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Acute pancreatitis risk after kidney transplantation: Propensity score matching analysis of a national cohort


Autoři: Ya-Wen Chuang aff001;  Shih-Ting Huang aff001;  Tung-Min Yu aff001;  Chi-Yuan Li aff004;  Mu-Chi Chung aff001;  Cheng-Li Lin aff005;  Chi-Sen Chang aff001;  Ming-Ju Wu aff001;  Chia-Hung Kao aff004
Působiště autorů: Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan aff001;  College of Medicine, China Medical University, Taichung, Taiwan aff002;  Graduate Institute of Public Health, China Medical University, Taichung, Taiwan aff003;  Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan aff004;  Office for Health Data, China Medical University Hospital, Taichung, Taiwan aff005;  Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan aff006;  Department of Nuclear Medicine and PET Center, and Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung, Taiwan aff007;  Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan aff008
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0222169

Souhrn

Purpose

Data for elucidating post-kidney transplantation (KT) acute pancreatitis (AP) risk are limited and no large-scale cohort study has investigated the impact of AP after KT.

Method

Data from Taiwan National Health Insurance (NHI) Research Database (NHIRD) were calculated through the method of propensity score matching to compare the pancreatitis risk in patients with and without KT.

Results

The overall pancreatitis incidence rates were 1.71 and 0.61 per 1,000 person-years in the KT and non-KT groups, respectively and corresponding adjusted HR (aHR [95% CI]) for pancreatitis was 2.48 (1.51–4.09) in the KT group. In the multivariable model, AP risk was higher in transplant patients with alcohol-related illnesses (aHR: 3.78, 95% CI: 1.32–10.8), gall stone disease (aHR: 3.53, 95% CI: 1.48–8.44), or past history of pancreatitis (aHR: 10.3, 95% CI: 5.08–20.8). Of note, recurrent AP risk was significantly higher in the KT group (aHR: 8.19, 95% CI: 2.89–23.2). Patients with post-KT AP demonstrated shorter patient and allograft survival than did those without (both P < 0.001, respectively).

Conclusion

In conclusion, KT recipients are very likely to be associated with AP. Moreover, their inferior outcomes are strongly associated with post-KT AP.

Klíčová slova:

Biology and life sciences – Research and analysis methods – Medicine and health sciences – Pathology and laboratory medicine – Diagnostic medicine – Signs and symptoms – Endocrinology – Endocrine disorders – Metabolic disorders – Research design – Cohort studies – Nutrition – Gastroenterology and hepatology – Diet – Alcohol consumption – Surgical and invasive medical procedures – Pancreatitis – Transplantation – Organ transplantation – Renal transplantation – Urinary system procedures – Nephrology – Chronic kidney disease – Medical dialysis – Hyperlipidemia


Zdroje

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