody, Nebelivka, and Maidanetske, the frequently occurring dot-like anomalies along the longitudinal axis of the buildings usually represent repeatedly renewed fireplaces [30, 58, 59].
In contrast, thirty mega-structures show higher degrees of magnetization in large parts of their inner surface. Based on the measurements of the magnetic flux density and inversions of daub masses recorded during excavations it was possible to preliminarily estimate the masses of daub of four mega-structures from Maidanetske situated in the ring-corridor [46]. These estimations show for these special buildings clearly lower total masses and average masses per square-meter than for residential buildings. Accordingly, similar to the roofed parts of mega-structure 3, we can assume also in these cases single-level structures without the platforms characteristic for residential buildings.
Pits are associated with some mega-structures. In contrast to dwellings, these pits are in most cases not located on a gable side but on a longitudinal side of the building. In some cases, there is a row of single pits; in other cases longer pits stretch along the entire length of the building.
The comparison with a larger sample reveals a greater variability of mega-structures. At the same time, the comparison underpins the clear architectural differences between mega-structures and dwellings based on high versus low magnetization of the inner surface. Furthermore, where the mega-structures exhibit high internal magnetization there are still characteristic differences from residential buildings probably based on different masses of fired clay.
Comparison with other excavated mega-structures
Although the number of archaeologically investigated mega-structures is still low, the reasons for the above illustrated differences can be partly determined by examining those that have been excavated.
In the Precucuteni settlement Baia near Suceava in the Romanian Bucovina an ‘exceptional building’ was excavated which clearly differs from other dwellings of the site by its large size of at least 200 m2 and location in the centre of the settlement [38, 40]. According to preliminary reports the building was subdivided into eight rooms. The so far only very selective published inventory of this building consisted of grinding tools, chipped stone implements, and at least 200 vessels, among them a singular concentration of 25 vessels with anthropomorphic representations. Accordingly, as in Maidanetske mega-structure 3, many domestic activities are documented in Baia, although it is necessary to wait for a detailed publication of the find assemblage in order to make a more thorough comparison.
In the giant-settlement Dobrovody 144 m2 of a mega-structure were excavated [60]. This 46 x 26 m (ca. 1200 m2) large building structure is situated in an unbuilt ring-corridor of the site and appears in the magnetic plan as a rectangular structure with an enclosing wall and low magnetisation of the entire interior space [7]. During excavation debris of a lightweight built outside wall, remains of a poorly fired floor, and a round installation with three layers of repeated renewals were found. Only about sixty sherds and a fragment of an anthropomorphic figurine were documented. Based on these observations the excavators reconstruct an unroofed enclosure for unspecified ‘socio-economic purposes’. The case of Dobrovody shows that completely unroofed mega-structures likely existed in which obviously activities only with very low intensity took place.
In the Tripolye B2 mega-site Nebelivka the so-called mega-structure with dimensions of ca. 1200 m2 (60 x 20 m) was excavated completely [9, 30, 31, 59]. This building was located in the eastern part of the settlement separated on a primary plaza in alignment with the inner row of houses of the ring corridor. It shows a division into two or three parts (Fig 18): The eastern probably unroofed part (20 x 20 m) consisted only of linear deposits of daub from an enclosing wall and was to a large extent free of finds. In contrast, considerably higher quantities of daub and other materials were deposited in the larger western part (38–40 x 20 m). It is not completely clear if this part was completely or only partly roofed. In addition, a possible multi-storey construction is under controversial discussion [30]. The interior design shows some elements of and a general arrangement similar to normal houses [53] like a “podium” along the southern longitudinal wall, clay bins, clay platforms, and internal walls. At least six cross-shaped and partly decorated fireplaces were arranged in two parallel rows in its middle part next to two grinding installations. The seventh, largest and also cross-shaped installation was located on the long axis of the building decentralized in front of the western gable wall [59].
Fig. 18. The rather small find-inventory displayed no striking differences to residential houses apart from a small golden spiral, a few large storage vessels and several tokens. Some objects, such as anthropomorphic figurines were underrepresented in comparison to ‘normal’ buildings. According to Chapman, the associated find inventory is generally marked by a certain poverty [11]. Apart from a gold spiral, the inventory is not a material representation of any social hierarchy.
The case of Nebelivka confirms the finding that in mega-structures different 'domestic' activities took place. At the same time, the multiple occurrences of fireplaces and installations for milling of grain represent a remarkable difference from numerous other mega-structures.
Preliminary conclusions on the nature setup of mega-structures
Beside their high visibility in the public space of Tripolye settlements, different archaeological observations show clear differences between mega-structures and dwellings which support the idea of communal functions associated with mega-structures.
There are major architectural differences indicating that the daub deposits in the interior space of mega-structures rather represents remnants of wall debris and do not derive from raised platforms like in residential buildings.
Other differences in the architectural design are the presence of roofed and unroofed but enclosed spaces on a single level in contrast with the two-storey houses.
Completely unroofed mega-structures can be distinguished from partially to completely roofed mega-structures.
The spatial organisation of mega-structures clearly differs from that of domestic houses. Within normal dwellings activities took place in the enclosed private sphere, while the mega-structures had both an enclosed space and some kind of semi-public open part.
Within the three excavated Tripolye mega-structures fireplaces but no ovens were present.
While usually only one fireplace is present, in Nebelivka the occurrence of multiple fireplaces points to a special case.
Although numerous activities of ‘domestic character’ took place in the investigated mega-structure 3, the different character of the building is indicated by clearly lower densities of certain artefact classes. This concerns, for example, vessels for the handling of food and figurines for ritual activities.
Beyond these absolute quantitative differences, differences in relative abundances of vessels indicate a lesser importance of food preparation and consumption and a greater importance of short-term storage of food in the mega structures compared to domestic dwellings.
If there are pits associated with mega-structures they are situated not along the narrow but along the longitudinal side of the building.
According to the presented extensive evidences, mega-structures represent buildings whose architecture and locations in the settlement clearly differ from dwellings. The absence of ovens and the associated smaller find inventories suggest that mega-structures probably represent places which were not permanently inhabited.
Categories of mega-structures
The following section uses a regional sample to systematically explore the extent to which different categories of mega-structures within Tripolye settlements can be identified that could correspond to different integrative social levels. This study will include the positioning of mega-structures within settlements, their dimensions, and architectural features. Based on these characteristics, a typological classification of Tripolye mega structures is proposed.
Identifying different positions of mega-structures in magnetic plans
In the site plans of Tripolye settlements, mega-structures are located not within concentric house rings, but within the ring corridor, radial trackways, or at the outskirt of the settlement. Some of them are located in empty spaces which are demarcated by lines of houses that we term ‘plazas’. These places are in a special location at the main entrance area of the settlements–singular primary plazas–and in other places, which are not so prominent for the whole site concept–secondary plazas.
The location of mega-structures within the site is one of the most important criteria for their identification in the magnetic maps. For classification purposes we consider six different categories of positons (Fig 19): P1 in the centre of the settlement; P2 on the primary plaza of the settlement (Fig 20); P3 within the main ring corridor, mostly spaced at regular distances from each other; P4 in the radial pathways; P5 before the outer ring of the settlement; P6 at the inner end of radial trackways, often in a kind of secondary plaza.
Fig. 19. Schematic representation of the observed positioning of mega-structures in Tripolye settlements. Fig. 20. Hlybochok. So far there is only one example for position P1 from the Precucuteni settlement Baia where, however, the integration of the mega-structure into the layout of the surrounding buildings is unclear [40]. In contrast, the mega-structures in the settlements Petreni and Trostiyanchyk represent rather a variant of the position P2 [43, 44]. In these cases, mega-structures were positioned at the end of the “plaza” and not in its centre.
In the analysed sample of settlements the number of different positions per site varies considerably depending on the scale of their investigation, size, regional setting, and dating (see below). In no settlement mega-structures are present at all positions. Rather, only single types occur or certain characteristic combinations, as exemplified by pairings of mega-structures in the ring corridor (P3) and at the outskirt of the settlement (P5) in Nebelivka and Volodymyrivka. In Maidanetske, contrastingly, mega-structures in the position P5 are missing while buildings in different positions on the radial streets (P4, P6) occur.
Measuring of mega-structures
In relation with the locations P1–P6, the mega-structures display differences in floor size; their size and proportions thus represent a second important criterion for a classification system. A scatterplot displays two sub-sets of buildings with different dimensions and length/width ratios (Fig 21). The first sub-set is exclusively located on primary plazas (P2); elongated length/width ratios between 1 : 2 and 1 : 4 and widths of not more than 12 m are characteristic, even if occasionally up to 16 m, and lengths between 18.5–65 m are observed.
Fig. 21. Scatterplot diagram of length and width of 104 special buildings from Cucuteni-Tripolye settlements between the Carpathians in the west and the Southern Bug-Dnieper Interfluve area in the east. In contrast, buildings of the second sub-set (P3–P6) are shorter and wider with length/width ratios lower than 1 : 2. Larger widths of frequently 20 and occasionally up to 26 m make the difference in terms of their size. Larger examples occur exclusively in the ring corridors (P3), smaller ones in or near radial trackways (P4–5) and outside the outer concentric house-ring (P6).
Mega-structures had large differences in floor area according to their position in the settlement. The biggest examples and at the same time the largest variance in floor area are found in constructions on primary plazas (P2), which range between 175 to 1200 m2 (mean 420 m2; median 315 m2, n = 24). Clearly larger than the majority of dwellings are also special constructions located in ring-streets whose floor sizes range between about 100 and 1200 m2 (mean 375; median 360 m2, n = 40). In contrast, clearly smaller are the vast majority of constructions situated in the outer ring of houses in the positions P4 and P5 and inside of the main ring in position P6: Their floor spaces range between 93–586 m2 (mean 200 m2; median 176 m2, n = 29).
Consequently, there are very clear differences in proportions and size of mega-structures between different positions in the settlements: The largest category is associated with primary plazas, a second category with the house-free ring-corridor, and a third category with other locations.
Typology and placement of mega-structures
To come up with the typology of mega-structures the length-to-width ratio, internal partitioning, and other architectural features were used as criteria. (S2 Table). As the length-to-width ratio could successfully be used to subdivide the mega-structures according not only to their size, but also to their location within the giant-settlements, we use this criterion as a primary tool for categorisation. Additionally, the main visible internal subdivision of the mega-structures is used as a secondary criterion. Differences in further elements are used as an additional tool for classification. Thus, a three-level typology allows a phenomenological division of the special buildings under discussion (Fig 22):
Undivided building structures whose interior space is completely free of daub deposits or shows only some higher magnetized areas (types 1–3).
Two - to three-part building structures whose interior spaces was also largely free of daub deposits (types 4, 6 and 7).
One - to two-part building structures which show also in the interior space high magnetizations from daub deposits (subtypes 5, 8 and 9). Buildings of the latter group reach enormous lengths of up to 65 m.
Fig. 22. Sorting of Tripolye mega-structures by (A) length-/width-ratio, (B) division in longitudinal direction and (C) architectural characteristics and application of a type classification based on data of magnetic surveys. With regard to the placement of the different types of mega-structures within settlements some clear preferences exist (Fig 23). Constructions with open interior surface (types 1, 2, 3 and 6a and 6c occur almost exclusively within ring streets (P3), at the outskirt of settlements (P4 and P5), and in radial pathways and secondary plazas (P6). In contrast, the open types (4, 6b and 7) and most of the overlong and interior magnetized representatives of types 5b, 8 and 9 are characteristic of primary plazas.
Fig. 23. Bar chart displaying the frequency of positioning of the different types of special buildings in Tripolye settlements. Preliminary conclusions on categories of mega-structures
Based on the analysis of a large sample of mega-structures from Tripolye settlements with regard to their locations within settlements, their dimensions, and their architecture, the earlier made distinction [34] of two main categories of mega-structures can be confirmed and complemented by additional arguments. Accordingly, large and architecturally singular mega-structures on a plaza near the main entrance of the settlement can be distinguished from smaller repeatedly occurring mega-structures in other positions. The latter buildings in many cases had at least partly unroofed parts while the majority of the area of a larger number of the former group was roofed. Most likely this dichotomy corresponds to central institutions for the whole community on the one hand (first group), and institutions for parts of the community on the other hand (second group); this is also known from integrative architecture in ethnographically investigated non-ranked societies and referred to as ‘high-level’ (first group) versus ‘low-level’ (second group) architecture [27].
In addition to the distinction between low and high-level buildings, different categories within the low-level group have been identified based on their intra-site positioning and size. Accordingly, larger mega-structures in the ring-corridor can be distinguished from smaller buildings located at different positions on radial pathways and at the outskirts of settlements. However, in order to be able to discuss to what extent these different categories reflect also different integrative levels, use group size and diachronic developments need to be included in our analysis.
Use group size of mega-structures
The size of use groups associated with each low-level integrative building can be roughly estimated by using the numerical relation between the total number of dwellings and mega-structures within a settlement. The uniform distribution of low-level mega-structures within individual settlement is considered as key argument to assume their rough contemporaneity. For Maidanetske, on average, a 9 ha settlement area or 185 house-pit combinations were calculated as belonging to one mega-structure [8]. With an average house size of 72 m2 and a space requirement of 7 m2 per person this would correspond to a use group of 1900 persons. However, this should be understood as an absolute maximum value, since the contemporaneous occupation of all houses is a very improbable scenario.
For Maidanetske, a more realistic estimation of potential use group size is possible based on detailed stratigraphic analyses and Bayesian modelling of more than 80 14C dates [25, 34, 45]. Accordingly, we need to take into consideration a settlement duration of 260–350 years with a population peak in the 38th century BCE. Assuming an average duration of house occupation of 50 years, in settlement phase 3 the total number of contemporaneous houses amounts to 1550 houses. This would reduce the number of houses, which in purely arithmetical terms belonged to one mega-structure during Phase 3 to about 130 and the maximum use group size to around 1340 individuals.
Pronounced differences in the size of potential use groups of mega-structures are indicated by a high variability in the numerical relation between dwelling and mega-structures. The application of a similar calculation method resulted in significantly lower maximum use group size per special building between about 300 and 350 persons in Volodymyrivka and Petreni and 750 persons in Nebelivka (Table 1 and Fig 24). Similar values have also been calculated in the small settlement of Moshuriv 1 (280 persons) and the giant-settlement Dobrovody (600–750 persons). These are all significantly exceeded by the potential maximum use group sizes per mega-structure in Maidanetske (1340 persons) and Talianky (1500 persons).
Fig. 24. To conclude, there is an enormous variability in the ratio of dwellings and mega-structures and the potential use group sizes of low-level mega-structures. This variability increases if high-level integrative facilities are also considered.
Mega-structures in time and space
In order to identify social processes in the archaeological record, it is necessary to analyse how mega-structures developed through time and how they vary across space. Thus, in the following section the attempt is made to explore basic trends in the development of mega-structures and to show aspects of their spatio-temporal variability.
The chronological development of mega-structures
Chronologically, a considerable variability in the frequency of mega-structures and their architecture is observed. The regular occurrence of mega-structures as a standard element of settlements begins at the latest in the period Tripolye B1–B2 between about 4200–4050 BCE. The highest frequency of special buildings was reached in the period Tripolye C1 between 3900–3600 BCE (Table 5). Considering additionally the different lengths of the periods, the highest density per 100 ha settlement area already existed earlier, in the period Tripolye B2 between 4050 and 3900 BCE.
Tab. 5. Frequency of special buildings in relation to the size of magnetically surveyed areas and to the duration of periods. Until ca. 4200 BCE, mega-structures are very rare which might at least partly reflect the lack of magnetically surveyed sites belonging to these early Tripolye periods [61]. One of the earliest examples with a small-spatially structured ground plan was excavated in Baia south of Suceava in the Romanian part of Moldova.
Mega-structures are more frequent at the end of the period Tripolye B1 (Chyzhivka) and during period Tripolye B1–B2 in the last centuries of the 5th millennium. This development parallels the trend towards significant enlargement of settlements. In the Southern Bug-Dniester interfluve both constructions of the type 6b with partly open interior space (Zab-2) and oversized buildings of the types 5b, 8b and 9 with extensive daub deposits (Ter-1, Vil-1, Zab-1) occur. In Volodymyrivka, in the Southern Bug-Dnieper Interfluve, the so far earliest known ring-corridor buildings of the types 2b and 2c occur in addition to a large mega-structure with multiple rooms on the primary plaza of the settlement.
In the Southern Bug-Dnieper interfluve the development towards a rising number of special buildings arranged in the ring corridor and other positions of Tripolye settlements continued also in sites of the periods Tripolye B2 (Volodymyrivka, Nebelivka, Hlybochok) and Tripolye C1 (Moshuriv 1, Dobrovody, Maidanetske). In the Tripolye B2 period, we observe in the Southern Bug-Dnieper interfluve increasing architectural differentiation between buildings on the primary plaza and structures at other locations, even within small settlements. In earlier settlements like Volodymyrivka and Nebelivka buildings of the types 2, 6, and 7 with open interior spaces are the predominate types in all positions. Also on the main plaza in Hlybochok two buildings of the type 6b were situated. In addition, on this main plaza, an elongated oversized construction with highly magnetised interior space occurs for the first time in the region. Corresponding types of architecture might be adopted from the region west of the Southern Bug, where they occur already earlier in the period Tripolye B1-B2 (e.g. Zabolotne). The architectural diversity of the ensemble in Hlybochok might suggest that cases with multiple buildings on the same plaza represent different stages of settlement occupation.
The observed architectural differentiation is accompanied by two reversal trends regarding the size of mega-structures in different settlement locations (Fig 25). Constructions in the positions P3–P6, which generally occur several times per settlement, became smaller between the phases Tripolye B2 (Volodymyrivka, Nebelivka) and late Tripolye C1 (Talianky). However, at least in the case of Talianky, this is due to the lack of special constructions in the ring corridor, which are usually larger than the here dominant buildings in the position P5.
Fig. 25. Boxplot diagram of floor areas of Tripolye mega-structures in a diachronic view differentiated according to positions within settlements. In contrast, mega-structures on primary plazas (P2) show ever larger floor plans until the period C1 (Fig 25). However, as the regional comparison shows, this variability may also reflect regional differences due to imbalances of the sample. According to this, the average floor size of mega-structures on the main plaza is reduced from eastern to western Tripolye regions: from approximately 500 m2 (median 380 m2, n = 9) in region A to ca. 425 m2 (median 317 m2, n = 11) in region B, and ca. 219 m2 (median 220 m2, n = 4) in region C. However, the currently available sample from region C is still very small and represents only the periods Tripolye B1, B1-B2 and B2.
The described changes were accompanied by a clear trend towards rising number of contemporaneous houses and potential size of use groups which were associated with an individual mega-structure. While the maximum use group size of low-level buildings in the period Tripolye B2 is estimated in a range between 300 (Volodymyrivka, Petreni) and 750 (Nebelivka), there is a clear increase in the period Tripolye C1 with a total range between 280 (Moshuriv 1) to 1500 (Talianky) persons. This strong increase is even clearer in relation to the central, high-level mega-structures whose use groups potentially were the whole population of the settlement; in the case of Maidanetske this is estimated at between 10,000 and 20,000 people (Table 1).
The described trends are in particular remarkable if we consider the simultaneous reduction in size of special buildings. This applies specifically for buildings in the ring corridor (P3), radial streets (P4 and P6), and on the settlement outskirts (P5). In contrast, the size increase of the central mega-structures is rather plausible against the background of growing use group sizes.
Consequently, from middle to late Tripolye, important variations of the mega-structures developed. While originally only central, high-level mega-structures existed, around 4100 BCE additional low-level, ring-corridor buildings appeared in the process of mega-site formation. Subsequently, an increase in variation of both central and other mega-structures implies perhaps an increasing functional differentiation. In the later phase of the mega-site development, smaller mega-structures declined before they widely disappeared at the final stage. In the final stage the centralized power reflected in the primary plaza mega-structures not only survived, but extended its local dominance.
Regional differences
At the spatial macro scale, there are significant differences in settlement size and density within the Cucuteni-Tripolye complex. Accordingly, from west to east, the maximum size of settlements increases while the density of settlements decreases [13]. The majority of mega-sites are concentrated in the Southern Bug-Dnieper interfluve [32]. In the following section, the question will be examined to what extent these differences are also reflected in the use of mega-structures.
Pronounced regional differences exist with regard to the frequency of special buildings which only partially result from the unevenly distributed sample. With 74 (74%) cases, the majority of the examined buildings originate from the Bug-Dnieper interfluve (region A), while only 13 (12%) come from the Dniester-Southern Bug interfluve (region B) and 17 (16%) from the region between the Dniester and the foothills of the Carpathians (region C).
The reason for the different frequencies of mega-structures is primarily due to the absence of certain classes of buildings in the western part of the study area. In the regions C (Prut-Dniester interfluve) and B (Southern Bug-Dniester interfluve) mega-structures occur almost exclusively in the centres of settlements (P1) or on eccentrically located main plazas (P2). In contrast, the occurrence of buildings situated in the ring street (P3), in the outer house rings (P4 and P5), and in radial streets and secondary plazas (P6) is mainly limited to region A (Southern Bug-Dnieper interfluve).
One of the few known exceptions to this rule concerns the site Petreni in the north-western part of Moldova which was occupied ca. 3950–3700 BCE [62, 63]. In this site, special buildings are located at regular intervals in the ring road of the settlement similar to distributions recognized in the Bug-Dnieper interfluve area. However, the majority of these buildings show not the characteristic empty interior space of such ring structures, but have a completely magnetised floor plan. In regions B and C, types with low width-length ratios and open interior space are generally very rare. On the contrary, in these regions types with narrower proportions and magnetised inner surfaces prevail already in the period B1-B2. The same types were adopted later also in region A.
In principle, the regional differences display an increase in the presence and variability of mega-structures within sites from west to east. Surely this is linked to an increase in site sizes from west to east. Consequently, the diverging developmental trends of primary and secondary mega-structures reflect the necessity to negotiate old and new institutional governance of giant-settlements.
Discussion: Integrative architecture
What are mega-structures?
Until now, the main argument for the public character and communal functions of mega-structures consisted of the placement of the buildings in highly visible positions within Tripolye settlements. This was demonstrated for the site of Maidanetske by René Ohlrau based on view-shed analysis [8]. This high-visibility aspect applies not only for buildings placed in the ring corridors, but also for those in radial pathways. Recently, this aspect can also be realised in the most impressive ensemble of three huge mega-structures from Bilyi Kamin which were positioned next to each other in landscape-dominating position on a widely visible promontory showing definitely some kind of monumental character [41].
Newly identified aspects of mega-structures are their major differences compared to normal houses. These differences concern architectural design such as the presence of roofed and unroofed parts and the terrain level construction. Other differences concern their semi-public character and different spatial organisation. Rather unusual aspects are also represented by at least ten tokens, several pendants, and a small golden spiral. Additionally, comparatively low artefact densities and the absence of ovens suggest that mega-structures were not or not permanently inhabited.
Besides these striking differences, there are also important common aspects with normal houses. This applies, for example, to partly decorated and repeatedly renewed fireplaces which obviously represent an important standard element not only of houses but also of mega-structures. These installations are interpreted as communicative cores of Tripolye houses due to their prominent placement on the central axis of the buildings [37].
Shared aspects of dwellings and mega-structures also concern numerous ‘domestic’ activities which were identified in both types of buildings such as storage, preparation and consumption of food, the milling of grain, the craft production and specific ritual activities, represented by vessel assemblages, animal bones, botanical macro-remains, querns, artefacts for textile production, and anthropomorphic figurines.
Important for our interpretation of mega-structures is comparison with integrative buildings in 28 ethnographically documented societies from North America, South America, New Guinea/Oceania, and Africa. In ethnographic situations, a poly-functional character and a frequent use for both ritual and non-ritual activities have consistently been observed [26, 27]. This use can include various aspects such as information sharing, joint decision-making, administrative purposes, body cleansing, stockpiling, or the redistribution of goods. Consequently, performing day-to-day ‘domestic’ activities in integrative facilities is the normal state rather than the exception.
Thus, we do not consider the various domestic activities which have been proven for the excavated examples from Maidanetske and Nebelivka as a reason to question the expected public functions. In contrast, in our opinion, the described wide range of activities associated with Tripolye mega-structures completely prevents the interpretation of these constructions as specialized production or central storage facilities, but rather indicates their communal nature as a place for integrative action. Such integrative actions could include feasting during which certain rituals of consumption were performed to share surplus, to acquire prestige and social power, or to maintain existing inequalities [64]. In another context in Maidanetske feasting activities have been already proven connected with the deposition of two cattle skulls and numerous bowls at the bottom of a pit [37]. Generally, in Tripolye mega-sites we can assume an increased importance of ritual and ceremonial activities that provide a frequently observed mechanism for reducing scalar stress in large human groups [15]. This is also not contradicted by the rarity of anthropomorphic and zoomorphic figurines in the mega-structure, since these objects might mainly be related to specific ritual activities linked to the domestic sphere of normal households.
Mega-structures and social organization in Tripolye settlements
As shown above we identified four different locations of mega-structures within the evaluated sites, which probably can be placed in a kind of hierarchical order:
Mega-structures at the main entrances of giant-settlements are usually the largest and integrate functions for the organisation of the whole mega-site community.
Mega-structures in the ring-corridors are usually smaller and integrate organization efforts of only segmented parts of the mega-site community.
Mega-structures in the radial trackways are also smaller and they integrate purposes which might be associated with the control of the trackways or of subsequently added quarters.
Mega-structures at the periphery near the outer house-ring are of similar size to those mentioned in no. 3.
In our view, these four different spatial locations reflect some kind of system of hierarchical levels of social and political organisation related to different use groups. Therefore, buildings on these different levels show also different architectural characteristics and dimensions. It is not surprising that with the increasing size of Tripolye sites, the number of organizational levels also increased. As we already stated, high-level mega-structures associated with the whole settlement were complemented by low-level buildings for smaller sub-groups successively during phases of settlement growth. The new integrative architecture is a reflection of the situation in giant villages where it is impossible for everybody to know everybody and therefore the means of political organization have to increase.
Potentially, the different categories of mega-structures were related to different integrative activities or different kinds of local sub-groups which constituted as a whole a settlement community. This hypothesis is supported by the striking pairings of buildings in the ring-corridor on the one hand and on the outskirts of the settlement on the other hand observed in Nebelivka and Volodymyrivka. Also the pattern in Talianky points in the same direction where buildings in the ring-corridor are completely missing and only small buildings in radial trackways occur.
With regard to the question who actually took part in the integrative actions within mega-structures, we observing a systematic discrepancy between the estimated use group sizes of Tripolye mega-structures and use groups of integrative buildings which were documented in the cross-cultural ethnographic sample (Fig 24). Use group sizes in ethnographic case studies are usually much smaller and never exceed maximum 600 people even in high-level integrative units [26, 27]. Thus, in particular in the case of Tripolye giant-settlements with their large estimated use group sizes, we need to take into account that only a limited part of the total population was involved in the decision-making processes in mega-structures or that preceding estimations of numbers of inhabitants resulted in to high numbers.
Indirectly this supports the ideas that also at lower levels than larger districts or quarters additional integrative institutions existed which could be, for example, related to house clusters [10]. Additionally, mega-structures in less prominent positions such as those buildings at the fringe of the settlement area could represent lower levels of decision-making or different sub-groups.
Mega-site collapse and the loss of middle-lower decision-making levels?
If we accept the arguments regarding the integrative nature of mega-structures and the different hierarchical scales represented in the different positions of mega-structures in Tripolye settlements, we are able to deduce also the societal institutions behind these structure and to track their development. Accordingly, integrative architecture existed already since the early stages of Tripolye societies in the first half of the fifth millennium but were for a long time exclusively related (or visible) to the organisational level of whole communities much smaller in terms of population size [40]. Related to the beginning of the formation phase of giant-settlements in the last centuries of the fifth millennium BCE, villages of partly already enormous size emerged which regulated decision-making further on the level of the whole community.
The emergence of additional integrative social and political institutions below the level of the entire Tripolye giant-settlement is most likely the result of the fusion of different local units which attempted to maintain their local organisational structure (Fig 26). Within the Tripolye giant-settlements these units might be equated with some kind of ‘quarters’ or ‘districts’ [65]. Thus, the uniform distribution of mega-structures within Tripolye giant-settlements probably reflects the planned and equal process of the fusion of different smaller communities in giant-settlements. The lower decision-making levels are as necessary to keep the mega-site manageable as the central level for the whole mega-site.
Fig. 26. Schematic reconstruction of transformation processes of political integrative institutions and architecture in Tripolye settlements. Around 4600 BCE–In small settlements, integrative activities took place in central mega-structures. Around 4100/4000 BCE–Giant-settlements developed through the fusion of smaller communities, which maintained their integrative institutions and established high-level central institutions for the entire settlement. Around 3900/3800 BCE–Ongoing centralisation of integrative activities is indicated by increasing functional and architectural differentiation between high-level and middle-low-level integrative buildings. Around 3700 BCE–Increasing centralisation of social and political activities led to the loss of the middle-lower integrative decision-making levels. Around 3650/3500 BCE–Disintegration of Tripolye giant-settlements and re-emergence of a dispersed settlement system without (visible) integrative architecture. Therefore, upon their arrival in the new settlements, representatives of the different segments or sub-communities of mega-site populations founded new central institutions together, which are represented in the mega-structures on the main public plaza of large settlements. In these high-level structures, the concerns of the whole community were managed; these central institutions were necessary in order to manage information flow and decision-making and to reduce scalar stress at the organisational level of the whole settlement [66, 67]. In terms of population size these new institutions are related to significantly larger populations quantified, for example, in the case of Maidanetske to more than 10,000 inhabitants [25].
In the following 400 years, until about 3600 BCE, the political integrative institutions underwent substantial transformations. As is suggested by reverses in the size and architectural development of mega-structures in different positions, integration at the level of sub-communities lost importance while high-level integrative institutions at the community level became more important. As a result of this process, probably more political decisions were made at the community level while the sub-communities became focused on other integrative activities. Consequently, the institutional differentiation was accompanied by increasing architectural and functional differentiation. The differentiation process described was probably the result of increasing integration at the community level and a blurring of social boundaries between the original settlement units. Thus, we see a centralization process in which obviously decreasing numbers of people were involved in political decisions.
Although in Talianky the detection of central mega-structures is pending due to inaccessibility, the absence of mega-structures in the ring-corridor seems to indicate that low-level integrative institutions had largely lost their importance at the end of the sequence of Tripolye giant-settlements. Obviously, the integrative action and power, which was in earlier sites much more equally distributed within a segmented society, passed over to central institutions.
The observed centralization certainly concerned not only political decision-making processes, but probably also the ritual dimension of mega-structures and the composition of the group of people involved in shared consumption of surplus. Indeed, the ritual importance of mega-structures is reflected only to a lesser extent in the composition of the artefact inventories. However, increased ritual importance is indicated inter alia by an increasingly elaborated architectural design of the main plaza in the ground plan of settlements as clearly demarked public square spatially separated from the ring corridor. Overall, we regard the food, which was consumed in mega-structures, as surplus that has been removed from the domestic context and consumed in commensal meals by a now much smaller group of people. This advanced centralization of political decision-making, ritual activities, and possibly also the redistribution of a low-scale surplus might indicate the emergence of certain hierarchies or a change in cooperative modes of production and consumption. The observed regional differences are probably partly the result of different formation processes of giant-settlements, which seem to correlate with a general trend towards smaller settlements west of the Southern Bug. Accordingly, large settlements to the west of the Southern Bug are perhaps to a lesser extent the result of inter-site-mobility but rather of natural population growth? Additionally, there is certainly an overall lesser degree of population agglomeration and a certain temporal focus of the examined sample on periods in which there were no mega-structures in secondary positions to the east of the Southern Bug.
Consequently, the developing centralisation in decision-making might reflect an increase in social inequality and resulting imbalances of group interests within large Tripolye communities should be taken into account as a critical factor for the disintegration of Tripolye giant-settlements. This is especially the case since previously discussed factors such as the non-availability of firewood and timber [45], insufficient carrying capacity [68] and soil depletion [69] can meanwhile be excluded with certain probability. Instead, scalar stress resulting from dysfunctional collective decision-making and the non-acceptance of emerging hierarchies could be important determinants for the end of the mega-structures beside of other possible factors such as climatic change [70] and epidemics [71].
From the point of view of the population sizes of ca. 10.000 + - 5000 inhabitants reconstructed for Tripolye mega-settlements [8, 14, 25], a high degree of scalar stress must inevitably be presupposed, which had to be reduced by effective mechanisms. The mega-structures discussed in this paper represent the aspect of sequential decision-making as one of the possible mechanisms for managing social complexity and reducing scalar stress [15]. According to our data, this bottom up mechanism increasingly turned into an increasing dominance of centralized decision making in contrast to institutionalized decision making on different scales.
The increased social complexity as prerequisite for the described centralization process is only weakly supported through the archaeological data or masked by selective preservation conditions. Anyway, in Tripolye mega-sites, for example, significant differences in floor size of houses existed beyond apparently uniform find-inventories [8]. A certain complexity is also indicated by increased specializations in pottery production [72], textile manufacture [10], supply with stone raw materials [73], and possibly food production [10]
Decisive for the failure of the just emerged hierarchical decision making, was in our view the continued predominant ideology of social autonomy of segmented lineages. Thus, in Tripolye mega-sites we don’t see the generalized failure of the dispersed (bottom up) decision making structure but rather the result of social contradictions arising from dissatisfaction and non-acceptance with central (top-down) decisions of centralized institutions of the settlement. Conceivable areas of conflict might include access to arable land nearby the settlements or social asymmetries resulting from the growing social complexity and specialization. The value of mega-structures for the reconstruction of social space within Tripolye settlements lies in the fact that this special category of buildings reflect in a very specific way different aspects of the social organisation in segmentary Tripolye societies: In Tripolye giant-settlements they reflect different stages of social integration of societal sub-groups and signify social tensions and organizational insecurities within the concept of mega-sites. Additionally, they can be used to reconstruct central institutions within these villages. Consequently, the configuration of integrative architecture can serve as a proxy for different historical states and processes including political decision-making structures, ritual integration, surplus redistribution, and different scales of political and economic organization.
Supporting information
S1 Table [docx]
Maidanetske, botanical macro-remains from trench 111 and mega-structure 3.S2 Table [docx]
Type description of the typology of Tripolye mega-structures.S1 File [docx]
Maidanetske, trench 111, OxCal codes and results of Bayesian modelling.
Zdroje
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- Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Upgraded molecular models of the human KCNQ1 potassium channel
- Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells
- The extraordinary osteology and functional morphology of the limbs in Palorchestidae, a family of strange extinct marsupial giants
- Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro
- Implementation of home blood pressure monitoring among French GPs: A long and winding road
- In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues
- Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
- The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study
- Retraction: Comprehensive Comparison of Three Different Immunosuppressive Regimens for Liver Transplant Patients with Hepatocellular Carcinoma: Steroid-Free Immunosuppression, Induction Immunosuppression and Standard Immunosuppression
- Can acute suicidality be predicted by Instagram data? Results from qualitative and quantitative language analyses
- Computational and experimental analysis of the glycophosphatidylinositol-anchored proteome of the human parasitic nematode Brugia malayi
- Antibacterial activity of silver nanoparticles of different particle size against Vibrio Natriegens
- Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
- To eat or not to eat: Reward delay impulsivity in children with loss of control eating, attention deficit / hyperactivity disorder, a double diagnosis, and healthy children
- Factors associated with newborn care knowledge and practices in the upper Himalayas
- Correction: A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment
- Correlates of concurrent partnerships and patterns of condom use among men who have sex with men and transgender women in Peru
- Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma
- Development of a denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis for arthroplasty: A phantom study
- Low-level sensory processes play a more crucial role than high-level cognitive ones in the size-weight illusion
- The prevalence of asthma and allergic rhinitis in Nigeria: A nationwide survey among children, adolescents and adults
- Retraction: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium
- Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study
- Characteristics of diabetic macular edema patients refractory to anti-VEGF treatments and a dexamethasone implant
- Correction: Effects of dietary n-6: n-3 polyunsaturated fatty acid ratios on meat quality, carcass characteristics, tissue fatty acid profiles, and expression of lipogenic genes in growing goats
- Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study
- Impact of pterygium on the ocular surface and meibomian glands
- Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- Transcriptome divergence during leaf development in two contrasting switchgrass (Panicum virgatum L.) cultivars
- Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis
- Circulating progenitor cells and the expression of Cxcl12, Cxcr4 and angiopoietin-like 4 during wound healing in the murine ear
- EUSKOR: End-to-end coreference resolution system for Basque
- Inactivating pathogenic bacteria in greywater by biosynthesized Cu/Zn nanoparticles from secondary metabolite of Aspergillus iizukae; optimization, mechanism and techno economic analysis
- Exopolysaccharide producing rhizobacteria and their impact on growth and drought tolerance of wheat grown under rainfed conditions
- Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes
- Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study
- Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
- Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae)
- PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
- Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients
- “I do all I can but I still fail them”: Health system barriers to providing Option B+ to pregnant and lactating women in Malawi
- Impact of major illnesses and geographic regions on do-not-resuscitate rate and its potential cost savings in Taiwan
- Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis
- Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration
- Correction: Artificial neural networks reveal individual differences in metacognitive monitoring of memory
- Combining fish and environmental PCR for diagnostics of diseased laboratory zebrafish in recirculating systems
- Reading skill modulates the effect of parafoveal distractors on foveal lexical decision in deaf students
- Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia
- Exposure to marital conflict: Gender differences in internalizing and externalizing problems among children
- Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials
- The effect of age and perturbation time on online control during rapid pointing
- Oilseed rape (Brassica napus) resistance to growth of Leptosphaeria maculans in leaves of young plants contributes to quantitative resistance in stems of adult plants
- Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitis
- Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin
- Genomic characterization of the complete terpene synthase gene family from Cannabis sativa
- Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine
- Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana
- Plant growth promoting rhizobacterium Stenotrophomonas maltophilia BJ01 augments endurance against N2 starvation by modulating physiology and biochemical activities of Arachis hypogea
- Hierarchical integrated and segregated processing in the functional brain default mode network within attention-deficit/hyperactivity disorder
- Rising co-payments coincide with unwanted effects on continuity of healthcare for patients with schizophrenia in the Netherlands
- Analysis of Zobellella denitrificans ZD1 draft genome: Genes and gene clusters responsible for high polyhydroxybutyrate (PHB) production from glycerol under saline conditions and its CRISPR-Cas system
- False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases
- Identification of potassium phosphite responsive miRNAs and their targets in potato
- Quantification of bell-shaped size selectivity in shrimp trawl fisheries using square mesh panels and a sorting cone after a Nordmøre grid
- Deactivation of somatosensory and visual cortices during vestibular stimulation is associated with older age and poorer balance
- Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice
- Flooding performance evaluation of alkyl aryl sulfonate in various alkaline environments
- An artificial intelligent diagnostic system on mobile Android terminals for cholelithiasis by lightweight convolutional neural network
- Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads
- COI metabarcoding primer choice affects richness and recovery of indicator taxa in freshwater systems
- Retraction: APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway
- The intake pattern and feed preference of layer hens selected for high or low feed conversion ratio
- Individualized pattern recognition for detecting mind wandering from EEG during live lectures
- Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison
- Post-activation potentiation effect of eccentric overload and traditional weightlifting exercise on jumping and sprinting performance in male athletes
- Effectiveness of different central venous catheter fixation suture techniques: An in vitro crossover study
- Quantitative detection of ALK fusion breakpoints in plasma cell-free DNA from patients with non-small cell lung cancer using PCR-based target sequencing with a tiling primer set and two-step mapping/alignment
- Nuclei deformation reveals pressure distributions in 3D cell clusters
- Strategies for increasing diagnostic yield of community-onset bacteraemia within the emergency department: A retrospective study
- Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry
- Certified service dogs – A cost-effectiveness analysis appraisal
- Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy
- Assessing the impact of a research funder’s recommendation to consider core outcome sets
- Validity of six consumer-level activity monitors for measuring steps in patients with chronic heart failure
- Detection of deceptive motions in rugby from visual motion cues
- The impact of antenatal care on neonatal mortality in sub-Saharan Africa: A systematic review and meta-analysis
- Epidemiological investigation and management of bloody diarrhea among children in India
- Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation
- Bacteria isolated from Bengal cat (Felis catus × Prionailurus bengalensis) anal sac secretions produce volatile compounds potentially associated with animal signaling
- Petri net–based model of the human DNA base excision repair pathway
- Complexation and conformation of lead ion with poly-γ-glutamic acid in soluble state
- The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- The Youth-Physical Activity Towards Health (Y-PATH) intervention: Results of a 24 month cluster randomised controlled trial
- The COPD multi-dimensional phenotype: A new classification from the STORICO Italian observational study
- Morphological identification of Amphitetranychus species (Acari: Tetranychidae) with crossbreeding, esterase zymograms and DNA barcode data
- Maintaining hope after a disabling stroke: A longitudinal qualitative study of patients’ experiences, views, information needs and approaches towards making treatment decisions
- Cultural differences in the use of acoustic cues for musical emotion experience
- Effects of a rifampicin pre-treatment on linezolid pharmacokinetics
- High prevalence of multidrug resistant Enterobacteriaceae among residents of long term care facilities in Amsterdam, the Netherlands
- Infection/inflammation-associated preterm delivery within 14 days of presentation with symptoms of preterm labour: A multivariate predictive model
- Prognostic value of preoperative hydronephrosis in patients with bladder cancer undergoing radical cystectomy: A meta-analysis
- Correction: Early life predictors of midlife allostatic load: A prospective cohort study
- PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations
- Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments
- Symbiotic incompatibility between soybean and Bradyrhizobium arises from one amino acid determinant in soybean Rj2 protein
- Does anticoagulation needed for distally located incidental pulmonary thromboembolism in patients with active cancer?
- Control of human testis-specific gene expression
- Speaking up culture of medical students within an academic teaching hospital: Need of faculty working in patient safety
- Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations
- Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study
- Results of scoping review do not support mild traumatic brain injury being associated with a high incidence of chronic cognitive impairment: Commentary on McInnes et al. 2017
- Native seed, soil and atmosphere respond to boreal forest topsoil (LFH) storage
- Development of a quantitative polymerase chain reaction assay and environmental DNA sampling methods for Giant Gartersnake (Thamnophis gigas)
- Genetic diversity and population structure of four Chinese rabbit breeds
- Knowledge, attitude and behaviors towards patients with mental illness: Results from a national Lebanese study
- Correction: An impact evaluation of two rounds of mass drug administration on the prevalence of active trachoma: A clustered cross sectional survey
- Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Graph convolutional network approach applied to predict hourly bike-sharing demands considering spatial, temporal, and global effects
- Impact of traffic variability on geographic accessibility to 24/7 emergency healthcare for the urban poor: A GIS study in Dhaka, Bangladesh
- Feeling the heat: Elevated temperature affects male display activity of a lekking grassland bird
- Constructing a comprehensive disaster resilience index: The case of Italy
- Intraocular pressure according to different types of tonometry (non-contact and Goldmann applanation) in patients with different degrees of bilateral tearing
- Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus
- Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging
- Nonverbal synchrony in virtual reality
- Do speed cameras reduce road traffic collisions?
- A zero-shot learning approach to the development of brain-computer interfaces for image retrieval
- Use of non-HIV medication among people living with HIV and receiving antiretroviral treatment in Côte d’Ivoire, West Africa: A cross-sectional study
- DNA barcoding of southern African crustaceans reveals a mix of invasive species and potential cryptic diversity
- Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay
- Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs
- Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6
- Transport oil product consumption and GHG emission reduction potential in China: An electric vehicle-based scenario analysis
- Ontogenetic shift in the energy allocation strategy and physiological condition of larval plaice (Pleuronectes platessa)
- Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Diagnostic accuracy of Xpert MTB/RIF assay and non-molecular methods for the diagnosis of tuberculosis lymphadenitis
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
- Spatial distribution of breast cancer in Sudan 2010-2016
- Human-induced fire regime shifts during 19th century industrialization: A robust fire regime reconstruction using northern Polish lake sediments
- Enhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions
- Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
- Iron and manganese co-limit growth of the Southern Ocean diatom Chaetoceros debilis
- Bilateral and unilateral load-velocity profiling in a machine-based, single-joint, lower body exercise
- Veterans Health Administration nurses’ training and beliefs related to care of patients with traumatic brain injury
- Supplementation strategies affect the feed intake and performance of grazing replacement heifers
- Active transcutaneous bone conduction hearing implants: Systematic review and meta-analysis
- Parameterization-induced uncertainties and impacts of crop management harmonization in a global gridded crop model ensemble
- Acidification effects on isolation of extracellular vesicles from bovine milk
- GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve
- Mining version history to predict the class instability
- Humpback whale song occurrence reflects ecosystem variability in feeding and migratory habitat of the northeast Pacific
- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes
- Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading
- Reconstructing systematic persistent impacts of promotional marketing with empirical nonlinear dynamics
- Trans-national conservation and infrastructure development in the Heart of Borneo
- Prediction of cardiovascular disease risk among people with severe mental illness: A cohort study
- Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
- Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
- Reconstructing birth in Australopithecus sediba
- Value of contrast-enhanced ultrasound for preoperative assessment of liver reserve function in patients with liver tumors
- Correction: Identifying obesity/overweight status in children and adolescents; A cross-sectional medical record review of physicians’ weight screening practice in outpatient clinics, Saudi Arabia
- Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program
- Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
- Functional role and evolutionary contributions of floral gland morphoanatomy in the Paleotropical genus Acridocarpus (Malpighiaceae)
- On the efficiency of HIV transmission: Insights through discrete time HIV models
- Metabolic cost calculations of gait using musculoskeletal energy models, a comparison study
- Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype
- Evolutionary analysis of six chloroplast genomes from three Persea americana ecological races: Insights into sequence divergences and phylogenetic relationships
- Cultural transmission in a food preparation task: The role of interactivity, innovation and storytelling
- Correction: Effects of affective priming through music on the use of emotion words
- Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial
- Estimation of vaccination coverage from electronic healthcare records; methods performance evaluation – A contribution of the ADVANCE-project
- Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation
- Suicide by hanging: Results from a national survey in Switzerland and its implications for suicide prevention
- Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders
- Genome wide genetic dissection of wheat quality and yield related traits and their relationship with grain shape and size traits in an elite × non-adapted bread wheat cross
- Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
- Factors influencing the admission decision for Medical Psychiatry Units: A concept mapping approach
- Comparison of post-traumatic changes in circulating and bone marrow leukocytes between BALB/c and CD-1 mouse strains
- Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)
- Associations between birth order with mental wellbeing and psychological distress in midlife: Findings from the 1970 British Cohort Study (BCS70)
- Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
- The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
- Ancient technology and punctuated change: Detecting the emergence of the Edomite Kingdom in the Southern Levant
- Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- Randomized control trial of Tools of the Mind: Marked benefits to kindergarten children and their teachers
- Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration
- PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age
- Correction: Unraveling the genetic complexity underlying sorghum response to water availability
- Impact of tear metrics on the reliability of perimetry in patients with dry eye
- Using DNA barcoding to improve invasive pest identification at U.S. ports-of-entry
- Correction: Effects of Lactobacillus plantarum 15-1 and fructooligosaccharides on the response of broilers to pathogenic Escherichia coli O78 challenge
- Physico-chemical characterization and transcriptome analysis of 5-methyltryptophan resistant lines in rice
- Patient factors affecting successful linkage to treatment in a cervical cancer prevention program in Kenya: A prospective cohort study
- Is this a man’s world? The effect of gender diversity and gender equality on firm innovativeness
- Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit—The PROSACAB study
- Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock
- Quantitation of free glycation compounds in saliva
- Resolving an 87-year-old taxonomical curiosity with the description of Psylla frodobagginsi sp. nov. (Hemiptera: Sternorrhyncha: Psyllidae), a second distinct Psylla species on the New Zealand endemic plant kōwhai
- The effect of cathodal tDCS on fear extinction: A cross-measures study
- Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome
- Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells
- Investigating the dispersal of antibiotic resistance associated genes from manure application to soil and drainage waters in simulated agricultural farmland systems
- Continuous norming of psychometric tests: A simulation study of parametric and semi-parametric approaches
- Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method
- Cost-effectiveness of apixaban compared to other anticoagulants in patients with atrial fibrillation in the real-world and trial settings
- Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia
- Low genetic differentiation yet high phenotypic variation in the invasive populations of Spartina alterniflora in Guangxi, China
- A mathematical model for designing networks of C-Reactive Protein point of care testing
- Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis
- Femtosecond laser induced step-like structures inside transparent hydrogel due to laser induced threshold reduction
- From In Situ to satellite observations of pelagic Sargassum distribution and aggregation in the Tropical North Atlantic Ocean
- The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology
- BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis
- HIV prevalence and risk behavior among male and female adults screened for enrolment into a vaccine preparedness study in Maputo, Mozambique
- Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
- Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing
- Occurrence mechanism and coping paths of accidents of highly aggregated tourist crowds based on system dynamics
- Correction: Low Dose Aerosol Fitness at the Innate Phase of Murine Infection Better Predicts Virulence amongst Clinical Strains of Mycobacterium tuberculosis
- Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats
- Correction: Public reaction to Chikungunya outbreaks in Italy—Insights from an extensive novel data streams-based structural equation modeling analysis
- Correction: Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer’s dementia
- Intra-individual variability of sleep and nocturnal cardiac autonomic activity in elite female soccer players during an international tournament
- Therapeutic efficacy of equine botulism heptavalent antitoxin against all seven botulinum neurotoxins in symptomatic guinea pigs
- Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis
- Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis
- Scope and efficacy of the broad-spectrum topical antiseptic choline geranate
- Hematological and biochemical parameters for Chinese rhesus macaque
- Veterinary peer study groups as a method of continuous education—A new approach to identify and address factors associated with antimicrobial prescribing
- Correction: The prognosis of heart failure patients: Does sodium level play a significant role?
- Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin
- Systematic identification of facility-based stillbirths and neonatal deaths through the piloted use of an adapted RAPID tool in Liberia and Nepal
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis
- Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal population
- Reasons to care: Personal motivation as a key factor in the practice of the professional foster carer in Romania
- Determinants of clinical, functional and personal recovery for people with schizophrenia and other severe mental illnesses: A cross-sectional analysis
- Continuity of care for TB patients at a South African hospital: A qualitative participatory study of the experiences of hospital staff
- EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling
- The Better Management of Patients with Osteoarthritis Program: Outcomes after evidence-based education and exercise delivered nationwide in Sweden
- The negative effects of short-term extreme thermal events on the seagrass Posidonia oceanica are exacerbated by ammonium additions
- Pathogen invasion history elucidates contemporary host pathogen dynamics
- Chinese herbal formulae for the treatment of menopausal hot flushes: A systematic review and meta-analysis
- Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery
- Deconstruction of central line insertion guidelines based on the positive deviance approach—Reducing gaps between guidelines and implementation: A qualitative ethnographic research
- PBMCs transcriptome profiles identified breed-specific transcriptome signatures for PRRSV vaccination in German Landrace and Pietrain pigs
- The impact of admission serum lactate on children with moderate to severe traumatic brain injury
- Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface
- Determination of the bruise degree for cherry using Vis-NIR reflection spectroscopy coupled with multivariate analysis
- Genome-wide identification and expression profile analysis of nuclear factor Y family genes in Sorghum bicolor L. (Moench)
- Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007–2016: A retrospective cohort study
- Distribution of the Duffy genotypes in Malaysian Borneo and its relation to Plasmodium knowlesi malaria susceptibility
- Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
- A self-adaptive deep learning method for automated eye laterality detection based on color fundus photography
- The effect of child marriage on the utilization of maternal health care in Nepal: A cross-sectional analysis of Demographic and Health Survey 2016
- Identification of QTLs for powdery mildew (Podosphaera aphanis; syn. Sphaerotheca macularis f. sp. fragariae) susceptibility in cultivated strawberry (Fragaria ×ananassa)
- Chemical volatiles present in cotton gin trash: A by-product of cotton processing
- PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils
- Differential metabolomics networks analysis of menopausal status
- Experimental study of the temporal profile of breath alcohol concentration in a Chinese population after a light meal
- Association between regional brain volumes and BMI z-score change over one year in children
- Relationships between Potentially Toxic Elements in intertidal sediments and their bioaccumulation by benthic invertebrates
- Long-term outcomes of dialysis in patients with chronic kidney disease and new-onset atrial fibrillation: A population-based cohort study
- Hospital burden of pulmonary arterial hypertension in France
- Understanding the variability of Australian fire weather between 1973 and 2017
- Photon-counting cine-cardiac CT in the mouse
- Ecophysiological impacts of Esca, a devastating grapevine trunk disease, on Vitis vinifera L.
- Black “Reading the Mind in the Eyes” task: The development of a task assessing mentalizing from black faces
- Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae
- Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects
- Validation of the Rainbow Model of Integrated Care Measurement Tools (RMIC-MTs) in renal care for patient and care providers
- Multiple origins and the population genetic structure of Rubus takesimensis (Rosaceae) on Ulleung Island: Implications for the genetic consequences of anagenetic speciation
- Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction—Post-hoc analysis from the OMEGA-REMODEL randomized controlled trial
- A randomized controlled trial examining the efficacy of an internet-based cognitive behavioral therapy program for adolescents with anxiety disorders
- Optimising outputs from a validated online instrument to measure health-related quality of life (HRQL) in dogs
- Young adults’ perceptions of using wearables, social media and other technologies to detect worsening mental health: A qualitative study
- Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research
- Genetic characterization of fall armyworm (Spodoptera frugiperda) in Ecuador and comparisons with regional populations identify likely migratory relationships
- Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
- Cardiac resynchronization therapy-heart failure (CRT-HF) clinic: A novel model of care
- Synteny and phylogenetic analysis of paralogous thyrostimulin beta subunits (GpB5) in vertebrates
- Dual-Subpopulation as reciprocal optional external archives for differential evolution
- NGS analysis in Marfan syndrome spectrum: Combination of rare and common genetic variants to improve genotype-phenotype correlation analysis
- Optimization of cataract surgery follow-up: A standard set of questions can predict unexpected management changes at postoperative week one
- Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
- Clinical evaluation of General Electric new Swiftscan solution in bone scintigraphy on NaI-camera: A head to head comparison with Siemens Symbia
- Pharmacist-led academic detailing improves statin therapy prescribing for Malaysian patients with type 2 diabetes: Quasi-experimental design
- Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor
- Clinical outcomes with neoadjuvant versus adjuvant chemotherapy for triple negative breast cancer: A report from the National Cancer Database
- Identification and characterization of a novel heparan sulfate-binding domain in Activin A longest variants and implications for function
- Wikipedia network analysis of cancer interactions and world influence
- Using path signatures to predict a diagnosis of Alzheimer’s disease
- Development and verification of prediction models for preventing cardiovascular diseases
- Additive and heterozygous (dis)advantage GWAS models reveal candidate genes involved in the genotypic variation of maize hybrids to Azospirillum brasilense
- Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
- Transience effect in capture-recapture studies: The importance of its biological meaning
- Detailed global modelling of soil organic carbon in cropland, grassland and forest soils
- Oral dosing for antenatal corticosteroids in the Rhesus macaque
- Retraction: Modulation of the Pentose Phosphate Pathway Induces Endodermal Differentiation in Embryonic Stem Cells
- An analysis on HBsAg, Anti-HCV, Anti-HIV½ and VDRL test results in blood donors according to gender, age range and years
- Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study
- Meaningful work and resilience among teachers: The mediating role of work engagement and job crafting
- The conditional Fama-French model and endogenous illiquidity: A robust instrumental variables test
- Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes
- Characterization of sequentially-staged cancer cells using electrorotation
- Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model
- Genetic evidence for plural introduction pathways of the invasive weed Paterson’s curse (Echium plantagineum L.) to southern Australia
- Risk of major autoimmune diseases in female breast cancer patients: A nationwide, population-based cohort study
- Real-time three-dimensional MRI for the assessment of dynamic carpal instability
- Interim report on the effective intraperitoneal therapy of insulin-dependent diabetes mellitus in pet dogs using “Neo-Islets,” aggregates of adipose stem and pancreatic islet cells (INAD 012-776)
- The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue: A single centre experience
- Retraction: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection
- The association between role model presence and self-regulation in early adolescence: A cross-sectional study
- Correction: A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk
- Methamphetamine regulation of activity and topology of ventral midbrain networks
- Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis
- Occult periprosthetic femoral fractures occur frequently during a long, trapezoidal, double-tapered cementless femoral stem fixation in primary THA
- TCF4 induces enzalutamide resistance via neuroendocrine differentiation in prostate cancer
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- Correction: Reward abundance interferes with error-based learning in a visuomotor adaptation task
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- Correction: Recombinant rabbit beta nerve growth factor production and its biological effects on sperm and ovulation in rabbits
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- Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy
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- The impact of a rapid molecular identification test on positive blood cultures from critically ill with bacteremia: A pre-post intervention study
- Shortening duration of ertapenem in outpatient parenteral antimicrobial therapy for complicated urinary tract infections: A retrospective study
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- Repeated transspinal stimulation decreases soleus H-reflex excitability and restores spinal inhibition in human spinal cord injury
- Expression of Concern: Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor
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- Retraction: Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3
- Correction: In Porphyromonas gingivalis VimF Is Involved in Gingipain Maturation through the Transfer of Galactose
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- Correction: Development of a high-throughput assay to measure measles neutralizing antibodies
- Correction: Provider preference for payment method under a national health insurance scheme: A survey of health insurance-credentialed health care providers in Ghana
- Correction: Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis
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- Retraction: IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
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- Ground reaction forces and muscle activity while walking on sand versus stable ground in individuals with pronated feet compared with healthy controls
- Correction: Roadway traffic crash prediction using a state-space model based support vector regression approach
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- Clinical features of pulmonary embolism in patients with lung cancer: A meta-analysis
- Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiota
- Factors restraining the population growth of Varroa destructor in Ethiopian honey bees (Apis mellifera simensis)
- Coastal proximity of populations in 22 Pacific Island Countries and Territories
- DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1
- Genetic characterization of Angiostrongylus larvae and their intermediate host, Achatina fulica, in Thailand
- Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy
- Influence of ocean circulation and the Kuroshio large meander on the 2018 Japanese eel recruitment season
- Growth response of the ichthyotoxic haptophyte, Prymnesium parvum Carter, to changes in sulfate and fluoride concentrations
- Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome
- Prognostic nomogram predicts overall survival in pulmonary large cell neuroendocrine carcinoma
- Microbiome profiling of the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae)
- Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
- Retraction: Impacts of rock properties on Danxia landform formation based on lithological experiments at Kongtongshan National Geopark, northwest China
- Correction: SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience
- Retraction: Plexin-B1 Activates NF-κB and IL-8 to Promote a Pro-Angiogenic Response in Endothelial Cells
- Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis
- Association between temperature, sunlight hours and alcohol consumption
- Using graph learning to understand adverse pregnancy outcomes and stress pathways
- Correction: The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?
- Surgical referral systems in low- and middle-income countries: A review of the evidence
- In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells
- Correction: The Economic Impact of Malignant Catarrhal Fever on Pastoralist Livelihoods
- Correction: Identification of miRNAs involved in fruit ripening by deep sequencing of Olea europaea L. transcriptome
- Correction: Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Correction: Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells
- Correction: Plant traits linked to field-scale flammability metrics in prescribed burns in Eucalyptus forest
- Correction: Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation
- Correction: To keep or not to keep? Decision making in adolescent pregnancies in Jamestown, Ghana
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