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Ancient technology and punctuated change: Detecting the emergence of the Edomite Kingdom in the Southern Levant
Authors: Erez Ben-Yosef aff001; Brady Liss aff002; Omri A. Yagel aff001; Ofir Tirosh aff004; Mohammad Najjar aff002; Thomas E. Levy aff002
Authors place of work: Department of Archaeology and Ancient Near Eastern Cultures, Tel Aviv University, Tel Aviv-Yafo, Israel aff001; Department of Anthropology, University of California, San Diego, La Jolla, California, United States of America aff002; Levantine and Cyber-Archaeology Lab, University of California, San Diego, La Jolla, California, United States of America aff003; Institute of Earth Sciences, Hebrew University of Jerusalem, Jerusalem, Israel aff004
Published in the journal: PLoS ONE 14(9)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0221967Summary
While the punctuated equilibrium model has been employed in paleontological and archaeological research, it has rarely been applied for technological and social evolution in the Holocene. Using metallurgical technologies from the Wadi Arabah (Jordan/Israel) as a case study, we demonstrate a gradual technological development (13th-10th c. BCE) followed by a human agency-triggered punctuated “leap” (late-10th c. BCE) simultaneously across the entire region (an area of ~2000 km2). Here, we present an unparalleled, diachronic archaeometallurgical dataset focusing on elemental analysis of dozens of well-dated slag samples. Based on the results, we suggest punctuated equilibrium provides an innovative theoretical model for exploring ancient technological changes in relation to larger sociopolitical conditions—in the case at hand the emergence of biblical Edom–, exemplifying its potential for more general cross-cultural applications.
Keywords:
Biology and life sciences – Physical sciences – Research and analysis methods – Evolutionary biology – Social sciences – People and places – Geographical locations – Materials science – Africa – Metallurgy – Earth sciences – Asia – Chemical characterization – Geology – Archaeology – Archaeological dating – Radioactive carbon dating – Archaeological excavation – Isotope analysis – Stratigraphy – Evolutionary theory – Egypt
Introduction
Archaeology is uniquely suited through its deep-time perspective to holistically and diachronically examine ancient human, social, and technological evolutions. Changes in technology provide unique opportunities for quantitatively measuring the refashioning of material culture through time to monitor underlying social change. From the perspective of metallurgical technologies in the Southern Levant, for example, archaeological research has identified the inception and sustained growth of copper metallurgy since circa 5000–4000 BCE [1–3]. However, while moments of radical metallurgical transformation, such as novel casting technologies and the innovation of bronze, have also been identified [1], there has been little investigation of small-scale changes in technological practices; although requiring considerable research efforts, the identification and modeling of such technological evolutions have broad significance in archaeological research, as technology can function as a proxy for otherwise indiscernible social processes [4]. Recent archaeological research in the Wadi Arabah [5, 6], one of the largest copper ore resource zones in the Levant, allowed for investigating in unprecedented detail a continuous record of technological development that spans a period of significant social changes in the transition between the Late Bronze Age (LB) to the Iron Age (IA).
Almost unharmed by modern exploitation, the industrial landscapes of Faynan and Timna within the Wadi Arabah (Fig 1, S1 and S2 Figs) function as exceptional “field laboratories” for examining developments in ancient metallurgical technologies [7, 8]. While previous research has demonstrated that the IA witnessed the most intense industrial activity in the history of the region—surpassing the later eastern Roman Empire operations, until now, it was impossible to measure technological change at the sub-century level to precisely map the peak in production and associate changes with social and cultural processes. During the IA, both regions were populated by large copper smelting centers supported by networks of smaller, ephemeral mining camps [5, 6]. These smelting sites remain identifiable on the surface by significant accumulations of metallurgical slag (>100,000/10,000 tons of slag in the Faynan and Timna respectively) [7, 8]. Slag was typically deposited in mounds mixed with other metallurgical debris; these constitute a unique, quasi-continuous record of the smelting activities (S3 Fig) [7, 8] that can typically be dated by radiocarbon measurements of charcoal (fuel remains) [9, 10] and archaeomagnetic investigation of the slag material itself [10, 11]. To explore these archaeological features, the Edom Lowlands Regional Archaeology Project (ELRAP—directed by T.E.L. and M.N. [5]) and the Central Timna Valley Project (CTV—directed by E.B.-Y. [6], http://archaeology.tau.ac.il/ben-yosef/CTV/) systematically excavated slag mounds in Faynan and Timna respectively. Securely dated slag samples from these excavations were analyzed as part of the current study, resulting in a robust archaeometallurgical dataset. In the following we demonstrate how the application of evolutionary theory helps extract social insights out of the new data and discuss the implications on our understanding of the genesis and structure of the Edomite Kingdom.
Fig. 1. Map of main copper producing regions in the Wadi Arabah (Israel/Jordan).
Punctuated equilibrium and technological change
Proposed as an alternative to phyletic gradualism, the Darwinian process entailing new species evolving through gradual and steady transformations, punctuated equilibrium suggests biological evolution is characterized by rare, rapid, and episodic events of speciation (cladogenesis) [12, 13]. Between these speciation events, biological organisms and communities are believed to exist in stability or stasis, essentially unchanging [12]. This reinterpretation of the evolutionary process provided an improved explanation for the discontinuous fossil record which lacks the long sequences of intermediate forms between origin and ancestral species expected by phyletic gradualism [12]. Paleontologists continue to find punctuated equilibrium a useful model for identifying and explaining rapid speciation in the fossil record (e.g., [14], often complementing phyletic gradualism based on the recognition of stasis as a meaningful and predominant pattern within the history of species [15]. As with the fossil record, this evolutionary approach can assist in interpreting change or “evolution” within the “deep-time” archaeological record, contributing to a macro history understanding of parts of the world. In following, evolutionary perspectives based in biology and paleontology have significantly influenced the history and growth of archaeological theory [16, 17]. Traditionally, this theoretical borrowing was archaeologically applied to cultural phenomena in place of biological species, using evolutionary models to interpret/understand developments in material culture and social complexity [16].
Punctuated equilibrium in archaeology has been predominantly applied to cases from the Paleolithic period. Kolodny et al. [18] review a wide range of studies going back to the 1940s, that illustrate how gradually accumulated changes in prehistoric human stone tool assemblages can culminate in empirically punctuated “events” of invention/innovation or loss. However, as these studies deal with deep-time prehistory and processes of change, it is difficult to identify the role of human agency. Human agents driving punctuated change were identified by Schiffer [19], who—as part of his study of 19th century electromagnetic technology—refers to technological change as invention “cascades” that produce new technologies, each cascade being a punctuated change that can be linked with specific inventors (human agents). O’Brian and Bentley [20] review a wide range of studies on the tempo of technological and social evolution in relation to Schiffer’s Behavioral Archaeology use of cascade models to explain the evolution of “complex technological systems”. Regarding ancient metallurgical technologies, evolutionary theory was only rarely applied, such as in the work of Charlton et al. [21, 22] concerning iron production in Wales. In the case at hand we apply evolutionary theory—and in particular punctuated equilibrium—in order to highlight, better characterize and make sense of detectable changes in copper production technologies, and in particular a “leap” in copper smelting efficiency that occurred during a very short period of time within a longer sequence of gradual changes. By considering the historical context, high precision radiometric dating and recent epigraphic finds, we identify a possible mode of change, i.e. the punctuation event that interrupted the preceding quasi-stasis.
Investigating technological change in the Wadi Arabah
For this study, 154 slag samples collected from stratigraphically controlled contexts in Faynan and Timna were pulverized for homogenization and analyzed with a pXRF (n = 109), ICP-OES (n = 10) and ICP-MS (n = 35). The conceptual framework for investigating technological change in the Wadi Arabah was to diachronically and synchronically map slag chemical compositions in a period of seemingly continuous production in the region. The Cu contents of slag can function as a proxy for the efficiency of the smelting technology, especially in comparative observations (less Cu reflects improved efficiency, assuming no change in ore quality), while other elements can reveal additional technological information (e.g., flux usage) [7, 8].
Results
Our results fall within the range of previously analyzed samples from LB and IA smelting sites of the Wadi Arabah (n = 72, S1 Dataset). The latter, lacking stratigraphic information and poorly dated, can be used only for a broad characterization of the period as a whole. Our new data, coupled with a tight control over well-dated stratigraphic contexts, enable investigation of technological change in a high resolution of time and space. A list of all radiocarbon dates used in this study, including ages modeled by Bayesian statistics where stratigraphic observations allowed, is provided in S2 Dataset.
Based on Cu content in slag, we were able to identify and contextualize a gradual improvement in technology within the LB-IA sequence that was followed by a “leap” that occurred sometime in the second half of the 10th c. BCE (S3 Dataset, Figs 2 and 3); the correlation between Cu contents in slag and stratigraphic contexts is striking (Fig 2A–2C). This trend is evident, for example, in the deep sounding excavated in the slag mound of Khirbat en-Nahas (KEN), Area M (S3 Fig). The average Cu content in slag decreases gradually according to stratigraphy (Fig 2A, from 1.49±0.50 wt.-% [M4-5] to 01.14±0.58 wt.-% [M3]), with a rapid drop in the transition to the youngest layers (0.69± 0.22 wt.-% [M2] and 0.47±0.24 wt.-% [M1]). There is also a correlation between stratigraphy and the tightness of distribution of Cu contents, represented by the standard deviations [SD] of the measurements, suggesting a better control on the smelting technology through time. This pattern is definitely the case in KEN-Area M, where the transition between the “pre-leap” (ca. 1300–925 BCE) technologies (represented by M4-5 and M3, SD = 0.50 and 0.58 respectively) and “post-leap” (ca. 925–830 BCE) technology (represented by M2 and M1, SD = 0.22 and 0.24 respectively) was accompanied by a tightening of the standard deviation by a factor of two. That said, these observed trends are even more pronounced when all contemporaneous contexts across the Wadi Arabah are considered together (Fig 3).
Fig. 2. A-C) Cu content of samples from Khirbat en-Nahas (KEN) Area M (A), Timna Site 30 [T30] (B), and Khirbat al-Jariya (KAJ) (C). Note the “leap” in efficiency and standardization between KEN M3 and M2, and T30 L2 and L1 (not represented at KAJ as the site was abandoned at the time). D) Mn and Fe content of samples from T30. The abrupt change between L2 (n = 3) and L1 (n = 4) reflects a deliberate replacement of the fluxing material (in Timna) that corresponds to the “leap” in efficiency noted in the Cu content.
Fig. 3. A comparison between data from Faynan and Timna reveals another striking correlation, as the two regions, separated by ~105 km, demonstrate the exact same trend of technological changes (Figs 2 and 3; note for example the results from the contemporaneous sites of Timna 30 [T30] L2 and Khirbat al-Jariya [KAJ] A3-4 [1.55±0.93 wt.-%, 1.58±0.93 wt.-%, respectively], and T30 L1 and KEN M1 [0.40±0.15 wt.-%, 0.47±0.24 wt.-%, respectively]). In Timna, the elemental analysis revealed an abrupt change in the use of flux from Fe oxides to the more effective Mn oxides that accompanied the “leap” in efficiency (Fig 2D). In Faynan, where manganese oxides are associated with the main source of copper ore and more readily available, fluxing was done using these minerals throughout the period [8].
When copper content averages in slag samples are plotted by context (Site/Area/Layer), distinct clusters can be distinguished (Fig 3; see more on the chronological boundaries below). The large sample number enables further, statistical conclusions: (1) the low copper-content group discussed above (T30-L1, KEN-M1, KEN-M2, KEN-F2A, and KEN-A2-3) are not only tight at the context level, but also in the inter-context level (average of all samples from low copper-content contexts is 0.51±0.18 wt.-%); this means that in addition to having more control over smelting processes in the level of each individual workshop, there was a standard, and well-established technology across sites in the entire Wadi Arabah. (2) KEN-M3, KAJ-A1, KAJ-C1, and Timna Site 34 [T34] represent a cluster, with an average content of copper in slag of 1.03±0.57 wt.-%; also here there is an excellent agreement across contexts of similar dates across the Wadi Arabah, with technological tradition that lasted about a century around the turn of the 1st millennium BCE. (3) The highest copper-content group (1.65±0.87 wt.-%), which is also the most scattered one, spans the transition between the LB and IA (ca. 1140 BCE [23]). Key observation here is that the transition is not reflected in the technology (note in particular the results of Timna Site 3 [T3], which—based on finds at the site—is considered to represent LB technology [23]).
Finally, the technological leap is evident also when considering the bulk chemical composition of the analyzed slag (Fig 4). Although the major chemical components were basically the same throughout the period (an observation that strengthens the use of Cu content as a proxy for technological change), the improvement in standardization and the overall efficiency of the smelting process is readily apparent.
Fig. 4. Discussion
Archaeological and historical context
The technological record studied here represents half-a-millennium of continuous copper production in the Wadi Arabah (~1300–800 BCE), which was preceded and followed by centuries of hiatus [5, 10, 25] (Fig 5). As such, this record provides a unique window into evolutionary processes of a given society; this society, identified with the Edomites of the Old Testament (Hebrew Bible) and non-biblical sources (Assyrian and Egyptian) [9, 26, 27], was based on the local tribes of the region that practiced a (semi-)nomadic way of life throughout the period [26]. The beginning of copper production took place in Timna under the control of the Egyptian New Kingdom [7]. The technologies, which were disparate from the wind-based ones used in the preceding Early Bronze production in the region (3rd millennium BCE), were introduced from the outside, possibly based on developments in the Sinai Peninsula or the Hijaz [5, 28]. The subsequent, local technological developments were based on these technologies, in the center of which there were furnaces operated by sack-bellows [5].
Fig. 5. Main features of the organization of production and detailed chaîne opératoires for the copper industry in the Wadi Arabah during the Late Bronze and early Iron Ages (dashed arrows and boxes indicate optional components with weak or no evidence).
The Egyptian-controlled production phase in Timna has no equivalent in Faynan and should probably be understood as an extension of the Egyptian activities in the Sinai Peninsula [28]. The absence of a New Kingdom Egyptian activity in the northern Wadi Arabah may be due to distance-parity and the inability of this core civilization to project their power in this area [29]. The degree of the Egyptian ‘hands-on’ involvement in the production activities is a matter of active discussion; however, it is evident that the labor force was predominantly based on the local tribes, working under the Egyptian hegemonic power that at the time was exercised over the core regions of the Southern Levant (Canaan). Following the collapse of the Egyptian civilization at the end of the LB [30] and the consequent Egyptian withdrawal from Timna (ca. 1140 BCE [23]), metal production spread throughout the Wadi Arabah at an industrial scale [5, 10]. From this time until the end of the large-scale industry around ca. 800 BCE, two major transformations are evident in the archaeological record (Fig 5): (1) An introduction of fortifications around the turn of the 1st millennium BCE (e.g., the large fortress at KEN), which also entailed abandonment of unprotected sites (e.g., Timna Site 15) and the establishment of new ones in naturally fortified locations (e.g., “Slaves’ Hill” [T34] [31, 32]). The need for defense was manifested simultaneously in Timna and Faynan, and probably reflects changes in the ultra-regional geopolitical situation at the time [31]. Based on macro observations, these changes are not reflected in the technological practice, and the basic ‘toolkit’ remained the same [5]. (2) A substantial reorganization of the industry at the second half of the 10th century BCE [5], which included efforts for centralization (abandonment of most sites except one in Timna and two in Faynan), decommissioning of defensive features (e.g., the transformation of KEN fortress into metallurgical workshops), the introduction of camels as draft animal [33], and major changes of organization on an intra-site level (e.g., establishment of a building in an area previously used for dumping metallurgical waste [KEN Area M]). These changes were accompanied by the introduction of a new technological ‘toolkit’, which consisted of larger furnaces and tuyères, and produced a visually-different type of slag [5]. It has been suggested that this major transformation should be associated with the campaign of Sheshonq I to the Southern Levant [5, 10].
Pharaoh Sheshonq I, one of the few Egyptian pharaohs identified by name in the Hebrew Bible (there “Shishak”), was the founder of the 22nd Dynasty in Egypt. Following his ascension, he dedicated efforts to reunifying Egypt and incursions abroad [34]. His military campaigns included an invasion into Judah and Israel “5 years after the death of King Solomon” (1 Kings 14 : 25, 2 Chronicles 12 : 1–12) in response to hostile incidents on Egypt’s eastern border. This event is commonly dated to around 925 BCE, although difficulties with the biblical background for this date and insecurities regarding the exact years of Sheshonq I’s reign gave rise to slightly different (usually earlier) suggestions (e.g., [35]). Based on the appearance of names from the Negev region in the description of this event in Egypt (topographical list at the Temple of Amun in Karnak) it has been suggested that one of the destinations of Shoshenq I’s campaign was the Wadi Arabah and its copper industry [36]. This hypothesis was strengthened recently by the accidental discovery of a rare scarab bearing the throne name of Sheshonq I in Faynan [5].
The coincidence of Shoshenq I’s campaign to the region and the major reorganization of the copper industry mentioned above, together with the assumption that Egypt’s interest was to secure its supply of Arabah copper [28], suggests that Egypt had a certain role in bringing about these observable changes in the copper production industry. The new data presented here, coupled with punctuated evolution theory, help shed light on that role vis-à-vis internal processes within the local society.
Technological evolution and the Edomite society
Treating technological developments from an evolutionary perspective assumes that a positive feedback for improvements in efficiency (= less efforts spent per unit of outcome) exists in a given techno-social system. This assumption should be treated with caution in the study of technological trajectories in human societies [40], as discrete cases within the longue durée of a given region can easily deviate from a unilinear development model [41]. However, for a continuous record of the same system such as the one studied here, this assumption seems valid, and an evolutionary model can be suggested.
Prior to the present study only two copper smelting technologies were identified in the LB/IA archaeological record of the Wadi Arabah, the one represented by the “Small Tuyères” (~1300–925 BCE) that was followed by the one represented by the “Large Tuyères” (~925–800 BCE) [5, 7, 8] (Fig 5). A ‘stasis’ in technological development was assumed for the duration of each of the technologies, and the advantages of the newer technology was discussed only in relation to increased production intensity based on the amount of slag. The new data (Fig 3) provide quantifiable observations on the efficiency of the two technologies; they also reveal hitherto indiscernible diachronic technological changes and help characterizing the macroscopically visible technological transformation.
The analytical data (Fig 3) demonstrate that the earlier technology was not entirely static, and that during the ca. 400 years of use it went through changes, indicating that efforts to improve its efficiency were deliberately—and probably constantly—invested. The changes were gradual and thus are best discernable in the general trend; however, within this trend the data suggest that significant technological changes were associated with the reorganization of the industry around the turn of the 1st millennium BCE. The appearance of fortifications and redistribution of smelting sites at this time coincides with a tighter control over the smelting protocol (cf., SD of averages of Cu-High and Cu-Low in Fig 3), and an overall more efficient technology. Prior to these changes the standardization of production across the Wadi Arabah was rather poor, reflecting a different practice for each smelting site. Furthermore, the seamless transition from the Egyptian-controlled industry to the local (Edomite) one around ca. 1140 BCE supports the hypothesis that the tribes of the region were responsible for operating the industry even when it was orchestrated by the Egyptians; it reveals that under the Egyptian auspices the local tribes had a high degree of independence, a situation that constituted a fertile ground for them to emulate Egyptian political practices that would later serve as the basis for the consolidation of their own polity (cf., [6, 26].
The new technological observations also shed light on the latter process, the formation of the tribal confederation of the Edomite Kingdom. While the biblical narrative describes an early, pre-10th century BCE kingdom (“…the kings who reigned in Edom before any Israelite king reigned” [Genesis 36 : 31]), the archaeological record has been subjected to conflicting interpretations, even after the publication of the new chronology that clearly demonstrates the flourishing of the region during the 12th – 11th centuries BCE [5, 10, 42]. Here, the striking synchronous agreement between the technology in Timna and Faynan, evident as early as the 11th century BCE (note in particular T30-L2 and KAJ-A3-4 in Fig 3), suggests that an overarching political body existed in the region already at this time. Further centralization of this political body is evident in the changes observed towards 1000 BCE mentioned above.
The ca. 400-years of gradual technological improvements, which from an evolutionary perspective can be regarded as a quasi-stasis, was “punctuated” by a technological “leap” in the second half of the 10th century BCE. The major, macro-scale changes described above are reflected in the analytical results, which indicate a much more efficient technology that was practiced with unprecedented control over the smelting protocol (Fig 3); after the “leap”, the technology reached an “equilibrium”, continuing for more than a century with no discernable changes. The historical context makes human agency a key factor in explaining this “punctuation event”: after generations of internal efforts to better the technology—with limited success—the techno-social system was receptive of extraneous influences that facilitated the same cause. Thus, changes imposed or triggered by the Egyptian intervention at the time of Shoshenq I’s campaign resulted in unparalleled flourishing of the industry, rather than a catastrophic clash. This is evident not only in the industrial landscapes but also in the nearby regions that thrived as a result of trade with Egypt [43] and even further destinations such as Greece [25, 44].
The triggering of the technological leap by extraneous intervention is best explained when considering the characterization of periods of stasis in punctuated equilibrium theory. Such periods are stable a result of feedback systems that prevent change, and the punctuation is a result of destabilization of these systems. The feedback systems in the case at hand (Fig 5) are related to the complexity of the technological operation—which was based on multitude of co-dependent components—and the embeddedness of the industry in an existing trade system(s); only when these were destabilized by a military campaign (that probably also reflects changes in markets and trade) an opportunity emerged for the Edomites to adopt innovations and make technological changes that no doubt had—in turn—profound effects on their society. The case study of the Wadi Arabah demonstrates how technological developments can be interpreted through the lens of punctuated evolutionary theory; this not only helps in extracting social insights on a given society (in our case, Edom), but is a useful tool for comparative studies; its potential depends on its application to other detailed, high resolution records of technological change across time and cultures, world-wide.
Materials and methods
Slag samples for the present study were obtained by excavation methods detailed in [5] and [6], and their dating is based on previously published radiocarbon results (S2 Dataset). As slag is typically a heterogeneous material, all samples were pulverized into a very fine homogenized powder (particles of several tens of microns) that provides a reliable average of the bulk chemistry of a sample. The chemical analysis was based principally on the use of a portable X-ray fluorescence (pXRF) instrument (n = 109). Inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS) were also used for additional 10 and 35 samples respectively; the agreement between the results strengthens their accuracy.
pXRF: Instrument used: Bruker TRACeR III-V+ (Levantine Archaeology Laboratory, University of California San Diego). In order to gain quantitative results from the produced XRF spectra, we calibrated the instrument using samples of slag with known elemental values (all of the samples were Mn-rich slag in order to account for this unique quality of slags in Faynan). Samples were pulverized using an agate mortar and pestle and a SPEX alumina ceramic grinder, in the Petrographic Laboratory of Scripps Institution of Oceanography. Powdered samples were collected in specialized cups with transparent thin-film bases (four microns thick). Focusing on heavier elements, copper and above on the periodic table, the Bruker pXRF was set to 40Kv, 15μA, no vacuum, and the green filter for timed assays of 300 seconds. Cu values discussed in this paper are much greater than the estimated detection limit for Cu using these settings.
ICP-OES, ICP-MS: All samples were pulverized using Retsch Jaw Crusher BB200 and Retsch Vibratory Disc Mill RS200, both equipped with tungsten components (Archaeometallurgical Laboratory, Institute of Archaeology of Tel Aviv University). The homogenized powders were stored in sealed bags and transferred to the Geochemistry Laboratory of the Institute of Earth Science, the Hebrew University of Jerusalem (headed by Y. Erel). From each sample, 0.1g was put into separate beakers and dissolved using multiple acids (HNO3 [69% concentration], HF [49% con.], HClO4 [35% con.]). After vaporizing the acids, all beakers were filled with 0.5ml of nitric acid and 49.5ml of distilled water. The chemical composition of 10 samples was then analyzed by Perkin Elmer Optima 3000 Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) and due to machine availability the rest 36 samples were analyzed using Agilent (HP) 7500cx ICP - Mass Spectroscopy (MS).
Provenience of archaeological samples used in the current study:
Samples stored in the University of California San Diego Levantine Archaeology Laboratory (available for study, metadata for Khirbat en-Nahas is available as a digital collection at - https://library.ucsd.edu/dc/collection/bb41653353):
Samples excavated under license number 2006/74 of the Department of Antiquities of Jordan: L170-1, L174-1, L193-1, L180-1, L180-1-C, L192-1, L816-1, L842-1, L859-1, L860-1, L860-1-C, L893-1, 10482, 10483, 10250, 10484, 10485, 10487, 10478, 10479, 10481, 10486, 10488, 10489, 10256, 10475, 10476, 10477, 10490, 10492, 10493, L602-1, L606-1, L615-1, L620-2, L620-1, L622-1, 10259, 10260, 10262, MAR0904, 10267, 10270, 10474, 10468, 10460, 10461, 10462, 10480, L629-1, L647-1, L659-1, L660-1, 10463, 10465, 10467, 10471, L666-2, L666-1, 10277, 10280, 10282, 10283, L667-1, L670-1, L670-2, L671-1, 10464, 10466, L674-1 // 3275, 3262, 3263, 3278, 3261, 3283, 3276, 3287, 3266, 3267, 3281, 3282, 3280, 3279, 3277, 3269, 3274, 3272, 3271
Samples excavated under license number 2014/60 of the Department of Antiquities of Jordan: B10314_1, B10314_2, B10338_1, B10338_2, B10233, B10234, B10235, B10236, B10237, B10238, B10502, B001
Samples stored in the Tel Aviv University, Laboratory of Archaeometallurgy (available for study):
Samples excavated under license number G-38/2009 of the Department of Antiquities of Israel: L809-1, S2-510, S2-51, S2-52, L902-1, L903-1, L907-1, L808-1
Samples excavated under license number G-3/2013 of the Department of Antiquities of Israel: oyT3;02;P, oyT3;03;C, oyT3;04.1;C/P, oyT3;04.2;C/P, oyT3;04.3;C/P, oyT3;04.4;C/P, oyT3;05.1;C/P, oyT3;05.2;C/P, oyT3;05.3;C/P, oyT3;05.4;C/P, oyT3;06.1;C/P, oyT3;06.2;C/P, oyT3;06.3;C/P, oyT3;06.4;C/P, oyT3;07.1;C/P, oyT3;07.2;C/P, oyT3;07.3;C/P, oyT3;07.4;C/P, oyT3;08;C/P, oyT3;09;C/P, oyT3;10;C/P, oyT3;11;C/P, oyT3;12;C/P, oyT3;13;C/P, oyT3-14-C/P, oyT3-15-C/P, oyT3-16-C/P, oyT3-17-C/P // oyT34;10.1;C/P, oyT34;11/1;C/P, oyT34;11/2;C/P, oyT34;12.1;C/p, oyT34;12/2;C/P, oyT34;13.1;C/P, oyT34;13/2;C/P, oyT34;14.1;C/P, oyT34;14/2;C/P, oyT34;15/1;C/P, oyT34;15/2;C/P, oyT34;16/1;C/P, oyT34;16/2;C/P, oyT34;17/1;C/P, oyT34;17/2;C/P, oyT34;18/1;C/P, oyT34;18/2;C/P
Supporting information
S1 Fig [esa]
Detailed map of Iron Age copper production and related sites in Faynan, Jordan.S2 Fig [esa]
Detailed map of the Late Bronze and Iron Age copper production and related sites in Timna, Israel.S3 Fig [tif]
Students excavating metallurgical debris in a deep sounding of a slag mound in Faynan, Jordan (Khirbat en-Nahas [KEN], Area M).S1 Dataset [xlsx]
A compilation of all previously published analytical data of Late Bronze and Iron Age slag samples from the Wadi Arabah.S2 Dataset [xlsx]
Radiocarbon dates (original, calibrated and modeled) from contexts discussed in the text and their sources.S3 Dataset [xlsx]
Analytical data from current study of Late Bronze and Iron Age slag samples from the Wadi Arabah by archaeological context (cf., for dating).
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- Role of phospholipase A2 receptor 1 antibody level at diagnosis for long-term renal outcome in membranous nephropathy
- Prevalence of anemia in diabetic adult outpatients in Northeast Ethiopia
- Characterization of melanin and optimal conditions for pigment production by an endophytic fungus, Spissiomyces endophytica SDBR-CMU319
- Genetic variability and consequence of Mycobacterium tuberculosis lineage 3 in Kampala-Uganda
- Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes
- Current and potential contributions of community pharmacy teams to self-harm and suicide prevention: A qualitative interview study
- Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway
- With or without U(K): A pre-Brexit network analysis of the EU ETS
- Graph-theoretical analysis for energy landscape reveals the organization of state transitions in the resting-state human cerebral cortex
- Task-uninformative visual stimuli improve auditory spatial discrimination in humans but not the ideal observer
- Residual stenosis after carotid artery stenting: Effect on periprocedural and long-term outcomes
- gapFinisher: A reliable gap filling pipeline for SSPACE-LongRead scaffolder output
- A plant biostimulant made from the marine brown algae Ascophyllum nodosum and chitosan reduce Fusarium head blight and mycotoxin contamination in wheat
- Monte-Carlo value analysis of High-Throughput Satellites: Value levers, tradeoffs, and implications for operators and investors
- Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm
- Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning
- Neuropathy and neural plasticity in the subcutaneous white adipose depot
- Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells
- The enemy’s gaze: Immersive virtual environments enhance peace promoting attitudes and emotions in violent intergroup conflicts
- Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae
- Koopman Mode Analysis of agent-based models of logistics processes
- Empirical mode decomposition based long short-term memory neural network forecasting model for the short-term metro passenger flow
- Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy
- Multi-agent reinforcement learning with approximate model learning for competitive games
- Identification of olfactory genes and functional analysis of BminCSP and BminOBP21 in Bactrocera minax
- The use of urinary fluoride excretion to facilitate monitoring fluoride intake: A systematic scoping review
- Development of a family caregiver needs-assessment scale for end-of-life care for senility at home (FADE)
- Epidemiology of pneumonia in the pre-pneumococcal conjugate vaccine era in children 2-59 months of age, in Ulaanbaatar, Mongolia, 2015-2016
- H-EM: An algorithm for simultaneous cell diameter and intensity quantification in low-resolution imaging cytometry
- Public expenditure on Non-Communicable Diseases & Injuries in India: A budget-based analysis
- Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways
- uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading frames
- Comparative analysis of postural control and vertical jump performance between three different measurement devices
- Hierarchical multi-view aggregation network for sensor-based human activity recognition
- Clavien–Dindo classification for grading complications after total pharyngolaryngectomy and free jejunum transfer
- Significantly different expression levels of microRNAs associated with vascular invasion in hepatocellular carcinoma and their prognostic significance after surgical resection
- Clinical correlates of workplace injury occurrence and recurrence in adults
- Medicine and the media: Medical experts’ problems and solutions while working with journalists
- Phylogenic classification and virulence genes profiles of uropathogenic E. coli and diarrhegenic E. coli strains isolated from community acquired infections
- Genetic relatedness in carbapenem-resistant isolates from clinical specimens in Ghana using ERIC-PCR technique
- Forest resilience under global environmental change: Do we have the information we need? A systematic review
- Improving the production of podophyllotoxin in hairy roots of Hyptis suaveolens induced from regenerated plantlets
- Controls on planktonic foraminifera apparent calcification depths for the northern equatorial Indian Ocean
- Notch and Delta are required for survival of the germline stem cell lineage in testes of Drosophila melanogaster
- Children with HIV: A scoping review of auditory processing skills
- Correction: Two distinct actin waves correlated with turns-and-runs of crawling microglia
- Expression of Concern: Neurotoxicity Induced by Bupivacaine via T-Type Calcium Channels in SH-SY5Y Cells
- Sex-dependent and -independent transcriptional changes during haploid phase gametogenesis in the sugar kelp Saccharina latissima
- Vehicle modeling for the analysis of the response of detectors based on inductive loops
- New Mycobacteroides abscessus subsp. massiliense strains with recombinant hsp65 gene laterally transferred from Mycobacteroides abscessus subsp. abscessus: Potential for misidentification of M. abscessus strains with the hsp65-based method
- A prognostic Bayesian network that makes personalized predictions of poor prognostic outcome post resection of pancreatic ductal adenocarcinoma
- Impact of care provider network characteristics on patient outcomes: Usage of social network analysis and a multi-scale community detection
- Valid group comparisons can be made with the Patient Health Questionnaire (PHQ-9): A measurement invariance study across groups by demographic characteristics
- Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Upgraded molecular models of the human KCNQ1 potassium channel
- Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells
- The extraordinary osteology and functional morphology of the limbs in Palorchestidae, a family of strange extinct marsupial giants
- Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro
- Implementation of home blood pressure monitoring among French GPs: A long and winding road
- In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues
- Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
- The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study
- Retraction: Comprehensive Comparison of Three Different Immunosuppressive Regimens for Liver Transplant Patients with Hepatocellular Carcinoma: Steroid-Free Immunosuppression, Induction Immunosuppression and Standard Immunosuppression
- Can acute suicidality be predicted by Instagram data? Results from qualitative and quantitative language analyses
- Computational and experimental analysis of the glycophosphatidylinositol-anchored proteome of the human parasitic nematode Brugia malayi
- Antibacterial activity of silver nanoparticles of different particle size against Vibrio Natriegens
- Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
- To eat or not to eat: Reward delay impulsivity in children with loss of control eating, attention deficit / hyperactivity disorder, a double diagnosis, and healthy children
- Factors associated with newborn care knowledge and practices in the upper Himalayas
- Correction: A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment
- Correlates of concurrent partnerships and patterns of condom use among men who have sex with men and transgender women in Peru
- Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma
- Development of a denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis for arthroplasty: A phantom study
- Low-level sensory processes play a more crucial role than high-level cognitive ones in the size-weight illusion
- The prevalence of asthma and allergic rhinitis in Nigeria: A nationwide survey among children, adolescents and adults
- Retraction: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium
- Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study
- Characteristics of diabetic macular edema patients refractory to anti-VEGF treatments and a dexamethasone implant
- Correction: Effects of dietary n-6: n-3 polyunsaturated fatty acid ratios on meat quality, carcass characteristics, tissue fatty acid profiles, and expression of lipogenic genes in growing goats
- Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study
- Impact of pterygium on the ocular surface and meibomian glands
- Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- Transcriptome divergence during leaf development in two contrasting switchgrass (Panicum virgatum L.) cultivars
- Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis
- Circulating progenitor cells and the expression of Cxcl12, Cxcr4 and angiopoietin-like 4 during wound healing in the murine ear
- EUSKOR: End-to-end coreference resolution system for Basque
- Inactivating pathogenic bacteria in greywater by biosynthesized Cu/Zn nanoparticles from secondary metabolite of Aspergillus iizukae; optimization, mechanism and techno economic analysis
- Exopolysaccharide producing rhizobacteria and their impact on growth and drought tolerance of wheat grown under rainfed conditions
- Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes
- Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study
- Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
- Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae)
- PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
- Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients
- “I do all I can but I still fail them”: Health system barriers to providing Option B+ to pregnant and lactating women in Malawi
- Impact of major illnesses and geographic regions on do-not-resuscitate rate and its potential cost savings in Taiwan
- Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis
- Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration
- Correction: Artificial neural networks reveal individual differences in metacognitive monitoring of memory
- Combining fish and environmental PCR for diagnostics of diseased laboratory zebrafish in recirculating systems
- Reading skill modulates the effect of parafoveal distractors on foveal lexical decision in deaf students
- Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia
- Exposure to marital conflict: Gender differences in internalizing and externalizing problems among children
- Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials
- The effect of age and perturbation time on online control during rapid pointing
- Oilseed rape (Brassica napus) resistance to growth of Leptosphaeria maculans in leaves of young plants contributes to quantitative resistance in stems of adult plants
- Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitis
- Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin
- Genomic characterization of the complete terpene synthase gene family from Cannabis sativa
- Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine
- Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana
- Plant growth promoting rhizobacterium Stenotrophomonas maltophilia BJ01 augments endurance against N2 starvation by modulating physiology and biochemical activities of Arachis hypogea
- Hierarchical integrated and segregated processing in the functional brain default mode network within attention-deficit/hyperactivity disorder
- Rising co-payments coincide with unwanted effects on continuity of healthcare for patients with schizophrenia in the Netherlands
- Analysis of Zobellella denitrificans ZD1 draft genome: Genes and gene clusters responsible for high polyhydroxybutyrate (PHB) production from glycerol under saline conditions and its CRISPR-Cas system
- False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases
- Identification of potassium phosphite responsive miRNAs and their targets in potato
- Quantification of bell-shaped size selectivity in shrimp trawl fisheries using square mesh panels and a sorting cone after a Nordmøre grid
- Deactivation of somatosensory and visual cortices during vestibular stimulation is associated with older age and poorer balance
- Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice
- Flooding performance evaluation of alkyl aryl sulfonate in various alkaline environments
- An artificial intelligent diagnostic system on mobile Android terminals for cholelithiasis by lightweight convolutional neural network
- Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads
- COI metabarcoding primer choice affects richness and recovery of indicator taxa in freshwater systems
- Retraction: APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway
- The intake pattern and feed preference of layer hens selected for high or low feed conversion ratio
- Individualized pattern recognition for detecting mind wandering from EEG during live lectures
- Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison
- Post-activation potentiation effect of eccentric overload and traditional weightlifting exercise on jumping and sprinting performance in male athletes
- Effectiveness of different central venous catheter fixation suture techniques: An in vitro crossover study
- Quantitative detection of ALK fusion breakpoints in plasma cell-free DNA from patients with non-small cell lung cancer using PCR-based target sequencing with a tiling primer set and two-step mapping/alignment
- Nuclei deformation reveals pressure distributions in 3D cell clusters
- Strategies for increasing diagnostic yield of community-onset bacteraemia within the emergency department: A retrospective study
- Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry
- Certified service dogs – A cost-effectiveness analysis appraisal
- Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy
- Assessing the impact of a research funder’s recommendation to consider core outcome sets
- Validity of six consumer-level activity monitors for measuring steps in patients with chronic heart failure
- Detection of deceptive motions in rugby from visual motion cues
- The impact of antenatal care on neonatal mortality in sub-Saharan Africa: A systematic review and meta-analysis
- Epidemiological investigation and management of bloody diarrhea among children in India
- Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation
- Bacteria isolated from Bengal cat (Felis catus × Prionailurus bengalensis) anal sac secretions produce volatile compounds potentially associated with animal signaling
- Petri net–based model of the human DNA base excision repair pathway
- Complexation and conformation of lead ion with poly-γ-glutamic acid in soluble state
- The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- The Youth-Physical Activity Towards Health (Y-PATH) intervention: Results of a 24 month cluster randomised controlled trial
- The COPD multi-dimensional phenotype: A new classification from the STORICO Italian observational study
- Morphological identification of Amphitetranychus species (Acari: Tetranychidae) with crossbreeding, esterase zymograms and DNA barcode data
- Maintaining hope after a disabling stroke: A longitudinal qualitative study of patients’ experiences, views, information needs and approaches towards making treatment decisions
- Cultural differences in the use of acoustic cues for musical emotion experience
- Effects of a rifampicin pre-treatment on linezolid pharmacokinetics
- High prevalence of multidrug resistant Enterobacteriaceae among residents of long term care facilities in Amsterdam, the Netherlands
- Infection/inflammation-associated preterm delivery within 14 days of presentation with symptoms of preterm labour: A multivariate predictive model
- Prognostic value of preoperative hydronephrosis in patients with bladder cancer undergoing radical cystectomy: A meta-analysis
- Correction: Early life predictors of midlife allostatic load: A prospective cohort study
- PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations
- Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments
- Symbiotic incompatibility between soybean and Bradyrhizobium arises from one amino acid determinant in soybean Rj2 protein
- Does anticoagulation needed for distally located incidental pulmonary thromboembolism in patients with active cancer?
- Control of human testis-specific gene expression
- Speaking up culture of medical students within an academic teaching hospital: Need of faculty working in patient safety
- Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations
- Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study
- Results of scoping review do not support mild traumatic brain injury being associated with a high incidence of chronic cognitive impairment: Commentary on McInnes et al. 2017
- Native seed, soil and atmosphere respond to boreal forest topsoil (LFH) storage
- Development of a quantitative polymerase chain reaction assay and environmental DNA sampling methods for Giant Gartersnake (Thamnophis gigas)
- Genetic diversity and population structure of four Chinese rabbit breeds
- Knowledge, attitude and behaviors towards patients with mental illness: Results from a national Lebanese study
- Correction: An impact evaluation of two rounds of mass drug administration on the prevalence of active trachoma: A clustered cross sectional survey
- Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Graph convolutional network approach applied to predict hourly bike-sharing demands considering spatial, temporal, and global effects
- Impact of traffic variability on geographic accessibility to 24/7 emergency healthcare for the urban poor: A GIS study in Dhaka, Bangladesh
- Feeling the heat: Elevated temperature affects male display activity of a lekking grassland bird
- Constructing a comprehensive disaster resilience index: The case of Italy
- Intraocular pressure according to different types of tonometry (non-contact and Goldmann applanation) in patients with different degrees of bilateral tearing
- Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus
- Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging
- Nonverbal synchrony in virtual reality
- Do speed cameras reduce road traffic collisions?
- A zero-shot learning approach to the development of brain-computer interfaces for image retrieval
- Use of non-HIV medication among people living with HIV and receiving antiretroviral treatment in Côte d’Ivoire, West Africa: A cross-sectional study
- DNA barcoding of southern African crustaceans reveals a mix of invasive species and potential cryptic diversity
- Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay
- Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs
- Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6
- Transport oil product consumption and GHG emission reduction potential in China: An electric vehicle-based scenario analysis
- Ontogenetic shift in the energy allocation strategy and physiological condition of larval plaice (Pleuronectes platessa)
- Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Diagnostic accuracy of Xpert MTB/RIF assay and non-molecular methods for the diagnosis of tuberculosis lymphadenitis
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
- Spatial distribution of breast cancer in Sudan 2010-2016
- Human-induced fire regime shifts during 19th century industrialization: A robust fire regime reconstruction using northern Polish lake sediments
- Enhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions
- Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
- Iron and manganese co-limit growth of the Southern Ocean diatom Chaetoceros debilis
- Bilateral and unilateral load-velocity profiling in a machine-based, single-joint, lower body exercise
- Veterans Health Administration nurses’ training and beliefs related to care of patients with traumatic brain injury
- Supplementation strategies affect the feed intake and performance of grazing replacement heifers
- Active transcutaneous bone conduction hearing implants: Systematic review and meta-analysis
- Parameterization-induced uncertainties and impacts of crop management harmonization in a global gridded crop model ensemble
- Acidification effects on isolation of extracellular vesicles from bovine milk
- GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve
- Mining version history to predict the class instability
- Humpback whale song occurrence reflects ecosystem variability in feeding and migratory habitat of the northeast Pacific
- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes
- Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading
- Reconstructing systematic persistent impacts of promotional marketing with empirical nonlinear dynamics
- Trans-national conservation and infrastructure development in the Heart of Borneo
- Prediction of cardiovascular disease risk among people with severe mental illness: A cohort study
- Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
- Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
- Reconstructing birth in Australopithecus sediba
- Value of contrast-enhanced ultrasound for preoperative assessment of liver reserve function in patients with liver tumors
- Correction: Identifying obesity/overweight status in children and adolescents; A cross-sectional medical record review of physicians’ weight screening practice in outpatient clinics, Saudi Arabia
- Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program
- Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
- Functional role and evolutionary contributions of floral gland morphoanatomy in the Paleotropical genus Acridocarpus (Malpighiaceae)
- On the efficiency of HIV transmission: Insights through discrete time HIV models
- Metabolic cost calculations of gait using musculoskeletal energy models, a comparison study
- Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype
- Evolutionary analysis of six chloroplast genomes from three Persea americana ecological races: Insights into sequence divergences and phylogenetic relationships
- Cultural transmission in a food preparation task: The role of interactivity, innovation and storytelling
- Correction: Effects of affective priming through music on the use of emotion words
- Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial
- Estimation of vaccination coverage from electronic healthcare records; methods performance evaluation – A contribution of the ADVANCE-project
- Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation
- Suicide by hanging: Results from a national survey in Switzerland and its implications for suicide prevention
- Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders
- Genome wide genetic dissection of wheat quality and yield related traits and their relationship with grain shape and size traits in an elite × non-adapted bread wheat cross
- Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
- Factors influencing the admission decision for Medical Psychiatry Units: A concept mapping approach
- Comparison of post-traumatic changes in circulating and bone marrow leukocytes between BALB/c and CD-1 mouse strains
- Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)
- Associations between birth order with mental wellbeing and psychological distress in midlife: Findings from the 1970 British Cohort Study (BCS70)
- Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
- The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
- Ancient technology and punctuated change: Detecting the emergence of the Edomite Kingdom in the Southern Levant
- Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- Randomized control trial of Tools of the Mind: Marked benefits to kindergarten children and their teachers
- Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration
- PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age
- Correction: Unraveling the genetic complexity underlying sorghum response to water availability
- Impact of tear metrics on the reliability of perimetry in patients with dry eye
- Using DNA barcoding to improve invasive pest identification at U.S. ports-of-entry
- Correction: Effects of Lactobacillus plantarum 15-1 and fructooligosaccharides on the response of broilers to pathogenic Escherichia coli O78 challenge
- Physico-chemical characterization and transcriptome analysis of 5-methyltryptophan resistant lines in rice
- Patient factors affecting successful linkage to treatment in a cervical cancer prevention program in Kenya: A prospective cohort study
- Is this a man’s world? The effect of gender diversity and gender equality on firm innovativeness
- Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit—The PROSACAB study
- Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock
- Quantitation of free glycation compounds in saliva
- Resolving an 87-year-old taxonomical curiosity with the description of Psylla frodobagginsi sp. nov. (Hemiptera: Sternorrhyncha: Psyllidae), a second distinct Psylla species on the New Zealand endemic plant kōwhai
- The effect of cathodal tDCS on fear extinction: A cross-measures study
- Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome
- Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells
- Investigating the dispersal of antibiotic resistance associated genes from manure application to soil and drainage waters in simulated agricultural farmland systems
- Continuous norming of psychometric tests: A simulation study of parametric and semi-parametric approaches
- Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method
- Cost-effectiveness of apixaban compared to other anticoagulants in patients with atrial fibrillation in the real-world and trial settings
- Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia
- Low genetic differentiation yet high phenotypic variation in the invasive populations of Spartina alterniflora in Guangxi, China
- A mathematical model for designing networks of C-Reactive Protein point of care testing
- Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis
- Femtosecond laser induced step-like structures inside transparent hydrogel due to laser induced threshold reduction
- From In Situ to satellite observations of pelagic Sargassum distribution and aggregation in the Tropical North Atlantic Ocean
- The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology
- BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis
- HIV prevalence and risk behavior among male and female adults screened for enrolment into a vaccine preparedness study in Maputo, Mozambique
- Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
- Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing
- Occurrence mechanism and coping paths of accidents of highly aggregated tourist crowds based on system dynamics
- Correction: Low Dose Aerosol Fitness at the Innate Phase of Murine Infection Better Predicts Virulence amongst Clinical Strains of Mycobacterium tuberculosis
- Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats
- Correction: Public reaction to Chikungunya outbreaks in Italy—Insights from an extensive novel data streams-based structural equation modeling analysis
- Correction: Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer’s dementia
- Intra-individual variability of sleep and nocturnal cardiac autonomic activity in elite female soccer players during an international tournament
- Therapeutic efficacy of equine botulism heptavalent antitoxin against all seven botulinum neurotoxins in symptomatic guinea pigs
- Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis
- Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis
- Scope and efficacy of the broad-spectrum topical antiseptic choline geranate
- Hematological and biochemical parameters for Chinese rhesus macaque
- Veterinary peer study groups as a method of continuous education—A new approach to identify and address factors associated with antimicrobial prescribing
- Correction: The prognosis of heart failure patients: Does sodium level play a significant role?
- Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin
- Systematic identification of facility-based stillbirths and neonatal deaths through the piloted use of an adapted RAPID tool in Liberia and Nepal
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis
- Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal population
- Reasons to care: Personal motivation as a key factor in the practice of the professional foster carer in Romania
- Determinants of clinical, functional and personal recovery for people with schizophrenia and other severe mental illnesses: A cross-sectional analysis
- Continuity of care for TB patients at a South African hospital: A qualitative participatory study of the experiences of hospital staff
- EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling
- The Better Management of Patients with Osteoarthritis Program: Outcomes after evidence-based education and exercise delivered nationwide in Sweden
- The negative effects of short-term extreme thermal events on the seagrass Posidonia oceanica are exacerbated by ammonium additions
- Pathogen invasion history elucidates contemporary host pathogen dynamics
- Chinese herbal formulae for the treatment of menopausal hot flushes: A systematic review and meta-analysis
- Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery
- Deconstruction of central line insertion guidelines based on the positive deviance approach—Reducing gaps between guidelines and implementation: A qualitative ethnographic research
- PBMCs transcriptome profiles identified breed-specific transcriptome signatures for PRRSV vaccination in German Landrace and Pietrain pigs
- The impact of admission serum lactate on children with moderate to severe traumatic brain injury
- Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface
- Determination of the bruise degree for cherry using Vis-NIR reflection spectroscopy coupled with multivariate analysis
- Genome-wide identification and expression profile analysis of nuclear factor Y family genes in Sorghum bicolor L. (Moench)
- Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007–2016: A retrospective cohort study
- Distribution of the Duffy genotypes in Malaysian Borneo and its relation to Plasmodium knowlesi malaria susceptibility
- Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
- A self-adaptive deep learning method for automated eye laterality detection based on color fundus photography
- The effect of child marriage on the utilization of maternal health care in Nepal: A cross-sectional analysis of Demographic and Health Survey 2016
- Identification of QTLs for powdery mildew (Podosphaera aphanis; syn. Sphaerotheca macularis f. sp. fragariae) susceptibility in cultivated strawberry (Fragaria ×ananassa)
- Chemical volatiles present in cotton gin trash: A by-product of cotton processing
- PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils
- Differential metabolomics networks analysis of menopausal status
- Experimental study of the temporal profile of breath alcohol concentration in a Chinese population after a light meal
- Association between regional brain volumes and BMI z-score change over one year in children
- Relationships between Potentially Toxic Elements in intertidal sediments and their bioaccumulation by benthic invertebrates
- Long-term outcomes of dialysis in patients with chronic kidney disease and new-onset atrial fibrillation: A population-based cohort study
- Hospital burden of pulmonary arterial hypertension in France
- Understanding the variability of Australian fire weather between 1973 and 2017
- Photon-counting cine-cardiac CT in the mouse
- Ecophysiological impacts of Esca, a devastating grapevine trunk disease, on Vitis vinifera L.
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- Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae
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- Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
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- Genetic evidence for plural introduction pathways of the invasive weed Paterson’s curse (Echium plantagineum L.) to southern Australia
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- Retraction: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection
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- Correction: A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk
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- Correction: Permissivity of Primary Human Hepatocytes and Different Hepatoma Cell Lines to Cell Culture Adapted Hepatitis C Virus
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- Correction: In vitro larval rearing protocol for the stingless bee species Melipona scutellaris for toxicological studies
- Correction: Morphological and molecular identification of the dioecious “African species Volvox rousseletii (Chlorophyceae) in the water column of a Japanese lake based on field-collected and cultured materials
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- Expression of Concern: miRNA 17 Family Regulates Cisplatin-Resistant and Metastasis by Targeting TGFbetaR2 in NSCLC
- Group leaders establish cooperative norms that persist in subsequent interactions
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- Agreement between the Cochrane risk of bias tool and Physiotherapy Evidence Database (PEDro) scale: A meta-epidemiological study of randomized controlled trials of physical therapy interventions
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- The performance of different case definitions for severe influenza surveillance among HIV-infected and HIV-uninfected children aged <5 years in South Africa, 2011–2015
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- Different levels of statistical learning - Hidden potentials of sequence learning tasks
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- National trends in inpatient endometriosis admissions: Patients, procedures and outcomes, 2006−2015
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- Implicit learning of artificial grammatical structures after inferior frontal cortex lesions
- Potential survival benefits from optimized chemotherapy implementation in advanced ovarian cancer: Projections from a microsimulation model
- Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in Malaysia
- Heat stress responses in a large set of winter wheat cultivars (Triticum aestivum L.) depend on the timing and duration of stress
- Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model
- Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissues
- Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia
- Evaluation of suitable reference genes in Brassica juncea and its wild relative Camelina sativa for qRT-PCR analysis under various stress conditions
- Time-related immunomodulation by stressors and corticosterone transdermal application in toads
- Machine learning discovery of longitudinal patterns of depression and suicidal ideation
- Multi-scale patterns of tick occupancy and abundance across an agricultural landscape in southern Africa
- A matter of taste: Spatial and ontogenetic variations on the trophic ecology of the tiger shark at the Galapagos Marine Reserve
- Retraction: Adaptive double threshold energy detection based on Markov model for cognitive radio
- Adrenal gland size in obstructive sleep apnea: Morphological assessment of hypothalamic pituitary adrenal axis activity
- Out-of-pocket health spending among Medicare beneficiaries: Which chronic diseases are most costly?
- A large-scale chromosomal inversion is not associated with life history development in rainbow trout from Southeast Alaska
- Deployment, suicide, and overdose among comorbidity phenotypes following mild traumatic brain injury: A retrospective cohort study from the Chronic Effects of Neurotrauma Consortium
- Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data
- Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
- A quantitative approach for the analysis of clinician recognition of acute respiratory distress syndrome using electronic health record data
- Morphological, microbiological and ultrastructural aspects of sepsis by Aeromonas hydrophila in Piaractus mesopotamicus
- Recidivism rates in individuals receiving community sentences: A systematic review
- The association of intensive care with utilization and costs of outpatient healthcare services and quality of life
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- Explaining age-related decline in theory of mind: Evidence for intact competence but compromised executive function
- Role of GDF15 in methylseleninic acid-mediated inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
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- Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits
- Barriers and enablers to the implementation of a complex quality improvement intervention for acute kidney injury: A qualitative evaluation of stakeholder perceptions of the Tackling AKI study
- Soil and vegetation conditions changes following the different sand dune restoration measures on the Zoige Plateau
- Experimental H1N1pdm09 infection in pigs mimics human seasonal influenza infections
- Emission characteristics of diethylhexyl phthalate (DEHP) from building materials determined using a passive flux sampler and micro-chamber
- Multi-focus microscope with HiLo algorithm for fast 3-D fluorescent imaging
- Pontoscolex corethrurus: A homeless invasive tropical earthworm?
- Modeling reciprocal effects in medical research: Critical discussion on the current practices and potential alternative models
- Does palliative chemotherapy really palliate and are we measuring it correctly? A mixed methods longitudinal study of health related quality of life in advanced soft tissue sarcoma
- Developing cookies formulated with goat cream enriched with conjugated linoleic acid
- The effects of combining focus of attention and autonomy support on shot accuracy in the penalty kick
- Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: A cross-sectional study
- A combined strategy of neuropeptide prediction and tandem mass spectrometry identifies evolutionarily conserved ancient neuropeptides in the sea anemone Nematostella vectensis
- Lipidome profiles of postnatal day 2 vaginal swabs reflect fat composition of gilt’s postnatal diet
- Antitumor activity of a novel dual functional podophyllotoxin derivative involved PI3K/AKT/mTOR pathway
- Genome-wide developed microsatellites reveal a weak population differentiation in the hoverfly Eupeodes corollae (Diptera: Syrphidae) across China
- Prognosis of severe acquired brain injury: Short and long-term outcome determinants and their potential clinical relevance after rehabilitation. A comprehensive approach to analyze cohort studies
- An in silico investigation of menthol metabolism
- Variant analysis pipeline for accurate detection of genomic variants from transcriptome sequencing data
- Identification of candidate flowering and sex genes in white Guinea yam (D. rotundata Poir.) by SuperSAGE transcriptome profiling
- Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation
- The quality of guidelines for diabetic foot ulcers: A critical appraisal using the AGREE II instrument
- Mastitis risk effect on the economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study
- Confounding by indication of the safety of de-escalation in community-acquired pneumonia: A simulation study embedded in a prospective cohort
- Effects from diet-induced gut microbiota dysbiosis and obesity can be ameliorated by fecal microbiota transplantation: A multiomics approach
- Drivers of HIV-1 transmission: The Portuguese case
- Integration of a FT expression cassette into CRISPR/Cas9 construct enables fast generation and easy identification of transgene-free mutants in Arabidopsis
- A biface production older than 600 ka ago at Notarchirico (Southern Italy) contribution to understanding early Acheulean cognition and skills in Europe
- Mass evacuation and increases in long-term care benefits: Lessons from the Fukushima nuclear disaster
- Circulating levels of free 25(OH)D increase at the onset of rheumatoid arthritis
- The expression of equine keratins K42 and K124 is restricted to the hoof epidermal lamellae of Equus caballus
- Soil respiration from fields under three crop rotation treatments and three straw retention treatments
- Inhibition of polymerase chain reaction: Pathogen-specific controls are better than human gene amplification
- Linkage disequilibrium and haplotype block patterns in popcorn populations
- Downscaling satellite soil moisture using geomorphometry and machine learning
- Choosing efficient actions: Deciding where to walk
- The zooarchaeology and isotopic ecology of the Bahamian hutia (Geocapromys ingrahami): Evidence for pre-Columbian anthropogenic management
- Synergy of the flow behaviour and disperse phase of cellulose nanoparticles in enhancing oil recovery at reservoir condition
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- Human papillomavirus infection among head and neck squamous cell carcinomas in southern China
- Comparison of feature point detectors for multimodal image registration in plant phenotyping
- Quartet-based inference of cell differentiation trees from ChIP-Seq histone modification data
- Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform
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- Comparing record linkage software programs and algorithms using real-world data
- Antimicrobial resistance and molecular genotyping of Salmonella enterica serovar Enteritidis clinical isolates from Guizhou province of Southwestern China
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- Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice – Vie-KinD study
- The genome of Alcaligenes aquatilis strain BU33N: Insights into hydrocarbon degradation capacity
- A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome
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- Effect of PEPFAR funding policy change on HIV service delivery in a large HIV care and treatment network in Nigeria
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- An overview of the quality assurance programme for HIV rapid testing in South Africa: Outcome of a 2-year phased implementation of quality assurance program
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- Tipping the balance towards long-term retention in the HIV care cascade: A mixed methods study in southern Mozambique
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- Preferences for formal and traditional sources of childbirth and postnatal care among women in rural Africa: A systematic review
- Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix)
- Associations between industry involvement and study characteristics at the time of trial registration in biomedical research
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- Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1
- The predictive performance of SAPS 2 and SAPS 3 in an intermediate care unit for internal medicine at a German university transplant center; A retrospective analysis
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- Multiple biomarkers of sepsis identified by novel time-lapse proteomics of patient serum
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- Use of high-content analysis and machine learning to characterize complex microbial samples via morphological analysis
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- Characterization of a new composite membrane for point of need paper-based micro-scale microbial fuel cell analytical devices
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- Improved ICU mortality prediction based on SOFA scores and gastrointestinal parameters
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- The diagnostic value of pleural fluid homocysteine in malignant pleural effusion
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- Factors associated with burnout amongst healthcare workers providing HIV care in Malawi
- A high-density exome capture genotype-by-sequencing panel for forestry breeding in Pinus radiata
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- A prospective randomized trial on abacavir/lamivudine plus darunavir/ritonavir or raltegravir in HIV-positive drug-naïve patients with CD4<200 cells/uL (the PRADAR study)
- Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
- Multi-dimensional evaluation of response to salt stress in wheat
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- Enhanced mechanical and thermal properties of electrically conductive TPNR/GNP nanocomposites assisted with ultrasonication
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- Maternal cardiovascular-related single nucleotide polymorphisms, genes, and pathways associated with early-onset preeclampsia
- A ten-year review of ESBL and non-ESBL Escherichia coli bloodstream infections among children at a tertiary referral hospital in South Africa
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- Dynamic mechanical characteristics and failure mode of serpentine under a three-dimensional high static load and frequent dynamic disturbance
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- Regulation of NF-κB- and STAT1-mediated plasmacytoid dendritic cell functions by A20
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- New space-time block codes from spectral norm
- Mexican BRCA1 founder mutation: Shortening the gap in genetic assessment for hereditary breast and ovarian cancer patients
- GIVE me your attention: Differentiating goal identification and goal execution components of the anti-saccade effect
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- The accuracy of the frontal extent in stereoscopic environments: A comparison of direct selection and virtual cursor techniques
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- Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling
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- Antifungal effects of a 1,3,4-thiadiazole derivative determined by cytochemical and vibrational spectroscopic studies
- Risk factors for unsuccessful tuberculosis treatment outcomes in children
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- Reliability of high-resolution ultrasound and magnetic resonance arthrography of the shoulder in patients with sports-related shoulder injuries
- Spatial-temporal variation characteristics and evolution of the global industrial robot trade: A complex network analysis
- Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
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- Injury severity level and associated factors among road traffic accident victims attending emergency department of Tirunesh Beijing Hospital, Addis Ababa, Ethiopia: A cross sectional hospital-based study
- How chimpanzees (Pan troglodytes) share the spoils with collaborators and bystanders
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- Learning to assist smokers through encounters with standardized patients: An innovative training for physicians in an Eastern European country
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- The risk, perceived and actual, of developing type 2 diabetes mellitus for mothers of preschool children in urban China
- Effects of turning frequency on the nutrients of Camellia oleifera shell co-compost with goat dung and evaluation of co-compost maturity
- Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers
- Distribution of SET/I2PP2A protein in gastrointestinal tissues
- Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs
- Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study
- Anatomy of a demand shock: Quantitative analysis of crowding in hospital emergency departments in Victoria, Australia during the 2009 influenza pandemic
- Oregano essential oil vapour prevents Plasmopara viticola infection in grapevine (Vitis Vinifera) and primes plant immunity mechanisms
- Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism
- Optimising poly(lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach
- Repetitive finger movement and circle drawing in persons with Parkinson’s disease
- The association between family members’ migration and cognitive function among people left behind in China
- Association between long-term adherence to class-I recommended medications and risk for potentially preventable heart failure hospitalizations among younger adults
- Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals
- Agreement between the spatiotemporal gait parameters from two different wearable devices and high-speed video analysis
- In-hospital cardiopulmonary resuscitation of patients with cirrhosis: A population-based analysis
- Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes
- Someone like me: Size-assortative pairing and mating in an Amazonian fish, sailfin tetra Crenuchus spilurus
- Seasonality of antenatal care attendance, maternal dietary intake, and fetal growth in the VHEMBE birth cohort, South Africa
- Are trials of psychological and psychosocial interventions for schizophrenia and psychosis included in the NICE guidelines pragmatic? A systematic review
- Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
- Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes
- Intensity modulated radiation therapy following lumpectomy in early-stage breast cancer: Patterns of use and cost consequences among Medicare beneficiaries
- The ‘Saw but Forgot’ error: A role for short-term memory failures in understanding junction crashes?
- Multiscale Modelling Tool: Mathematical modelling of collective behaviour without the maths
- A comparison of machine learning algorithms for the surveillance of autism spectrum disorder
- Drivers of deforestation in the basin of the Usumacinta River: Inference on process from pattern analysis using generalised additive models
- Structure of Dictyostelium discoideum telomeres. Analysis of possible replication mechanisms
- Multidrug-resistant profile and prevalence of extended spectrum β-lactamase and carbapenemase production in fermentative Gram-negative bacilli recovered from patients and specimens referred to National Reference Laboratory, Addis Ababa, Ethiopia
- Primary myelofibrosis marrow-derived CD14+/CD34- monocytes induce myelofibrosis-like phenotype in immunodeficient mice and give rise to megakaryocytes
- Intersubject MVPD: Empirical comparison of fMRI denoising methods for connectivity analysis
- Why Cohen’s Kappa should be avoided as performance measure in classification
- A novel strategy for interpreting the T-SPOT.TB test results read by an ELISPOT plate imager
- Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer’s patients
- NPHP proteins are binding partners of nucleoporins at the base of the primary cilium
- Intensive measures of luminescence in GaN/InGaN heterostructures
- The effect of a web-based training for improving primary health care providers’ knowledge about diabetes mellitus management in rural China: A pre-post intervention study
- Isolation, identification and characterization of Streptomyces metabolites as a potential bioherbicide
- Quantitative magnetic resonance imaging indicates brain tissue alterations in patients after liver transplantation
- DNA analysis of Castanea sativa (sweet chestnut) in Britain and Ireland: Elucidating European origins and genepool diversity
- Forecasting the impact of population ageing on tuberculosis incidence
- Conformation and mechanical property of rpoS mRNA inhibitory stem studied by optical tweezers and X-ray scattering
- Voxelwise statistical methods to localize practice variation in brain tumor surgery
- Identification and evolutionary characterization of salt-responsive transcription factors in the succulent halophyte Suaeda fruticosa
- Integrating temperature-dependent life table data into Insect Life Cycle Model for predicting the potential distribution of Scapsipedus icipe Hugel & Tanga
- Rollout of ShangRing circumcision with active surveillance for adverse events and monitoring for uptake in Kenya
- Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures
- Analyzing a networked social algorithm for collective selection of representative committees
- Gene expression profiling of skeletal myogenesis in human embryonic stem cells reveals a potential cascade of transcription factors regulating stages of myogenesis, including quiescent/activated satellite cell-like gene expression
- Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components
- EFForTS-LGraf: A landscape generator for creating smallholder-driven land-use mosaics
- Impact of the severity of negative energy balance on gene expression in the subcutaneous adipose tissue of periparturient primiparous Holstein dairy cows: Identification of potential novel metabolic signals for the reproductive system
- Precision and consistency of the passive leg raising maneuver for determining fluid responsiveness with bioreactance non-invasive cardiac output monitoring in critically ill patients and healthy volunteers
- Optimizing bacterial DNA extraction in urine
- Adherences to oral nutritional supplementation among hospital outpatients: An online cross-sectional survey in Japan
- Effects of inorganic nitrogen and litters of Masson Pine on soil organic carbon decomposition
- Antioxidant properties of potato tubers (Solanum tuberosum L.) as a consequence of genetic potential and growing conditions
- Transcatheter aortic valve implantation versus conservative management for severe aortic stenosis in real clinical practice
- “I put it in my head that the supplement would help me”: Open-placebo improves exercise performance in female cyclists
- Automated diagnosis of heart valve degradation using novelty detection algorithms and machine learning
- Spatiotemporal clustering of malaria in southern-central Ethiopia: A community-based cohort study
- Studying the link between physiological performance of Crotalaria ochroleuca and the distribution of Ca, P, K and S in seeds with X-ray fluorescence
- Characterization of bony changes localized to the cervical articular processes in a mixed population of horses
- Heat shock-induced chaperoning by Hsp70 is enabled in-cell
- Disability and its association with sociodemographic factors among elderly persons residing in an urban resettlement colony, New Delhi, India
- Correlates of prenatal and postnatal mother-to-infant bonding quality: A systematic review
- IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma
- Dietary supplementation with the extract from Eucommia ulmoides leaves changed epithelial restitution and gut microbial community and composition of weanling piglets
- How did that interaction make you feel? The relationship between quality of everyday social experiences and emotion in people with and without schizophrenia
- Effects of Lyse-It on endonuclease fragmentation, function and activity
- Overexpression of rice gene OsATG8b confers tolerance to nitrogen starvation and increases yield and nitrogen use efficiency (NUE) in Arabidopsis
- Gait can reveal sleep quality with machine learning models
- Blast vacuolization in AML patients indicates adverse-risk AML and is associated with impaired survival after intensive induction chemotherapy
- Mitochondrial fragmentation and network architecture in degenerative diseases
- Quadriceps muscle strength is a discriminant predictor of dependence in daily activities in nursing home residents
- Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds
- Skin-associated lactic acid bacteria from North American bullfrogs as potential control agents of Batrachochytrium dendrobatidis
- Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection
- The responses of extracellular enzyme activities and microbial community composition under nitrogen addition in an upland soil
- Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking
- Absolute pitch can be learned by some adults
- Anger while driving in Mexico City
- Glomerular hyperfiltration may be a novel risk factor of restrictive spirometry pattern: Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2015
- Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database
- Multiple evoked and induced alpha modulations in a visual attention task: Latency, amplitude and topographical profiles
- Heart rate variability reduction is related to a high amount of visceral adiposity in healthy young women
- Serum and urinary metabolomics and outcomes in cirrhosis
- Optimal threshold of adherence to lipid lowering drugs in predicting acute coronary syndrome, stroke, or mortality: A cohort study
- Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis
- How Knowledge Stock Exchanges can increase student success in Massive Open Online Courses
- CT-perfusion in peripheral arterial disease – Correlation with angiographic and hemodynamic parameters
- Pattern of health care utilization and traditional and complementary medicine use among Ebola survivors in Sierra Leone
- Respiratory variations in pulse pressure and photoplethysmographic waveform amplitude during positive expiratory pressure and continuous positive airway pressure in a model of progressive hypovolemia
- Dorsal tongue porphyrin autofluorescence and Candida saprophytism: A prospective observational study
- A usability study to improve a clinical decision support system for the prescription of antibiotic drugs
- Occurrence of and risk factors for extended-spectrum cephalosporin-resistant Enterobacteriaceae determined by sampling of all Norwegian broiler flocks during a six month period
- Healthcare facility-based strategies to improve tuberculosis testing and linkage to care in non-U.S.-born population in the United States: A systematic review
- Correction: Reward abundance interferes with error-based learning in a visuomotor adaptation task
- Correction: Potential user interest in new long-acting contraceptives: Results from a mixed methods study in Burkina Faso and Uganda
- Correction: Recombinant rabbit beta nerve growth factor production and its biological effects on sperm and ovulation in rabbits
- Critically ill patients with community-onset intraabdominal infections: Influence of healthcare exposure on resistance rates and mortality
- Validating a popular outpatient antibiotic database to reliably identify high prescribing physicians for patients 65 years of age and older
- Metabolisable energy content in canine and feline foods is best predicted by the NRC2006 equation
- Group conquers efficacy: Preschoolers’ imitation under conflict between minimal group membership and behavior efficacy
- Warmth and competence stereotypes about immigrant groups in Germany
- Social resistance drives persistent transmission of Ebola virus disease in Eastern Democratic Republic of Congo: A mixed-methods study
- ER stress activation in the intestinal mucosa but not in mesenteric adipose tissue is associated with inflammation in Crohn’s disease patients
- Enhancing percutaneous pedicle screw fixation with hydroxyapatite granules: A biomechanical study using an osteoporotic bone model
- Optimum plant density for crowding stress tolerant processing sweet corn
- Sign and goal tracker rats process differently the incentive salience of a conditioned stimulus
- Interocular symmetry, intraobserver repeatability, and interobserver reliability of cone density measurements in the 13-lined ground squirrel
- Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy
- Knowledge, attitudes and practices of livestock and aquaculture producers regarding antimicrobial use and resistance in Vietnam
- Scientific sinkhole: The pernicious price of formatting
- Resource consumption of multi-substance users in the emergency room: A neglected patient group
- Association between distress and knowledge among parents of autistic children
- Surgical approach for complete cochlear coverage in EAS-patients after residual hearing loss
- The impact of a rapid molecular identification test on positive blood cultures from critically ill with bacteremia: A pre-post intervention study
- Shortening duration of ertapenem in outpatient parenteral antimicrobial therapy for complicated urinary tract infections: A retrospective study
- Measurement and analysis of partial lightning currents in a head phantom
- Within species expressed genetic variability and gene expression response to different temperatures in the rotifer Brachionus calyciflorus sensu stricto
- Repeated transspinal stimulation decreases soleus H-reflex excitability and restores spinal inhibition in human spinal cord injury
- Expression of Concern: Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor
- Correlation of CT texture changes with treatment response during radiation therapy for esophageal cancer: An exploratory study
- Modeling spatial variation in density of golden eagle nest sites in the western United States
- Retraction: Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3
- Correction: In Porphyromonas gingivalis VimF Is Involved in Gingipain Maturation through the Transfer of Galactose
- Gibberellic acid in Citrus spp. flowering and fruiting: A systematic review
- Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey
- A novel therapeutic strategy for esophageal varices using endoscopic treatment combined with splenic artery embolization according to the Child-Pugh classification
- Correction: Development of a high-throughput assay to measure measles neutralizing antibodies
- Correction: Provider preference for payment method under a national health insurance scheme: A survey of health insurance-credentialed health care providers in Ghana
- Correction: Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis
- Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India
- Feed-forward visual processing suffices for coarse localization but fine-grained localization in an attention-demanding context needs feedback processing
- Level Set method-based two-dimensional numerical model for simulation of nonuniform open-channel flow
- Compared to non-drinkers, individuals who drink alcohol have a more favorable multisystem physiologic risk score as measured by allostatic load
- Effect of poor glycaemic control on plasma levels and activity of protein C, protein S, and antithrombin III in type 2 diabetes mellitus
- Retraction: IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
- Sugar transporters in Fabaceae, featuring SUT MST and SWEET families of the model plant Medicago truncatula and the agricultural crop Pisum sativum
- Prediction of lymphovascular space invasion in endometrial cancer using the 55-gene signature selected by DNA microarray analysis
- Research on multi-agent genetic algorithm based on tabu search for the job shop scheduling problem
- Diagnosing the current state of out-of-field teaching in high school science and mathematics
- Sensitivity of the fasciae to sex hormone levels: Modulation of collagen-I, collagen-III and fibrillin production
- Comorbidity of age-related macular degeneration with Alzheimer’s disease: A histopathologic case-control study
- Acute ex vivo changes in brain white matter diffusion tensor metrics
- Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock
- The effect of bacteria on planula-larvae settlement and metamorphosis in the octocoral Rhytisma fulvum fulvum
- Sodium alginate potentiates antioxidant defense and PR proteins against early blight disease caused by Alternaria solani in Solanum lycopersicum Linn.
- Ground reaction forces and muscle activity while walking on sand versus stable ground in individuals with pronated feet compared with healthy controls
- Correction: Roadway traffic crash prediction using a state-space model based support vector regression approach
- MET as resistance factor for afatinib therapy and motility driver in gastric cancer cells
- Genetic analysis and fine mapping of a qualitative trait locus wpb1 for albino panicle branches in rice
- Clinical features of pulmonary embolism in patients with lung cancer: A meta-analysis
- Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiota
- Factors restraining the population growth of Varroa destructor in Ethiopian honey bees (Apis mellifera simensis)
- Coastal proximity of populations in 22 Pacific Island Countries and Territories
- DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1
- Genetic characterization of Angiostrongylus larvae and their intermediate host, Achatina fulica, in Thailand
- Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy
- Influence of ocean circulation and the Kuroshio large meander on the 2018 Japanese eel recruitment season
- Growth response of the ichthyotoxic haptophyte, Prymnesium parvum Carter, to changes in sulfate and fluoride concentrations
- Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome
- Prognostic nomogram predicts overall survival in pulmonary large cell neuroendocrine carcinoma
- Microbiome profiling of the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae)
- Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
- Retraction: Impacts of rock properties on Danxia landform formation based on lithological experiments at Kongtongshan National Geopark, northwest China
- Correction: SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience
- Retraction: Plexin-B1 Activates NF-κB and IL-8 to Promote a Pro-Angiogenic Response in Endothelial Cells
- Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis
- Association between temperature, sunlight hours and alcohol consumption
- Using graph learning to understand adverse pregnancy outcomes and stress pathways
- Correction: The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?
- Surgical referral systems in low- and middle-income countries: A review of the evidence
- In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells
- Correction: The Economic Impact of Malignant Catarrhal Fever on Pastoralist Livelihoods
- Correction: Identification of miRNAs involved in fruit ripening by deep sequencing of Olea europaea L. transcriptome
- Correction: Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Correction: Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells
- Correction: Plant traits linked to field-scale flammability metrics in prescribed burns in Eucalyptus forest
- Correction: Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation
- Correction: To keep or not to keep? Decision making in adolescent pregnancies in Jamestown, Ghana
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