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Qualitative analysis of ward staff experiences during research of a novel suicide-prevention psychological therapy for psychiatric inpatients: Understanding the barriers and facilitators
Authors: Yvonne F. Awenat aff001; Sarah Peters aff001; Patricia A. Gooding aff001; Daniel Pratt aff001; Charlotte Huggett aff001; Kamelia Harris aff001; Christopher J. Armitage aff001; Gillian Haddock aff001
Authors place of work: Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biological, Medical and Health Sciences, Manchester, University of Manchester, United Kingdom aff001; Manchester Academic Health Science Centre, MAHSC, Manchester, United Kingdom aff002; Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom aff003; Manchester Centre for Health Psychology, Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biological, Medical and Health Sciences, University of Manchester, Manchester, United Kingdom aff004; Manchester University NHS Foundation Trust, Manchester, United Kingdom aff005
Published in the journal: PLoS ONE 14(9)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0222482Summary
Background
Suicide prevention is a global priority. Psychiatric hospitalization presents an opportunity to intervene positively with, for example, psychological therapies. However, evidenced-based suicide-prevention psychological treatments are rarely available on in-patient wards. Understanding staff engagement with research investigating suicide-prevention psychological treatments is crucial for their effective, efficacious, and pragmatic implementation. A pilot randomised control trial and feasibility study of Cognitive Behavioural Suicide Prevention therapy provided the opportunity for a qualitative investigation of staff experiences and views of a psychological intervention for people with suicidal experiences on psychiatric in-patient wards.
Aims
To investigate staff acceptability of Cognitive Behavioural Suicide Prevention therapy for psychiatric inpatients based on their perceptions of their experiences during the conduct of a clinical trial.
Method
Transcribed audio-recordings of qualitative interviews and a focus group (n = 19) of purposively sampled staff from eight psychiatric wards were analysed using inductive Thematic Analysis.
Results
Facilitators and barriers were identified for: i) the conduct of the research, and, ii) the suicide-prevention intervention (Cognitive Behavioural Suicide Prevention therapy). Research-related barriers comprised communication difficulties between staff and researchers, and increased staff workload. Research-related facilitators included effective staff/researcher relationships, and alignment of the intervention with organisational goals. Suicide-prevention intervention-related barriers comprised staffs’ negative beliefs about suicide which impacted on their referral of inpatients to the clinical trial, and staff perceptions of insufficient information and unfulfilled expectations for involvement in the therapy. Facilitators included staff beliefs that the therapy was beneficial for inpatients, the service and their own clinical practice.
Conclusions
Staff beliefs that ‘suicide-talk’ could precipitate suicidal behaviour resulted in covert gatekeeping and restricted referral of only inpatients judged as stable or likely to engage in therapy, which may not be those who could most benefit. Such threats to sample representativeness have implications for future therapy research design. The findings provide novel information for researchers and practitioners regarding the conduct of psychological treatment and research in psychiatric units.
Keywords:
Nurses – Patients – Behavior – Qualitative studies – Mental health and psychiatry – Inpatients – suicide – Mental health therapies
Introduction
Psychiatric inpatient fatalities account for between 3–5% of all suicide fatalities worldwide equating to 250 per 100,000 inpatient admissions [1]. Inpatient death by suicide is considered the most preventable of all suicides due to the 24 hour staff contact time with inpatients [2]. Despite this intensive contact time, 8% of UK patient suicides occur during psychiatric hospitalization, which can double to 16% within three months of discharge [3]. Hence, there is an urgent need for evidence-based treatments to prevent avoidable suicide deaths among psychiatric inpatients. This is of the highest priority for policy makers, service providers, clinicians, service users and carers both globally [4] and within the UK [5–7]. The primary function of mental health wards is purported to be the maintenance of inpatient safety by assessing and treating mental health problems [8]. The main criteria for admission is risk of harm to self or others [9]. Consequently, suicidal behaviour is common in psychiatric wards where self-harm rates of up to 68.8% of inpatients has been reported [10].
Psychological therapy has an established evidence base for suicide prevention [11–13], and Cognitive Behavioural Therapy (CBT) is recommended by the UK National Institute for Health and Care Excellence [14, 15] for the treatment of individuals who have suicidal thoughts and/or behaviours. However, provision of psychological treatment in inpatient settings is uncommon within the UK, where it is more likely to be offered post-discharge [16].
Within mental healthcare there is increasing awareness of the unsatisfactory gap between the existence of evidence-based treatments and their timely implementation into usual practice [17, 18]. Paradoxically, psychiatric treatments lacking rigorous evaluation are delivered [19], while treatments with demonstrated efficacy fail to be implemented [20]. Ingrained organisational cultures of resistance to change [21] that operate across all levels of mental health services [22] contribute to the difficulties of implementation of evidence-based treatments thereby preventing access by service users most in need [20].
It is recognized that avoidance of failure to achieve translation of evidence-based treatments into clinical practice requires consideration during the initial planning stages of early feasibility / acceptability research [23, 24]. This is particularly important regarding ‘complex interventions’ such as psychological therapy treatments [24].
One of the most important issues in translating the results of psychological treatment trials into clinical practice is that research trials may not reflect the real world environment of service users and clinicians. For example, research samples may be too homogenous [25]; manualised protocols used in trials may not be applicable to everyday settings [26]; and statistical significance may not equate to clinical significance [27].
Clinicians’ perceptions that research lacks clinical credibility can be a barrier to implementation of evidence-based treatments [28, 29] highlighting the importance of investigating staff acceptability during the development of new treatments [23, 24]. This is especially important within psychiatric wards where complex contextual challenges exist [30, 31]. Inpatient safety is of paramount importance to ward staff who are accountable for the care of large numbers of suicidal inpatients [9]. It is especially important to investigate ward staff views and perspectives regarding implementation of a clinical trial of suicide-prevention psychological therapy because, i) changes to staff’s usual working practices are necessary regarding their essential co-operation with participant recruitment procedures and facilitation of therapy delivery, and ii) evidence of adversarial attitudes and beliefs around caring for suicidal inpatients has been documented [30].
Mixed-method research designs incorporating qualitative and quantitative research [32] are recommended for the study of contextual factors [33–35]. We therefore conducted the INSITE study (Inpatient Suicide Intervention and Therapy Evaluation [36, 37] comprising a pilot Randomised Clinical Trial (RCT) with nested qualitative work-streams to evaluate the feasibility and acceptability of a suicide-prevention psychological treatment (Cognitive Behavioural Suicide Prevention therapy[38] [CBSP]) for suicidal inpatients.
Brief summary of Cognitive Behavioural Suicide Prevention therapy
CBSP[38] is a manualised treatment programme adapted by the authors for the inpatient setting [35]
Up to 20 individual therapy sessions were offered over 6 months
Initial therapy sessions were delivered on the ward once or twice weekly
Session duration is typically up to 1 hour, but early sessions may be much shorter depending on inpatient’s psychological status
Therapy usually continues weekly on the ward or in a community setting if the inpatient is discharged during the treatment programme
CBSP is a recovery-based intervention aiming to develop / strengthen resilience whist also countering suicidal thoughts and behaviour
The therapist aims to formulate an inpatient’s suicidal cognitions and behaviour and assist the inpatient to understand and make sense of these experiences
CBSP treatment aims to change the cognitive processes underpinning suicide schema activation, maintenance and elaboration of suicidal thinking and behaviour using cognitive behavioural approaches.
The trial presented the opportunity to investigate staff perceptions of barriers and facilitators to the delivery of CBSP therapy for suicidal inpatients in a psychiatric inpatient setting. Ward staff, as key stakeholders, are likely to be highly influential in terms of constraining or facilitating treatment innovation [39]. Accordingly, the qualitative study reported here aimed to investigate and understand the views of ward staff during the conduct of the INSITE pilot RCT that was carried out in eight mental health wards within a large NHS mental health trust in the North West of England, UK [36]. There were two goals: First, to understand staffs’ perceptions of their experiences during the conduct of a clinical trial in the complex and challenging setting of acute psychiatric wards. Second, to investigate staff views regarding acceptability of the provision of a suicide-prevention psychological therapy for suicidal inpatients.
Methods
Thematic analysis of individual, semi-structured qualitative interviews with staff working on psychiatric inpatient wards in the context of the INSITE pilot RCT[36].
Epistemology and ontology
The epistemological stance underpinning this qualitative study was influenced by contextualism [40,41], which upholds the view that the social context within which people exist impacts symbiotically on how they understand and describe their experiences. This affiliated with our aim of understanding the experiences and views of psychiatric staff within the particular context of their role working with suicidal inpatient participants of the INSITE study. In tandem, our ontological stance is reflective of the belief in multiple realities (rather than a single truth) that are socially influenced and context dependent, thereby drawing on critical realist ontology [40,41].
Analytic method
Thematic analysis [42] is a generic, theoretically-free, approach that is compatible with contextualism [42–44]. Thematic analysis[42] was selected for its: i) simplicity and flexibility in identifying patterns of meaning across the data corpus; ii) accessibility of use within mixed-method psychological research; and, iii) ability to produce results comprehensible to non-specialist audiences [43].
Reflexivity
The authors uphold the principle that knowledge produced from qualitative investigations represents a co-produced endeavour within which researcher and participant both play an active part [45]. As most authors were working on the trial and some had developed the intervention, we understood that influences from our own backgrounds, beliefs and preconceptions could impact on biases affecting data generation and analysis [45–47]. Hence, in order to accurately portray participants’ own worldviews we engaged in reflexive self-scrutiny during analytic meetings [45–47] seeking to ‘bracket’ our own beliefs and preconceptions and adopt a stance of ‘empathic neutrality’ [48]
The first author, YA’s, professional background included over 30 years’ experience in senior general nursing positions within NHS hospitals prior to working in mental health research for over a decade. The other two qualitative interviewers (KM, CH), were both psychology graduates with experience of working in community mental health settings. The wider research team comprised senior psychology academics (SP, PG, CA) and clinical academics (GH, DP) with several years’ experience of conducting suicide prevention research. All but two authors (DP, CA) were female, including the authors who conducted the qualitative interviews (YA, KH, CH).
In presenting information at ward managers meetings and to staff who volunteered to participate in the qualitative research we outlined our roles and stated our aim of advancing evidence-based suicide prevention treatments by conducting research. Knowing that a participant’s relationship with the qualitative interviewer can impact on their responses[49] we delivered a standard introduction prior to every research interaction with staff stressing that the study aimed to investigate feasibility and acceptability rather than the efficacy of the intervention. We also stressed our wishes to hear their genuinely held views, and in particular to hear and understand about any difficulties encountered as a result of the study, as this would help us to design a high quality future definitive trial.
Methodological rigour
We have aspired to conduct and to report a scientifically rigorous study, therefore to demonstrate methodological and reporting quality we have provided an inventory based on the Consolidated Criteria for Reporting Qualitative Research (COREQ)[49]. (S1 Appendix)
Recruitment procedure
Members of staff were offered the choice to attend either a focus group or an individual interview. This was intended to, firstly, optimise uptake in recognition of staff difficulty in committing to time away from clinical duties [30] and, secondly, to facilitate personal choice preferences for individual or group interviews. This also enhanced methodological rigour as data triangulation is advocated to improve data quality[35]. Specifically, focus groups can encourage disclosure of potentially contentious views whilst individual interviews offer greater confidentiality [32, 50].
Purposive sampling [51] sought to recruit staff of varying grades and professions with experience of working in one of the eight the psychiatric wards across two hospital sites where the INSITE study was conducted[36]. Sampling continued until sufficient data were obtained to address the research aims[52] which was determined by consensus agreement of research team. Information about this qualitative study was presented by the first author (YA) at ward meetings, via posters on information boards, and through existing staff email systems. Those interested were provided with further verbal and written information and allowed a minimum of 24 hours to consider participation. Written informed consent was provided prior to participation. All researchers involved in recruitment and data collection were trained in qualitative research, research governance, ethics, and adhered to study standard operating procedures. Ethical approval was granted from the National Research Ethics Service Committee, Lancaster, North West England, UK (13/NW/0504).
Participants
Of 31 staff expressing an interest, 19 people volunteered to participate. Reminder emails were sent to those who had initially expressed interest but no further replies were received. Of those who did participate, nine staff attended the focus group and ten were interviewed individually. Participants’ comprised three men and 16 women whose ages ranged from 22–56 years, their professional experience ranged from 2–27 years, and duration of employment in the host organization spanned from four months to 27 years. The sample reflected the full range of ward team roles, with 13 registered mental health nurses, two nursing assistants, three ward administrators and one psychiatrist. All participants worked in wards where the trial had been conducted and some had direct experience of working with inpatient participants recruited by the INSITE[36] study. At the time when the study was conducted there were no psychological therapists employed to work in the psychiatric wards.
Data collection
A semi-structured interview schedule was developed with open questions [44] to elicit staff experiences, views and reflections of the conduct of the INSITE study (see S2 Appendix). Individual interviews were conducted by YA (n = 6) and KM (n = 4). The focus group was moderated by YA with assistance from KM and CH. All data collection occurred in private rooms in the participant’s workplace. Questions were designed to elicit information about staff expectations, views about provision of study information, and relationships and interactions with research staff. We also asked staff about their views of providing suicide-prevention psychological therapy for suicidal inpatients and invited views of any impact on inpatients who had received CBSP. Perceptions of how the research procedures and delivery of therapy had impacted on usual ward routines and workload were also sought. Staff were encouraged to suggest solutions to any challenges discussed and to freely introduce additional relevant topics that were not pre-defined in the interview schedule.
Field notes detailing relevant contextual issues were made to aide later analysis. Interviews and focus groups were digitally audio-recorded and transcribed verbatim during which identifying information was anonymised. Individual interviews ranged from 11–39 minutes duration (median = 18 minutes) and the focus group lasted 45 minutes. All audio-recordings were destroyed following transcription.
Data analysis
Thematic analysis [42] was selected as a flexible, yet systematic method of analysing the data corpus of focus group and individual interviews. An inductive approach [42] to analysis was led by YA, with multiple coding to broaden the range of interpretative perspectives from SP, KH, and CH. All authors contributed to critical discussions to agree interpretation of the final themes. Analytic procedures followed Braun and Clarke’s [42–44] six-phase approach, commencing with several readings of the transcripts, prior to manual line-by-line scrutiny to identify relevant units of meaning as codes, which were then clustered together as tentative themes. There followed an iterative process of reviewing and restructuring the themes, culminating in the final thematic structure.
Results
The analysis was organised into two discrete, yet interrelated areas depicting facilitators and barriers related to: i) research specific issues regarding the conduct of the RCT, and ii) staff views and beliefs regarding delivery of ward-based suicide-prevention psychological therapy for suicidal inpatients.
Research related results
Staff descriptions of their experiences of the research procedures revealed two main research related barriers (Fig 1) and two main research related facilitators (Fig 2) to the successful conduct of the RCT. Barriers comprised: (a) limited opportunities for researchers to engage with staff, and (b) negative impact on staff workload. Facilitators comprised (a) effective working relationships, and (b) research intervention accords with organization’s goals.
Fig. 1. Research related barriers. Fig. 2. Research related facilitators. Research related barriers
(a) Limited opportunities for researchers to engage with staff
Researchers were required to make contact with ward staff to provide information about the INSITE study and to agree methods of ongoing liaison with staff for the purpose of identifying potential participants for the trial and conducting research assessments.
(i) Communicating recruitment information
Recruitment of inpatients was dependant on referral by ward staff. It was, therefore, crucial to find acceptable ways of liaising with staff to provide study information. On commencement of the research, multiple methods of imparting introductory information to key opinion leaders at organizational and ward level included presentations at meetings, wall mounted poster information and staff internal email alerts. For some staff these methods were successful:-
“I did see the information. I think it was good, it was concise, it wasn’t too much to read… It was quite straightforward and it, it kind of told you what the project was about properly.” (009).
However, despite multi-faceted approaches, information failed to reach all staff with some reporting no knowledge of the research;
“I’ve worked here two years… to be honest I’d never even heard of it until today.” (FG038).
Communicating information to such large volumes of staff proved challenging as researchers encountered inconsistent availability of key permanent staff due to high staff turnover as illustrated by one participant;
“Since this study started I’ve got completely different team. So I think eleven of staff members left, nine started and we were in a recruitment process.” (011)
Forming relationships with key ward staff was further hampered by the unpredictability of their availability, which was determined by a system that rotated staff between day and night shifts. Another factor was the frequent use of external temporary agency nurses who were unfamiliar with strategic projects (such as research).
(ii) Communicating with all staff stakeholders
Particular difficulties were encountered in gaining access to ward team staff based elsewhere who only attended the ward periodically. It was, therefore, evident that certain staff groups, including psychiatrists, may have been overlooked;
“some of the medical staff here weren’t really fully au fait with what [INSITE] was all about and… and they play just an integral part.” (FG030)
Opportunities may also have been missed to engage with Health Care Assistants (HCAs) whose role involved greater direct contact with inpatients. As HCAs were more numerous than qualified nurses, they were potentially more available to provide assistance with recruitment, yet, it was suggested, they may have had little knowledge of the study;
“the HCAs and the support staff that we’ve got, like [name] just said she doesn’t know anything about, but [name] might have a better relationship with the patients than I do, she might see them a lot more, and you know [name] primarily will be the one talking.”(FG039)
(b) Negative impact on staff workload
Introduction of the INSITE trial onto the wards required certain organisational and behavioural changes to the usual work routines of staff that added to their already demanding workload.
(i) Unscheduled interruptions
Researchers made frequent visits to the wards to remind staff about the study, identify any eligible potential participants, and negotiate access to participants and interview rooms. Staff reflected on the difficulties experienced when receiving unannounced visits from researchers describing how this added to their stress and amplified the burden of their usual demands and competing priorities;
“and a lot of the time… we never know what it’s gonna be like from one minute to the next,.. we lose out and the patient loses out then ‘cos you can’t really identify the most appropriate, ‘cos like you could be in a restraint, you could be busy, you could be short [of staff] so it’s just like time” (FG 032)
“when you’re right in the middle of something and like got the phone going, you’re in the office on your own, and you’ve got, you know, people knocking at the door… “(FG012)
(ii) Increased patient care burden
When staff were informed of an inpatients’ disclosure of suicidal intent during therapy or research interviews, it created additional demands on staff who had to provide more intensive levels of observation, support and record associated additional documentation;
“And we was told about that [risk disclosure] and obviously … asked to start look at the patient, you know make sure the patient was safe and sometimes we had to write on [electronic record].” (FG012)
Situations incurring additional workload were also described when inpatients’ became distressed following a therapy session, leaving staff believing that therapy was causing distress, leading them to feel more burdened and ill equipped to manage the ensuing outfall;
“And then it’s left there and you’ve done a session and you’ve gone and then we’re left there while someone’s still feeling quite distressed.” (FG017).
Such experiences influenced subsequent referral decisions as staff considered the potential for negative impact on individual inpatients and the consequent increase demands on staff;
“One thing that you would worry about when you, when you’re nominating someone for the and the trial would be someone who would, talking about this could trigger maladaptive behaviour once the session had ended, and then we’d have a whole can of worms to put back in the can afterwards. So that’s a bit of a concern.” (FG016)
A clear priority for staff was to maintain a calm ward environment and avoid unrest and conflict between staff and inpatients that would create additional workload. Some concerns were therefore expressed of the potential for resentment from inpatients’ who were not INSITE participants, and who might feel upset because they had been denied access to a treatment that others were receiving;
“I think that would be difficult for some patients who would have thought, maybe if they thought that they were getting better treatment over them, … and, obviously, they are living together in quite close quarters for quite a bit so the last thing you want is a bit of resentment going on, on the ward.. .. they can be like that and compare themselves, ‘Why do you get that and we don’t get that?’ … So I think that could be… with the trial obviously, that could have been an issue”. (005)
Research related facilitators
(a) Effective working relationships
The negative impact of additional workload pressures was buffered by the perceptions of staff of having effective working relationships with researchers and therapists. This provided staff with a level of reassurance that mitigated concerns about maintaining the safety of suicidal inpatient participants.
(i) Trust
It was reported to be vital that ward staff could trust researchers and therapists to inform them of any heightened risk identified during research interviews or therapy. This was especially important as some staff were concerned that talking about suicide with researchers might increase inpatients’ suicide risk. Confidence that researchers and therapists would share any risk information with staff was viewed as an indicator of the quality of working relationships:
“I think they worked really, really well, … if there was kind of information that we needed to know obviously about suicide risk they would hand that over to qualified staff so think the communication was really good, really good” (009)
“The research assistants, we developed quite a relationship with on our ward, and they were really good at providing feedback, if somebody had concerned them during the session, they were good at providing feedback about that and it was good to see that our ladies were quite clearly engaging with the researchers.” (FG016)
(ii) Mutual understanding
Researchers and therapists visited the ward to attend meetings, discuss participant recruitment, conduct research assessments or see inpatients for therapy. Despite that staff sometimes perceived this to be an intrusion, they, nevertheless, tolerated this understanding that such interactions were necessary. The manner by which researchers and therapists demonstrated empathy and understanding of the pressures facing ward staff during occasions when they were unable to make time for liaison was appreciated and perceived to be influential in maintaining constructive relationships:
“they (researchers) were always very, very accommodating, we’d be like, please can you just, do you mind even coming back tomorrow or come back in an hour… they were very understanding, yeah, ‘cos they can see we’re snowed under” (FG06).
(iii) Shared professional clinical values. Congruence of values formed the basis of a powerful bond that assisted the establishment of professional relationships between staff and researchers. For example, staff were supportive of the study as it addressed suicide prevention which was a high priority professional clinical value;
“Well, the patient safety is always your number one priority.” (FG016)
This shared value helped to maintain staff’s commitment to the study despite the difficulties encountered.
(b) Intervention accords with organization’s goals
Throughout interviews, staff alluded to their responsibility to uphold the NHS and organizational objectives of keeping patients safe, offering treatment choice and promoting recovery, all of which they recognised as embedded within the provision of CBSP therapy. Staff accounts portrayed positive attitudes towards the therapy that they believed would enhance suicidal inpatients’ treatment and improve their own professional practice, and therefore wished to support the study despite the demands this added to their workload.
(i) Expanding and supporting patient choice
Aside from any inherent benefits from receiving therapy, staff perceived a potential therapeutic value for some of their most vulnerable, often detained, inpatients from merely being offered a choice of treatment;
“I think for our ladies [inpatients] it’s very empowering to be given the choice, because, a lot of our ladies come onto the ward and they’re very disempowered.” (FG016)
(ii) Timely service provision. The opportunity for inpatients’ to access therapy during their suicidal crisis was perceived as timely and preferential to current practice that only offered post-discharge referral for therapy;
“It’s like an in-reach service, so you’re actually providing a service for clients that they usually have been discharged to receive, so at the time when they most need it, when they’re inpatient.” (FG016)
Staff views and beliefs about Cognitive Behavioural Suicide Prevention therapy
Personal and professionally derived beliefs and attitudes were important determinants of how staff perceived the introduction of this novel suicide-prevention psychological therapy for suicidal inpatients under their care.
Barriers to Cognitive Behavioural Suicide Prevention therapy
Two main barriers (see Fig 3) of ‘Gatekeeping to protect inpatients from harm’, and ‘Staff need for involvement in the therapy’ were evident. Introduction of CBSP challenged the pre-existing beliefs of staff about the appropriate treatment of suicidal inpatients, which were compounded by perceptions of insufficient knowledge of the therapy and lack of opportunity to collaborate with the therapist and to play an active part in the therapy process.
Fig. 3. Barriers to Cognitive Behavioural Suicide Prevention therapy. (a) Gatekeeping to protect inpatients from harm
Researchers sought to recruit inpatients who met the study inclusion criteria of being aged 18 years or older; having mental capacity to provide consent; and experience of suicidal thoughts or behaviours during the past three months. However, during the qualitative investigations it became apparent that staffs’ referral decisions were based on a range of other factors external to the study eligibility criteria.
(i) Suitability for suicide-prevention therapy
Staffs’ decisions regarding referral of inpatients to the study were influenced by their own views and judgements of who might benefit from therapy and who might become distressed or be de-stabilized by therapy rather than the study eligibility criteria. These included diagnosis, level of psychiatric symptom acuity and predictions of which inpatients would be interested and willing to engage in therapy;
“You honestly just think, right who would be willing to sit and have a chat? ‘cos you know some patients wouldn’t even entertain it.” (FG032)
“So if someone came in and was nowhere near ready to sit and engage, then we’d flag up as an appropriate referral, but say not just yet.”(011)
Psychological therapy had not previously been available to inpatients in the wards where this study took place. Hence, beliefs that therapy was essentially a community treatment and was unsuitable for acutely unwell inpatients were evident:
“it would be up to the discretion of the, like, that named nurse, whether they think that they are well enough or would benefit from participating, so the nurses would know, they’d think “oh they’ve been doing really well, they’re stable”. Or maybe people who are nearing discharge.”(005)
(ii) Therapy considered ‘risky’. For some staff, the notion of encouraging suicidal inpatients’ to reflect on and discuss their suicidality during therapy, challenged their understanding and usual practices of working with suicidal inpatients. Staff whose practice aimed to avoid such discussions espoused the common lay belief that talking about suicide would precipitate suicidal behaviour;
“in case you might say the wrong things… and that might, would trigger off a thought in them.” (042).
When ‘suicide-talk’ was instigated by an inpatient, staffs’ usual practice comprised conversational techniques to distract and curtail such talk;
“I’d just ask, ‘How’s the weather?’ Or, you know, when a record comes on, ‘Oh, what kind of music do you like?’ or just general chit-chat, which you would do with anybody, once they start chatting before you know it the hour’s gone. Another hour and I’ve kept them safe.” (041)
Referral decisions were also influenced by staffs’ judgement of inpatients’ symptom acuity and the potential of becoming distressed and relapse following talk about sensitive matters including suicide;
“I think, especially on my ward, it would be about how unwell they were, and it’s not necessarily how much they’ll engage, it’s about the risk to others, the risk to self, it’s about, if they’re, appropriate for discussions to talk about those things, … if they’re on like increased observations, or if they’re, … if there’s a certain date coming up that’s like a trigger point for them. if they, … we’ve got a few patients on ours that if they’re progressing but then reflecting back on certain incidents it can cause them to,
” .. to become quite unwell again, and then they’ll go right back to where they started, which takes quite a while to build them back up again.” (FG039)
(b) Staffs’ need for involvement in the therapy
Staff were acutely aware of their responsibility to prevent suicide, and it was therefore important to them to be fully cognisant of factors that could impact on an individual inpatient’s risk status. The potential to miss a possible risk issue was of concern and staff would have liked more detailed information about the nature of the therapy and of individual inpatients’ progress during therapy.
(i) Understanding the therapy
Staff wanted to support access to CBSP onto the wards but had expected much more information about the structure, process and potential impact of the therapy which, they suggested, would have helped them to select suitable inpatients to refer to the study:
“We didn’t really have any great knowledge of what it would be that patients would be doing and what benefits it might have.” (035)
Staff were keen to learn about psychological approaches to suicide prevention including therapy and would have liked formal training which may have allayed some of their fears and uncertainties by increasing their knowledge and confidence in the therapy and research team:
“Maybe have, like, a bit of a training course for all the staff, give us an insight into what you actually you do” (041)
(ii) Collaboration with the therapist
Discussions revealed that staff would have liked greater collaboration with the therapist regarding inpatients’ progress in therapy, which they wished to understand and to be able to positively support the inpatient’s therapy journey. Staff portrayed a perception of carrying the burden of 24-hour responsibility for inpatients’ safety yet being denied important information perceived as necessary to fulfil this duty. They felt uncomfortable at not knowing about issues discussed during therapy, perceiving that more information and alerts from the therapist to particular inpatients’ idiosyncratic risks revealed during therapy would have enabled them to provide better support for therapy participants;
“I think it obviously would be useful to get a kind of summary of what had been discussed, sort of the perspective of triggers to suicide risk and things like that. So we could understand a bit more.” (009)
“So it would be useful, as a team, especially if a named nurse to know just how well they’re engaging… it could be a trigger point for us as nursing staff, cos we have to manage their behaviour for the week” (FG039)
Staff also expressed interest, and were curious about, the outcomes of inpatients who had been discharged and had continued their course of therapy in the community;
“Whatever happened? Did they engage afterwards? Did they attend sessions? Did it go well? We just didn’t get that, there was a gap… that is the sort of stuff that will keep nurses motivated, ‘cos it’s a lot of work to engage someone and then never find out what happened.” (011)
Facilitators to Cognitive Behavioural Suicide Prevention therapy
Two main ‘Facilitators’ (see Fig 4) of: (a) ‘Improving suicide prevention practices’, and (b) ‘Staff perceptions of benefit from the intervention’ were identified. Although staff experienced conceptual and practical challenges resulting from introduction of access to CBSP in the context of a trial, they also described positive effects, which, by buffering the negative effects, facilitated its introduction.
Fig. 4. Facilitators to Cognitive Behavioural Suicide Prevention therapy. (a) Improving suicide prevention practices, (i) Intervention supports existing clinical priorities. As patient safety and suicide prevention was of prime concern to staff, CBSP was viewed positively, particularly as it complemented other ongoing practice development projects. For example, the hospital was participating in a national quality improvement initiative named “Safewards”[53] which aimed to improve inpatients’ safety:
“when it [the research] was starting we were starting the first time of implementing ‘Safewards’ … so it fit in beautifully with the de-escalation modules and, mutual help, it fit along in, so yeah, people were receptive of it.” (011)
(ii) Intervention stimulates improvements in clinical practice
Staff took the initiative to translate ideas gained from the study into usual practice to improve suicide prevention. For example, inpatient staff frequently conduct suicide risk assessments guided by a standard questionnaire yet some struggled to know how best to open conversations aimed at eliciting suicide risk and had found it helpful to use questions found on study flyers;
“to have somebody say, when you’re asking about suicidal ideation, you could follow this, and you could include this in your risk assessment and that’s how we did it on our ward, so we incorporated the questions that had come through on the flyers. What it did do was help some of the newer and junior staff to use the questioning form… we used the template to get a more in-depth approach to suicidality, it’s shown in our risk assessments” (011)
(iii) Intervention overcomes service limitations
Discussions revealed staff concerns that some suicidal inpatients were reluctant to trust them, resulting in an unwillingness to disclose their suicidal experiences, which staff attributed to inpatients’ knowledge of their legal powers of detention;
“I mean there could well be a situation where I’m involved in sort of like enforcing treatment or doing something which might not all together be particularly welcomed.” (FG033)
However, staff had noticed that the relationship was different between inpatients and their therapist who they were more willing to disclose suicidal ideation and acts to;
“the patient may not be, feel comfortable to disclose things to us, they will disclose to the psychologist what was in them, and then we were able to intervene if we needed to support the patient.” (034)
This provided reassurance to staff that suicidal inpatients would receive help from the therapist, who they were confidant would alert them to any increased suicide risk. In this situation staff appeared reassured to know that a ‘specialist’ was dealing with the ‘suicide specific’ issues enabling them to assume a more distal monitoring and support role;
“It helps to give us some good insight into current thoughts of some of the patients who were happier to engage, maybe with the therapists than they were with the ward staff about their specific, specifics of how they were feeling, … so getting that feedback then, kind of let us know maybe which areas to further probe with the patient who let us think that everything was okay… and so I think everybody found it useful to have, kind of, objective opinion sometimes of what the current risks were because it can be very different how somebody presents themselves on a day-to-day basis and what they are really up to.” (035)
(b) Staff perceptions of benefit from the intervention
Staff perceived several benefits of CBSP for suicidal inpatients, for the service, and for their own professional practice. Therapy was perceived to complement key existing professional practice and organisational ideals.
(i) Benefits for service delivery
Therapy for suicide prevention was recognised to fulfil an unmet need in current service provision for suicidal inpatients. Staff were aware of the limitations of current practice which primarily focussed on identifying imminent risk by completion of standard assessment forms, which, whilst quantifying static risk variables (e.g., previous attempts) failed to explore and address individual inpatient’s emotional experiences and psychological needs;
“…they [risk assessment forms] tend to be, kind of, quite focused on immediate feelings of current mood, current, um, psychotic symptoms and the like, and so, although you can infer a lot from that, it doesn’t necessarily pull out exactly how somebody’s feeling, say about historical thoughts of self-harm, suicide and the like, which seems to have been something that came across better in the context of the therapy that the people were doing with the patients that came because they had the chance to, kind of, reflect on everything as a longer term measure, rather than what we a lot of the time are focused on, just the immediate risk.” (035)
There was awareness of how the organisations’ need for documentation in itself contributed to objectification of the suicidal inpatient and legitimisation of a reductionist rather that a humanistic model of care;
“I think we become very focused on risk and being mindful that we must assess that, document that, and respond to it in whatever way, and therefore it seems like it’s a bit mechanistic, its, it takes you away from entering the patient’s world in a way. That sounds a bit ironic, you’re talking to them, you’re speaking, asking their views… but, but, with, from the perspective of right, now, this is what we can do, we’re going to write this down, I’m not saying that we shouldn’t do those, we have to do those things, but it also, puts a bit of an unnatural barrier into stepping into those shoes for a minute, and trying to understand what that risk is relating to.” (037)
Staff also anticipated that provision of CBSP could assist the achievement of key organisational targets for rapid discharge and avoidance of readmission;
“I think it would help people to get discharged quicker, it would help people to not have repeat admissions all the time.” (009)
(ii) Benefits for suicidal inpatients
Staff with direct experience of caring for inpatients who had received CBSP described several ways that they had observed therapy to provide benefit. Improvements in inpatients’ understanding of their suicidality along with enhanced personal agency to implement coping strategies learned in therapy were observed by staff to improve inpatients’ independence and ability to self-manage thereby reducing dependence on staff and services;
“One patient who’d said she found it very helpful having the therapy, it had really, kind of, helped her understand a bit more about herself and what her risks were and how to manage her suicidal thoughts… I think its badly needed to be honest, I think it helps people become less dependent on services because they, kind of, learn to manage their own symptoms and their own feelings, and their own, kind of, suicidal ideas, or any, whatever it is they are working on. I think it encourages people to be a bit more independent and, it gives them a bit more autonomy. I think it’s really important.” (009)
“We noticed that they [inpatients] seemed to get a great deal of benefit from it, they were having an increased ability, maybe to reflect on their own behaviour, and so the, um, the study proved to be very useful in the end, as I say it wasn’t necessarily that before signing people up that we would have had a great deal of idea about what it was that was, kind of, involved but as it went on we could kind of see the benefit of it.” (035)
(iii) Benefits for staff
Being aware of the potential of acclimatisation to suicide risk when continuously caring for large numbers of very acute and complex suicidal inpatients, staff welcomed the study as an opportunity to enhance and ‘refresh’ their practice;
“when you work the wards a long time risk becomes part of your bread and butter - everyday management of somebody, so, to have an additional scheme that highlights and focuses in on suicidality and coping techniques as a direct line of working has been really helpful” (011)
Working with suicidal inpatients was stressful but knowing that the therapist was working with the inpatient to offer focussed treatment for their suicidality helped to reduce staff anxiety and portrayed a sense of shared responsibility;
“I feel a little bit apprehensive when someone comes that is suicidal, it’s something, a client group that I do get a bit nervous about, so I think it might help break down, sort of eliminate that nervousness.” (041)
Collaboration with the therapist was valued by staff, who were able to gain a broader ‘psychological-formulation’ based understanding of an inpatient’s suicidal ideation and behaviour. This empowered staff to provide more focussed support and increased their confidence in their ability to keep suicidal inpatients safe;
“It was useful for us to hear a different, sort of, side to what we were seeing. [Therapist] did build a plan with the patient and we worked through that and I put together a care plan from that information… I think it gave me something to use with this patient, to focus on and to, sort of reflect back on, if she’s struggling to say look at what you’ve done in your session. I think it helped, because to give us something to work on together cos I was her named nurse” (040)
Staff reflected on how their practice might change if ward-based psychological therapy became available as a commissioned service, anticipating positive impact for their professional role development and more effective care delivery. Frustrations were expressed by staff who aspired to integrate psychologically informed approaches within their practice, but were inhibited by lack of organisational support structures including clinical supervision. Positive views were particularly evident regarding the potential of benefit for staff and inpatients of access to a ward-based psychological consultation facility that was currently unavailable;
“.. support for the staff as well ‘cos there’s lots of staff that are trying to, that are trying to do psychological interventions, but they need the support of the clinical psychologist.” (FG 033)
Discussion
Main findings
This is the first study to present a detailed analysis of psychiatric ward staff experiences and perspectives of delivery of a suicide-prevention psychological therapy for suicidal inpatients (CBSP). Our results advance new knowledge of value to psychological therapy researchers, practitioners and policy makers of: 1) the particular contextual factors that can inhibit or enable the successful conduct of psychological intervention research in acute psychiatric ward settings, and 2) how the role, beliefs and priorities of ward staff can impact to either facilitate or impede the provision of suicide-prevention psychological therapy for suicidal inpatients.
Staff role and beliefs
Staff perceive working with suicidal inpatients as stressful, with some having experienced considerable distress and trauma following experiences of inpatient suicide [30]. It is, therefore, understandable that staff behaved risk-aversely in referring only those inpatients judged as stable and less likely to engage in suicidal behaviour to the INSITE trial. Reticence to initiate conversations about suicide may also have deterred some staff from providing initial information to suicidal inpatients about the INSITE study.
Initiatives requiring staff to change their behaviour, as required for implementation of a novel psychological therapy, will be affected by their expectations of the value of the novel intervention [54]. Therefore, it was important to examine staff views regarding the expected value of CBSP. We found mixed views. Some staff, whilst initially sceptical, became impressed following observed improvements in patients who were receiving CBSP. For others, the secondary effects from their interactions with the therapist led to positive expectations of the value of CBSP. Staff perceived that interactions with the therapist enabled them to acquire a greater understanding of the idiosyncratic psychological influences underpinning the suicidal behaviour of inpatients under their care. Such psychological formulation based insights thereby empowered staff to engage in more professionally rewarding and meaningful interactions with inpatients.
However, our results also revealed negative views of the expected value of CBSP as some ward staff feared that talking about suicide could ‘trigger’ suicidal behaviour. Similarly, staffs’ concerns of increased workload should inpatients experience post-therapy distress may also have contributed to negative expectations of the consequences of CBSP. Such views have previously been documented[32] and may explain staff gatekeeping resulting in restricted referral behaviour due to their concerns that CBSP may cause distress and provoke relapse. This is consistent with prior research purporting gatekeeping to be motivated by attempts to shield vulnerable patients from exposure to the perceived threats of a research intervention that clinicians lack confidence in [55–57].
Staff accounts also described perceptions of inadequate knowledge of the structure and process of CBSP, which may also have impacted on their ability to make informed judgements of its expected value. Potentially then, intuitive beliefs may have dominated resulting in reluctance to refer inpatients to the trial to avoid exposing vulnerable suicidal inpatients to an intervention which staff knew little about and believed could increase suicide risk.
Inpatient nursing activity is largely defined by pressures and events beyond the control of the staff [58] who, despite being charged with the serious responsibility of caring for suicidal inpatients, have limited control over ward life. Our research protocol required that staff initiate discussions with inpatients to provide information about INSITE and gain consent for researchers to meet them to give further information about the trial. However, situations characterised by organisationally defined priorities with inadequate staffing and unpredictable workloads would suggest challenges to staffs’ perceptions of control regarding their ability to find the time and the confidence to talk with inpatients about suicide. Similarly, staffs’ fears that inpatients could become distressed following therapy and subsequently require additional support may have triggered concerns related to staffing resources and skill deficits.
Staff imposition of unofficial additional eligibility criteria could potentially have threatened the external validity of results if this had continued undiscovered in a definitive trial. However, paradoxically a sample more closely reflective of those inpatients that clinicians’ would deem suitable to receive the intervention (i.e., a ‘real-world’ population) could more closely resonate with clinical practice [25]. This is because, had access to the therapy been delivered in the context of a commissioned service, rather than as a research intervention, referral of inpatients would occur at ward team meetings where broader discussion of service resource use and individual patient factors may be justified.
Consistent with our ‘contextualist’ [40] assumptions the results of the current study confirmed a commitment by staff to improving the treatment of suicidal inpatients, which was a fundamental facilitator for our study. An unexpected positive consequence was that some staff instigated changes to individual and ward level practices based on ideas arising from the study. For example, liaison with INSITE researchers and therapists, who were confident and comfortable to talk about suicide, provided a positive ‘modelling’ effect leading to staff emulating the more direct questioning style used by researchers to ask about suicidal thoughts or behaviour when conducting risk assessments.
Impact of ward culture
It is important that researchers understand the real-world contextual challenges specific to conducting research in psychiatric wards which are typically chaotic and unpredictable environments [8–10, 58–60] Workforce instability is cited as a barrier to implementation of psychological approaches in psychiatric settings [61], and rapid staff turnover certainly inhibited our ability to form sustainable relationships with key clinicians.
Staff are accustomed to working in ‘fire-fighting’ mode to get themselves and the inpatients safely through their present shift [9, 10]. Whilst appreciating the complex personal, environmental and organisational challenges experienced by ward staff, such ‘short-termism’ presents challenges to conducting inpatient psychological therapy research and to improving the quality and efficacy of current treatments for suicidal inpatients.
Working in such stressful unstable conditions, staff understandably, prioritised ward management before the needs of researchers. However, as our results demonstrated, it was possible to negotiate and agree workable research procedures with staff, although ward preferences were idiosyncratic rather than global.
Psychological therapy and inpatient settings
The difficulties of integrating psychological approaches into usual psychiatric ward practice has been described previously [59–63]. However, our results revealed surprisingly high levels of staff support for the introduction of CBSP, which could have been expected to challenge some traditionally held beliefs and practices. For example, ward purpose and culture prioritises rapid discharge achieved by containment and stabilisation of acute symptoms [8,9] rather than longer duration approaches (e.g., psychological therapy) to address the generic drivers of hospitalization. Distress is typically suppressed by sedative medication as opposed to psychological approaches enabling inpatients to discuss and find meaning from their experiences [25, 58]. Psychological therapy is not commonly provided in acute psychiatric wards, although such therapies may be suggested for post-discharge referral [16]. Hence, little is known about how staff would make decisions about referral to ward-based psychological therapy. In community settings the referral decisions of General Practitioners were found to be influenced by the clinician’s judgement of patient factors including the patient’s demand, motivation, insight, ‘psychological mindedness’, intelligence, education and the clinician’s prediction of the patient’s reliability of attending sessions [64]. Further research to investigate referral decision pathways for psychological therapy by inpatient staff is indicated.
Compatibility of a novel intervention with the organisation’s values and performance targets is recognised to be beneficial to staff uptake [21, 22, 29]. The compatibility of CBSP with local suicide prevention strategies may have been a contributory factor to staff engagement with the research, as despite additional workload pressures, staff generally welcomed and showed enthusiasm for CBSP.
Similarly, staff perceptions of positive collegial relationships with researchers and therapists appeared to be associated with the shared ‘burden’ of negotiating the challenges of preventing inpatient suicide. This may have exerted a buffering effect in countering some of the effects of increased staff workload. Staff accounts alluded to flaws in current models of suicidal inpatient treatment, valuing the involvement of the therapist, which provided some reassurance that therapy-arm suicidal inpatient participants’ were receiving a specific suicide prevention treatment not otherwise available.
Real world clinical practice versus research practice
Staff discussed how their custodial role inhibited inpatients from disclosing suicidal thoughts or behaviours to them. This is corroborated by research of suicidal inpatients’ perspectives depicting their fears that disclosure of suicidality would prevent their desired discharge [65]. Hence, the combined impact of staff reluctance to engage in discussion about suicide and with suicidal inpatients’ reluctance to disclose suicidal thoughts to staff, suggests that staff are unlikely to be fully aware of which inpatients are suicidal. This highlights the need to consider participant recruitment procedures that do not rely solely on referral by ward staff. Under-recruitment to suicide intervention research is problematic [66] and when compounded by clinician gatekeeping [55–57] raises concerns about the external validity of some existing suicide intervention research where such factors may not have been considered.
Staff misinterpretation of their role by referring inpatient participants based on their own professional concerns rather than the research protocol defined criteria has serious implications for scientific rigour and is another example of the challenges of implementing standard RCT design for psychological therapy research in psychiatric ward settings [67]. We may have overestimated staff’s understanding of how the research processes necessary to maintain the parameters of a single-blind RCT of a novel treatment differ from those applicable when introducing a new commissioned service.
By striving to uphold the scientific principles of RCT design [68] that required controlling conditions so that outcomes could be confidently attributed to intervention effects, contact between the therapist and ward staff was limited to essential communication of disclosure of suicide risk. An unintended consequence was that staff desires for collaboration and active involvement in therapy patients’ treatment was thwarted. So, although staff desire to be actively involved in the therapy was a positive facilitator, paradoxically, the resultant unfulfilled expectations became a barrier to staff acceptance of the intervention. This may also have compounded staff perceptions of lack of control to fulfil their responsibility to maintain inpatients’ safe yet feeling excluded from a potentially ‘risky’ suicide-prevention treatment.
Similarly, whilst it was positive that staff were interested and requested training about psychological approaches to suicide prevention, this was withheld during the conduct of the trial to avoid confounding influences on trial outcomes. Arguably, additional training and any resulting changes in staff behaviour could confuse interpretation of whether RCT outcomes were attributable to CBSP, or to a ‘whole systems’ intervention comprising CBSP plus staff training. The latter may actually be a better approach for generating research, which, by more closely emulating real-world practice, is more likely to achieve translation into practice [67]. A potential solution to such challenges may be to consider alternative research designs for future ward-based psychological therapy research. In psychiatric research where standard RCT design was impractical, or threatened by contamination effects, pragmatic and standard cluster randomised controlled trials have been successfully implemented [69] including in inpatient settings [53].
Strengths
This is the first study involving an in-depth investigation into how the role, perceptions and practices of psychiatric ward staff impact on the acceptability of introduction of a suicide-focused psychological treatment for suicidal inpatients. Our results, by illuminating the key barriers and facilitators, offer psychological interventionist researchers / clinicians specific guidance regarding the development and delivery of psychological interventions within psychiatric inpatient settings, which has hitherto been lacking. Flexibility within our research design by offering the choice of attendance at an individual interview or focus group facilitated good recruitment from ward staff whose clinical demands presented challenges to uptake. In addition to the pragmatic benefits, choice of interview mode also allowed for staffs’ idiosyncratic preferences of enhanced confidentiality within 1 : 1 interviews, or for the peer support and group cohesion found in focus groups which can facilitate revelation of contentious views [50].
Limitations
At the time when this study was conducted the host psychiatric facility served populations from the geographical area with the highest suicide rate in UK [70], and the fourth most socio-economically deprived area in England UK [71]. Population and service complexity may suggest that the views and perspectives of staff in this study which was confined to one NHS mental health facility could differ from those in other organizations with lower concentrations of suicidal patients, more stable workforces and different contextual factors.
All three interviewers were female and interviewees mainly comprised female nurses, therefore the views expressed may be influenced by gender and professional orientations. However, nurses are arguably the most influential stakeholder group regarding the introduction and evaluation of ward-based innovations and the participant sample reflected the typical ward workforce. Psychiatrists, who hold particular status in seniority and authority within wards, were underrepresented, hence it would be important to ensure greater inclusion in future research. As staff self-selected it is possible that those who participated held more positive views than others not represented, therefore the barriers to introduction of CBSP may be underestimated.
A further limitation is that this study was conducted by the researchers who were conducting the trial which may have inhibited staff from divulging their genuine views. Similarly, it is possible that our affiliation with the trial may have biased our interpretations of the data. However, we did explicitly encourage staff to give feedback of negative experiences and to suggest improvements and this strategy was successful as staff did inform us about many barriers.
Recommendations
In terms of staffs’ referral of inpatients to the RCT, and based on their views that they were not given sufficient information about CBSP, it would have been beneficial to invest greater resources in provision of information about the therapy to improve staffs’ knowledge and confidence in the intervention. The provision of information about the therapy, qualifications and skills of therapists, and also of the extensive safety protocols built around therapy delivery should be included in discussions as this may offer staff more confidence to refer in accordance with the study eligibility criteria. Further, an explicit negotiated protocol regarding sharing of risk-pertinent information between staff and researchers may be of mutual benefit. Discussions with ward staff should take a proactive stance to exploring potential fears about increasing suicidal inpatients’ risk by talking about suicide as this opens the opportunity to counter such concerns with research evidence [72].
As provision of psychological therapy is uncommon within inpatient settings little is known of how ward staff make decisions regarding referral of inpatients. This would therefore be an important area to study in the future.
In terms of research practice in psychiatric wards the potential for contamination effects and the challenges of recruitment strategies that rely solely on ward staff to refer participants indicates the need for careful choice of appropriate research methods and designs. It is also important to be aware that clinical staff may be unfamiliar with research practice. Therefore, provision of information should include explanations of the need to obtain a representative sample strictly in accordance with specified eligibility criteria.
Staff suggested some solutions to improve communication and liaison practices including adoption of existing approaches used by other visiting professionals comprising advance booking of regular meeting dates. Other suggestions included attendance at weekly multi-disciplinary ward meetings by researchers, and liaising with the inpatient’s ‘named-nurse’ rather than any nurse available. However, our experience indicated extensive variations of preferred approaches across wards, therefore further research is required to find effective methods of communicating with large numbers of constantly changing staff populations across several locations.
Staffs’ essential role within the INSITE trial required their willingness, motivation and ability to change their usual work behaviours to support the recruitment and care of research participants. This study did not set out to examine staff change behaviour from a behaviour change theory perspective, however on post-hoc reflection it appears that some findings may map onto concepts within theories such as the Theory of Planned Behaviour (TPB) [73, 74], which has previously been applied within suicide research [75,76].
The TPB [73] suggests the importance of an individual’s normative beliefs regarding the expectations of important others (i.e., their managers). In this respect it may have been beneficial if staff had experienced greater support and encouragement from their senior managers to make explicit the organization’s formal commitment to the study, including their investment of significant funds in support of the study. Potentially, this may have encouraged staff cooperation by legitimizing use of their time for research related activity. However, this may have had limited impact if not practically supported by provision of additional staffing resources. It may be helpful to consider a more detailed examination of behavioural change factors in future studies.
Summary of recommendations for research investigating the delivery of therapy in psychiatric inpatient units
Identify and meet with key opinion leaders within the hospital hierarchy to engage their support, ensure inclusion of all professional groups
Provide information of research team members experience and expertise, and of the relevant ethics, research governance and safety protocols.
Preliminary investigations to understand the prevailing contextual influences
Be aware that ward activity, culture and staff views may differ even within the same hospital unit
Identify staff expectations and agree plans to meet identified needs (e.g., information needs)
Whenever possible involve staff in decisions regarding future plans
Be mindful of creating procedures that cause additional staff workload, aim to utilize existing ward processes where possible
Avoid assumptions of staff knowledge of research procedures, be prepared to explain reasons for eligibility criteria, randomisation etc
Ascertain ward staff experience of psychological therapy treatment programmes for inpatients
Pre-empt potential contentious issues by proactive discussion (e.g., misconceptions that talking about suicide is harmful; inpatients must be stable to receive psychological therapy)
Provide information of the specific therapy model to be introduced and the role required of ward staff (referral mechanisms, level of involvement in therapy, potential support needs of therapy recipients, e.t.c.)
Agree best ways of liaising with ward staff, including preferred times and days and times to avoid.
Develop a protocol for two-way sharing of risk-pertinent information.
Be prepared to provide multiple information sessions to ensure optimal staff coverage across 24 hour shift systems
Conclusions
This study aimed to understand ward staffs’ perceptions of the barriers and facilitators to introduction of ward-based CBSP therapy in the context of a clinical trial. Our results illuminated the real-world contextual challenges that impact on: i) the conduct of psychological research in psychiatric wards, and ii) staff acceptability of delivery of ward-based CBSP. Conducting a pilot clinical trial in psychiatric wards was achievable although was hampered by staffs’ reluctance / inability to find time to engage with researchers. This may be reflective of the lack of a research culture, as despite NHS rhetoric purporting the importance of clinical research [77], staff viewed research as somewhat divorced from clinical practice. Overall, our findings indicated that despite concerns regarding potential workload challenges, and the philosophical opposition of some ward staff, the introduction of CBSP therapy was generally welcomed. The scale and depth of such highly impactful data gained from this qualitative study confirms the value of conducting acceptability / feasibility studies prior to definitive trials of novel interventions [24,32,34]. As researchers we cannot rectify the reality of the unpredictable, often chaotic nature of everyday life in psychiatric wards, however, the results of this qualitative study have provided us with knowledge of the modifiable challenges that can be pre-empted and addressed in future research.
The beliefs of some staff that talking about suicide is harmful reflect systemic failings fuelled by inadequate educational preparation of mental health staff and resource deficient service delivery models. Such organisationally driven ward practices neither value nor resource staff time to talk with suicidal inpatients. The prevailing organisational goals within psychiatric wards of stabilisation of acute distress and rapid discharge are neither clinically nor cost effective, as repetition of suicidality is common, often necessitating re-admission and / or more intensive community services. The escalation of post-discharge suicide rates and the displacement of numerical statistics, but not actual suicide deaths, from inpatient settings to community crisis-intervention services [78] mainly illuminates the difficulties of preventing suicide in community settings rather than the increased success of treating suicidal inpatients. Effective interventions are urgently needed and psychological treatments, which are currently underexploited, demonstrate potential warranting further research [79].
Supporting information
S1 Appendix [docx]
Consolidated Criteria for Reporting Qualitative studies (COREQ) inventory.S2 Appendix [docx]
Interview schedule.
Zdroje
1. Martelli C., Awad H., Hardy P. In-patient suicides: epidemiology and prevention. Encephale. 2010;36. Supp 2. 83–91
2. Appleby L., Shaw J., Kapur N., Windfuhr K., Ashton A., Swinson N., et al. Avoidable deaths: Five-year Report of the National Confidential Inquiry into Suicide and Homicide by People with Mental Illness (NCISH). University of Manchester, UK. 2006.
3. National Confidential Inquiry into Suicide and Safety in Mental Health. Annual Report: England, Northern Ireland, Scotland, Wales. 2018. University of Manchester. UK.
4. WHO. World Health Organisation. Preventing Suicide: A global imperative. Geneva. WHO. 2014: Available at: www.who.int/mental_health/suicide-prevention/world_report_2014/en/ Accessed 24/01/19
5. Department of Health. DH. Preventing Suicide in England. A Cross-Government Outcomes Strategy to Save Lives. 2012. London, UK. Department of Health / Government
6. Department of Health. DH. The Five Year Forward View for Mental Health. 2016. Mental Health Taskforce. London, UK.
7. Large M., Chung D., Davidson M., Weiser M., Ryan C. In-patient suicide. 2017: Journal of Psychiatry Open. 3. 102–105.
8. Bowers L., Simpson A., Alexander J., Hackney D., Nijman H., Grange A., Warren J. The nature and purpose of acute psychiatric wards: The tompkins acute ward study. Journal of Mental Health. 2009 : 14 (6).625–635
9. Bowers L. Reasons for admission and their implications for the nature of acute inpatient psychiatric nursing. Journal of Psychiatric and Mental Health Nursing. 2005 : 12 (2) 231–236. doi: 10.1111/j.1365-2850.2004.00825.x 15788042
10. James K., Stewart D., Bowers L. Self-harm and attempted suicide within inpatient psychiatric services: A review of the literature. International Journal of Mental Health Nursing. 2012 : 21 (1) 301–309.
11. Hawton K., Witt K., Taylor Salisbury T., Arensman E., Gunnell D., Hazell P., Townsend E. Van Heeringen K. et al. Psychosocial interventions following self-harm in adults: a systematic review and meta-analysis. The Lancet. 2016 : 3(8) 740–750. doi: 10.1016/S2215-0366(16)30070-0 27422028
12. Winter D., Bradshaw S., Bunn F., Wellsted D. A systematic review of the literature on counselling and psychotherapy for the prevention of suicide: 1. Quantitative outcome and process studies. Counselling and Psychotherapy Research.2013 : 13(3) 164–183.
13. Winter D., Bradshaw S., Bunn F., Wellsted D. A systematic review of the literature on counselling and psychotherapy for the prevention of suicide: 2. Qualitative studies. Counselling and Psychotherapy Research. 2014 : 14(1) 64–79.
14. National Institute for Health & Care Excellence. (NICE). Self-harm: the short term physical and psychological management and secondary prevention of self-harm in primary and secondary care. NICE CG 16.2004: Available at www.nice.org.uk/guidance/CG16 accessed 10/04/19
15. National Institute for Clinical Excellence (NICE). Self-harm: Longer term management. CG133. 2011: Available at: www.nice.org.uk/guidance/CG133 accessed 04/03/19.
16. Durrant C., Clarke I., Tolland A., Wilson H. Designing a CBT service for acute inpatient settings: A pilot evaluation study. Clinical Psychology and Psychotherapy. 2007 : 14. 117–125
17. Munk-Jorgensen P., Blanner Kristiansen C., Uwawke R., Larsen J., Okkels N., Christiansen B., Hjorth P. The gap between available knowledge and its use in clinical psychiatry. Acta Psychiatrica Scandinavica. 2015 : 132. 441–450 doi: 10.1111/acps.12512 26463889
18. Proctor E., Landsverk J., Aarons G., Chambers D., Glisson C., Mittman B. Implementation research in mental health services: an emerging science with conceptual, methodological, and training challenges. Adm Policy Mental Health. 2009 : 36. 24–34
19. Gotham H. Diffusion of mental health and substance abuse treatments: Development, dissemination, and implementation. Clinical Psychology: Science and Practice. 2004 : 11(2) 160–176.
20. Haddock G., Eisner E., Boone C., Davies G., Coogan C., Barrowclough C. An investigation of the implementation of NICE-recommended CBT interventions for people with schizophrenia. Journal of Mental Health. 2004 : 23(4) 162–165.
21. Aarons G. Measuring provider attitudes toward adoption of evidence-based practice: Organizational context and individual differences. Child and Adolescent Psychiatric Clinics of North America.2005 : 14. 255–271. doi: 10.1016/j.chc.2004.04.008 15694785
22. Aarons G., Sawitzky A. Organizational culture and climate and mental health provider attitudes toward evidence-based practice. Psychological Services. 2006 : 3(1) 61–72 doi: 10.1037/1541-1559.3.1.61 17183411
23. Cooksey D. A Review of UK Health Research Funding. 2006. Norwich. HMSO.
24. Medical Research Council. UK. MRC. (2008). Developing and evaluation complex interventions: New guidance. 2008: London. MRC. Available at: www.mrc.ac.uk/complexinterventionsguidance.
25. Kennedy-Martin J., Curtis S., Faries D., Robinson S., Johnson J. A literature review on the representativeness of randomized controlled trial samples and implications for the external validity of trial results. Trials. 2015 : 16.495. doi: 10.1186/s13063-015-1023-4 26530985
26. Mullen A. Mental health nurses establishing psychosocial interventions within acute inpatient settings. International Journal of Mental Health Nursing. 2009 : 18(2) 83–90 doi: 10.1111/j.1447-0349.2008.00578.x 19290971
27. Heneghan C., Goldacre B., Mahtani K. Why clinical trial outcomes fail to translate into benefits for patients. Trials. 2017 : 18.122. doi: 10.1186/s13063-017-1870-2 28288676
28. Retsas A., Barriers to using research evidence in nursing practice. Journal of Advanced Nursing. 2000 : 31(3) 599–606 doi: 10.1046/j.1365-2648.2000.01315.x 10718879
29. Rycroft-Malone J., Harvey G., Seers K., Kitson A., McCormack B., Titchen A. An exploration of the factors that influence the implementation of evidence into practice. Journal of Clinical Nursing. 2004 : 13. 913–924 doi: 10.1111/j.1365-2702.2004.01007.x 15533097
30. Awenat Y., Peters S., Shaw Nunez E., Gooding P., Pratt D., Haddock G. Staff experiences and perceptions of working with in-patients who are suicidal: qualitative analysis. British Journal of Psychiatry. 2017: doi: 10.1192/bjp.bp.116.191817 28642259
31. Laker C., Callard C., Flach C., Williams P., Sayer J., Wykes T. The challenge of change in acute mental health services: measuring staff perceptions of barriers to change and their relationship to job status and satisfaction using a new measure (VOCALISE). Implementation Science. 2014 : 9 (23)
32. Tashakkori A., Teddlie C. Mixed Methodology. Combining Qualitative and Quantitative Approaches. 1998. London. Sage
33. Cochrane L., Olsen C., Murray S., Dupuis M., Tooman T., Hayes S. Gaps between knowing and doing: Understanding and assessing the barriers to optimal health care. Journal of Continuing Education in the Health Professions. 2007 : 27(2) 94–102 doi: 10.1002/chp.106 17576625
34. Dixon T., Stein E., Ngak S., Srean C., Maly P., Sokunny M., Carrico A., Page K, Maher L. Qualitative research and implementation science: Informing the acceptability and implementation of a trial of a conditional cash transfer intervention designed to reduce drug and HIV. Methodological Innovations. 2016. doi: 10.1177/2059799115622751 30956811
35. Thurmond V. The point of triangulation. Journal of Nursing Scholarship. 2001 : 33(3) 253–258.
36. Haddock G., Pratt D., Gooding P., Peters S., Emsley R., Evans E., Kelly J., Huggett C., Munroe A., Harris K., Davies L., Awenat Y. Randomised controlled trial of feasibility and acceptability of suicide prevention therapy in acute psychiatric wards. British Journal of Psychiatry Open. 2019 5(1) doi: 10.1192/bjo.2018.85
37. Haddock, G., NIHR. 2014 A pilot study to investigate the feasibility and acceptability of a cognitive behavioural suicide prevention therapy for people in acute psychiatric wards. PB-PG-1111-26026. 2014. Final report to the National Institute for Health Research
38. Tarrier N., Kelly J., Gooding P., Pratt D., Awenat Y., Maxwell J. Cognitive Behavioural Prevention of Suicide in Psychosis: A treatment manual. 2013. London. Routledge.
39. Rapp C., Etzel-Wise D., Mary D., Coffman M., Carlson L., Asher D., Callaghan J., Holter M. Barriers to evidence-based practice implementation: Results of a qualitative study. Community Mental Health Journal. 2010 : 46(2) 112–118. doi: 10.1007/s10597-009-9238-z 19685185
40. Madill A., Jordan A., Shirley C. Objectivity and reliability in qualitative analysis: Realist, contextualist and radical constructionist epistemologies. British Journal of Psychology 2000. 91, 1–20. doi: 10.1348/000712600161646 10717768
41. Herbert J., Padovani F. Contextualism, psychological science, and the question of ontology. Journal of Contextual Behavioral Science. 2015 : 4 225–230.
42. Braun V., Clarke V. Using thematic analysis in psychology. Qualitative Research in Psychology. 2006 : 3. 77–101.
43. Braun V. & Clarke V. Chapter 4. Thematic Analysis. In American Psychological Association Handbook of Research Methods in Psychology. 2012. Vol 2. Research Designs, Cooper H. (Editor-in-Chief) American Psychological Association. doi: 10.1037/1362-004
44. Braun V. & Clarke V. Successful Qualitative Research. A practical guide for beginners. 2013. London. Sage.
45. Finlay L. Negotiating the swamp: the opportunity and challenge of reflexivity in research practice. Qualitative Research. 2 (2) 209–230.
46. Mays N., Pope C. Qualitative research in healthcare. Assessing quality in qualitative research. British Medical Journal. 2000 : 320. 50–52 doi: 10.1136/bmj.320.7226.50 10617534
47. Hellawell D. Inside-out: analysis of the insider-outsider concept as a heuristic device to develop reflexivity in students doing qualitative research. Teaching in Higher Education. 2006 : 11(4) 483–494
48. Ritchie J., Lewis J., McNaughton Nicholls C., Ormston R. Qualitative Research Practice. A guide for social science students. 2014:p22: (2nd Edition) London. Sage
49. Tong A., Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ). International Journal for Quality in Health Care. 2007 : 19(6) 349–357 doi: 10.1093/intqhc/mzm042 17872937
50. Lambert S., Loiselle C. Combining individual interviews and focus groups to enhance data richness. Journal of Advanced Nursing. 2008 : 62(2) 228–237. doi: 10.1111/j.1365-2648.2007.04559.x 18394035
51. Marshall M. Sampling for qualitative research. Family Practice 1996. 13(6) 522–525. doi: 10.1093/fampra/13.6.522 9023528
52. Dey I. Grounding grounded theory guidelines for qualitative inquiry. 1999. San Diego, Academic Press
53. Bowers L., James K., Quirk A., Simpson A., SUGAR, Stewart D., Hodsell J. Reducing conflict and containment on acute psychiatric wards: The Safewards cluster randomised controlled trial. International Journal of Nursing Studies. 2015 : 52(9) 1412–1422 doi: 10.1016/j.ijnurstu.2015.05.001 26166187
54. Armitage C., Norman P., Alganem S., Connor M. Expectations are more predictive of behaviour than behavioural intentions: evidence from two prospective studies. Annals of Behavioral Medicine. 2015 : 49(2) 239–246 doi: 10.1007/s12160-014-9653-4 25623893
55. Borschmann R., Patterson S., Dilkushi P., Wilson D., Weaver T. Influences on recruitment to randomised controlled trials in mental health settings in England: a national cross-sectional survey of researchers working for the Mental Health Research Network. BMC Medical Research Methodology. 2014 : 14. 23. doi: 10.1186/1471-2288-14-23 24533721
56. Bucci S., Butcher I., Hartley S., Neil S., Mulligan J., Haddock G. Barriers and facilitators to research in mental health services: Care coordinators’ expectations and experiences of referring to a psychosis research trial. Psychology and Psychotherapy. 2014 : 88(3) 335–350 doi: 10.1111/papt.12042 25257960
57. Mairs H. Lovell K., Keeley P. Clinician views of referring people with negative symptoms to outcome research. International Journal of Mental Health Nursing. 2012 : 21(2) 138–144 doi: 10.1111/j.1447-0349.2011.00770.x 21951838
58. Cleary M., Hunt G., Horsfall J., Deacon M. Ethnographic research into nursing in acute adult mental health units: A review. Issues in Mental Health Nursing 2011 : 32(7) 424–435 doi: 10.3109/01612840.2011.563339 21736465
59. Holmes J. Acute wards: problems and solutions. Psychiatric Bulletin. 2002 : 26. 383–385
60. Flood C., Brennan G., Bowers L., Hamilton B., Lipong M., Oladapo P. Reflections on the process of change on acute psychiatric wards during the City Nurse project. Journal of Psychiatric and Mental Health Nursing. 2006 : 13 (3) 260–268 doi: 10.1111/j.1365-2850.2006.00932.x 16737492
61. Woltmann E., Whitley R., McHugo G., Brunette M., Torrey W., Coots L., Lynde D., Drake R. The role of staff turnover in the implementation of evidence based practices in mental health care. Psychiatric Services. 2008 : 59(7) 732–737 doi: 10.1176/appi.ps.59.7.732 18586989
62. Hurley J., & Rankin R. As mental health nursing roles expand, is education expanding mental health nurses? An emotionally intelligent view towards preparation for psychological therapies and relatedness. Nursing Inquiry.2008 : 15 (3) 199–205 doi: 10.1111/j.1440-1800.2008.00412.x 18786212
63. McCann E., Bowers L. Training in cognitive behavioural interventions on acute psychiatric inpatient wards. Journal of Psychiatric and Mental Health Nursing. 2005 : 12(2) 215–222 doi: 10.1111/j.1365-2850.2004.00822.x 15788040
64. Stavrou S., Cape J., Barker C. Decisions about referrals for psychological therapies: a matched-patient qualitative study. British Journal of General Practice. 2009 : 59(566) e289–e298 doi: 10.3399/bjgp09X454089 19761656
65. Awenat Y., Peters S., Gooding P., Pratt D., Shaw-Nunez E., Harris K., Haddock G. A qualitative analysis of suicidal inpatients views and expectations of psychological therapy to counter suicidal thoughts, acts and deaths. BMC Psychiatry. 2018: doi: 10.1186/s12888-018-1921-6 30326878
66. Striman S., Brown G., Ghahramanlou-Holloway M., Fox A., Chohan M., Beck A. Participation bias among suicidal adults in a randomized controlled trial. Suicide and Life Threatening Behavior.2011 : 41(2) 203–209 doi: 10.1111/j.1943-278X.2010.00011.x 21470296
67. Hendricks Brown C., Curran G., Palinkas L., Aarons G., Wells K., Jones L., Collins L., Duan N., Mittman B., Wallace A., Tabac R., Ducharme L., Chambers D., Neta G., Wiley T., Landsverk J., Cheung K., Cruden G. An overview of research and evaluation designs for dissemination and implementation. Annual Review of Public Health. 2017 : 38. 1–22 doi: 10.1146/annurev-publhealth-031816-044215 28384085
68. Sibbald B., Roland M. Understanding controlled trials: Why are randomised controlled trials important? British Medical Journal. 1998 : 316. 201 doi: 10.1136/bmj.316.7126.201 9468688
69. Lovell K., Bee P., Brooks H., Cahoon P., Callaghan P., Carter L., Cree L., Davies L., Drake R., Fraser C., Gibbons C., Hinsliff-Smith K., Bower P. Embedding shared decision-making in the care of patients with severe and enduring mental health problems. The EQUIP pragmatic cluster randomised trial. PLOS One.2018: http://doi.org/10.1371/journal.pone.0201533
70. National Confidential Inquiry into Suicide and Homicide by People with Mental Illness (NCISH). Annual report. 2013. University of Manchester, Manchester. UK.
71. UK Index of Deprivation (2015) http://www.gov.uk/government/statistics/english-indices-of-deprivation-2015 Accessed 10/11/18
72. Dazzi T., Gribble R. Wessely S., Fear N. Does asking about suicide and related behaviours induce suicidal ideation. What is the evidence? Psychological Medicine. 2014. 44(16) 3361–3363 doi: 10.1017/S0033291714001299 24998511
73. Ajzen I. From intentions to actions: A theory of planned behaviour.p11-39, In Kuhl J. & Beckmann J., (Eds) Action Control: From Cognition to Behaviour. 1985. Berlin. Springer-Verlag
74. Armitage C. Connor M. Efficacy of the theory of planned behaviour; A meta-analytic review. British Journal of Social Psychology. 2001 : 40. 471–499 11795063
75. O’Connor R., Armitage C. Theory of planned behaviour and parasuicide: An exploratory study. Current Psychology. 2003 : 22(3) 196–205
76. Armitage C., Rahim W., Rowe R., O’Connor R. An exploratory trial of a simple, brief psychological intervention to reduce subsequent suicidal ideation and behaviour in patients admitted to hospital for self-harm. The British Journal of Psychiatry. 2016 : 208(5) 470–476 doi: 10.1192/bjp.bp.114.162495 26743808
77. NHS England Research Plan. 2017. Leeds, UK. NHS England / Policy, Partnerships, & Innovation / Innovation and research Unit. Available at https://www.england.nhs.uk/wp-content/uploads/2017/04/nhse-research-plan.pdf accessed 19.06.19
78. National Confidential Inquiry into Suicide and Homicide by People with Mental Illness. Making Mental Health Care Safer: Annual Report and 20 –year review (2016) University of Manchester, Manchester, UK.
79. Hawton K. Pirkis J. Suicide is a complex problem that requires a range of prevention initiatives and methods of evaluation. The British Journal of Psychiatry (Editorial) 2017 : 210 381–383
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- Radiation hardness of cadmium telluride solar cells in proton therapy beam mode
- Bourdieu, networks, and movements: Using the concepts of habitus, field and capital to understand a network analysis of gender differences in undergraduate physics
- A 32-channel parallel transmit system add-on for 7T MRI
- Comparison between Aptima Assays (Hologic) and the Allplex STI Essential Assay (Seegene) for the diagnosis of Sexually transmitted infections
- Knowledge gaps of STIs in Africa; Systematic review
- Correction: Bovine herpesvirus 1 can cross the intact zona pellucida of bovine oocytes after artificial infection
- Distribution of corneal spherical aberration in a Tanzanian population
- Correction: Determinants of physical activity: A path model based on an ecological model of active living
- Wild pollinator activity negatively related to honey bee colony densities in urban context
- Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status
- The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century
- Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation
- Nitric oxide regulates the expression of heme carrier protein-1 via hypoxia inducible factor-1α stabilization
- Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes
- Construction of pseudomolecule sequences of Brassica rapa ssp. pekinensis inbred line CT001 and analysis of spontaneous mutations derived via sexual propagation
- Effects of flavoring compounds used in electronic cigarette refill liquids on endothelial and vascular function
- Rural pipeline and willingness to work in rural areas: Mixed method study on students in midwifery and obstetric nursing in Mali
- Role of phospholipase A2 receptor 1 antibody level at diagnosis for long-term renal outcome in membranous nephropathy
- Prevalence of anemia in diabetic adult outpatients in Northeast Ethiopia
- Characterization of melanin and optimal conditions for pigment production by an endophytic fungus, Spissiomyces endophytica SDBR-CMU319
- Genetic variability and consequence of Mycobacterium tuberculosis lineage 3 in Kampala-Uganda
- Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes
- Current and potential contributions of community pharmacy teams to self-harm and suicide prevention: A qualitative interview study
- Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway
- With or without U(K): A pre-Brexit network analysis of the EU ETS
- Graph-theoretical analysis for energy landscape reveals the organization of state transitions in the resting-state human cerebral cortex
- Task-uninformative visual stimuli improve auditory spatial discrimination in humans but not the ideal observer
- Residual stenosis after carotid artery stenting: Effect on periprocedural and long-term outcomes
- gapFinisher: A reliable gap filling pipeline for SSPACE-LongRead scaffolder output
- A plant biostimulant made from the marine brown algae Ascophyllum nodosum and chitosan reduce Fusarium head blight and mycotoxin contamination in wheat
- Monte-Carlo value analysis of High-Throughput Satellites: Value levers, tradeoffs, and implications for operators and investors
- Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm
- Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning
- Neuropathy and neural plasticity in the subcutaneous white adipose depot
- Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells
- The enemy’s gaze: Immersive virtual environments enhance peace promoting attitudes and emotions in violent intergroup conflicts
- Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae
- Koopman Mode Analysis of agent-based models of logistics processes
- Empirical mode decomposition based long short-term memory neural network forecasting model for the short-term metro passenger flow
- Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy
- Multi-agent reinforcement learning with approximate model learning for competitive games
- Identification of olfactory genes and functional analysis of BminCSP and BminOBP21 in Bactrocera minax
- The use of urinary fluoride excretion to facilitate monitoring fluoride intake: A systematic scoping review
- Development of a family caregiver needs-assessment scale for end-of-life care for senility at home (FADE)
- Epidemiology of pneumonia in the pre-pneumococcal conjugate vaccine era in children 2-59 months of age, in Ulaanbaatar, Mongolia, 2015-2016
- H-EM: An algorithm for simultaneous cell diameter and intensity quantification in low-resolution imaging cytometry
- Public expenditure on Non-Communicable Diseases & Injuries in India: A budget-based analysis
- Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways
- uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading frames
- Comparative analysis of postural control and vertical jump performance between three different measurement devices
- Hierarchical multi-view aggregation network for sensor-based human activity recognition
- Clavien–Dindo classification for grading complications after total pharyngolaryngectomy and free jejunum transfer
- Significantly different expression levels of microRNAs associated with vascular invasion in hepatocellular carcinoma and their prognostic significance after surgical resection
- Clinical correlates of workplace injury occurrence and recurrence in adults
- Medicine and the media: Medical experts’ problems and solutions while working with journalists
- Phylogenic classification and virulence genes profiles of uropathogenic E. coli and diarrhegenic E. coli strains isolated from community acquired infections
- Genetic relatedness in carbapenem-resistant isolates from clinical specimens in Ghana using ERIC-PCR technique
- Forest resilience under global environmental change: Do we have the information we need? A systematic review
- Improving the production of podophyllotoxin in hairy roots of Hyptis suaveolens induced from regenerated plantlets
- Controls on planktonic foraminifera apparent calcification depths for the northern equatorial Indian Ocean
- Notch and Delta are required for survival of the germline stem cell lineage in testes of Drosophila melanogaster
- Children with HIV: A scoping review of auditory processing skills
- Correction: Two distinct actin waves correlated with turns-and-runs of crawling microglia
- Expression of Concern: Neurotoxicity Induced by Bupivacaine via T-Type Calcium Channels in SH-SY5Y Cells
- Sex-dependent and -independent transcriptional changes during haploid phase gametogenesis in the sugar kelp Saccharina latissima
- Vehicle modeling for the analysis of the response of detectors based on inductive loops
- New Mycobacteroides abscessus subsp. massiliense strains with recombinant hsp65 gene laterally transferred from Mycobacteroides abscessus subsp. abscessus: Potential for misidentification of M. abscessus strains with the hsp65-based method
- A prognostic Bayesian network that makes personalized predictions of poor prognostic outcome post resection of pancreatic ductal adenocarcinoma
- Impact of care provider network characteristics on patient outcomes: Usage of social network analysis and a multi-scale community detection
- Valid group comparisons can be made with the Patient Health Questionnaire (PHQ-9): A measurement invariance study across groups by demographic characteristics
- Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Upgraded molecular models of the human KCNQ1 potassium channel
- Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells
- The extraordinary osteology and functional morphology of the limbs in Palorchestidae, a family of strange extinct marsupial giants
- Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro
- Implementation of home blood pressure monitoring among French GPs: A long and winding road
- In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues
- Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
- The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study
- Retraction: Comprehensive Comparison of Three Different Immunosuppressive Regimens for Liver Transplant Patients with Hepatocellular Carcinoma: Steroid-Free Immunosuppression, Induction Immunosuppression and Standard Immunosuppression
- Can acute suicidality be predicted by Instagram data? Results from qualitative and quantitative language analyses
- Computational and experimental analysis of the glycophosphatidylinositol-anchored proteome of the human parasitic nematode Brugia malayi
- Antibacterial activity of silver nanoparticles of different particle size against Vibrio Natriegens
- Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
- To eat or not to eat: Reward delay impulsivity in children with loss of control eating, attention deficit / hyperactivity disorder, a double diagnosis, and healthy children
- Factors associated with newborn care knowledge and practices in the upper Himalayas
- Correction: A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment
- Correlates of concurrent partnerships and patterns of condom use among men who have sex with men and transgender women in Peru
- Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma
- Development of a denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis for arthroplasty: A phantom study
- Low-level sensory processes play a more crucial role than high-level cognitive ones in the size-weight illusion
- The prevalence of asthma and allergic rhinitis in Nigeria: A nationwide survey among children, adolescents and adults
- Retraction: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium
- Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study
- Characteristics of diabetic macular edema patients refractory to anti-VEGF treatments and a dexamethasone implant
- Correction: Effects of dietary n-6: n-3 polyunsaturated fatty acid ratios on meat quality, carcass characteristics, tissue fatty acid profiles, and expression of lipogenic genes in growing goats
- Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study
- Impact of pterygium on the ocular surface and meibomian glands
- Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- Transcriptome divergence during leaf development in two contrasting switchgrass (Panicum virgatum L.) cultivars
- Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis
- Circulating progenitor cells and the expression of Cxcl12, Cxcr4 and angiopoietin-like 4 during wound healing in the murine ear
- EUSKOR: End-to-end coreference resolution system for Basque
- Inactivating pathogenic bacteria in greywater by biosynthesized Cu/Zn nanoparticles from secondary metabolite of Aspergillus iizukae; optimization, mechanism and techno economic analysis
- Exopolysaccharide producing rhizobacteria and their impact on growth and drought tolerance of wheat grown under rainfed conditions
- Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes
- Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study
- Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
- Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae)
- PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
- Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients
- “I do all I can but I still fail them”: Health system barriers to providing Option B+ to pregnant and lactating women in Malawi
- Impact of major illnesses and geographic regions on do-not-resuscitate rate and its potential cost savings in Taiwan
- Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis
- Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration
- Correction: Artificial neural networks reveal individual differences in metacognitive monitoring of memory
- Combining fish and environmental PCR for diagnostics of diseased laboratory zebrafish in recirculating systems
- Reading skill modulates the effect of parafoveal distractors on foveal lexical decision in deaf students
- Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia
- Exposure to marital conflict: Gender differences in internalizing and externalizing problems among children
- Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials
- The effect of age and perturbation time on online control during rapid pointing
- Oilseed rape (Brassica napus) resistance to growth of Leptosphaeria maculans in leaves of young plants contributes to quantitative resistance in stems of adult plants
- Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitis
- Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin
- Genomic characterization of the complete terpene synthase gene family from Cannabis sativa
- Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine
- Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana
- Plant growth promoting rhizobacterium Stenotrophomonas maltophilia BJ01 augments endurance against N2 starvation by modulating physiology and biochemical activities of Arachis hypogea
- Hierarchical integrated and segregated processing in the functional brain default mode network within attention-deficit/hyperactivity disorder
- Rising co-payments coincide with unwanted effects on continuity of healthcare for patients with schizophrenia in the Netherlands
- Analysis of Zobellella denitrificans ZD1 draft genome: Genes and gene clusters responsible for high polyhydroxybutyrate (PHB) production from glycerol under saline conditions and its CRISPR-Cas system
- False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases
- Identification of potassium phosphite responsive miRNAs and their targets in potato
- Quantification of bell-shaped size selectivity in shrimp trawl fisheries using square mesh panels and a sorting cone after a Nordmøre grid
- Deactivation of somatosensory and visual cortices during vestibular stimulation is associated with older age and poorer balance
- Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice
- Flooding performance evaluation of alkyl aryl sulfonate in various alkaline environments
- An artificial intelligent diagnostic system on mobile Android terminals for cholelithiasis by lightweight convolutional neural network
- Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads
- COI metabarcoding primer choice affects richness and recovery of indicator taxa in freshwater systems
- Retraction: APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway
- The intake pattern and feed preference of layer hens selected for high or low feed conversion ratio
- Individualized pattern recognition for detecting mind wandering from EEG during live lectures
- Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison
- Post-activation potentiation effect of eccentric overload and traditional weightlifting exercise on jumping and sprinting performance in male athletes
- Effectiveness of different central venous catheter fixation suture techniques: An in vitro crossover study
- Quantitative detection of ALK fusion breakpoints in plasma cell-free DNA from patients with non-small cell lung cancer using PCR-based target sequencing with a tiling primer set and two-step mapping/alignment
- Nuclei deformation reveals pressure distributions in 3D cell clusters
- Strategies for increasing diagnostic yield of community-onset bacteraemia within the emergency department: A retrospective study
- Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry
- Certified service dogs – A cost-effectiveness analysis appraisal
- Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy
- Assessing the impact of a research funder’s recommendation to consider core outcome sets
- Validity of six consumer-level activity monitors for measuring steps in patients with chronic heart failure
- Detection of deceptive motions in rugby from visual motion cues
- The impact of antenatal care on neonatal mortality in sub-Saharan Africa: A systematic review and meta-analysis
- Epidemiological investigation and management of bloody diarrhea among children in India
- Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation
- Bacteria isolated from Bengal cat (Felis catus × Prionailurus bengalensis) anal sac secretions produce volatile compounds potentially associated with animal signaling
- Petri net–based model of the human DNA base excision repair pathway
- Complexation and conformation of lead ion with poly-γ-glutamic acid in soluble state
- The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- The Youth-Physical Activity Towards Health (Y-PATH) intervention: Results of a 24 month cluster randomised controlled trial
- The COPD multi-dimensional phenotype: A new classification from the STORICO Italian observational study
- Morphological identification of Amphitetranychus species (Acari: Tetranychidae) with crossbreeding, esterase zymograms and DNA barcode data
- Maintaining hope after a disabling stroke: A longitudinal qualitative study of patients’ experiences, views, information needs and approaches towards making treatment decisions
- Cultural differences in the use of acoustic cues for musical emotion experience
- Effects of a rifampicin pre-treatment on linezolid pharmacokinetics
- High prevalence of multidrug resistant Enterobacteriaceae among residents of long term care facilities in Amsterdam, the Netherlands
- Infection/inflammation-associated preterm delivery within 14 days of presentation with symptoms of preterm labour: A multivariate predictive model
- Prognostic value of preoperative hydronephrosis in patients with bladder cancer undergoing radical cystectomy: A meta-analysis
- Correction: Early life predictors of midlife allostatic load: A prospective cohort study
- PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations
- Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments
- Symbiotic incompatibility between soybean and Bradyrhizobium arises from one amino acid determinant in soybean Rj2 protein
- Does anticoagulation needed for distally located incidental pulmonary thromboembolism in patients with active cancer?
- Control of human testis-specific gene expression
- Speaking up culture of medical students within an academic teaching hospital: Need of faculty working in patient safety
- Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations
- Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study
- Results of scoping review do not support mild traumatic brain injury being associated with a high incidence of chronic cognitive impairment: Commentary on McInnes et al. 2017
- Native seed, soil and atmosphere respond to boreal forest topsoil (LFH) storage
- Development of a quantitative polymerase chain reaction assay and environmental DNA sampling methods for Giant Gartersnake (Thamnophis gigas)
- Genetic diversity and population structure of four Chinese rabbit breeds
- Knowledge, attitude and behaviors towards patients with mental illness: Results from a national Lebanese study
- Correction: An impact evaluation of two rounds of mass drug administration on the prevalence of active trachoma: A clustered cross sectional survey
- Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Graph convolutional network approach applied to predict hourly bike-sharing demands considering spatial, temporal, and global effects
- Impact of traffic variability on geographic accessibility to 24/7 emergency healthcare for the urban poor: A GIS study in Dhaka, Bangladesh
- Feeling the heat: Elevated temperature affects male display activity of a lekking grassland bird
- Constructing a comprehensive disaster resilience index: The case of Italy
- Intraocular pressure according to different types of tonometry (non-contact and Goldmann applanation) in patients with different degrees of bilateral tearing
- Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus
- Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging
- Nonverbal synchrony in virtual reality
- Do speed cameras reduce road traffic collisions?
- A zero-shot learning approach to the development of brain-computer interfaces for image retrieval
- Use of non-HIV medication among people living with HIV and receiving antiretroviral treatment in Côte d’Ivoire, West Africa: A cross-sectional study
- DNA barcoding of southern African crustaceans reveals a mix of invasive species and potential cryptic diversity
- Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay
- Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs
- Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6
- Transport oil product consumption and GHG emission reduction potential in China: An electric vehicle-based scenario analysis
- Ontogenetic shift in the energy allocation strategy and physiological condition of larval plaice (Pleuronectes platessa)
- Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Diagnostic accuracy of Xpert MTB/RIF assay and non-molecular methods for the diagnosis of tuberculosis lymphadenitis
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
- Spatial distribution of breast cancer in Sudan 2010-2016
- Human-induced fire regime shifts during 19th century industrialization: A robust fire regime reconstruction using northern Polish lake sediments
- Enhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions
- Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
- Iron and manganese co-limit growth of the Southern Ocean diatom Chaetoceros debilis
- Bilateral and unilateral load-velocity profiling in a machine-based, single-joint, lower body exercise
- Veterans Health Administration nurses’ training and beliefs related to care of patients with traumatic brain injury
- Supplementation strategies affect the feed intake and performance of grazing replacement heifers
- Active transcutaneous bone conduction hearing implants: Systematic review and meta-analysis
- Parameterization-induced uncertainties and impacts of crop management harmonization in a global gridded crop model ensemble
- Acidification effects on isolation of extracellular vesicles from bovine milk
- GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve
- Mining version history to predict the class instability
- Humpback whale song occurrence reflects ecosystem variability in feeding and migratory habitat of the northeast Pacific
- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes
- Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading
- Reconstructing systematic persistent impacts of promotional marketing with empirical nonlinear dynamics
- Trans-national conservation and infrastructure development in the Heart of Borneo
- Prediction of cardiovascular disease risk among people with severe mental illness: A cohort study
- Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
- Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
- Reconstructing birth in Australopithecus sediba
- Value of contrast-enhanced ultrasound for preoperative assessment of liver reserve function in patients with liver tumors
- Correction: Identifying obesity/overweight status in children and adolescents; A cross-sectional medical record review of physicians’ weight screening practice in outpatient clinics, Saudi Arabia
- Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program
- Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
- Functional role and evolutionary contributions of floral gland morphoanatomy in the Paleotropical genus Acridocarpus (Malpighiaceae)
- On the efficiency of HIV transmission: Insights through discrete time HIV models
- Metabolic cost calculations of gait using musculoskeletal energy models, a comparison study
- Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype
- Evolutionary analysis of six chloroplast genomes from three Persea americana ecological races: Insights into sequence divergences and phylogenetic relationships
- Cultural transmission in a food preparation task: The role of interactivity, innovation and storytelling
- Correction: Effects of affective priming through music on the use of emotion words
- Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial
- Estimation of vaccination coverage from electronic healthcare records; methods performance evaluation – A contribution of the ADVANCE-project
- Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation
- Suicide by hanging: Results from a national survey in Switzerland and its implications for suicide prevention
- Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders
- Genome wide genetic dissection of wheat quality and yield related traits and their relationship with grain shape and size traits in an elite × non-adapted bread wheat cross
- Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
- Factors influencing the admission decision for Medical Psychiatry Units: A concept mapping approach
- Comparison of post-traumatic changes in circulating and bone marrow leukocytes between BALB/c and CD-1 mouse strains
- Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)
- Associations between birth order with mental wellbeing and psychological distress in midlife: Findings from the 1970 British Cohort Study (BCS70)
- Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
- The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
- Ancient technology and punctuated change: Detecting the emergence of the Edomite Kingdom in the Southern Levant
- Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- Randomized control trial of Tools of the Mind: Marked benefits to kindergarten children and their teachers
- Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration
- PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age
- Correction: Unraveling the genetic complexity underlying sorghum response to water availability
- Impact of tear metrics on the reliability of perimetry in patients with dry eye
- Using DNA barcoding to improve invasive pest identification at U.S. ports-of-entry
- Correction: Effects of Lactobacillus plantarum 15-1 and fructooligosaccharides on the response of broilers to pathogenic Escherichia coli O78 challenge
- Physico-chemical characterization and transcriptome analysis of 5-methyltryptophan resistant lines in rice
- Patient factors affecting successful linkage to treatment in a cervical cancer prevention program in Kenya: A prospective cohort study
- Is this a man’s world? The effect of gender diversity and gender equality on firm innovativeness
- Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit—The PROSACAB study
- Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock
- Quantitation of free glycation compounds in saliva
- Resolving an 87-year-old taxonomical curiosity with the description of Psylla frodobagginsi sp. nov. (Hemiptera: Sternorrhyncha: Psyllidae), a second distinct Psylla species on the New Zealand endemic plant kōwhai
- The effect of cathodal tDCS on fear extinction: A cross-measures study
- Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome
- Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells
- Investigating the dispersal of antibiotic resistance associated genes from manure application to soil and drainage waters in simulated agricultural farmland systems
- Continuous norming of psychometric tests: A simulation study of parametric and semi-parametric approaches
- Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method
- Cost-effectiveness of apixaban compared to other anticoagulants in patients with atrial fibrillation in the real-world and trial settings
- Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia
- Low genetic differentiation yet high phenotypic variation in the invasive populations of Spartina alterniflora in Guangxi, China
- A mathematical model for designing networks of C-Reactive Protein point of care testing
- Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis
- Femtosecond laser induced step-like structures inside transparent hydrogel due to laser induced threshold reduction
- From In Situ to satellite observations of pelagic Sargassum distribution and aggregation in the Tropical North Atlantic Ocean
- The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology
- BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis
- HIV prevalence and risk behavior among male and female adults screened for enrolment into a vaccine preparedness study in Maputo, Mozambique
- Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
- Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing
- Occurrence mechanism and coping paths of accidents of highly aggregated tourist crowds based on system dynamics
- Correction: Low Dose Aerosol Fitness at the Innate Phase of Murine Infection Better Predicts Virulence amongst Clinical Strains of Mycobacterium tuberculosis
- Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats
- Correction: Public reaction to Chikungunya outbreaks in Italy—Insights from an extensive novel data streams-based structural equation modeling analysis
- Correction: Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer’s dementia
- Intra-individual variability of sleep and nocturnal cardiac autonomic activity in elite female soccer players during an international tournament
- Therapeutic efficacy of equine botulism heptavalent antitoxin against all seven botulinum neurotoxins in symptomatic guinea pigs
- Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis
- Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis
- Scope and efficacy of the broad-spectrum topical antiseptic choline geranate
- Hematological and biochemical parameters for Chinese rhesus macaque
- Veterinary peer study groups as a method of continuous education—A new approach to identify and address factors associated with antimicrobial prescribing
- Correction: The prognosis of heart failure patients: Does sodium level play a significant role?
- Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin
- Systematic identification of facility-based stillbirths and neonatal deaths through the piloted use of an adapted RAPID tool in Liberia and Nepal
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis
- Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal population
- Reasons to care: Personal motivation as a key factor in the practice of the professional foster carer in Romania
- Determinants of clinical, functional and personal recovery for people with schizophrenia and other severe mental illnesses: A cross-sectional analysis
- Continuity of care for TB patients at a South African hospital: A qualitative participatory study of the experiences of hospital staff
- EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling
- The Better Management of Patients with Osteoarthritis Program: Outcomes after evidence-based education and exercise delivered nationwide in Sweden
- The negative effects of short-term extreme thermal events on the seagrass Posidonia oceanica are exacerbated by ammonium additions
- Pathogen invasion history elucidates contemporary host pathogen dynamics
- Chinese herbal formulae for the treatment of menopausal hot flushes: A systematic review and meta-analysis
- Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery
- Deconstruction of central line insertion guidelines based on the positive deviance approach—Reducing gaps between guidelines and implementation: A qualitative ethnographic research
- PBMCs transcriptome profiles identified breed-specific transcriptome signatures for PRRSV vaccination in German Landrace and Pietrain pigs
- The impact of admission serum lactate on children with moderate to severe traumatic brain injury
- Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface
- Determination of the bruise degree for cherry using Vis-NIR reflection spectroscopy coupled with multivariate analysis
- Genome-wide identification and expression profile analysis of nuclear factor Y family genes in Sorghum bicolor L. (Moench)
- Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007–2016: A retrospective cohort study
- Distribution of the Duffy genotypes in Malaysian Borneo and its relation to Plasmodium knowlesi malaria susceptibility
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- Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
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- Retraction: Modulation of the Pentose Phosphate Pathway Induces Endodermal Differentiation in Embryonic Stem Cells
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- The conditional Fama-French model and endogenous illiquidity: A robust instrumental variables test
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- Genetic evidence for plural introduction pathways of the invasive weed Paterson’s curse (Echium plantagineum L.) to southern Australia
- Risk of major autoimmune diseases in female breast cancer patients: A nationwide, population-based cohort study
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- Retraction: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection
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- Correction: A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk
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- Correction: Permissivity of Primary Human Hepatocytes and Different Hepatoma Cell Lines to Cell Culture Adapted Hepatitis C Virus
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- Correction: In vitro larval rearing protocol for the stingless bee species Melipona scutellaris for toxicological studies
- Correction: Morphological and molecular identification of the dioecious “African species Volvox rousseletii (Chlorophyceae) in the water column of a Japanese lake based on field-collected and cultured materials
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- Expression of Concern: miRNA 17 Family Regulates Cisplatin-Resistant and Metastasis by Targeting TGFbetaR2 in NSCLC
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- Agreement between the Cochrane risk of bias tool and Physiotherapy Evidence Database (PEDro) scale: A meta-epidemiological study of randomized controlled trials of physical therapy interventions
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- The performance of different case definitions for severe influenza surveillance among HIV-infected and HIV-uninfected children aged <5 years in South Africa, 2011–2015
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- Different levels of statistical learning - Hidden potentials of sequence learning tasks
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- Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responses
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- Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2
- Does effectiveness in performance appraisal improve with rater training?
- National trends in inpatient endometriosis admissions: Patients, procedures and outcomes, 2006−2015
- Affective and enjoyment responses to 12 weeks of high intensity interval training and moderate continuous training in adults with Crohn’s disease
- Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up
- Cabbage stem flea beetle’s (Psylliodes chrysocephala L.) susceptibility to pyrethroids and tolerance to thiacloprid in the Czech Republic
- Implicit learning of artificial grammatical structures after inferior frontal cortex lesions
- Potential survival benefits from optimized chemotherapy implementation in advanced ovarian cancer: Projections from a microsimulation model
- Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in Malaysia
- Heat stress responses in a large set of winter wheat cultivars (Triticum aestivum L.) depend on the timing and duration of stress
- Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model
- Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissues
- Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia
- Evaluation of suitable reference genes in Brassica juncea and its wild relative Camelina sativa for qRT-PCR analysis under various stress conditions
- Time-related immunomodulation by stressors and corticosterone transdermal application in toads
- Machine learning discovery of longitudinal patterns of depression and suicidal ideation
- Multi-scale patterns of tick occupancy and abundance across an agricultural landscape in southern Africa
- A matter of taste: Spatial and ontogenetic variations on the trophic ecology of the tiger shark at the Galapagos Marine Reserve
- Retraction: Adaptive double threshold energy detection based on Markov model for cognitive radio
- Adrenal gland size in obstructive sleep apnea: Morphological assessment of hypothalamic pituitary adrenal axis activity
- Out-of-pocket health spending among Medicare beneficiaries: Which chronic diseases are most costly?
- A large-scale chromosomal inversion is not associated with life history development in rainbow trout from Southeast Alaska
- Deployment, suicide, and overdose among comorbidity phenotypes following mild traumatic brain injury: A retrospective cohort study from the Chronic Effects of Neurotrauma Consortium
- Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data
- Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
- A quantitative approach for the analysis of clinician recognition of acute respiratory distress syndrome using electronic health record data
- Morphological, microbiological and ultrastructural aspects of sepsis by Aeromonas hydrophila in Piaractus mesopotamicus
- Recidivism rates in individuals receiving community sentences: A systematic review
- The association of intensive care with utilization and costs of outpatient healthcare services and quality of life
- How well do cancer survivor self-classifications of anxiety, depression and stress agree with a standardised tool? Results of a cross-sectional study
- Comparative nutritional characteristics of the three major Chinese Dendrobium species with different growth years
- Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
- Geographic differentiation of agritourism activities in Poland vs. cultural and natural attractiveness of destinations at district level
- Social participation reduces isolation among Japanese older people in urban area: A 3-year longitudinal study
- Explaining age-related decline in theory of mind: Evidence for intact competence but compromised executive function
- Role of GDF15 in methylseleninic acid-mediated inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
- Black people are convicted more for being black than for being poor: The role of social norms and cultural prejudice on biased racial judgments
- Bulked segregant analysis RNA-seq (BSR-Seq) validated a stem resistance locus in Aegilops umbellulata, a wild relative of wheat
- Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits
- Barriers and enablers to the implementation of a complex quality improvement intervention for acute kidney injury: A qualitative evaluation of stakeholder perceptions of the Tackling AKI study
- Soil and vegetation conditions changes following the different sand dune restoration measures on the Zoige Plateau
- Experimental H1N1pdm09 infection in pigs mimics human seasonal influenza infections
- Emission characteristics of diethylhexyl phthalate (DEHP) from building materials determined using a passive flux sampler and micro-chamber
- Multi-focus microscope with HiLo algorithm for fast 3-D fluorescent imaging
- Pontoscolex corethrurus: A homeless invasive tropical earthworm?
- Modeling reciprocal effects in medical research: Critical discussion on the current practices and potential alternative models
- Does palliative chemotherapy really palliate and are we measuring it correctly? A mixed methods longitudinal study of health related quality of life in advanced soft tissue sarcoma
- Developing cookies formulated with goat cream enriched with conjugated linoleic acid
- The effects of combining focus of attention and autonomy support on shot accuracy in the penalty kick
- Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: A cross-sectional study
- A combined strategy of neuropeptide prediction and tandem mass spectrometry identifies evolutionarily conserved ancient neuropeptides in the sea anemone Nematostella vectensis
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- Antitumor activity of a novel dual functional podophyllotoxin derivative involved PI3K/AKT/mTOR pathway
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- Prognosis of severe acquired brain injury: Short and long-term outcome determinants and their potential clinical relevance after rehabilitation. A comprehensive approach to analyze cohort studies
- An in silico investigation of menthol metabolism
- Variant analysis pipeline for accurate detection of genomic variants from transcriptome sequencing data
- Identification of candidate flowering and sex genes in white Guinea yam (D. rotundata Poir.) by SuperSAGE transcriptome profiling
- Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation
- The quality of guidelines for diabetic foot ulcers: A critical appraisal using the AGREE II instrument
- Mastitis risk effect on the economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study
- Confounding by indication of the safety of de-escalation in community-acquired pneumonia: A simulation study embedded in a prospective cohort
- Effects from diet-induced gut microbiota dysbiosis and obesity can be ameliorated by fecal microbiota transplantation: A multiomics approach
- Drivers of HIV-1 transmission: The Portuguese case
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- A biface production older than 600 ka ago at Notarchirico (Southern Italy) contribution to understanding early Acheulean cognition and skills in Europe
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- The expression of equine keratins K42 and K124 is restricted to the hoof epidermal lamellae of Equus caballus
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- Inhibition of polymerase chain reaction: Pathogen-specific controls are better than human gene amplification
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- Downscaling satellite soil moisture using geomorphometry and machine learning
- Choosing efficient actions: Deciding where to walk
- The zooarchaeology and isotopic ecology of the Bahamian hutia (Geocapromys ingrahami): Evidence for pre-Columbian anthropogenic management
- Synergy of the flow behaviour and disperse phase of cellulose nanoparticles in enhancing oil recovery at reservoir condition
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- Human papillomavirus infection among head and neck squamous cell carcinomas in southern China
- Comparison of feature point detectors for multimodal image registration in plant phenotyping
- Quartet-based inference of cell differentiation trees from ChIP-Seq histone modification data
- Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform
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- Comparing record linkage software programs and algorithms using real-world data
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- Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice – Vie-KinD study
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- A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome
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- Effect of PEPFAR funding policy change on HIV service delivery in a large HIV care and treatment network in Nigeria
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- Tipping the balance towards long-term retention in the HIV care cascade: A mixed methods study in southern Mozambique
- Diagnosis and classification of pediatric acute appendicitis by artificial intelligence methods: An investigator-independent approach
- Stylistic variation on the Donald Trump Twitter account: A linguistic analysis of tweets posted between 2009 and 2018
- Kinematic determinants of scoring success in the fencing flick: Logistic and linear multiple regression analysis
- Preferences for formal and traditional sources of childbirth and postnatal care among women in rural Africa: A systematic review
- Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix)
- Associations between industry involvement and study characteristics at the time of trial registration in biomedical research
- A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
- Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1
- The predictive performance of SAPS 2 and SAPS 3 in an intermediate care unit for internal medicine at a German university transplant center; A retrospective analysis
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- Multiple biomarkers of sepsis identified by novel time-lapse proteomics of patient serum
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- Beta power encodes contextual estimates of temporal event probability in the human brain
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- Improved ICU mortality prediction based on SOFA scores and gastrointestinal parameters
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- The diagnostic value of pleural fluid homocysteine in malignant pleural effusion
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- Multidrug-resistant profile and prevalence of extended spectrum β-lactamase and carbapenemase production in fermentative Gram-negative bacilli recovered from patients and specimens referred to National Reference Laboratory, Addis Ababa, Ethiopia
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- Why Cohen’s Kappa should be avoided as performance measure in classification
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- Isolation, identification and characterization of Streptomyces metabolites as a potential bioherbicide
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- Correction: Reward abundance interferes with error-based learning in a visuomotor adaptation task
- Correction: Potential user interest in new long-acting contraceptives: Results from a mixed methods study in Burkina Faso and Uganda
- Correction: Recombinant rabbit beta nerve growth factor production and its biological effects on sperm and ovulation in rabbits
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- Validating a popular outpatient antibiotic database to reliably identify high prescribing physicians for patients 65 years of age and older
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- Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy
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- Scientific sinkhole: The pernicious price of formatting
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- Repeated transspinal stimulation decreases soleus H-reflex excitability and restores spinal inhibition in human spinal cord injury
- Expression of Concern: Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor
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- Modeling spatial variation in density of golden eagle nest sites in the western United States
- Retraction: Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3
- Correction: In Porphyromonas gingivalis VimF Is Involved in Gingipain Maturation through the Transfer of Galactose
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- Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey
- A novel therapeutic strategy for esophageal varices using endoscopic treatment combined with splenic artery embolization according to the Child-Pugh classification
- Correction: Development of a high-throughput assay to measure measles neutralizing antibodies
- Correction: Provider preference for payment method under a national health insurance scheme: A survey of health insurance-credentialed health care providers in Ghana
- Correction: Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis
- Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India
- Feed-forward visual processing suffices for coarse localization but fine-grained localization in an attention-demanding context needs feedback processing
- Level Set method-based two-dimensional numerical model for simulation of nonuniform open-channel flow
- Compared to non-drinkers, individuals who drink alcohol have a more favorable multisystem physiologic risk score as measured by allostatic load
- Effect of poor glycaemic control on plasma levels and activity of protein C, protein S, and antithrombin III in type 2 diabetes mellitus
- Retraction: IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
- Sugar transporters in Fabaceae, featuring SUT MST and SWEET families of the model plant Medicago truncatula and the agricultural crop Pisum sativum
- Prediction of lymphovascular space invasion in endometrial cancer using the 55-gene signature selected by DNA microarray analysis
- Research on multi-agent genetic algorithm based on tabu search for the job shop scheduling problem
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- Acute ex vivo changes in brain white matter diffusion tensor metrics
- Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock
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- Sodium alginate potentiates antioxidant defense and PR proteins against early blight disease caused by Alternaria solani in Solanum lycopersicum Linn.
- Ground reaction forces and muscle activity while walking on sand versus stable ground in individuals with pronated feet compared with healthy controls
- Correction: Roadway traffic crash prediction using a state-space model based support vector regression approach
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- Factors restraining the population growth of Varroa destructor in Ethiopian honey bees (Apis mellifera simensis)
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- Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy
- Influence of ocean circulation and the Kuroshio large meander on the 2018 Japanese eel recruitment season
- Growth response of the ichthyotoxic haptophyte, Prymnesium parvum Carter, to changes in sulfate and fluoride concentrations
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- Microbiome profiling of the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae)
- Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
- Retraction: Impacts of rock properties on Danxia landform formation based on lithological experiments at Kongtongshan National Geopark, northwest China
- Correction: SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience
- Retraction: Plexin-B1 Activates NF-κB and IL-8 to Promote a Pro-Angiogenic Response in Endothelial Cells
- Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis
- Association between temperature, sunlight hours and alcohol consumption
- Using graph learning to understand adverse pregnancy outcomes and stress pathways
- Correction: The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?
- Surgical referral systems in low- and middle-income countries: A review of the evidence
- In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells
- Correction: The Economic Impact of Malignant Catarrhal Fever on Pastoralist Livelihoods
- Correction: Identification of miRNAs involved in fruit ripening by deep sequencing of Olea europaea L. transcriptome
- Correction: Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Correction: Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells
- Correction: Plant traits linked to field-scale flammability metrics in prescribed burns in Eucalyptus forest
- Correction: Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation
- Correction: To keep or not to keep? Decision making in adolescent pregnancies in Jamestown, Ghana
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