The Secreted Peptide PIP1 Amplifies Immunity through Receptor-Like Kinase 7

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Both animals and plants have evolved mechanisms to trigger innate immunity through perception of exogenous and endogenous molecules. In the model plant Arabidopsis thaliana, endogenous molecules such as the peptide elicitor PEP1 activate the immune response by means of cell surface-located receptors. Here we describe a new gene family in A. thaliana named prePIPs, whose members encode secreted peptide precursors, and show that one of its members, prePIP1, is secreted into extracellular space and cleaved at the C-terminus. Exogenous application of PIP1, the synthetic 13-amino acid peptide corresponding to the conserved C-terminal region of prePIP1, triggered immune responses and led to enhanced pathogen resistance in A. thaliana. We further provide evidence showing that PIP1 signals via the receptor-like kinase 7 (RLK7) and employs both shared and distinct components with the PEP1 signaling pathway. Both PIP1 and PEP1 cooperatively amplify the immune response triggered by flg22, the active epitope of bacterial flagellin.

Vyšlo v časopise: The Secreted Peptide PIP1 Amplifies Immunity through Receptor-Like Kinase 7. PLoS Pathog 10(9): e32767. doi:10.1371/journal.ppat.1004331
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004331

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