How Knowledge Stock Exchanges can increase student success in Massive Open Online Courses
Authors:
Andreas Heusler aff001; Dominik Molitor aff002; Martin Spann aff001
Authors place of work:
Ludwig-Maximilians-University of Munich, Institute of Electronic Commerce and Digital Markets, Munich, Germany
aff001; Gabelli School of Business, Fordham University, New York, NY, United States of America
aff002
Published in the journal:
PLoS ONE 14(9)
Category:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0223064
Summary
Massive Open Online Courses (MOOCs) allow lecturers to overcome spatiotemporal boundaries and reach large numbers of participants. However, the completion rates of MOOCs are relatively low, a critical obstacle to their ultimate success. Existing literature suggests that strengthening student interaction has the potential to increase student commitment. The goal of this study is to develop a novel, market-based knowledge-sharing method that fosters student engagement and interaction in MOOCs, addressing the problem of low completion rates and demonstrating how MOOC engagement can lead to greater student success. The proposed method, “Knowledge Stock Exchange” (KSX), is derived from the concept of crowd-based intelligence mechanisms for incentive-compatible information aggregation. Using a popular MOOC as the focus of our empirical study, we show that the KSX method increases student interaction as well as MOOC completion rates. Moreover, we find that KSX participation has a significant positive effect on participants’ exam grades.
Keywords:
Learning – Human learning – Finance – Supervisors – Motivation – Intelligence – Stock markets – Social theory
Introduction
Massive Open Online Courses (MOOCs) received considerable attention in higher education when companies such as edX, Udacity and Coursera began offering courses that attracted tens of thousands of students [1, 2]. Enabled by digital technologies, MOOCs provide a new level of scalability and open access to the course materials of top universities across the globe [2]. In terms of potential, MOOCs can be seen as an instrument for bridging the gap of temporal, geographical and social distances between students, lecturers and institutions.
Although many MOOCs exceed a participant level of 10,000 students, most of these same MOOCs show only modest completion rates of below 10 percent [3]. Initially, MOOCs were propagated in combination with the pedagogical approach of connectivism which demands a high level of social connectedness and interactivity [4, 5]. However, the next generation of MOOCs has focused on the demand for scalability, establishing such practices as video lectures, computer-graded exams and quizzes (with low collaboration among students) [2]. Recent studies hence attribute the low completion rates to the low student interaction [6, 7].
Beyond MOOCs, the question of how to motivate people to collaborate and share their private knowledge is an important topic in different fields of research [8, 9–11]. The threat of participants’ free-riding behavior and the design of targeted incentive mechanisms for knowledge sharing on platforms are key topics in e-learning and knowledge management [11]. To address these challenges, past research has experimented with the application of game design elements in organizations [12] as well as communities [13]. The use of digital game design elements in organizational contexts–also known as gamification–offers the potential to increase motivation and engagement in two dimensions: by enabling (1) more competitive and (2) more cooperative interactions [14]. Therefore, an incentive-compatible knowledge sharing method, which combines cooperative and competitive components (i.e., coopetitive), may offer a learning environment that stimulates engagement [15] and social interaction among course participants, eventually leading to greater commitment and better learning results [16–19].
In this article, we develop and evaluate an incentive-compatible knowledge sharing method–the Knowledge Stock Exchange (KSX)–that aims at increasing student completion rates in the context of MOOCs by combining cooperative (e.g., via forums) and competitive (e.g., via leaderboards) components. More specifically, the KSX is supposed to enable a more engaging and interactive learning experience by providing the opportunity to propose, trade, and discuss “virtual knowledge stocks,” in order to improve completion rates as well as exam grades. We conduct a field study that combines a large MOOC with the proposed KSX method to evaluate the method’s effectiveness. The results of the field study answer two substantial research questions: Does the KSX help to improve the MOOC completion rate? And does the KSX affect the MOOC’s final exam grades? We contribute to the field of e-learning and knowledge management by combining a scalable knowledge sharing method, the KSX, with a MOOC to incentivize student engagement and interaction, thereby addressing the problem of low completion rates and course success.
Theory and prior research
In the following, we focus on previous research on massive open online courses (MOOCs) in the context of completion rates. We then introduce the concept of virtual stock markets (VSM), which is a crowd-based intelligence mechanism that is well suited to increase engagement and completion rates in MOOCs. Finally, our research model combines the gamification-based coopetitive elements of crowd-based intelligence mechanisms, student engagement and interactions as well as student success.
Massive open online courses
Starting in 2008, the “Connectivism and Connective Knowledge” course (CCK08) was among the first to include the constituting elements of a MOOC [20]. While “massive” stands for their degree of scalability, the notion of “open” leaves room for interpretation [21]. Typically, a MOOC does not charge any tuition fees, requires no formal accreditation or pre-requisites other than internet access and the motivation to learn [2].
After its launch, the CCK08 course attracted a relatively large group of 2,200 participants worldwide and was based on an open online-learning environment [22]. Moreover, when Dave Cormier first mentioned the acronym MOOC in his educational blog, it was distinctively driven by the pedagogical ideal of connectivism [5]. Later on, this led to the term “Connectivist Massive Open Online Courses” (c-MOOC), indicating an autonomous, interactive and experimental way of developing an open knowledge base that is focused on the idea of social networking.
At the end of 2011, Stanford professors Sebastian Thrun and Peter Norvig offered their free introductory Artificial Intelligence (AI) course with 160,000 enrolled students [23]. Participants from 190 different countries were attracted by the promise to receive materials, assignments and exams similar to Stanford’s original AI course. Soon, this promise was echoed by other platforms such as Coursera, edX and Udacity (co-founded by Sebastian Thrun), also offering free high-quality content from top-universities around the globe. However, these so called “AI-Stanford like Courses” or “x-MOOCs” differ from the original c-MOOCs based on a more restrictive notion of “free access to premium but copyrighted content” [23] and less interaction among students [1].
Besides their IT-enabled scalability for tens of thousands of students [24], especially x-MOOCs struggle with low student completion rates [3, 24, 25]. Although x-MOOCs enroll about 43,000 students on average (ranging from 4,500 to 226,500 students), only about 6.5 percent of students successfully complete a course [26]. As a consequence, researchers started to invest considerable efforts in identifying the main influencing factors of low completion rates.
A comprehensive review of existing empirical studies on online course dropouts identified 69 influencing factors and assigned them to three major categories: student (i.e., academic background, relevant experiences, skills and psychological attributes), course/program (i.e., course design, institutional support and interactions) and environmental factors (i.e., work commitment and supportive environment) [27]. Additional identified factors include platform (e.g., platform usability) and provider-specific factors (e.g., university reputation, lecturer characteristics) [25, 28, 29].
Given the open access policy of most MOOCs, student and environmental factors are hard to tackle and are more or less taken for granted [27]. Platform and provider factors are rather specific and are often too detailed in order to be addressed by general methodical advice [25]. Therefore, many available counterstrategies aim at addressing course/program-specific factors, which in turn often include different elements of social interaction. For example, research on the interaction among students has shown that the use of forums is positively correlated with higher student completion rates and better final exam grades [30]. Related to the course design, there is also evidence that peer assessment increases student motivation compared to automated grading [25]. To summarize, these results suggest that specific aspects of the course design, such as social interaction and engagement, might help to increase the completion rates in the context of MOOCs.
Crowd-based intelligence mechanisms
Virtual stock markets
A Virtual Stock Market (VSM) is a web-based market on which securities contracts–referred to as “virtual stocks”–are traded by a crowd of people in order to gather and aggregate widely dispersed information [31]. These virtual stocks are linked to final payoff conditions and can be interpreted as bets on future events. Due to the continuous trading of shares, a stock’s reference price reflects the continuously updated value of its underlying contract and represents the crowd’s aggregated assessment about the probability of the event to occur.
The theoretical foundation of VSMs is based on the idea that asset prices in an efficient market fully reflect all value-related information available to participants and by that aggregate all expectations on the likelihood of future payoffs [32]. Furthermore, markets may also be seen as the most efficient mechanism to aggregate asymmetrically dispersed information [33, 34].
Contrary to conventional financial stock markets, VSMs can be restricted to the usage of virtual play money [35], without losing their ability to efficiently aggregate information or weakening their incentive-inducing effect on knowledgeable traders [36]. Nevertheless, most VSM studies are based on markets with relatively short trading cycles over a couple of weeks, days or even hours [37]. Knowledge about how to maintain participants’ long-term motivation (i.e., over several months), in combination with non-monetary incentives, is scarce [38].
There are several fields of applications for VSMs that are depending on the type of virtual stocks, the incentives for participation and information revelation, the intended purpose and various market design parameters [31]. The prediction of future events including election results [39], sales forecasts [40], sports forecasts [41], or scientific research [42] are summarized under the term “prediction markets.” Other VSM applications such as the sourcing and evaluation of ideas [43], or the testing of new product concepts [37] are known as “idea markets” or “preference markets.”
Knowledge stock exchange
In this study, we explore a new type of VSM, hereinafter referred to as the Knowledge Stock Exchange (KSX). To better differentiate between the proposed KSX method and other established types of VSMs, we highlight four distinct characteristics: First, the KSX is set up with a different purpose, making use of an incentive-compatible learning mechanism (i.e., reaching the best outcome by acting according to one’s true preferences) to motivate a crowd of permanent participants over a longer period of time (i.e., several months) as well as to cooperatively develop and evaluate an open knowledge base [44].
Second and in contrast to the fixed contract descriptions of other VSM types, each KSX-specific virtual stock represents an editable knowledge artifact, similar to an editable wiki page. This characteristic facilitates an iterative refinement of virtual stocks over the entire trading cycle. As each modification (“edit”) of a knowledge artifact changes the stock’s value and may subsequently lead to a price reaction of the market, price changes of virtual stocks can be interpreted as a prompt feedback on the current quality of a knowledge artifact.
Third, while the static nature of stocks in preference markets leads to converging prices in the sense of reaching a consensus about the value of a given idea or concept [37], the KSX incentivizes participants to continuously update their valuation due to repeated modifications of knowledge artifacts. In order to profit from arbitrage effects, participants can invest in low-quality stocks, if they are able to improve the quality of an artifact on their own.
Fourth, besides the characteristics of a crowd-based evaluation and improvement mechanism, the KSX also includes the sourcing of stocks by the crowd, not an authority. Triggered by an open call, participants are invited to voluntarily submit their solution (i.e., “knowledge stock”) to a given problem. This characteristic, which is similar to idea markets and other crowdsourcing methods [17, 45], strongly differs from the original notion of prediction and preference markets, where stocks are proposed by an authority.
Research model
Fig 1 shows our research model. Based on previous findings in gamification research, we make use of gamification elements including discussion forms and leaderboards, allowing us to combine cooperative and competitive components [14]. The underlying theories of competition and cooperation can be found in cognitive evaluation [46] and social comparison theory [47]. Cognitive evaluation theory states that rewards or feedback can enhance intrinsic motivation [46]. Social comparison theory in turn assumes that individuals have an innate need to evaluate their abilities in comparison with others [47].
To tab into these behaviors, we launch a Knowledge Stock Exchange as an effective and scalable mechanism to enable more student interaction on MOOCs. The interactions on the KSX platform can manifest itself by students’ active contribution to the knowledge stock (e.g., by posting tradeable solutions), forum discussions as well as peer evaluations, visualized via leaderboards. Based on previous literature [16], increased engagement and interactions–in the context of coopetive activities–are assumed to increase students’ success likelihood, measured by course completion rates and (final) exam grades. The outcomes, including measures for student engagement, interaction and student success, are the key factors of our empirical analyses.
Method
Knowledge stock exchange architecture
The KSX architecture consists of four main modules: (1) a communication module, providing basic forum functionalities and notification services, (2) a knowledge repository module, covering the essential functionalities of a content management system, (3) a VSM module, offering several trading and auction mechanisms, and (4) a knowledge challenges module, containing additional gamification elements. The latter includes a virtual currency (Virt$) system, a contribution point system and two corresponding leaderboards that can be used to display a performance and a contribution ranking. The integration of VSMs along with the extension of a knowledge challenges module and gamification elements is our core contribution, encouraging a coopetitive knowledge sharing and a more interactive learning experience.
Conceptual sequence of actions in knowledge stock exchange
Conceptually, the KSX consists of multiple knowledge challenges, which are independent of one another. Yet they all follow the same sequence of actions, as can be seen in Fig 2 below: (1) proposal stage, (2) offering stage, (3) trading stage, and (4) evaluation stage. In combination with a MOOC that typically contains a series of learning modules, it seems reasonable to connect each learning module with a corresponding KSX challenge. For each available learning module in the MOOC, students pass all four stages of the corresponding knowledge challenge. This allows synchronizing the KSX platform with the progress of an online course, starting a new knowledge challenge for each learning module. Moreover, due to the payoff (in virtual cash) after each knowledge challenge, students have the opportunity to get familiar with the VSM mechanism and learn about promising tactics that combine bidding, trading and editing of “[virtual knowledge] stocks.”
Proposal stage
In the proposal stage, a course supervisor first specifies the knowledge challenges, including a task description, a timeline, basic conditions, and evaluation criteria such as relevance to a challenge-specific problem, degree of newness, level of detail or quality of the solution. These criteria will be used by judges to determine the winning solution of a knowledge challenge (see evaluation stage). The sourcing of solutions requires the provision of a precise task description for each challenge. Typical tasks (i.e., potential solutions) comprise the creation of case studies, literature overviews, numerical examples, terminology dictionaries, as well as student exercises.
Once the knowledge challenge is posted, students are invited to propose their solutions. In doing so, they earn “contribution points,” which serve as a virtual score (see Table A in S1 File for more details). Contribution points are awarded irrespective of a solution’s quality. During the course, KSX participants can compare their current score with other participants on a leaderboard, the so-called contribution ranking. Besides proposing new solutions, participants can also upload supporting files, add ratings or comment on existing solutions which can thus be further refined and extended. Each proposed solution will be approved (or rejected) by a supervisor and converted into a so called “[virtual knowledge] stock”. Therefore, the terms “solution” and “[virtual knowledge] stock” are used interchangeably. Each challenge with its set of solutions will be treated as a separate market with a corresponding set of stocks.
Offering stage
All approved stocks are now offered to the participating students using a single-day sealed bid auction (i.e. “initial public offering” resp. IPO auction). This kind of IPO auction helps to determine the starting price for each stock and reduces the risk of herding behavior as all bids are hidden until the auction ends. Specifically, fixed price auction mechanisms are well-suited as they are easy to communicate and to understand by participants. Alternatively, the discriminatory or the uniform price auction could be used as IPO auctions [48].
During the offering stage, students have the option to set up their initial knowledge stock portfolios according to their personal beliefs and individual appreciation of the underlying solutions. The starting price of a stock represents the crowds’ aggregated opinion about the value of a solution and its probability to receive a final payoff in comparison to other solutions of the same challenge. As a consequence, the value of each solution is based on the predefined evaluation criteria of a challenge.
Besides the budget restrictions of their initial virtual endowments, participants do not have any further constraints on whether and how much money they invest in the offered stocks. As soon as the IPO ends, the aggregated demand of shares for each stock will be revealed in combination with the starting price.
Trading stage
With the start of the trading stage, all stocks are listed on the market. In order to link the prices of all stocks within the same market, the KSX uses Hanson’s logarithmic market scoring rules (LMSR) as an automated market maker algorithm [49]. As the LMSR requires a predefined maximum price (e.g., Virt$100.00), stock prices will always vary in a range between zero and the maximum price. In addition, the LMSR ensures permanent liquidity within the market [50, 51].
Depending on the number of shares circulating in the market, the LMSR calculates a reference price for each stock relative to all other stocks within the same market. This reference price indicates the current price for a minimum amount of shares. Accordingly, the stock price increases as a function of the number of ordered shares, while the reference price of all other stocks in the market decreases proportionally at the same time. Simultaneously, the reference price signals the market’s aggregated information about a stock’s probability to receive a final payoff according to the predefined evaluation criteria. Students can therefore interpret the reference price of a knowledge stock as an indicator for its current quality throughout the entire trading stage.
Similar to the contribution ranking, students can compare their financial assets in virtual currency (i.e., Virt$) via a performance ranking. Although students have to wait for the subsequent evaluation stage to receive their final payoffs, they can already realize significant arbitrage profits through the continuous trading of stocks. Starting with the initial wallet of Virt$20,000, the performance ranking keeps track of all realized and unrealized gains and losses of their trading activities.
In addition, a five percent-edit-rule allows shareholders to edit a stock’s content during the entire trading stage. A similar threshold was used in previous research [44]. This rule states that once a trader holds at least a five percent share of a stock, she is permitted to edit a stock’s description or upload supporting images and other files. Note that, as a shareholder, the trader has no incentive to decrease prizes and is rather assumed to improve the stock’s value in order to achieve arbitrage profits. Compared to conventional VSMs such as prediction, idea or preference markets that offer virtual stocks with fixed contractual specifications, the five percent-edit-rule is a key characteristic of the KSX method. It allows participants not only to trade but also to iteratively modify and improve the stocks, which are now treated as open knowledge artifacts. This extends the principle of VSMs from a crowd-based information aggregation mechanism to a crowd-based knowledge sharing mechanism. By requiring a certain degree of stock ownership, the rule also aims at increasing the costs of deliberately manipulating a shareholder’s knowledge stock.
Evaluation stage
In the evaluation stage, a judge (e.g., a course supervisor) assesses the quality of each stock according to the following four criteria: correctness, level of detail, comprehensibility and conciseness of a solution. These criteria are communicated in the evaluation stage.
Based on the average grade, we can determine the payoff in Virt$ for each stock. Due to our focus on the seamless communication of rules, we implement a winner-takes-all market [52]. Thereby, the solution with the best grading receives the full payoff in the respective challenge (e.g., Virt$100.00 per share). Dependent on the number of shares in their portfolio, students receive their payoffs for each winning stock.
Field study
In order to evaluate the method’s effectiveness, we conducted a field study in collaboration with a popular MOOC on advanced management. The course was launched on Coursera, one of the largest MOOC providers, and conducted in collaboration with a partner university. The target audience of the course consisted of a broad set of learners from around the globe. Similar to other courses on Coursera, our course was promoted via e-mail newsletters to existing students, combined with search and social media marketing. The course was held over a period of two months and consisted of seven learning modules including 7.5 hours of video material. The videos largely included lectures on strategic management and strategic industry analyses. Students were required to pass a quiz for each of these modules in order to get access to the final exam and to receive the course certificate. The final exam was a multiple choice test where students could score a maximum of 30 points.
After registering for the course, students were invited to additionally register for the KSX via a forum announcement on the MOOC platform. In parallel to the entire cycle of the course, the KSX offered 12 related knowledge challenges (see Table B in S1 File) and lasted for an overall period of 70 days (from the first to the last interaction). KSX participation was voluntary. Students neither receive any kind of grade improvement nor other forms of bonuses for quizzes and/or the final exam of the course. It is worth noting that all challenges on the KSX platform were related to the actual course module(s). Thus, students were able to benefit from knowledge exchanges with their fellow students, possibly by spending additional time and effort on the KSX platform. Moreover, the Top 15 students in the leaderboards (based on contribution and performance rankings) were allowed to choose between university branded coffee mugs, backpacks and writing sets as a reward for their efforts.
Participation, demographics and post-survey outcomes
As depicted in Table 1, the MOOC attracted a total of 61,893 registered students. From those, 992 students registered for both platforms (i.e., MOOC ∩ KSX), 60,901 students registered only for the MOOC. While most students showed some sort of activity (e.g., watching course videos or commenting in the forums), only 4,324 students (7.4%) successfully completed the course by passing seven quizzes and the final exam. Similar to participation rates of other MOOCs [26], we observed a completion rate of 6.4 percent for MOOC-only students. Students that additionally joined the KSX showed significantly higher completion rates of 64.9 percent. However, this may be driven by self-selection effects related to non-randomized groups, which we analyze in more detail below.
Table 2 shows the post-survey results based on the census of participants that were registered on both the MOOC and KSX and platform (N = 364; response rate: 39.5%). On average, students stayed 207.2 minutes per week on the MOOC platform and 36.4 minutes per week on the KSX platform respectively. Based on a mean of 6.4 visits per week and 54.6 minutes per visit, participants devoted most of their time to the MOOC, compared to 2.8 visits per week and 14.6 minutes per visit on the KSX platform. Although KSX participation required a modest investment of additional time, it did not seem to harm MOOC-specific activities.
Overall, this MOOCs had a truly global audience. Students from 74 countries all over the world joined both platforms. About 83 percent of the participants were male, 17 percent female, which is similar to other business and engineering MOOCs [53]. This resulted in the following age distribution (see Fig A in S1 File): under 18 (1.1%), 18–25 (24.7%), 26–35 (37.5%), 36–45 (19.9%), 46–55 (11.2%), 56–65 (4.5%), and over 65 (1.1%). Most of the students already obtained an academic degree (see also Fig B in S1 File), which is consistent with previous research on other MOOCs [54]. Note, however, that only 7.3 percent of all surveyed participants study or already have a degree in finance and/or accounting. In addition, the mean of participants’ self-assessed stock market knowledge is 3.91 (SD = 1.62) on a scale from 1 (no knowledge) to 7 (very knowledgeable). This indicates that there does not seem to be a strong latent effect beyond self-selection with respect to the context of finance and stock markets in particular.
We also asked whether students that were registered on the MOOC and the KSX consider the KSX as “very collaborative” (M = 4.59, SD = 1.26) or “very competitive” (M = 4.57, SD = 1.26) on a scale from 1 (disagree) to 7 (agree). Both items are highly correlated (r = 0.81) which indicates that students perceive the KSX platform as coopetitive, including both collaborative and competitive elements. This is consistent with our conceptual setting.
Platform statistics
The KSX platform offered twelve knowledge challenges (see Table B in S1 File), including seven challenges directly related to the MOOC’s seven knowledge modules. Four of the additional remaining KSX challenges referred to course-specific topics. Besides that, we also offered an introductory challenge as an opportunity to learn about the trading mechanism.
Forum activities
The MOOC as well as the KSX platform included forum functionalities. Table 3 shows the corresponding forum activities. On the KSX platform, 66 different commenting users started 444 forum discussions, leading to 800 comments and an average number of 12.12 comments per participant. Considering the total number of registered participants, forum interaction on the MOOC platform itself was rather low with 1,339 users posting 3.36 comments on average. By comparing between MOOC-only students (2.71 comments on average) and MOOC ∩ KSX students (6.14 MOOC comments and 12.12 KSX comments on average), we observe considerably stronger forum interactions for the latter group on both platforms. The lower average amount of discussions by MOOC-only students (1.98 discussions on average) compared to MOOC ∩ KSX students (4.25 MOOC discussions and 6.73 KSX discussions on average) confirms this observation. Besides the number of comments, there were 46 actively rating participants on the KSX platform that casted 333 positive and 44 negative votes on the discussions and comments. The KSX discussions also attracted a considerable amount of passive forum readers.
Proposal and trading activities
On the KSX platform, 36 students proposed a total of 117 solutions, which refers to 9.75 solutions per challenge on average. In the proposal stage, 100 stocks were approved by the course supervisors. These stocks were additionally supported by 48 uploaded documents and 88 uploaded images (including 50 preview images to provide a more individual character for the stock). The automated market maker processed 2,007 incoming orders from 94 different participants.
Model and results
The effect of KSX participation on MOOC completion rates
A main goal of our study is to test whether students’ completion rates can be increased via the interaction and engagement of the KSX platform. The descriptive statistics in Table 1 above already indicated a rather low completion rate of MOOC-only participants (6.4%), which is similar to other MOOC platforms [26]. Moreover, as most participants not just tried to register for the course but completed the registration process and start getting involved by watching videos, these low completion rates cannot simply be dismissed as consequences of a complex registration process. In order to understand the low completion rates in more detail, we take a closer look at the different course stages that students were required to pass.
Table 4 depicts the completion rates for each stage over the entire course period. The dropout rate of more than 80 percent before the very first quiz, indicates that a large fraction of students was not seriously willing to complete the course and receive a certificate. Some of them may only be interested in getting free access to the course material. This can be considered as a type of free-rider problem that many MOOCs deliberately accept in return to improved signup rates. In contrast, we observe 9,660 students who passed at least the first quiz, thereby indicating their serious interest in a successful completion of the course. Quiz by quiz we also detect overall increasing completion rates that can be interpreted as a continuously increasing lock-in effect. For MOOC ∩ KSX students, the completion rates are above 90 percent for every single stage.
As can be seen in Tables 1 and 4, the completion rate of MOOC-only participants (6.4%) is significantly lower compared to participants of both platforms (64.9%). However, as students joined the KSX platform on a voluntary basis, without random assignment to one of the two groups, it is important to address the possibility of self-selection effects [55]. One way to account for a possible self-selection bias is based on the propensity score matching (PSM) technique [56, 57]. For observational studies, the PSM substitutes a randomization process by balancing a sample of the treatment group with a sample of the control group. Therefore, the PSM estimates the “Average Treatment Effect on the Treated” (ATT) by accounting for a set of covariates that might influence an individual’s likelihood to receive a treatment [58, 59].
Propensity score matching
In the following, we apply different matching techniques via PSM that allow us to compare our treatment group (i.e., MOOC ∩ KSX participants) with their counterfactuals chosen from the control group of MOOC-only participants. This is done by predicting students’ decision to self-select into the treatment (i.e., active KSX participation: yes/no). In order to match MOOC ∩ KSX participants with a homogenous group of MOOC-only participants [59, 60], we chose a set of confounding variables that were available for both groups (i.e., registration order, scores of quiz 1, MOOC user ratings, MOOC forum posts, and the usage of late days, see Table C in S1 File) to calculate the propensity scores based on a standard probit model (Table D and Table E in S1 File). This allows us to directly compare students from both groups that have similar propensity scores. Table 5 below shows that the probability to pass all quizzes is significantly higher for the treatment group (i.e., MOOC ∩ KSX participants), independent of the applied matching algorithm (i.e., kernel matching, k-nearest neighbor matching (kNN)).
As an additional robustness check, we limited the sample of students to those that passed the first quiz to bypass the selection-effect of the first stage (and as an indication for students’ intention to receive a certificate). In doing so, we limited the set of covariates to those variables that were already observable before students passed the first quiz. The results can be seen in the last three rows of Table 4 (see sample “After Q1”). Although the difference between both groups slightly decreases, there is still a significant distinction that provides clear evidence for the positive effect of KSX participation on students’ motivation to pass all quizzes.
Survival analysis
In order to get deeper procedural insights into dropouts, we modelled students’ dropout hazard using a discrete time survival analysis [61, 62]. This method relies on a logistic regression, which predicts the likelihood that students will exit the course within a discrete period of time before writing the final exam. As a preparatory step, each person-specific observation has to be converted into a new person-period data set with multiple observations [62]. For each of the quizzes, a dummy-coded variable is introduced as a time indicator. As can be seen in Table 6, this procedure leads to 103,781 observations, clustered in 58,729 groups. The seven time indicators represent discrete time intervals at which a stage-specific dropout event can occur. In addition, we are using eight time-invariant predictors, four activity-based predictors of the KSX platform and four predictors to understand the effect of MOOC activities: IsStockProposer (KSX), IsDiscussionInitiator (KSX), IsDiscus-sionReplier (KSX), IsStockTrader (KSX), IsDiscussionInitiator (MOOC), IsDiscussionReplier (MOOC), IsVoter (MOOC), and LateDaysUsed (MOOC). We model the subsequent survival rates of individual i in time period j as follows [62]:
The results indicate that active participation on both platforms as well as the usage of late days reduce the risk of course dropout. The usage of binary predictor variables (except for the usage of late days) allows us compare their effect size. Besides the stage-specific time indicators, the most prominent effect for both platforms is related to active forum participation (i.e., initiating discussions and/or replying on existing discussions). Forum activity on the MOOC platform has a stronger effect size than on the KSX platform, as it is directly linked to the course content. With respect to the KSX platform, students that actively engaged in the trading of virtual knowledge stocks strongly increase the course completion likelihood, followed by students who initiated discussions on the KSX forum. Moreover, we observe a successively increasing effect size for the stage-specific indicators, suggesting a platform-specific lock-in effect that increases from quiz to quiz (except for stage 6).
The effect of KSX participation on MOOC final exam grades
We additionally analyze whether KSX participation can improve students’ final exam grades. The mean of final exam grade–based on 4,498 students that successfully passed the seven obligatory quizzes–is 24.41, with a standard deviation of 6.3 grade points. Three out of four students achieved a final exam grade of at least 23.52 points. A two-sample t-test (t = -3.902, p < 0.01) indicates that the average final exam grades of 3,885 active MOOC-only participants (M = 24.26, SD = 6.43) are significantly lower (4.4%) compared to 613 active MOOC∩KSX participants (M = 25.33, SD = 5.35).
Again, this model-free result does not allow us to rule out the possibility of a self-selection bias. Similar to the analysis on completion rates above, we match the treatment group of MOOC ∩ KSX participants with the control group of MOOC-only participants based on the propensity scores of a probit regression (see Table F in S1 File). Table 7 shows that the differences between both groups are significantly different, regardless of the applied matching algorithm. Contrary to initial concerns that the gamification elements of a KSX might have a distracting effect, potentially resulting in poor grades, we even observe an increase of students’ final exam grades.
Discussion
The results of the field study indicate that the combination of MOOCs and KSX is a promising approach to improve student completion rates as well as exam grades. We note in particular that the active trading of stocks and more intense discussions in KSX and MOOC forums, which encourage student-to-student interaction, are accompanied by an improvement in student completion rates. This outcome indicates that greater platform engagement is positively correlated to student success, findings that are similar to previous research [16]. In addition, our findings support the assumption that a gamified coopetitive design encourages a more interactive learning environment, also in line with the results from prior research [14], which in turn fosters higher completion rates and better exam grades. This coopetitive design is enabled by our proposed method, the KSX, a novel type of VSM mechanism designed to support knowledge management and e-learning.
Conceptually, we make us of elements from gamification research, based on insights from social psychology. Specifically, cognitive evaluation theory [46] that combines feedback and rewards with intrinsic motivation as well as social comparison theory [47] that reflects individuals needs to compare each other. Starting with a set of rudimentary knowledge artifacts, students are able to collaboratively improve proposed solutions in iterative cycles. Forum functionalities allow students to jointly discuss their solutions and to build learning networks. Students thus benefit from an engaging and interactive market-based validation of the knowledge artifacts through the crowd-based intelligence mechanism. Specifically, the learning environment allows students to learn with and from their peers, thereby improving memorization and comprehension in a coopetive atmosphere, without the pressure of an authority figure [16]. This might contribute to students’ improved exam grades. Leaderboards additionally reflect participants’ platforms activities, which might increase students’ ongoing engagement by their underlying need for social comparison.
We also should acknowledge some limitations, which provide avenues for future research. First, the study does not evaluate a fully integrated system of MOOC and KSX on a single web-platform. Instead, participants have to register on both platforms separately. The repeated switching between both platforms may have weakened KSX effectiveness. For MOOC providers, it therefore might be advisable to implement a fully integrated system of MOOC and KSX. Second, because most students perceived the learning environment as equally collaborative and competitive, we are not able to trace the motivating effect back to more specific environmental factors. Instead, interaction appears to be driven by a coopetitive overall impression of the KSX platform. Third, there might be heterogeneity in participants’ responses to the gamification mechanism as different participants might respond differently to the same mechanism, based on different personality traits and preferences. A randomized controlled trial would help to measure the causal impact of different gamification mechanisms via treatments groups, for example by varying the degrees of collaboration and competition, which could provide insights into the mechanisms’ effectiveness regarding learning outcomes. Estimating the resulting heterogeneity of treatment effects by taking participants’ personality traits, based on survey data, into account would deliver additional avenues for a more personalized approach to gamification [63].
Conclusions
To conclude, this paper contributes in three major ways to the ongoing problem of low engagement and interaction in MOOCs as well as knowledge management in general. First, we demonstrate that the underlying mechanism of Virtual Stock Markets (VSM), which have mainly been used to predict the probability of future events, can also be applied to knowledge sharing by gathering and aggregating widely dispersed information from a large crowd of MOOC participants. This new type of VSM is referred to as Knowledge Stock Exchange (KSX). The KSX offers open access to all MOOC participants to collaboratively develop an open knowledge base in an iterative and incentive-compatible way, allowing participants to reveal their true preferences in the trading process. Second, we can show that the KSX method increases student interaction and engagement in MOOCs. The KSX is engaging in the sense that it allows to actively trade knowledge stocks and to participate in various forum discussions. On average, MOOC and KSX participants comment 2.3 times more often in the MOOC forum compared to MOOC-only participants. From a theoretical perspective, our findings are consistent with engagement enhancing results observed in gamification research [14]. Third, the paper further supports the connection between engagement and better learning outcomes, manifested by higher course completion rates and better exam grades. This is achieved by applying the KSX in combination with competitive (leaderboards, challenges and contribution points) and cooperative (forums) gamification elements. Specifically, the completion rates for MOOC and KSX participants are 10.1 times higher than for MOOC-only participants. In addition, the average exam grade is 4.4 percent higher for MOOC and KSX participants.
The paper not only contributes to the gamification and knowledge management literature by integrating theories from social psychology, such as cognitive evaluation and social comparison theory, but also shows the potential of combining crowd-based intelligence mechanisms–the KSX–with e-learning platforms such as MOOCs as well as gamification elements. Thus, the study provides implications for the design of MOOC platforms going forward and the knowledge management field in general. For example, the integration of KSX and other engagement enhancing methods for the purpose of knowledge sharing within MOOCs seems to be a promising avenue. Future research could investigate more closely the iterative and reciprocal nature of knowledge sharing on KSX and MOOC platforms as well as focus on more personalized forms of gamification.
Supporting information
S1 File [docx]
Supporting tables and figures.
S1 Data [zip]
Data and code.
Zdroje
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- Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway
- With or without U(K): A pre-Brexit network analysis of the EU ETS
- Graph-theoretical analysis for energy landscape reveals the organization of state transitions in the resting-state human cerebral cortex
- Task-uninformative visual stimuli improve auditory spatial discrimination in humans but not the ideal observer
- Residual stenosis after carotid artery stenting: Effect on periprocedural and long-term outcomes
- gapFinisher: A reliable gap filling pipeline for SSPACE-LongRead scaffolder output
- A plant biostimulant made from the marine brown algae Ascophyllum nodosum and chitosan reduce Fusarium head blight and mycotoxin contamination in wheat
- Monte-Carlo value analysis of High-Throughput Satellites: Value levers, tradeoffs, and implications for operators and investors
- Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm
- Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning
- Neuropathy and neural plasticity in the subcutaneous white adipose depot
- Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells
- The enemy’s gaze: Immersive virtual environments enhance peace promoting attitudes and emotions in violent intergroup conflicts
- Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae
- Koopman Mode Analysis of agent-based models of logistics processes
- Empirical mode decomposition based long short-term memory neural network forecasting model for the short-term metro passenger flow
- Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy
- Multi-agent reinforcement learning with approximate model learning for competitive games
- Identification of olfactory genes and functional analysis of BminCSP and BminOBP21 in Bactrocera minax
- The use of urinary fluoride excretion to facilitate monitoring fluoride intake: A systematic scoping review
- Development of a family caregiver needs-assessment scale for end-of-life care for senility at home (FADE)
- Epidemiology of pneumonia in the pre-pneumococcal conjugate vaccine era in children 2-59 months of age, in Ulaanbaatar, Mongolia, 2015-2016
- H-EM: An algorithm for simultaneous cell diameter and intensity quantification in low-resolution imaging cytometry
- Public expenditure on Non-Communicable Diseases & Injuries in India: A budget-based analysis
- Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways
- uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading frames
- Comparative analysis of postural control and vertical jump performance between three different measurement devices
- Hierarchical multi-view aggregation network for sensor-based human activity recognition
- Clavien–Dindo classification for grading complications after total pharyngolaryngectomy and free jejunum transfer
- Significantly different expression levels of microRNAs associated with vascular invasion in hepatocellular carcinoma and their prognostic significance after surgical resection
- Clinical correlates of workplace injury occurrence and recurrence in adults
- Medicine and the media: Medical experts’ problems and solutions while working with journalists
- Phylogenic classification and virulence genes profiles of uropathogenic E. coli and diarrhegenic E. coli strains isolated from community acquired infections
- Genetic relatedness in carbapenem-resistant isolates from clinical specimens in Ghana using ERIC-PCR technique
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- Improving the production of podophyllotoxin in hairy roots of Hyptis suaveolens induced from regenerated plantlets
- Controls on planktonic foraminifera apparent calcification depths for the northern equatorial Indian Ocean
- Notch and Delta are required for survival of the germline stem cell lineage in testes of Drosophila melanogaster
- Children with HIV: A scoping review of auditory processing skills
- Correction: Two distinct actin waves correlated with turns-and-runs of crawling microglia
- Expression of Concern: Neurotoxicity Induced by Bupivacaine via T-Type Calcium Channels in SH-SY5Y Cells
- Sex-dependent and -independent transcriptional changes during haploid phase gametogenesis in the sugar kelp Saccharina latissima
- Vehicle modeling for the analysis of the response of detectors based on inductive loops
- New Mycobacteroides abscessus subsp. massiliense strains with recombinant hsp65 gene laterally transferred from Mycobacteroides abscessus subsp. abscessus: Potential for misidentification of M. abscessus strains with the hsp65-based method
- A prognostic Bayesian network that makes personalized predictions of poor prognostic outcome post resection of pancreatic ductal adenocarcinoma
- Impact of care provider network characteristics on patient outcomes: Usage of social network analysis and a multi-scale community detection
- Valid group comparisons can be made with the Patient Health Questionnaire (PHQ-9): A measurement invariance study across groups by demographic characteristics
- Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Upgraded molecular models of the human KCNQ1 potassium channel
- Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells
- The extraordinary osteology and functional morphology of the limbs in Palorchestidae, a family of strange extinct marsupial giants
- Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro
- Implementation of home blood pressure monitoring among French GPs: A long and winding road
- In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues
- Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
- The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study
- Retraction: Comprehensive Comparison of Three Different Immunosuppressive Regimens for Liver Transplant Patients with Hepatocellular Carcinoma: Steroid-Free Immunosuppression, Induction Immunosuppression and Standard Immunosuppression
- Can acute suicidality be predicted by Instagram data? Results from qualitative and quantitative language analyses
- Computational and experimental analysis of the glycophosphatidylinositol-anchored proteome of the human parasitic nematode Brugia malayi
- Antibacterial activity of silver nanoparticles of different particle size against Vibrio Natriegens
- Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
- To eat or not to eat: Reward delay impulsivity in children with loss of control eating, attention deficit / hyperactivity disorder, a double diagnosis, and healthy children
- Factors associated with newborn care knowledge and practices in the upper Himalayas
- Correction: A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment
- Correlates of concurrent partnerships and patterns of condom use among men who have sex with men and transgender women in Peru
- Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma
- Development of a denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis for arthroplasty: A phantom study
- Low-level sensory processes play a more crucial role than high-level cognitive ones in the size-weight illusion
- The prevalence of asthma and allergic rhinitis in Nigeria: A nationwide survey among children, adolescents and adults
- Retraction: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium
- Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study
- Characteristics of diabetic macular edema patients refractory to anti-VEGF treatments and a dexamethasone implant
- Correction: Effects of dietary n-6: n-3 polyunsaturated fatty acid ratios on meat quality, carcass characteristics, tissue fatty acid profiles, and expression of lipogenic genes in growing goats
- Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study
- Impact of pterygium on the ocular surface and meibomian glands
- Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- Transcriptome divergence during leaf development in two contrasting switchgrass (Panicum virgatum L.) cultivars
- Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis
- Circulating progenitor cells and the expression of Cxcl12, Cxcr4 and angiopoietin-like 4 during wound healing in the murine ear
- EUSKOR: End-to-end coreference resolution system for Basque
- Inactivating pathogenic bacteria in greywater by biosynthesized Cu/Zn nanoparticles from secondary metabolite of Aspergillus iizukae; optimization, mechanism and techno economic analysis
- Exopolysaccharide producing rhizobacteria and their impact on growth and drought tolerance of wheat grown under rainfed conditions
- Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes
- Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study
- Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
- Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae)
- PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
- Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients
- “I do all I can but I still fail them”: Health system barriers to providing Option B+ to pregnant and lactating women in Malawi
- Impact of major illnesses and geographic regions on do-not-resuscitate rate and its potential cost savings in Taiwan
- Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis
- Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration
- Correction: Artificial neural networks reveal individual differences in metacognitive monitoring of memory
- Combining fish and environmental PCR for diagnostics of diseased laboratory zebrafish in recirculating systems
- Reading skill modulates the effect of parafoveal distractors on foveal lexical decision in deaf students
- Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia
- Exposure to marital conflict: Gender differences in internalizing and externalizing problems among children
- Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials
- The effect of age and perturbation time on online control during rapid pointing
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- Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitis
- Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin
- Genomic characterization of the complete terpene synthase gene family from Cannabis sativa
- Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine
- Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana
- Plant growth promoting rhizobacterium Stenotrophomonas maltophilia BJ01 augments endurance against N2 starvation by modulating physiology and biochemical activities of Arachis hypogea
- Hierarchical integrated and segregated processing in the functional brain default mode network within attention-deficit/hyperactivity disorder
- Rising co-payments coincide with unwanted effects on continuity of healthcare for patients with schizophrenia in the Netherlands
- Analysis of Zobellella denitrificans ZD1 draft genome: Genes and gene clusters responsible for high polyhydroxybutyrate (PHB) production from glycerol under saline conditions and its CRISPR-Cas system
- False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases
- Identification of potassium phosphite responsive miRNAs and their targets in potato
- Quantification of bell-shaped size selectivity in shrimp trawl fisheries using square mesh panels and a sorting cone after a Nordmøre grid
- Deactivation of somatosensory and visual cortices during vestibular stimulation is associated with older age and poorer balance
- Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice
- Flooding performance evaluation of alkyl aryl sulfonate in various alkaline environments
- An artificial intelligent diagnostic system on mobile Android terminals for cholelithiasis by lightweight convolutional neural network
- Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads
- COI metabarcoding primer choice affects richness and recovery of indicator taxa in freshwater systems
- Retraction: APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway
- The intake pattern and feed preference of layer hens selected for high or low feed conversion ratio
- Individualized pattern recognition for detecting mind wandering from EEG during live lectures
- Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison
- Post-activation potentiation effect of eccentric overload and traditional weightlifting exercise on jumping and sprinting performance in male athletes
- Effectiveness of different central venous catheter fixation suture techniques: An in vitro crossover study
- Quantitative detection of ALK fusion breakpoints in plasma cell-free DNA from patients with non-small cell lung cancer using PCR-based target sequencing with a tiling primer set and two-step mapping/alignment
- Nuclei deformation reveals pressure distributions in 3D cell clusters
- Strategies for increasing diagnostic yield of community-onset bacteraemia within the emergency department: A retrospective study
- Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry
- Certified service dogs – A cost-effectiveness analysis appraisal
- Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy
- Assessing the impact of a research funder’s recommendation to consider core outcome sets
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- Detection of deceptive motions in rugby from visual motion cues
- The impact of antenatal care on neonatal mortality in sub-Saharan Africa: A systematic review and meta-analysis
- Epidemiological investigation and management of bloody diarrhea among children in India
- Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation
- Bacteria isolated from Bengal cat (Felis catus × Prionailurus bengalensis) anal sac secretions produce volatile compounds potentially associated with animal signaling
- Petri net–based model of the human DNA base excision repair pathway
- Complexation and conformation of lead ion with poly-γ-glutamic acid in soluble state
- The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- The Youth-Physical Activity Towards Health (Y-PATH) intervention: Results of a 24 month cluster randomised controlled trial
- The COPD multi-dimensional phenotype: A new classification from the STORICO Italian observational study
- Morphological identification of Amphitetranychus species (Acari: Tetranychidae) with crossbreeding, esterase zymograms and DNA barcode data
- Maintaining hope after a disabling stroke: A longitudinal qualitative study of patients’ experiences, views, information needs and approaches towards making treatment decisions
- Cultural differences in the use of acoustic cues for musical emotion experience
- Effects of a rifampicin pre-treatment on linezolid pharmacokinetics
- High prevalence of multidrug resistant Enterobacteriaceae among residents of long term care facilities in Amsterdam, the Netherlands
- Infection/inflammation-associated preterm delivery within 14 days of presentation with symptoms of preterm labour: A multivariate predictive model
- Prognostic value of preoperative hydronephrosis in patients with bladder cancer undergoing radical cystectomy: A meta-analysis
- Correction: Early life predictors of midlife allostatic load: A prospective cohort study
- PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations
- Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments
- Symbiotic incompatibility between soybean and Bradyrhizobium arises from one amino acid determinant in soybean Rj2 protein
- Does anticoagulation needed for distally located incidental pulmonary thromboembolism in patients with active cancer?
- Control of human testis-specific gene expression
- Speaking up culture of medical students within an academic teaching hospital: Need of faculty working in patient safety
- Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations
- Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study
- Results of scoping review do not support mild traumatic brain injury being associated with a high incidence of chronic cognitive impairment: Commentary on McInnes et al. 2017
- Native seed, soil and atmosphere respond to boreal forest topsoil (LFH) storage
- Development of a quantitative polymerase chain reaction assay and environmental DNA sampling methods for Giant Gartersnake (Thamnophis gigas)
- Genetic diversity and population structure of four Chinese rabbit breeds
- Knowledge, attitude and behaviors towards patients with mental illness: Results from a national Lebanese study
- Correction: An impact evaluation of two rounds of mass drug administration on the prevalence of active trachoma: A clustered cross sectional survey
- Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Graph convolutional network approach applied to predict hourly bike-sharing demands considering spatial, temporal, and global effects
- Impact of traffic variability on geographic accessibility to 24/7 emergency healthcare for the urban poor: A GIS study in Dhaka, Bangladesh
- Feeling the heat: Elevated temperature affects male display activity of a lekking grassland bird
- Constructing a comprehensive disaster resilience index: The case of Italy
- Intraocular pressure according to different types of tonometry (non-contact and Goldmann applanation) in patients with different degrees of bilateral tearing
- Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus
- Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging
- Nonverbal synchrony in virtual reality
- Do speed cameras reduce road traffic collisions?
- A zero-shot learning approach to the development of brain-computer interfaces for image retrieval
- Use of non-HIV medication among people living with HIV and receiving antiretroviral treatment in Côte d’Ivoire, West Africa: A cross-sectional study
- DNA barcoding of southern African crustaceans reveals a mix of invasive species and potential cryptic diversity
- Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay
- Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs
- Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6
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- Ontogenetic shift in the energy allocation strategy and physiological condition of larval plaice (Pleuronectes platessa)
- Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Diagnostic accuracy of Xpert MTB/RIF assay and non-molecular methods for the diagnosis of tuberculosis lymphadenitis
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
- Spatial distribution of breast cancer in Sudan 2010-2016
- Human-induced fire regime shifts during 19th century industrialization: A robust fire regime reconstruction using northern Polish lake sediments
- Enhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions
- Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
- Iron and manganese co-limit growth of the Southern Ocean diatom Chaetoceros debilis
- Bilateral and unilateral load-velocity profiling in a machine-based, single-joint, lower body exercise
- Veterans Health Administration nurses’ training and beliefs related to care of patients with traumatic brain injury
- Supplementation strategies affect the feed intake and performance of grazing replacement heifers
- Active transcutaneous bone conduction hearing implants: Systematic review and meta-analysis
- Parameterization-induced uncertainties and impacts of crop management harmonization in a global gridded crop model ensemble
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- Mining version history to predict the class instability
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- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes
- Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading
- Reconstructing systematic persistent impacts of promotional marketing with empirical nonlinear dynamics
- Trans-national conservation and infrastructure development in the Heart of Borneo
- Prediction of cardiovascular disease risk among people with severe mental illness: A cohort study
- Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
- Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
- Reconstructing birth in Australopithecus sediba
- Value of contrast-enhanced ultrasound for preoperative assessment of liver reserve function in patients with liver tumors
- Correction: Identifying obesity/overweight status in children and adolescents; A cross-sectional medical record review of physicians’ weight screening practice in outpatient clinics, Saudi Arabia
- Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program
- Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
- Functional role and evolutionary contributions of floral gland morphoanatomy in the Paleotropical genus Acridocarpus (Malpighiaceae)
- On the efficiency of HIV transmission: Insights through discrete time HIV models
- Metabolic cost calculations of gait using musculoskeletal energy models, a comparison study
- Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype
- Evolutionary analysis of six chloroplast genomes from three Persea americana ecological races: Insights into sequence divergences and phylogenetic relationships
- Cultural transmission in a food preparation task: The role of interactivity, innovation and storytelling
- Correction: Effects of affective priming through music on the use of emotion words
- Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial
- Estimation of vaccination coverage from electronic healthcare records; methods performance evaluation – A contribution of the ADVANCE-project
- Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation
- Suicide by hanging: Results from a national survey in Switzerland and its implications for suicide prevention
- Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders
- Genome wide genetic dissection of wheat quality and yield related traits and their relationship with grain shape and size traits in an elite × non-adapted bread wheat cross
- Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
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- Comparison of post-traumatic changes in circulating and bone marrow leukocytes between BALB/c and CD-1 mouse strains
- Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)
- Associations between birth order with mental wellbeing and psychological distress in midlife: Findings from the 1970 British Cohort Study (BCS70)
- Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
- The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
- Ancient technology and punctuated change: Detecting the emergence of the Edomite Kingdom in the Southern Levant
- Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- Randomized control trial of Tools of the Mind: Marked benefits to kindergarten children and their teachers
- Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration
- PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age
- Correction: Unraveling the genetic complexity underlying sorghum response to water availability
- Impact of tear metrics on the reliability of perimetry in patients with dry eye
- Using DNA barcoding to improve invasive pest identification at U.S. ports-of-entry
- Correction: Effects of Lactobacillus plantarum 15-1 and fructooligosaccharides on the response of broilers to pathogenic Escherichia coli O78 challenge
- Physico-chemical characterization and transcriptome analysis of 5-methyltryptophan resistant lines in rice
- Patient factors affecting successful linkage to treatment in a cervical cancer prevention program in Kenya: A prospective cohort study
- Is this a man’s world? The effect of gender diversity and gender equality on firm innovativeness
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- Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock
- Quantitation of free glycation compounds in saliva
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- The effect of cathodal tDCS on fear extinction: A cross-measures study
- Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome
- Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells
- Investigating the dispersal of antibiotic resistance associated genes from manure application to soil and drainage waters in simulated agricultural farmland systems
- Continuous norming of psychometric tests: A simulation study of parametric and semi-parametric approaches
- Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method
- Cost-effectiveness of apixaban compared to other anticoagulants in patients with atrial fibrillation in the real-world and trial settings
- Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia
- Low genetic differentiation yet high phenotypic variation in the invasive populations of Spartina alterniflora in Guangxi, China
- A mathematical model for designing networks of C-Reactive Protein point of care testing
- Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis
- Femtosecond laser induced step-like structures inside transparent hydrogel due to laser induced threshold reduction
- From In Situ to satellite observations of pelagic Sargassum distribution and aggregation in the Tropical North Atlantic Ocean
- The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology
- BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis
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- Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
- Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing
- Occurrence mechanism and coping paths of accidents of highly aggregated tourist crowds based on system dynamics
- Correction: Low Dose Aerosol Fitness at the Innate Phase of Murine Infection Better Predicts Virulence amongst Clinical Strains of Mycobacterium tuberculosis
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- Correction: Public reaction to Chikungunya outbreaks in Italy—Insights from an extensive novel data streams-based structural equation modeling analysis
- Correction: Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer’s dementia
- Intra-individual variability of sleep and nocturnal cardiac autonomic activity in elite female soccer players during an international tournament
- Therapeutic efficacy of equine botulism heptavalent antitoxin against all seven botulinum neurotoxins in symptomatic guinea pigs
- Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis
- Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis
- Scope and efficacy of the broad-spectrum topical antiseptic choline geranate
- Hematological and biochemical parameters for Chinese rhesus macaque
- Veterinary peer study groups as a method of continuous education—A new approach to identify and address factors associated with antimicrobial prescribing
- Correction: The prognosis of heart failure patients: Does sodium level play a significant role?
- Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin
- Systematic identification of facility-based stillbirths and neonatal deaths through the piloted use of an adapted RAPID tool in Liberia and Nepal
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis
- Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal population
- Reasons to care: Personal motivation as a key factor in the practice of the professional foster carer in Romania
- Determinants of clinical, functional and personal recovery for people with schizophrenia and other severe mental illnesses: A cross-sectional analysis
- Continuity of care for TB patients at a South African hospital: A qualitative participatory study of the experiences of hospital staff
- EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling
- The Better Management of Patients with Osteoarthritis Program: Outcomes after evidence-based education and exercise delivered nationwide in Sweden
- The negative effects of short-term extreme thermal events on the seagrass Posidonia oceanica are exacerbated by ammonium additions
- Pathogen invasion history elucidates contemporary host pathogen dynamics
- Chinese herbal formulae for the treatment of menopausal hot flushes: A systematic review and meta-analysis
- Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery
- Deconstruction of central line insertion guidelines based on the positive deviance approach—Reducing gaps between guidelines and implementation: A qualitative ethnographic research
- PBMCs transcriptome profiles identified breed-specific transcriptome signatures for PRRSV vaccination in German Landrace and Pietrain pigs
- The impact of admission serum lactate on children with moderate to severe traumatic brain injury
- Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface
- Determination of the bruise degree for cherry using Vis-NIR reflection spectroscopy coupled with multivariate analysis
- Genome-wide identification and expression profile analysis of nuclear factor Y family genes in Sorghum bicolor L. (Moench)
- Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007–2016: A retrospective cohort study
- Distribution of the Duffy genotypes in Malaysian Borneo and its relation to Plasmodium knowlesi malaria susceptibility
- Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
- A self-adaptive deep learning method for automated eye laterality detection based on color fundus photography
- The effect of child marriage on the utilization of maternal health care in Nepal: A cross-sectional analysis of Demographic and Health Survey 2016
- Identification of QTLs for powdery mildew (Podosphaera aphanis; syn. Sphaerotheca macularis f. sp. fragariae) susceptibility in cultivated strawberry (Fragaria ×ananassa)
- Chemical volatiles present in cotton gin trash: A by-product of cotton processing
- PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils
- Differential metabolomics networks analysis of menopausal status
- Experimental study of the temporal profile of breath alcohol concentration in a Chinese population after a light meal
- Association between regional brain volumes and BMI z-score change over one year in children
- Relationships between Potentially Toxic Elements in intertidal sediments and their bioaccumulation by benthic invertebrates
- Long-term outcomes of dialysis in patients with chronic kidney disease and new-onset atrial fibrillation: A population-based cohort study
- Hospital burden of pulmonary arterial hypertension in France
- Understanding the variability of Australian fire weather between 1973 and 2017
- Photon-counting cine-cardiac CT in the mouse
- Ecophysiological impacts of Esca, a devastating grapevine trunk disease, on Vitis vinifera L.
- Black “Reading the Mind in the Eyes” task: The development of a task assessing mentalizing from black faces
- Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae
- Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects
- Validation of the Rainbow Model of Integrated Care Measurement Tools (RMIC-MTs) in renal care for patient and care providers
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- Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction—Post-hoc analysis from the OMEGA-REMODEL randomized controlled trial
- A randomized controlled trial examining the efficacy of an internet-based cognitive behavioral therapy program for adolescents with anxiety disorders
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- Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
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- Retraction: Modulation of the Pentose Phosphate Pathway Induces Endodermal Differentiation in Embryonic Stem Cells
- An analysis on HBsAg, Anti-HCV, Anti-HIV½ and VDRL test results in blood donors according to gender, age range and years
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- Meaningful work and resilience among teachers: The mediating role of work engagement and job crafting
- The conditional Fama-French model and endogenous illiquidity: A robust instrumental variables test
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- Genetic evidence for plural introduction pathways of the invasive weed Paterson’s curse (Echium plantagineum L.) to southern Australia
- Risk of major autoimmune diseases in female breast cancer patients: A nationwide, population-based cohort study
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- The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue: A single centre experience
- Retraction: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection
- The association between role model presence and self-regulation in early adolescence: A cross-sectional study
- Correction: A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk
- Methamphetamine regulation of activity and topology of ventral midbrain networks
- Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis
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- Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation
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- Correction: Permissivity of Primary Human Hepatocytes and Different Hepatoma Cell Lines to Cell Culture Adapted Hepatitis C Virus
- Radiomics features of the primary tumor fail to improve prediction of overall survival in large cohorts of CT- and PET-imaged head and neck cancer patients
- The complete mitochondrial genome of Calyptogena marissinica (Heterodonta: Veneroida: Vesicomyidae): Insight into the deep-sea adaptive evolution of vesicomyids
- Correction: In vitro larval rearing protocol for the stingless bee species Melipona scutellaris for toxicological studies
- Correction: Morphological and molecular identification of the dioecious “African species Volvox rousseletii (Chlorophyceae) in the water column of a Japanese lake based on field-collected and cultured materials
- Upper versus lower airway microbiome and metagenome in children with cystic fibrosis and their correlation with lung inflammation
- “…or else I close my ears” How women with obesity want to be approached and treated regarding gestational weight management: A qualitative interview study
- Does a spinal implant alter dual energy X-ray absorptiometry body composition measurements?
- Economic and livestock health impacts of birds on dairies: Evidence from a survey of Washington dairy operators
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- Differences in the impedance of cochlear implant devices within 24 hours of their implantation
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- Expression of Concern: miRNA 17 Family Regulates Cisplatin-Resistant and Metastasis by Targeting TGFbetaR2 in NSCLC
- Group leaders establish cooperative norms that persist in subsequent interactions
- Addis Ababa population-based pattern of cancer therapy, Ethiopia
- Agreement between the Cochrane risk of bias tool and Physiotherapy Evidence Database (PEDro) scale: A meta-epidemiological study of randomized controlled trials of physical therapy interventions
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- Comparison of climbing-specific strength and endurance between lead and boulder climbers
- The performance of different case definitions for severe influenza surveillance among HIV-infected and HIV-uninfected children aged <5 years in South Africa, 2011–2015
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- RCER: Reliable Cluster-based Energy-aware Routing protocol for heterogeneous Wireless Sensor Networks
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- Changing educational gradient in long-term care-free life expectancy among German men, 1997-2012
- A non-parametric significance test to compare corpora
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- Different levels of statistical learning - Hidden potentials of sequence learning tasks
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- Organic resolution function and effects of platinum nanoparticles on bacteria and organic matter
- High levels of fasting glucose and glycosylated hemoglobin values are associated with hyperfiltration in a Spanish prediabetes cohort. The PREDAPS Study
- Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responses
- Dynamic up- and down-regulation of the default (DMN) and extrinsic (EMN) mode networks during alternating task-on and task-off periods
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- Everolimus in de novo kidney transplant recipients participating in the Eurotransplant senior program: Results of a prospective randomized multicenter study (SENATOR)
- Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2
- Does effectiveness in performance appraisal improve with rater training?
- National trends in inpatient endometriosis admissions: Patients, procedures and outcomes, 2006−2015
- Affective and enjoyment responses to 12 weeks of high intensity interval training and moderate continuous training in adults with Crohn’s disease
- Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up
- Cabbage stem flea beetle’s (Psylliodes chrysocephala L.) susceptibility to pyrethroids and tolerance to thiacloprid in the Czech Republic
- Implicit learning of artificial grammatical structures after inferior frontal cortex lesions
- Potential survival benefits from optimized chemotherapy implementation in advanced ovarian cancer: Projections from a microsimulation model
- Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in Malaysia
- Heat stress responses in a large set of winter wheat cultivars (Triticum aestivum L.) depend on the timing and duration of stress
- Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model
- Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissues
- Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia
- Evaluation of suitable reference genes in Brassica juncea and its wild relative Camelina sativa for qRT-PCR analysis under various stress conditions
- Time-related immunomodulation by stressors and corticosterone transdermal application in toads
- Machine learning discovery of longitudinal patterns of depression and suicidal ideation
- Multi-scale patterns of tick occupancy and abundance across an agricultural landscape in southern Africa
- A matter of taste: Spatial and ontogenetic variations on the trophic ecology of the tiger shark at the Galapagos Marine Reserve
- Retraction: Adaptive double threshold energy detection based on Markov model for cognitive radio
- Adrenal gland size in obstructive sleep apnea: Morphological assessment of hypothalamic pituitary adrenal axis activity
- Out-of-pocket health spending among Medicare beneficiaries: Which chronic diseases are most costly?
- A large-scale chromosomal inversion is not associated with life history development in rainbow trout from Southeast Alaska
- Deployment, suicide, and overdose among comorbidity phenotypes following mild traumatic brain injury: A retrospective cohort study from the Chronic Effects of Neurotrauma Consortium
- Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data
- Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
- A quantitative approach for the analysis of clinician recognition of acute respiratory distress syndrome using electronic health record data
- Morphological, microbiological and ultrastructural aspects of sepsis by Aeromonas hydrophila in Piaractus mesopotamicus
- Recidivism rates in individuals receiving community sentences: A systematic review
- The association of intensive care with utilization and costs of outpatient healthcare services and quality of life
- How well do cancer survivor self-classifications of anxiety, depression and stress agree with a standardised tool? Results of a cross-sectional study
- Comparative nutritional characteristics of the three major Chinese Dendrobium species with different growth years
- Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
- Geographic differentiation of agritourism activities in Poland vs. cultural and natural attractiveness of destinations at district level
- Social participation reduces isolation among Japanese older people in urban area: A 3-year longitudinal study
- Explaining age-related decline in theory of mind: Evidence for intact competence but compromised executive function
- Role of GDF15 in methylseleninic acid-mediated inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
- Black people are convicted more for being black than for being poor: The role of social norms and cultural prejudice on biased racial judgments
- Bulked segregant analysis RNA-seq (BSR-Seq) validated a stem resistance locus in Aegilops umbellulata, a wild relative of wheat
- Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits
- Barriers and enablers to the implementation of a complex quality improvement intervention for acute kidney injury: A qualitative evaluation of stakeholder perceptions of the Tackling AKI study
- Soil and vegetation conditions changes following the different sand dune restoration measures on the Zoige Plateau
- Experimental H1N1pdm09 infection in pigs mimics human seasonal influenza infections
- Emission characteristics of diethylhexyl phthalate (DEHP) from building materials determined using a passive flux sampler and micro-chamber
- Multi-focus microscope with HiLo algorithm for fast 3-D fluorescent imaging
- Pontoscolex corethrurus: A homeless invasive tropical earthworm?
- Modeling reciprocal effects in medical research: Critical discussion on the current practices and potential alternative models
- Does palliative chemotherapy really palliate and are we measuring it correctly? A mixed methods longitudinal study of health related quality of life in advanced soft tissue sarcoma
- Developing cookies formulated with goat cream enriched with conjugated linoleic acid
- The effects of combining focus of attention and autonomy support on shot accuracy in the penalty kick
- Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: A cross-sectional study
- A combined strategy of neuropeptide prediction and tandem mass spectrometry identifies evolutionarily conserved ancient neuropeptides in the sea anemone Nematostella vectensis
- Lipidome profiles of postnatal day 2 vaginal swabs reflect fat composition of gilt’s postnatal diet
- Antitumor activity of a novel dual functional podophyllotoxin derivative involved PI3K/AKT/mTOR pathway
- Genome-wide developed microsatellites reveal a weak population differentiation in the hoverfly Eupeodes corollae (Diptera: Syrphidae) across China
- Prognosis of severe acquired brain injury: Short and long-term outcome determinants and their potential clinical relevance after rehabilitation. A comprehensive approach to analyze cohort studies
- An in silico investigation of menthol metabolism
- Variant analysis pipeline for accurate detection of genomic variants from transcriptome sequencing data
- Identification of candidate flowering and sex genes in white Guinea yam (D. rotundata Poir.) by SuperSAGE transcriptome profiling
- Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation
- The quality of guidelines for diabetic foot ulcers: A critical appraisal using the AGREE II instrument
- Mastitis risk effect on the economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study
- Confounding by indication of the safety of de-escalation in community-acquired pneumonia: A simulation study embedded in a prospective cohort
- Effects from diet-induced gut microbiota dysbiosis and obesity can be ameliorated by fecal microbiota transplantation: A multiomics approach
- Drivers of HIV-1 transmission: The Portuguese case
- Integration of a FT expression cassette into CRISPR/Cas9 construct enables fast generation and easy identification of transgene-free mutants in Arabidopsis
- A biface production older than 600 ka ago at Notarchirico (Southern Italy) contribution to understanding early Acheulean cognition and skills in Europe
- Mass evacuation and increases in long-term care benefits: Lessons from the Fukushima nuclear disaster
- Circulating levels of free 25(OH)D increase at the onset of rheumatoid arthritis
- The expression of equine keratins K42 and K124 is restricted to the hoof epidermal lamellae of Equus caballus
- Soil respiration from fields under three crop rotation treatments and three straw retention treatments
- Inhibition of polymerase chain reaction: Pathogen-specific controls are better than human gene amplification
- Linkage disequilibrium and haplotype block patterns in popcorn populations
- Downscaling satellite soil moisture using geomorphometry and machine learning
- Choosing efficient actions: Deciding where to walk
- The zooarchaeology and isotopic ecology of the Bahamian hutia (Geocapromys ingrahami): Evidence for pre-Columbian anthropogenic management
- Synergy of the flow behaviour and disperse phase of cellulose nanoparticles in enhancing oil recovery at reservoir condition
- Accuracy of Determine TB-LAM Ag to detect TB in HIV infected patients associated with diagnostic methods used in Brazilian public health units
- Human papillomavirus infection among head and neck squamous cell carcinomas in southern China
- Comparison of feature point detectors for multimodal image registration in plant phenotyping
- Quartet-based inference of cell differentiation trees from ChIP-Seq histone modification data
- Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform
- Coralline algal calcification: A morphological and process-based understanding
- Comparing record linkage software programs and algorithms using real-world data
- Antimicrobial resistance and molecular genotyping of Salmonella enterica serovar Enteritidis clinical isolates from Guizhou province of Southwestern China
- Measuring sexual relationship power equity among young women and young men South Africa: Implications for gender-transformative programming
- Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice – Vie-KinD study
- The genome of Alcaligenes aquatilis strain BU33N: Insights into hydrocarbon degradation capacity
- A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome
- LMX1A inhibits C-Myc expression through ANGPTL4 to exert tumor suppressive role in gastric cancer
- Lung clearance index to detect the efficacy of Aztreonam lysine inhalation in patients with cystic fibrosis and near normal spirometry – A single-centre feasibility study
- Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh
- Effect of PEPFAR funding policy change on HIV service delivery in a large HIV care and treatment network in Nigeria
- Friends, relatives, sanity, and health: The costs of politics
- European public perceptions of homelessness: A knowledge, attitudes and practices survey
- An overview of the quality assurance programme for HIV rapid testing in South Africa: Outcome of a 2-year phased implementation of quality assurance program
- Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients at low and intermediate risk: A risk specific meta-analysis of randomized controlled trials
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- Tipping the balance towards long-term retention in the HIV care cascade: A mixed methods study in southern Mozambique
- Diagnosis and classification of pediatric acute appendicitis by artificial intelligence methods: An investigator-independent approach
- Stylistic variation on the Donald Trump Twitter account: A linguistic analysis of tweets posted between 2009 and 2018
- Kinematic determinants of scoring success in the fencing flick: Logistic and linear multiple regression analysis
- Preferences for formal and traditional sources of childbirth and postnatal care among women in rural Africa: A systematic review
- Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix)
- Associations between industry involvement and study characteristics at the time of trial registration in biomedical research
- A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
- Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1
- The predictive performance of SAPS 2 and SAPS 3 in an intermediate care unit for internal medicine at a German university transplant center; A retrospective analysis
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- Mapping online hate: A scientometric analysis on research trends and hotspots in research on online hate
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- DNA vaccine based on conserved HA-peptides induces strong immune response and rapidly clears influenza virus infection from vaccinated pigs
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- Genome-wide analysis of methylation in giant pandas with cataract by methylation-dependent restriction-site associated DNA sequencing (MethylRAD)
- A spherical falling film gas-liquid equilibrator for rapid and continuous measurements of CO2 and other trace gases
- The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review
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- De novo transcriptome analysis of Viola ×wittrockiana exposed to high temperature stress
- Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates
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- Effects of the Best Possible Self intervention: A systematic review and meta-analysis
- Metabolomic profiling of oxalate-degrading probiotic Lactobacillus acidophilus and Lactobacillus gasseri
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- Multiple biomarkers of sepsis identified by novel time-lapse proteomics of patient serum
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- The female presence in different organisational positions and performance in secondary schools: Does a woman leader function as mediator?
- Beta power encodes contextual estimates of temporal event probability in the human brain
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- Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain
- Comprehensive analysis of the internal structure and firmness in American cranberry (Vaccinium macrocarpon Ait.) fruit
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- Qualitative analysis of ward staff experiences during research of a novel suicide-prevention psychological therapy for psychiatric inpatients: Understanding the barriers and facilitators
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- Influence of musculotendon geometry variability in muscle forces and hip bone-on-bone forces during walking
- An international survey of perceptions of the 2014 FIFA World Cup: National levels of corruption as a context for perceptions of institutional corruption
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- High-throughput RNA-sequencing identifies mesenchymal stem cell-induced immunological signature in a rat model of corneal allograft rejection
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- Effects of chitin synthesis inhibitor treatment on Lepeophtheirus salmonis (Copepoda, Caligidae) larvae
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- Use of high-content analysis and machine learning to characterize complex microbial samples via morphological analysis
- Investigation of a spatial coupling relationship between carbon emission performance and regional urbanization in China
- A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic diet
- Excellent outcome after desensitization in high immunologic risk kidney transplantation
- Characterization of a new composite membrane for point of need paper-based micro-scale microbial fuel cell analytical devices
- Acute kidney injury during an ultra-distance race
- A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
- The role of C-reactive protein levels on the association of physical activity with lung function in adults
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- Therapeutic efficacy of neuregulin 1-expressing human adipose-derived mesenchymal stem cells for ischemic stroke
- CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein
- Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model
- Improved ICU mortality prediction based on SOFA scores and gastrointestinal parameters
- Social information use and collective foraging in a pursuit diving seabird
- Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES)
- Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis
- Prevalence of Epstein-Barr virus, human papillomavirus, cytomegalovirus and herpes simplex virus type 1 in patients with diabetes mellitus type 2 in south-eastern Poland
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- LPS induces inflammatory chemokines via TLR-4 signalling and enhances the Warburg Effect in THP-1 cells
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- The diagnostic value of pleural fluid homocysteine in malignant pleural effusion
- Spatio-temporal variations in wheat aphid populations and their natural enemies in four agro-ecological zones of Pakistan
- Factors associated with burnout amongst healthcare workers providing HIV care in Malawi
- A high-density exome capture genotype-by-sequencing panel for forestry breeding in Pinus radiata
- Self-management action and motivation of Pacific adults in New Zealand with end-stage renal disease
- Drought mediated physiological and molecular changes in muskmelon (Cucumis melo L.)
- A prospective randomized trial on abacavir/lamivudine plus darunavir/ritonavir or raltegravir in HIV-positive drug-naïve patients with CD4<200 cells/uL (the PRADAR study)
- Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
- Multi-dimensional evaluation of response to salt stress in wheat
- Tuberculosis in the wild boar: Frequentist and Bayesian estimations of diagnostic test parameters when Mycobacterium bovis is present in wild boars but at low prevalence
- Enhanced mechanical and thermal properties of electrically conductive TPNR/GNP nanocomposites assisted with ultrasonication
- Geospatial modeling of microcephaly and zika virus spread patterns in Brazil
- Maternal cardiovascular-related single nucleotide polymorphisms, genes, and pathways associated with early-onset preeclampsia
- A ten-year review of ESBL and non-ESBL Escherichia coli bloodstream infections among children at a tertiary referral hospital in South Africa
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- Dynamic mechanical characteristics and failure mode of serpentine under a three-dimensional high static load and frequent dynamic disturbance
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- Regulation of NF-κB- and STAT1-mediated plasmacytoid dendritic cell functions by A20
- The erythrocyte membrane stability is associated with sleep time and social jetlag in shift workers
- New space-time block codes from spectral norm
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- GIVE me your attention: Differentiating goal identification and goal execution components of the anti-saccade effect
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- Self Multi-Head Attention-based Convolutional Neural Networks for fake news detection
- Why are Chinese workers so unhappy? A comparative cross-national analysis of job satisfaction, job expectations, and job attributes
- Fecal indicator bacteria and virus removal in stormwater biofilters: Effects of biochar, media saturation, and field conditioning
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- Intraoperative measurement of intraventricular pressure in dogs with communicating internal hydrocephalus
- Relative importance of gene effects for nitrogen-use efficiency in popcorn
- Comparative analysis uncovers the limitations of current molecular detection methods for Fusarium oxysporum f. sp. cubense race 4 strains
- The accuracy of the frontal extent in stereoscopic environments: A comparison of direct selection and virtual cursor techniques
- Confronting pastoralists’ knowledge of cattle breeds raised in the extensive production systems of Benin with multivariate analyses of morphological traits
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- Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling
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- Antifungal effects of a 1,3,4-thiadiazole derivative determined by cytochemical and vibrational spectroscopic studies
- Risk factors for unsuccessful tuberculosis treatment outcomes in children
- CRISPR-based tools for targeted transcriptional and epigenetic regulation in plants
- Reliability of high-resolution ultrasound and magnetic resonance arthrography of the shoulder in patients with sports-related shoulder injuries
- Spatial-temporal variation characteristics and evolution of the global industrial robot trade: A complex network analysis
- Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- On the sustainability of a family planning program in Nigeria when funding ends
- The epidemiology of antidepressant use in South Korea: Does short-term antidepressant use affect the relapse and recurrence of depressive episodes?
- Injury severity level and associated factors among road traffic accident victims attending emergency department of Tirunesh Beijing Hospital, Addis Ababa, Ethiopia: A cross sectional hospital-based study
- How chimpanzees (Pan troglodytes) share the spoils with collaborators and bystanders
- Seed treatment using methyl jasmonate induces resistance to rice water weevil but reduces plant growth in rice
- Placebo analgesia induced by verbal suggestion in the context of experimentally induced fear and anxiety
- Reconsidering the associations between self-reported alcohol use disorder and mental health problems in the light of co-occurring addictions in young Swiss men
- Learning to assist smokers through encounters with standardized patients: An innovative training for physicians in an Eastern European country
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- Lipid and fatty acid dynamics by maternal Pacific bluefin tuna
- Adherence to evidence-based recommendations for surgical site infection prevention: Results among Italian surgical ward nurses
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- The risk, perceived and actual, of developing type 2 diabetes mellitus for mothers of preschool children in urban China
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- Studying the link between physiological performance of Crotalaria ochroleuca and the distribution of Ca, P, K and S in seeds with X-ray fluorescence
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- Retraction: Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3
- Correction: In Porphyromonas gingivalis VimF Is Involved in Gingipain Maturation through the Transfer of Galactose
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- Correction: Development of a high-throughput assay to measure measles neutralizing antibodies
- Correction: Provider preference for payment method under a national health insurance scheme: A survey of health insurance-credentialed health care providers in Ghana
- Correction: Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis
- Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India
- Feed-forward visual processing suffices for coarse localization but fine-grained localization in an attention-demanding context needs feedback processing
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- Compared to non-drinkers, individuals who drink alcohol have a more favorable multisystem physiologic risk score as measured by allostatic load
- Effect of poor glycaemic control on plasma levels and activity of protein C, protein S, and antithrombin III in type 2 diabetes mellitus
- Retraction: IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
- Sugar transporters in Fabaceae, featuring SUT MST and SWEET families of the model plant Medicago truncatula and the agricultural crop Pisum sativum
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- Ground reaction forces and muscle activity while walking on sand versus stable ground in individuals with pronated feet compared with healthy controls
- Correction: Roadway traffic crash prediction using a state-space model based support vector regression approach
- MET as resistance factor for afatinib therapy and motility driver in gastric cancer cells
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- Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy
- Influence of ocean circulation and the Kuroshio large meander on the 2018 Japanese eel recruitment season
- Growth response of the ichthyotoxic haptophyte, Prymnesium parvum Carter, to changes in sulfate and fluoride concentrations
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- Prognostic nomogram predicts overall survival in pulmonary large cell neuroendocrine carcinoma
- Microbiome profiling of the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae)
- Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
- Retraction: Impacts of rock properties on Danxia landform formation based on lithological experiments at Kongtongshan National Geopark, northwest China
- Correction: SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience
- Retraction: Plexin-B1 Activates NF-κB and IL-8 to Promote a Pro-Angiogenic Response in Endothelial Cells
- Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis
- Association between temperature, sunlight hours and alcohol consumption
- Using graph learning to understand adverse pregnancy outcomes and stress pathways
- Correction: The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?
- Surgical referral systems in low- and middle-income countries: A review of the evidence
- In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells
- Correction: The Economic Impact of Malignant Catarrhal Fever on Pastoralist Livelihoods
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- Correction: Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells
- Correction: Plant traits linked to field-scale flammability metrics in prescribed burns in Eucalyptus forest
- Correction: Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation
- Correction: To keep or not to keep? Decision making in adolescent pregnancies in Jamestown, Ghana
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