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Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia


Autoři: Anissa Mohammed Hassen aff001;  Girma Taye aff002;  Muluken Gizaw aff002;  Foziya Mohammed Hussien aff001
Působiště autorů: Department of Public Health, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia aff001;  School of Public Health, College of Medicine and Health Science, Addis Ababa University, Addis Ababa, Ethiopia aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0222629

Souhrn

Background

Breast cancer is the most common cancer affecting women in Ethiopia with increasing burden, and chemotherapy treatment produces a detrimental effect on individual wellbeing. Since last few years quality of life has been the primary goal of cancer treatment, yet little research has been conducted on quality of life of breast cancer patients under chemotherapy.

Objective

To determine the quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia.

Methods

Institution based cross-sectional study was conducted on 404 patients with breast cancer, who took at least one cycle of chemotherapy treatment using face to face interview at oncology unit of Tikur Anbessa specialized hospital day care center from February to April 2018. The validated Amharic version of European organization for research and treatment of cancer core 30 (EORTC QLQ-C30) and quality of life questionnaire specific to breast (QLQ-BR23) was used to measure health related quality of life. Both descriptive and inferential statistics were used. For the purpose of interpretation quality of life score was dichotomized in to two using the calculated mean score, which is 53 as a cutoff point, then, bi-variable and multivariable logistic regression was used to describe association between dependent and independent variables. Hence, patients who score above 53 for quality of life were considered to have good quality of life.

Result

Of the total sample, overall response rate was 99.77%. The average quality of life score of patients with breast cancer under chemotherapy treatment was 52.98 (SD = 25.61). Majority of patients had scored poor in emotional functioning, sexual functioning, and financial difficulties. Educational status of college and above, being divorced, higher household income, higher scores of physical and social functioning were associated with significantly improved (better) quality of life. Lower scores of fatigue, insomnia, financial difficulties and systemic therapy side effects all were associated with better scores of quality of life of breast cancer patients. Whereas, patients receiving < = 2 cycles of chemotherapy had significantly lower scores of quality of life.

Conclusion and recommendation

Quality of life of breast cancer patients under chemotherapy treatment is poor in comparison with the reference data and international findings. Therefore, quality of life assessment should be incorporated in patient’s treatment protocol. And financial aids may significantly improve the quality of life of breast cancer patients under chemotherapy treatment.

Klíčová slova:

Research and analysis methods – Social sciences – Medicine and health sciences – Health care – Economics – Research design – Clinical medicine – Pharmaceutics – Drug therapy – Public and occupational health – Oncology – Cancer treatment – Cancers and neoplasms – Quality of life – Clinical research design – Finance – Cancer chemotherapy – Clinical oncology – Chemotherapy – Breast tumors – Breast cancer – Global health – Symptom scales


Zdroje

1. World Health Organization: Latest world cancer statistics Geneva: International Agency For Research on Cancer (IARC); 2013 [cited 2017 Oct 23]. https://www.uicc.org/iarc-release-latest-world-cancer-statistics

2. International Agency For Resarch on Cancer; Estimated Breast Cancer Incidence, Mortality and Prevalence Worldwide in 2012: Globocan; 2012 http://globocaniarcfr/old/FactSheets/Cancers/breast-newasp.

3. World Health Organization: Cancer—a Growing Public Health Concern for Ethiopia 2015 [cited 2017 Dec]. http://www.afrowhoint/news/cancer-growing-public-health-concern-ethiopia.

4. Tigeneh W, Molla A, Abreha A and Assefa M. Pattern of Cancer in Tikur Anbessa Specialized Hospital Oncology Center in Ethiopia from 1998 to 2010 Int J Cancer Res Mol Mech 2015;1.1:5.

5. Sabate E. Adherence to long term therapies: Evidence for action. World health organization (WHO). 2003:110.

6. Kantelhardt E, Zerche P, Assefa M, Trocchi P., Addissie A, Aynalem A, et al. Breast cancer survival in Ethiopia: A cohort study of 1,070 women. Int J Cancer. 2014;135:8.

7. Paul B, Jacobsen K, and Cella D. Assessing Quality of Life in Research and Clinical Practice Cancer Network. 2002.

8. Osoba D. Health-related quality of life and cancer clinical trials. Ther Adv Med Oncol. 2011;3(2):15.

9. Montazeri A, Vahdininia M, Harirchi I, Ebrahimi M, Khaleghi F and Jarvandi S. Quality of life in patients with breast cancer before and after diagnosis: an eighteen months follow-up study. BMC. 2008;8(330):6.

10. Eisenbraun J, Scheer R, Kröz M, Schad F, and Huber R. Quality of life in breast cancer patients during chemotherapy and concurrent therapy with a mistletoe extract. Phytomedicine. 2010;18(2011):7.

11. Davies N. Measuring health-related quality of life in cancer patients. Nursing Standard. 2009;23(30):8.

12. Grabsch B, David M, Love A, Dean P, Raymond D, Bloch S, et al, Psychological morbidity and quality of life in women with advanced breast cancer: A cross-sectional survey. palliative and supportive care therapy. 2006;4:10.

13. Perry S, Kualski T, and Chang C. Quality of life assessment in women with breast cancer: benefits, acceptability and utilization. BMC. 2007;5(24):14.

14. Ediebah D, Coins C, Zikos E, Quinten C, Ringash J, King M, et al. Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial British Journal of Cancer 2014;110:7.

15. Sharma A, Walker L, and Monson J. Baseline Quality of Life Factors Predict Long Term Survival after Elective Resection for Colorectal Cancer. International Journal of Surgical Oncology. 2013:6.

16. Bekele M. Assessing The Quality Of Life Among Patients With Breast Cancer At Tikur Anbassa Specialized Hospital, Addis Ababa, Ethiopia: Oslo and Akershus University; 2016.

17. Aaronson N, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez N, et al. The European Organisation for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute 1993;85:78.

18. Fayers P, Aaronson N, Bjordal K, Groenvold M, Curran D, and Bottomley A, on behalf of the EORTC Quality of Life Group. The EORTC QLQ-C30 Scoring Manual (3rd Edition). Brussels: European Organisation for Research and Treatment of Cancer, Brussels 2011.

19. Jaiyesimi A, Sofela E, and Rufai A. Health related quality of life and its determinants in Nigerian breast cancer patients. African Journal Of Medicine and Medical Sciences. 2007;36:8.

20. Manandhar S, Shrestha D, Taechaboonsermsk P, Siri S, and Suparp J. Quality of Life among Breast Cancer Patients Undergoing Treatment in National Cancer Centers in Nepal. Asian Pac J Cancer Prev. 2014;15(22):5.

21. Haddou B, Rahou K, Hanchi Z, Ouasmani F, Benazzouz B, Ahid S, et al. Mesfioui Quality of Life among Moroccan Women Undergoing Treatment of Breast Cancer BJMMR. 2017;21(8):11.

22. Scott N, Fayers P, Aaronson N, Bottomley A, Graeff A, Grønvold M, et al. EORTC QLQ-C30 Reference Values 2008:427.

23. Safaee A, Dehkordi M, Zeighami B, Tabatabaee H, and Pourhoseingholi M. Predictors of quality of life in breast cancer patients under chemotherapy. Indian Journal of Cancer 2008;45(3).

24. Høyer M, Johansson B, Nordin K, Bergkvist L, Ahlgren J, Lidin-Lindqvist A, et al. Health-related quality of life among women with breast cancer–a population-based study. Acta-Oncologica. 2011;50(7):12.

25. Jassim G, and Whitford D. Quality of life of Bahraini women with breast cancer: a cross sectional study. BMC. 2013;13(212):14.

26. Lôbo S, Fernandes A, Almeida P, Carvalho C, and Sawada N. Quality of life in women with breast cancer undergoing chemotherapy Acta Paul Enferm. 2014;27(6):6.

27. Dubashi B, Vidhubala E, Xyriac S, and Sagar T. Quality of life among young women with breast cancer: Study from a tertiary cancer institute in south India. Indian Journal of Cancer. 2010;47(2):5.

28. Nakitare S. Health Related Quality of Life of Breast Cancer Patients at Kenyatta National Hospital. University of Nirobi Masters of medicine Thesis. 2002:78.

29. Yan B, Yang L, Hao L, Yang C, Quan L, Wang L, et al. Determinants of Quality of Life for Breast Cancer Patients in Shanghai,China. PLoS ONE. 2016;11(4):14.

30. Costanzo E, Lutgendorf S, Mattes M, Trehan S, Robinson C, and Tewfik F. Adjusting to life after treatment: distress and quality of life following treatment for breast cancer. Br J Cancer. 2007;97:7.

31. Mohsin S, UrRehman M, Azam N, and Mashhadi S. comparison of Quality of Life Of Cancer Patients Undergoing Chemotherapy In Tertiary Care Hospital, Rawalpindi. Pak Armaed Forces Med J. 2015;66(1):5.

32. Foubert J. Cancer-related anaemia and fatigue: assessment and treatment Nursing standard. 2006;20(36):8.

33. Smets E, and Visser M. Fatigue, depression and quality of life in cancer patients: how are they related? Suppport care cancer. 1998;6:8.

34. Ishak W, Bagot K, Thomas S; Maakian N, Bedwani D, Larson D, et al. Quality of Life in Patients Suffering from Insomnia. Innov Clin Neurosci. 2012;9(12):16.


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