Urban growth simulation in different scenarios using the SLEUTH model: A case study of Hefei, East China
Authors:
Yunqiang Liu aff001; Long Li aff001; Longqian Chen aff001; Liang Cheng aff001; Xisheng Zhou aff001; Yifan Cui aff001; Han Li aff001; Weiqiang Liu aff001
Authors place of work:
School of Environmental Science and Spatial Informatics, China University of Mining and Technology, Xuzhou, Jiangsu, China
aff001; Engineering Research Center of Ministry of Education for Mine Ecological Restoration, China University of Mining and Technology, Xuzhou, Jiangsu, China
aff002; Department of Geography, Earth System Science, Vrije Universiteit Brussel, Brussels, Belgium
aff003; College of Yingdong Agricultural Science and Engineering, Shaoguan University, Shaoguan, Guangdong, China
aff004
Published in the journal:
PLoS ONE 14(11)
Category:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0224998
Summary
As uncontrolled urban growth has increasingly challenged the sustainable use of urban land, it is critically important to model urban growth from different perspectives. Using the SLEUTH (Slope, Land use, Exclusion, Urban, Transportation, and Hill-shade) model, the historical data of Hefei in 2000, 2005, 2010, and 2015 were collected and input to simulate urban growth from 2015 to 2040. Three different urban growth scenarios were considered, namely a historical growth scenario, an urban planning growth scenario, and a land suitability growth scenario. Prediction results show that by 2040 urban built-up land would increase to 1434 km2 in the historical growth scenario, to 1190 km2 in the urban planning growth scenario, and to 1217 km2 in the land suitability growth scenario. We conclude that (1) exclusion layers without effective limits might result in unreasonable prediction of future built-up land; (2) based on the general land use map, the urban growth prediction took the governmental policies into account and could reveal the development hotspots in urban planning; and (3) the land suitability scenario prediction was the result of the trade-off between ecological land and built-up land as it used the MCR -based (minimum cumulative resistance model) land suitability assessment result. It would help to form a compact urban space and avoid excessive protection of farmland and ecological land. Findings derived from this study may provide urban planners with interesting insights on formulating urban planning strategies.
Keywords:
Simulation and modeling – Roads – Soil ecology – Urban ecology – Land use – Urban areas – Grasslands – Spreading centers
Introduction
Recent decades have seen an accelerating urban growth on a global scale. By 2050, the average urbanization rate is expected to reach 86% in developed countries, and 64% in developing countries [1]. Since 1978, the beginning of its reform and opening-up policy, China has been urbanized at an unprecedented pace. China’s urbanization rate was only 20.1% in 1981 while this figure rose to 57.4% in 2016. Such high-speed urban growth is considered responsible for a variety of issues such as climate change, ecosystem services degradation, and farmland loss, and challenging to the sustainable use of urban land [2,3]. It is therefore of great practical significance to coordinate the contradiction between urbanization and ecological protection and establish a model to simulate and analyze urban growth.
There exist a variety of urban growth simulation models, such as logistical regression [4–6], and agent-based model [7], cellular automata (CA) [8]. The logistic regression model can well explain the relationship between urban growth and various driving factors [4]. However, it is not explicit in time and does not account for the correlation between driving factors [9]. Although the agent-based modeling has satisfactory applicability in urban growth simulation, the uncertainty of the initial conditions and the behavioral rules of the agent can produce highly variable simulation results [9,10]. Among all the models, CA is the most widely used urban growth modeling approach due mainly to its flexibility, visualization, and capability to integrate spatial and temporal processes and simulate complex dynamic systems [8,11]. In addition, CA models can directly use raster data and this allows easy integration with remote sensing and GIS technologies [12–16].
Several different CA-based urban models have been proposed for urban growth simulation, land use change simulation, and planning policy evaluation [17,18], such as UrbanSim [19], ANN -CA (artificial neural network) [20], SVM-CA (support vector machine) [21], RF-CA (random forest) [22], and SLEUTH model. The UrbanSim model has not been widely used as it integrates seven submodules and requires huge data support and high requirements for data organization [19]. Although the conversion rules of CA established by intelligent algorithms can explore the relationship between urban land use change and driving factors [23], the resulting conversion rules are only applicable to the local urban growth mode. Consequently, these models are not suited to define general urban CA [8]. The SLEUTH model, developed by Clarke et al. [24] with predefined conversion rules applied spatially to gridded maps of the cities in a set of nested loops [25], has been widely used to simulate the urban growth worldwide due to its universal applicability and refined over the past decades. In 2007, Dietzel and Clarke used self-organizing map theory to calibrate the model and proposed goodness of fit metric, OSM (Optimal SLEUTH Metric), which would provide the most robust results for SLEUTH calibration [26]. A new version of the SLEUTH model was developed in 2010 by introducing new fit metrics, expanding the capability of SLEUTH to incorporate policy information and increasing the speed of model calculations [27]. The SLEUTH model can help create different future urban growth scenarios by changing the input data or modifying the coefficients of the model [26,28,29]. In addition, the model can be used as an important planning tool to incorporate different urban development factors into future urban growth projections [30]. A number of studies have incorporated policy planning, environmental quality, and hydrological models into the model to achieve coupling of the SLEUTH model with other data sets or methods [31–33]. Given its success in urban growth simulation and capability of defining scenarios and integrating other data and models, we used the SLEUTH model in conjunction with policies and land assessment for the future urban growth studies.
Suitability evaluation of urban built-up land is critical for both urban growth and the proper utilization of land resources [34]. This study uses the minimum cumulative resistance (MCR) model to construct an urban land suitability evaluation system. The minimum cumulative resistance model regards the urban land use change as a horizontal movement of the existing construction and ecological land on the resistance surface, which is reflected in the competitive relationship between the built-up land and the ecological land during the urban growth process. It would be interesting if the result of the MCR-based ecological suitability evaluation could be integrated into the SLEUTH model as the exclusion layer.
The study selected the main urban area of Hefei as the study area. The input data of the SLEUTH model include urban built-up land layers and traffic road layers in 2000, 2005, 2010, and 2015, a slope layer, a hill-shade layer, and exclusion layers. By changing the exclusion layer of the SLEUTH model, three urban growth scenarios were developed, namely a historical growth scenario, an urban planning growth scenario, and a land suitability growth scenario. The historical growth scenario only excluded the water. The urban planning growth scenario incorporated the 2006–2020 general land use planning map. The land suitability growth scenario achieved loose coupling between the MCR model and the SLEUTH model. After the three scenarios were independently calibrated, and their optimal parameter combinations were identified, we predicted the urban growth of Hefei from 2015 to 2040 for each scenario. The ultimate objective of this study is to provide decision-makers and urban planners with interesting insights on formulating urban management and urban planning strategies through projections of urban growth in different scenarios.
Study area and data
Study area
Located in the center of east China’s Anhui province (30°57′N~32°32′N, 116°41′E~117°58′E) (Fig 1A), Hefei covers an area of 11408.48 km2 with an average altitude of 30 m. As the provincial capital, Hefei is also the cultural, commercial, financial, and political center of Anhui. It is characterized by a subtropical monsoon climate with an average annual temperature of 16°C and total annual precipitation of 995.2 mm. The prefectural city of Hefei now comprises four counties (Changfeng, Feidong, Feixi, and Lujiang), four districts (Yaohai, Luyang, Shusha, and Baohe), and one county-level city (Chaohu, once an Anhui’s prefectural city incorporated by Hefei in 2011).
Since 2000, a number of urban development strategies have been implemented, such as the major development, large construction, large development strategy in 2006, the “141” urban development strategy in 2007, and the “1331” development strategy in 2013, making Hefei’s economy and urban extent fast growing. Statistics from the 2000 official census show that the population and GDP (Gross Domestic Product) of Hefei in 2000 were 4.47 million and 369.16 billion RMB. These figures rose to 7.87 million and 5660.27 billion RMB in 2015, respectively. Over the 15 years, the built-up area grew by 250.56% from 125 km2 to 438 km2. Demand for built-up land continues to grow due to priority given to economic development and urban construction. Land resources and environmental capacity outnumber their supply [35]. Since limited land resources are hindering the sustainable development of urbanization, among Hefei's urgent tasks is to assess the suitability of construction sites and to make reasonable use of limited land resources. As the capital city of Anhui and one of the central cities in the Yangtze Delta Region, Hefei leads the urbanization process in this east Chinese province. In the context of the National New-type urbanization Plan [36], the experience of its urban development will provide valuable insights to its neighboring and similar cities. Therefore, we chose the urban growth process of Hefei from 2000 to 2015 as the case study.
Data
Data used in this study includes multi-temporal Landsat datasets, Digital Elevation Model (DEM) data, traffic network vector data, the 2006–2020 land use planning map of Anhui province, soil type map and precipitation map. The Landsat datasets and DEM, both at a spatial resolution of 30 m, were obtained from the United States Geological Survey website (USGS, https://earthexplorer.usgs.gov/). The soil and precipitation maps were provided by the Data Center for Resources and Environmental Sciences, Chinese Academy of Sciences (RESDC, http://www.resdc.cn/). The four Landsat TM image data from 2000, 2005, 2010, and 2015 were used for landscape classification. After atmospherically corrected using the FLAASH (Fast Line-of-sight Atmospheric Analysis of Spectral Hypercubes) utility in ENVI 5.3 and geometrically corrected with total RMS (root mean squared) of less than half a pixel, they were classified into six broad categories using the support vector machine (SVM) supervised classifier, namely urban built-up land, farmland, forestland, grassland, water, and other land. The SVM is a group of theoretically superior machine learning algorithms [37], and has proven accurate for mapping urban land cover from medium-resolution imagery [38–40]. The SVM classifications in this study were implemented using an ENVI add-in known as EnMAP-box [41]. To assess classification accuracy for the 2010 and 2015 classification results, we used high-resolution Google Earth images, where a total of 400 sample points were randomly selected as reference data using ArcGIS 10.2’s Create Random Points tool. By the confusion matrices, the Kappa coefficients were both above 0.8 for the 2010 and 2015 classification results. Due to the lack of high-resolution remote sensing images, we were not able to perform independent classification accuracy assessments for the results of 2000 and 2005. However, as the images were all Landsat data and processed and classified using the same procedure and approach, we thus consider that similar classification accuracies were obtained for the 2000 and 2005 images [42]. As such, the Kappa coefficients (>0.8) we obtained indicates that the classification results were acceptable [43]. All raster and vector data were clipped to the same extent of the study area (Fig 1B), and the projection coordinate system was uniformly set to WGS_1984_UTM_Zone_50N.
Methods
SLEUTH model
The SLEUTH model consists of two sub-models: the urban growth model (UGM), which can be run independently, and land cover deltatron model (LCD) [15]. The SLEUTH model requires a minimum of four periods of city-wide layers, two periods of transportation layers, slope layers, hill - shade layers, and exclusion layers [29]. Based on grid cells, the SLEUTH model assigns the attributes of the city or non-city to each cell and simulates urban growth by four conversion rules—spontaneous growth, new spreading center growth, edge growth, and road-influenced growth [24]. Spontaneous growth defines the occurrence of random urbanization of land, i.e., randomly selected non-urbanized cells may be transformed into urbanized cells when slope conditions are appropriate. An urban spreading center is defined as a location with three or more adjacent urbanized cells. New spreading center growth determines whether any of the new, spontaneously urbanized cells would become new urban spreading centers. Edge growth defines the growth of an existing spreading center, which simulates the urban's fill-in growth and the expansion of boundaries [24,28]. Road-influenced growth encourages urbanized cells to develop along road network, which simulates the impact of existing transportation infrastructure on urban growth. The mentioned four urban growth rules are performed sequentially in each growth cycle and are controlled by five growth coefficients [44], namely dispersion coefficient, breed coefficient, spread coefficient, road gravity coefficient, and slope coefficient. The relationship between the four growth rules and the five coefficients is shown in Table 1.
The execution of the SLEUTH model is divided into four major steps (Fig 2): input data preparation, model calibration, model prediction, and model output [45]. Three urban growth scenarios were planned by changing the exclusion layer, and both the calibration and prediction of the three scenarios were performed independently. We used the SLEUTH 3.0 beta_p01 module (http://www.ncgia.ucsb.edu/projects/gig/) and completed the model compilation and operation with the help of the software of Cygwin.
Input data preparation
The input data required by the SLEUTH model include the urban layer, the slope layer, the hill-shade layer, the transportation layer, and the exclusion layer. Since the study only activated the UGM module, the land use layer was not included in the input data. Through satellite image classification, we extracted the urban built-up land and used it as the urban layers for the years of 2000, 2005, 2010, and 2015 (Fig 3). Both the slope layer and the hill-shade layer were derived from the DEM, and the unit of the slope was percentage (Fig 4). The road network data was vectorized from the satellite images to produce the transportation layers, and the road grade information was determined using the traffic thematic map (Fig 5). As roads may have a different impact on urban growth [46], we divided roads into three levels and assigned different weights to them. A weight of 100 was given to national highways and railways as they are highly conducive to urban growth while the weight of provincial highways was set at 50 due to their medium influence. In addition, the weight of county roads and the non-road area were determined as 25 and 0 [29]. The exclusion layers were used to discriminate different urban growth scenarios. The spatial resolution of all input data was uniformly re-sampled to 60 m in order to reduce the computational workload. This research used the same spatial resolution in both the model calibration and prediction phases. As required by the SLEUTH model, all input layers were converted into grayscale GIF (graphics interchange format) images.
Scenario setting
The range of gray values for the exclusion layer grid cells was set to 0–100, and the gray pixel value indicates the probability of the grid cells not being urbanized. Using the exclusion layer, users can define the probability of urbanization for different areas [26]. For example, the exclusion probability of the ocean would be defined as 100%, while forest parks would be defined as 75%. In this way, users could set up different urban growth scenarios.
The most straightforward practice is setting the exclusion probability for all areas at 0, though sometimes except for major water bodies [13,29,47]. Another approach is assigning different exclusion probabilities to land use type according to urban planning [13,25,48]. Among them, high exclusion probability can be set for nature reserves, forest areas and waters to reflect the protection of ecological land. These two methods were used for constructing two scenarios in this study for urban growth prediction. However, the two scenarios do not emphasize the competition between built-up land and ecological land, which plays a key role in urban growth. We, therefore, made use of the minimum cumulative resistance (MCR) model to generate a different exclusion layer for constructing the third scenario. This study set up three different urban growth scenarios: a historical growth scenario, an urban planning growth scenario, and a land suitability growth scenario.
Scenario 1: In the historical growth scenario, existing urban areas are expected to expand simply based on the previous growth pattern. Only large lakes and reservoirs were excluded (100% non-urbanization probability) and urbanization in other areas was not restricted (Fig 6A).
Scenario 2: In the urban planning growth scenario on the 2006–2020 general land use planning map of Hefei is used as the basic data. By summarizing the influence of different land planning types on urban growth [39,41], each types of exclusion probability were determined. The exclusion probability of land permitted for construction (LPC; the land that is allowed to be used as construction land for urban and rural construction [49]) in urban areas and rural areas was defined as 0 while the exclusion probability of land conditionally permitted for construction (LCPC; the land where urban and rural construction can be carried out after meeting certain conditions [49]) was defined as 30%. The exclusion probability was defined as 60% for cultural heritage reserve, and 90% for basic farmland, forestry areas, animal husbandry areas, water areas, and natural reserves (Fig 6B).
Scenario 3: In the land suitability growth scenario, the result of the MCR-based urban land suitability zoning was integrated into the exclusion layer. While detailed land suitability zoning would more objectively reflect the impact of land suitability on urban expansion and avoid overestimation or underestimation of suitability in certain areas, the computational cost would be considerably increased. As a comprise between prediction accuracy and computational cost, we, therefore, divided the urban land suitability zoning map into 20 grades according to the order of suitability from small to large. The area of each level was evenly assigned the corresponding gray value ranging from 0 to 100 (Fig 6C). The following sections provide a detailed description on producing the exclusion layer for the land suitability growth scenario.
Minimum cumulative resistance model
Originating from the study of dispersion processes of species [50], the minimum cumulative resistance refers to the minimum cost involved in the process of crossing a heterogeneous landscape between a source and a target and reflects the spatial accessibility between the source and the target [51,52]. Some researchers have recently applied the MCR model to the studies of urban spatial growth and land ecological suitability evaluation [21]. Traditional ecological suitability evaluation methods, such as map superposition and logical rule combination, superimpose the evaluation factors of landscape units and emphasize the vertical process of landscape units while ignoring the trend of various landscape horizontal directions [53]. The MCR model regards land expansion as horizontal spatial movements on the resistance surface. As such, it offset the disadvantage of the traditional methods, i.e., only considering vertical landscape evaluation. Proposed by Knaapen et al., this model was improved by Yu et al. [54], which is given by:
Expansion source and resistance surface
In this study, we assumed that land could be divided into two broad categories: ecological land suitable for establishing natural ecosystems and built-up land suitable for urban facilities construction. The expansion of the two land types could be seen as a spatial movement on the ecological/built-up land expansion resistance surface.
a. Source selection. The source region with internal homogeneity and spatial expansion capability is the starting point for an expansion movement [56]. The source of ecological land expansion is set as land with rich biodiversity and ecosystem services, e.g., lakes, rivers, green spaces, and wetlands. The ecological land sources in the study area include Chaohu Lake, Wabu Lake, Dongpu reservoir, Dafang reservoir, Lushan Forest Park, Zipeng mountain forest park, and Fucha Mountain. The urban built-up land in 2015 was set as the source of built-up land expansion.
b. Resistance surface. A resistance value indicates the difficulty of converting a land type into another type under the influence of certain environmental factors [57]. The resistance value in the same environment varies with the type of expansion. The resistance value is a relative value rather than an absolute value. Five evaluation factors of topography, ecological function, landscape type, soil erosion sensitivity, and ecological value were selected to establish a landscape process resistance evaluation system [57–59]. The resistance value of each evaluation factor was divided into five levels, which were assigned 1, 2, 3, 4, and 5, respectively. A higher level means greater resistance to a certain expansion type. The expansion motion of the two sources was performed in the resistance plane of the same evaluation system, but the resistance values of the two resistance surfaces were opposite. As water and vegetation are essential indicators of ecological values, the normalized vegetation index (NDVI) and the distance from water bodies were analyzed using a classification matrix [57]. Soil erosion sensitivity accounted for slope, vegetation coverage, soil type, and precipitation. Areas with strong ecological functions such as nature reserve, forest parks, and basic farmland were given the high resistance to built-up land expansion. The resistance scores of each evaluation factor are shown in Table 2. In this study, the extremum method was used to form the ecological/built-up resistance surface. The minimum values of the five resistance factors were used as the expansion resistance of ecological land, and the maximum values were used as the expansion resistance of built-up land.
Assessment of land suitability
The MCR model was used to find the minimum cumulative resistance surface of two expansion type. This study assumes the change of land type as the result of mutual competition between ecological land expansion and built-up land expansion. To reflect the spatial demand competitive relationship between ecological land and built-up land, the difference between the minimum cumulative resistance of ecological land expansion and the minimum cumulative resistance of built-up land expansion was calculated in a GIS environment. The formula is as follows:
In Fig 7, Curve L and Curve P indicate the minimum cumulative resistance of ecological land expansion and built-up land expansion, respectively. Positive MCRdiff in the A area means that the expansion resistance of ecological land is greater than the expansion resistance of built-up land while negative MCRdiff in the B area means the opposite. In other words, a smaller MCRdiff suggests a more suitable area is for the expansion of ecological land and a larger the MCRdiff suggests a more suitable area for the expansion of built-up land. Arranged in ascending order of MCRdiff, the natural breaks (Jenks) classification method was used to divide the negative MCRdiff into ten levels, i.e., 1 to 10 levels, representing a gradual decrease in the suitability of ecological land expansion. Similarly, the positive MCRdiff was divided into 10 levels, i.e., 11 to 20 levels, representing to a gradual increase in the suitability of built-up land expansion. The minimum cumulative resistance surface of ecological land and built-up land and minimum cumulative resistance difference surface can be found in S1 Fig.
Model calibration and prediction
As the most important step in the SLEUTH modeling process [25], model calibration aims to derive an optimal combination of the five coefficients. Using the earliest urban extent layer as the seed layer, the optimal coefficient combination is used to effectively simulate the urban growth during a historical period. Model calibration is implemented through a multi-stage, automated, and sequential process using a forced Monte Carlo iterative method [60]. The calibration process is divided into three phases: coarse calibration, fine calibration, and final calibration. First, users determine the iteration interval and iteration step size of the coefficients in the coarse calibration phase. Then each possible coefficient combination is tested for its ability to reproduce the historical growth patterns that took place between the input data years [61]. In the fine calibration and final calibration phase, based on the coarse calibration results, the range of the model coefficients and the iteration step size are sequentially reduced, and the optimal coefficients values are finally identified.
In order to assess the degree of fitting between simulated urban growth and actual urban growth, the model produces eight least-squares regression estimates for the calibration of each coefficient combination, i.e. Compare, Population, Edges, Clusters, Lee Sallee, Slope, X-mean, and Y-mean (descriptions given in Table 3) [26]. For each set of parameter combinations in the Monte Carlo iteration, the model counts the measurements of the simulated urban extent of the control year in its time series. The measurements of the simulated urban extent are compared to the actual urban extent to produce multiple least squares regression measurements [29]. Lee Sallee, the ratio of the intersection and the union of the simulated and actual urban extent, is a measurement of spatial fit [62]. These statistics are calculated internally in the model and output as log files. Despite a variety of methods for reducing the iteration interval, none has been ever considered the most effective [16]. In this study, the optimal coefficient combination of each calibration phase was selected by the Optimal SLEUTH Metric (OSM) parameter. The OSM parameter (product of seven parameters of Compare, Population, Edges, Clusters, Slope, X-mean, and Y-mean) developed by Dietzel and Clarke can provide reliable calibration results for the SLEUTH model [6,12]. The calibration process of this study are described as follows:
Coarse calibration. The iteration range of coefficients was set from 0 to 100, the step size was set at 25, and the number of the Monte Carlo iterations was set at 4. The results of the calibration were sorted in ascending order of the OSM parameter, and the top three highest scoring results were used to narrow the iteration interval.
Fine calibration. The iteration interval was set based on the coarse calibration result. The step size was set at 5~15, and the number of the Monte Carlo iterations was set at 8. The coarse calibration work was repeated to get a new narrower iteration interval.
Final calibration. The final iteration interval was obtained from the fine calibration results. The step size was set at 1~2, and the number of the Monte Carlo iterations was set at 12. The coefficient combination with the highest OSM parameter was selected as the optimal coefficient combination.
Due to the self-modifying nature of the SLEUTH model, the initial coefficient combination of the model is changed during the simulation process. Therefore, the optimal coefficient combination for obtaining the final calibration was used as the starting and stopping values for the iteration interval, and 100 Monte Carlo iterations were performed to obtain the optimal results [15,29].
The calibration process resulted in the optimal coefficient combination for urban growth. These optimal coefficient combinations were incorporated into the prediction module of the model as initialization coefficients. In the model prediction phase, the 2015 urban built-up land was used as the seed layer, the number of the Monte Carlo iterations was set at 100, and the urbanization probability threshold was set at 50%~100%. Finally, the prediction module of the SLEUTH model was used to predict urban growth from 2015 to 2040 in the three growth scenarios.
Results
Model calibration
Using the historical data from 2000 to 2015, model calibration was separately performed for the three scenarios, each of which had its own exclusion layer. The results of model calibration for the three scenarios are given in Table 4, Table 5, and Table 6. The optimal coefficient combination was 100, 75, 64, 39, and 73 for dispersion, breed, spread, slope, and road gravity in Scenario 1, 98, 99, 100, 2, and 82 in Scenario 2, and was 99, 100, 100, 1, and 62 in Scenario 3. Parameter values for the three phases of the calibration mode (coarse, fine, final) for each scenario are presented in Tables 3–5, which lists the highest OSM value from thousands of model calibration runs. The OSM parameter increased from 0.785 to 0.788 in Scenairo1, from 0.564 to 0.576 in Scenario 2, and from 0.710 to 0.716 in Scenario 3. Each round of calibration produced a higher SOM value, indicating that the model calibration was valid.
A practicable way to assess the accuracy of the SLETUH model, as done in most of previous studies, is examining whether the model can reproduce a similar urban extent of a historical year. Table 3 shows the assessment of the model calibration for the three scenarios. The Comparison and Population parameters represent the similarity between the actual urban area and the predicted urban area based on the final year. The values of the Compare parameter for Scenario 1 and Scenario 3 reached 0.999 and 0.952 respectively, both higher than that for Scenario 2 (0.72). The values of the Population parameter were all above 0.99. The values of the Edges parameter, indicating the correlation between the urban edge of the actual year and the urban edge of the simulated year, were 0.83,0.85,0.83, and the values of the Clusters parameter were all above 0.99 for the three scenarios, showing the capability of the model to simulate accurately both the changes of urban shape and urban clusters. The values of the Lee-Salle parameter were overall slightly low (ranging from 0.35 to 0.43) but acceptable (0.3 ~ 0.7). The values of the X-mean parameter and Y-mean parameter were all above 0.97, showing the high correlation between the urbanized cells location of the actual year and the urban of the simulated year. The results of each parameters evaluation show that the calibration results have satisfactory simulation effects in terms of the urban area, urban shape, urban cluster, urban location, etc., which allows us to be confident in using the SLEUTH model to predict the urban extent in the year of 2040.
Model prediction
Using the 2015 urban area as the seed layer, we used the SLEUTH model to predict Hefei’s urban growth in 2040 in three different urban growth scenarios (Fig 8).
In the historical growth scenario (Fig 8A), the urban built-up land area in 2040 would increase to 1434 km2 and gain 748 km2 newly added built-up land compared with 2015, with an average annual urban growth rate of 3.12%. Such an increase would be at the expense of other types of land, e.g., farmland decreased by 13.89%, forest land decreased by 4.32%, and grassland decreased by 15.67% (Table 7). In this scenario, the exclusion layer only set water as non-urbanizable areas, with few restrictions on urban growth. The urban growth would be based entirely on the trends of historical growth. The urban boundary expansion would be obvious, and the expansion distance would be uniform. Newly added urban built-up land of large areas would occur along major traffic roads while much newly added urban built-up land of small areas would be scattered non-water areas.
In the urban planning growth scenario (Fig 8B), by 2040, the urban built-up area would increase to 1190 km2, an increase of 504 km2 over 2015, with an average annual urban growth rate of 2.32%. Compared with the prediction from Scenario 1, it is clear that less farmland, forest, and grassland would be lost. According to Hefei’s 2006–2020 general land use planning map, 46.05% of the newly added urban built-up land would be from the LPC and LCPC. Newly added urban built-up land would be concentrated in the hot spots for urban development Feidong Economic Development Area (east of the main urban area), the Shushan Economic Development Area (west of the main urban area), and the Hefei Economic and Technological Development Area (south of the main urban area).
In the land suitability growth scenario (Fig 8C), the urban built-up land area in 2040 would be 1217 km2—there would be 531 km2 of newly added urban built-up land with an average annual urban growth rate of 2.41%. The contributions of farmland, forestland, and grassland to the newly added urban built-up land in Scenario 3 are quite similar to those in Scenario 2. Due to the limitation of ecological suitability, the marginal expansion of urban would be not uniform. As far as the main urban area is concerned, the eastern and northeastern borders would be more vigorously expanded. The impact of the road network on urban growth would be significant but, unlike Scenario 1, the growth along the road network in this scenario would occur mostly in the suburbs of Hefei.
Discussion
Optimal coefficient combination
The optimal coefficient combination reveals the historical expansion patterns and constraints of the urban area and determines how the future urban growth would expand [13]. In previous research, the optimal coefficient combination from a simple exclusion layer, like Scenario 1, is often used by other complex scenarios [15,46]. In this case, the simulation from complex scenarios may be underestimated [64]. Thus, the three exclusion layers in this study were separately calibrated and predicted. The calibration results show that the optimal coefficient combination varies with different the scenario. In other words, model calibration is sensitive to the exclusion layer.
Between 2000 and 2015, Hefei accelerated the revival of existing townships and construction of new ones. This explains why the values of the Dispersion coefficients were high for all scenarios (Tables 3–5). According to the urban development strategy of Hefei, four urban groups were gradually formed in the east, north, west, and southwest of the main urban area of Hefei. This urban spatial structure was evident in the urban extent layer of the year 2010 (Fig 3C). The high values of the Breed coefficient reflect the new growth center growth as the main way of urban growth. Scenario 1 did not limit the expansion of the urban edge. The urban margins of Scenario 2 and Scenario 3, however, were set to different urbanization exclusion probabilities. Edge growth was greatly limited. Thus, the SLEUTH model countered the limitations of the exclusion layer on historical expansion trends in Scenario 2 and Scenario 3 by significantly increasing the Spread coefficient. Similarly, the Slope coefficient in Scenario 2 and Scenario 3 had dropped to a very low level to increase the probability of urbanization. The Slope coefficient of the three scenarios was relatively low, which shows that urban extent tends to grow in flat areas, and terrain is not a major obstacle to urban growth. The high values of the Road Gravity coefficient in the three scenarios implied the strong attraction of transportation to urban growth.
Impact of exclusion layer on prediction
As shown in Table 7 and Fig 8, the exclusion layer has a significant impact on the rate and spatial structure of urban growth. The speed of urban simulation growth under the three scenarios is lower than the historical expansion speed. In particular, the expansion of urban built-up land in Scenario 2 and Scenario 3 would be regulated, and farmland, forestland, and grassland would be overall protected. In terms of urban spatial pattern, the urban area predicted from Scenario 1 would be clearly not ideal, because the impact of spontaneous growth and road network on urban growth would be overestimated. Unconstrained exclusion layers in some cases may lead to unreasonable predictions from the SLEUTH model.
Nevertheless, the exclusion layers of Scenario 2 and Scenario 3 would direct urban growth from the perspective of urban planning and land suitability. Scenario 2 would clearly illustrate the hot spots of future urban development, such as the southwest, north, and east parts of the main urban area. To some extent, we think that Scenario 2 agrees with planning policies of urban growth. Although the optimal coefficient combination of Scenario 2 and Scenario 3 were not remarkably different, the prediction was contrasting due to the different exclusion layers. Urban growth in Scenario 2 would be limited to areas of high suitability for built-up land. In the MCR-based land suitability assessment, the spatial distance is regarded as an important factor for the expansion of the source. The closer to the built-up land source, the higher the suitability of the built-up land expansion. Therefore, the edge growth of Scenario 3 would be obvious, and the spatial structure of urban growth would also be closer.
In previous researches, the setting of the exclusion layer was relatively simplified as they usually assigned a few different exclusion probabilities. Examples include the simulation of Busan in South Korea where the exclusion probabilities for the three levels were 100% for a greenbelt and 75%, and 0% for two levels of legal conservation areas, respectively [48], and a study of Shanghai in China where the exclusion probability was divided into three levels, 100% for water areas and wetlands, 80% for farmlands, and 60% for grassland [65]. By dividing the MCR-based land suitability assessment map into 20 grades in our study, the exclusion probability was however continuously changed, from 0% to 100%, and the exclusion layer that we generated for Scenario 3 would better characterize the suitability of land for urbanization. The land suitability urban growth would avoid the scattered distribution of small-area built-up land as well as excessive protection of farmland ecological land.
Limitations
Using a decreased data resolution (60 m) facilitate data processing, but it might lower the accuracy of urban growth prediction. Although urban planning was incorporated into the exclusion layer for Scenario 2 to represent the role of governmental policies in urban growth, it did not consider may other socioeconomic factors, e.g., population, agricultural land value and industrialization [66,67]. As such, adding more urban growth drivers to the SLEUTH model can be a direction for future work.
Conclusions
Using the SLEUTH model, we predicted the expansion of urban built-up land in Hefei from 2015 to 2040 in three different urban growth scenarios, each of which had its own exclusion layer and optimal coefficient combination. Results of each scenario were compared and analyzed. The main findings and conclusions are summarized as follows:
Compared with the other two scenarios, the historical growth scenario produces an improper urban built-up land distribution, the highest urban growth rate, and the highest loss of farmland, forestland, and grassland. It suggests that exclusion layers without effective restrictions may result in unreasonable urban growth predictions.
Despite a medium urban growth rate, the urban planning growth scenario would occupy the least amount of other land. Based on the general land use map, the urban growth prediction took the governmental policies into account and could reveal the development hotspots in urban planning.
The land suitability scenario prediction was the result of the trade-off between ecological land and built-up land as it used the MCR-based land suitability assessment result. This scenario predicts the lowest urban growth rate and a medium loss of farmland, forestland, and grassland. It would help to form a compact urban space and avoid excessive protection of farmland and ecological land.
In summary, the urban built-up land in Hefei remains in a rapid growth stage in the next two decades. The expansion of built-up land would be at the expense of main farmland, and to a lesser extent, of ecological land. Coordinating the contradiction between urban growth and the protection of farmland and ecological land would be the key to sustainable urban development in Hefei. At the same time, the planning of urban space should be given importance. Findings of this study provide useful insights into the characteristics of urban development and formulating urban development plans.
Supporting information
S1 Fig [a]
Results of the minimum cumulative resistance evaluation.
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- Effect of self-rated health status on functioning difficulties among older adults in Ghana: Coarsened exact matching method of analysis of the World Health Organization’s study on global AGEing and adult health, Wave 2
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- Effect of community based health education on knowledge and attitude towards iron and folic acid supplementation among pregnant women in Kiambu County, Kenya: A quasi experimental study
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- Differences in clinical features of cluster headache between drinkers and nondrinkers in Japan
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- The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma
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- Pragmatic language dysfunction in systemic lupus erythematosus patients: Results from a single center Italian study
- Association between cerebral atrophy and osteoporotic vertebral compression fractures
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- Questioning the lasting effect of galvanic vestibular stimulation on postural control
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- Identifying resurrection genes through the differentially expressed genes between Selaginella tamariscina (Beauv.) spring and Selaginella moellendorffii Hieron under drought stress
- Impact of hemodialysis on the concentrations of sodium and potassium during infusion of sodium thiosulfate using an In Vitro hemodialysis model
- Minimal effects of oyster aquaculture on local water quality: Examples from southern Chesapeake Bay
- Suboptimal infant and young child feeding practices in rural Boucle du Mouhoun, Burkina Faso: Findings from a cross-sectional population-based survey
- High salinity tolerance of invasive blue catfish suggests potential for further range expansion in the Chesapeake Bay region
- From waste to food: Optimising the breakdown of oil palm waste to provide substrate for insects farmed as animal feed
- Quantitative assessment of interstitial lung disease in Sjögren’s syndrome
- Comparative efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naive chronic hepatitis B: A systematic review and meta-analysis
- Reference ranges for ultrasonographic renal dimensions as functions of age and body indices: A retrospective observational study in Taiwan
- Finding phrases: On the role of co-verbal facial information in learning word order in infancy
- Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization
- Effects of forest management and roe deer impact on a mountain forest development in the Italian Apennines: A modelling approach using LANDIS-II
- Evaluation of comprehensive improvement for mild and moderate soil salinization in arid zone
- Efficacy, acceptability and feasibility of daily text-messaging in promoting glycaemic control and other clinical outcomes in a low-resource setting of South Africa: A randomised controlled trial
- Magnitude and associated factors of postpartum depression among women in Nekemte town, East Wollega zone, west Ethiopia, 2019: A community-based study
- Comparison of continuous wave and cold lateral condensation filling techniques in 3D printed simulated C-shape canals instrumented with Reciproc Blue or Hyflex EDM
- Effect of caffeine on neuromuscular function following eccentric-based exercise
- AtUBL5 regulates growth and development through pre-mRNA splicing in Arabidopsis thaliana
- The gut microbiome of freshwater Unionidae mussels is determined by host species and is selectively retained from filtered seston
- Alcohol consumption and survival after breast cancer diagnosis in Japanese women: A prospective patient cohort study
- Selection of reference genes for normalization of cranberry (Vaccinium macrocarpon Ait.) gene expression under different experimental conditions
- The household economic costs associated with depression symptoms: A cross-sectional household study conducted in the North West province of South Africa
- Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping
- Acute low- compared to high-load resistance training to failure results in greater energy expenditure during exercise in healthy young men
- Impact of body mass index and metabolically unhealthy status on mortality in the Japanese general population: The JMS cohort study
- Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis
- Ecohydrology of urban trees under passive and active irrigation in a semiarid city
- Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model
- LFastqC: A lossless non-reference-based FASTQ compressor
- Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models
- Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats
- A popular Indian clove-based mosquito repellent is less effective against Culex quinquefasciatus and Aedes aegypti than DEET
- Yeasts affect tolerance of Drosophila melanogaster to food substrate with high NaCl concentration
- The effect of climate change on cholera disease: The road ahead using artificial neural network
- Grit (effortful persistence) can be measured with a short scale, shows little variation across socio-demographic subgroups, and is associated with career success and career engagement
- Micro-dislodgement during transcatheter aortic valve implantation with a contemporary self-expandable prosthesis
- Improving the antimicrobial efficacy against resistant Staphylococcus aureus by a combined use of conjugated oligoelectrolytes
- Kin discrimination and outer membrane exchange in Myxococcus xanthus: Experimental analysis of a natural population
- Inflammatory cell infiltrates, hypoxia, vascularization, pentraxin 3 and osteoprotegerin in abdominal aortic aneurysms – A quantitative histological study
- Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson's disease: A systematic review
- Serum miR-33a is associated with steatosis and inflammation in patients with non-alcoholic fatty liver disease after liver transplantation
- Association between housing tenure and self-rated health in Japan: Findings from a nationwide cross-sectional survey
- Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China
- One-year follow-up of changes in refraction and aberrations induced by corneal incision
- Evaluation of upper limb superficial venous percussion as a sign of anatomical location and venous permeability. A comparative study of superficial venous percussion to ultrasound findings on non-renal patients and on chronic kidney disease patients
- An assessment of the Dutch experience with health insurers acting as healthcare advisors
- Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania
- Veterans with Gulf War Illness exhibit distinct respiratory patterns during maximal cardiopulmonary exercise
- Deep brain stimulation restores the glutamatergic and GABAergic synaptic transmission and plasticity to normal levels in kindled rats
- Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals
- Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model
- Long-term retention on antiretroviral therapy among infants, children, adolescents and adults in Malawi: A cohort study
- Histochemical quantification of collagen content in articular cartilage
- Optogenetically transduced human ES cell-derived neural progenitors and their neuronal progenies: Phenotypic characterization and responses to optical stimulation
- Ion torrent high throughput mitochondrial genome sequencing (HTMGS)
- Outpatient antibiotic prescription rate and pattern in the private sector in India: Evidence from medical audit data
- Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination
- Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon
- Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures
- CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say
- Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
- Proton pump inhibitor use increases the risk of peritonitis in peritoneal dialysis patients
- Comparative distribution of extended-spectrum beta-lactamase–producing Escherichia coli from urine infections and environmental waters
- Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters
- Maternal serum and cord blood leptin concentrations at delivery
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- Intolerance of uncertainty fuels depressive symptoms through rumination: Cross-sectional and longitudinal studies
- Monitoring exercise-induced muscle damage indicators and myoelectric activity during two weeks of knee extensor exercise training in young and old men
- Can adoption of pollution prevention techniques reduce pollution substitution?
- The association between self-efficacy and self-management behaviors among Chinese patients with type 2 diabetes
- Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat
- Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study
- Evaluation of forearm vascular resistance during orthostatic stress: Velocity is proportional to flow and size doesn’t matter
- Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size
- Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring
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- Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology
- Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal
- Clinical characteristics of neonatal fulminant necrotizing enterocolitis in a tertiary Children's hospital in the last 10 years
- Effects of neuromuscular electrical stimulation training on muscle size in collegiate track and field athletes
- Adaptive fuzzy flow rate control considering multifractal traffic modeling and 5G communications
- Evaluation of four commercial tests for detecting ceftiofur in waste milk bulk tank samples
- A smart tele-cytology point-of-care platform for oral cancer screening
- Vasopressin SNP pain factors and stress in sickle cell disease
- Carbonate production of Micronesian reefs suppressed by thermal anomalies and Acanthaster as sea-level rises
- Microbial metabolisms in an abyssal ferromanganese crust from the Takuyo-Daigo Seamount as revealed by metagenomics
- Incidence of chronic kidney disease hospitalisations and mortality in Espírito Santo between 1996 to 2017
- The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death
- Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS)
- Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012
- The effects of prolonged single night session of videogaming on sleep and declarative memory
- Diversity, distribution and dynamics of large trees across an old-growth lowland tropical rain forest landscape
- Mapping developmental QTL for plant height in soybean [Glycine max (L.) Merr.] using a four-way recombinant inbred line population
- Vaginal ring acceptability and related preferences among women in low- and middle-income countries: A systematic review and narrative synthesis
- UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
- Positive selection and precipitation effects on the mitochondrial NADH dehydrogenase subunit 6 gene in brown hares (Lepus europaeus) under a phylogeographic perspective
- Evaluation of Minimum Inhibitory Concentrations for 154 Mycoplasma synoviae isolates from Italy collected during 2012-2017
- Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane
- Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
- Correction: Effect of corruption on perceived difficulties in healthcare access in sub-Saharan Africa
- Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters
- Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects
- Integrated value-chain and risk assessment of Pig-Related Zoonoses in Ghana
- Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy
- Cassava yield traits predicted by genomic selection methods
- Verification of hub genes in the expression profile of aortic dissection
- Pig farmers’ willingness to pay for management strategies to reduce aggression between pigs
- Metabolomic response of Euglena gracilis and its bleached mutant strain to light
- Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis
- Newly educated care managers’ experiences of providing care for persons with stress-related mental disorders in the clinical primary care context
- Real-time telemetry monitoring of oxygen in the central complex of freely-walking Gromphadorhina portentosa
- Qualification programmes for immigrant health professionals: A systematic review
- An analytical model to minimize the latency in healthcare internet-of-things in fog computing environment
- Grain filling of early-season rice cultivars grown under mechanical transplanting
- Intercalation of small molecules into DNA in chromatin is primarily controlled by superhelical constraint
- Correlative evidence for co-regulation of phosphorus and carbon exchanges with symbiotic fungus in the arbuscular mycorrhizal Medicago truncatula
- How to design a dose-finding study on combined agents: Choice of design and development of R functions
- Altered expression of Notch1 in Alzheimer's disease
- The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women
- Trunk velocity-dependent Light Touch reduces postural sway during standing
- Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines
- Trade-offs in motivating volunteer effort: Experimental evidence on voluntary contributions to science
- Does caching strategy vary with microclimate in endangered Mt. Graham red squirrels?
- Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults
- Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
- Implementation of a screening, brief intervention and referral to treatment programme for risky substance use in South African emergency centres: A mixed methods evaluation study
- Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study
- The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice
- Acceptability of and treatment preferences for recurrent bacterial vaginosis—Topical lactic acid gel or oral metronidazole antibiotic: Qualitative findings from the VITA trial
- Mathematical determination of the HIV-1 matrix shell structure and its impact on the biology of HIV-1
- Contingent negative variation during a modified cueing task in simulated driving
- CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition
- Effect of feeding patterns on growth and nutritional status of children aged 0-24 months: A Chinese cohort study
- A fecal sequel: Testing the limits of a genetic assay for bat species identification
- Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study
- Short and long-term clinical effectiveness and cost-effectiveness of a late-phase community-based balance and gait exercise program following hip fracture. The EVA-Hip Randomised Controlled Trial
- Vaccine cold chain in general practices: A prospective study in 75 refrigerators (Keep Cool study)
- Brazilian norms for the Bank of Standardized Stimuli (BOSS)
- Distinct varieties of aesthetic chills in response to multimedia
- Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses’ Health Study
- Correction: Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
- New formulation of the Gompertz equation to describe the kinetics of untreated tumors
- Development of visual perception of others’ actions: Children’s judgment of lifted weight
- Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery
- Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution
- Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children
- Arthroscopic release for frozen shoulder: Does the timing of intervention and diabetes affect outcome?
- Risk factors affecting dairy cattle protective grouping behavior, commonly known as bunching, against Stomoxys calcitrans (L.) on California dairies
- Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing
- Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation
- Sexuality in male partners of women with fibromyalgia syndrome: A qualitative study
- Exploring optimization strategies for improving explicit water models: Rigid n-point model and polarizable model based on Drude oscillator
- Artificial insemination with fresh, liquid stored and frozen thawed semen in dromedary camels
- Moving into an urban drug scene among people who use drugs in Vancouver, Canada: Latent class growth analysis
- Numerical study on the start and unstart phenomena in a scramjet inlet-isolator model
- Effects of dietary supplementation with apple peel powder on the growth, blood and liver parameters, and transcriptome of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
- Urban growth simulation in different scenarios using the SLEUTH model: A case study of Hefei, East China
- Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
- Factors associated with medication adherence among people with diabetes mellitus in poor urban areas of Cambodia: A cross-sectional study
- Mammary microbiome of lactating organic dairy cows varies by time, tissue site, and infection status
- Force field generalization and the internal representation of motor learning
- Polyphenism of visual and chemical secondary sexually-selected wing traits in the butterfly Bicyclus anynana: How different is the intermediate phenotype?
- Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil
- The impact of leisure activities on older adults’ cognitive function, physical function, and mental health
- scafSLICR: A MATLAB-based slicing algorithm to enable 3D-printing of tissue engineering scaffolds with heterogeneous porous microarchitecture
- Association of serum leptin and adiponectin concentrations with echocardiographic parameters and pathophysiological states in patients with cardiovascular disease receiving cardiovascular surgery
- Operation of cognitive memory inhibition in adults with Down syndrome: Effects of maintenance load and material
- Influences on surgical antimicrobial prophylaxis decision making by surgical craft groups, anaesthetists, pharmacists and nurses in public and private hospitals
- Post-treatment Lyme disease symptoms score: Developing a new tool for research
- Expression of Concern: The Role of the RACK1 Ortholog Cpc2p in Modulating Pheromone-Induced Cell Cycle Arrest in Fission Yeast
- Equine bronchial fibroblasts enhance proliferation and differentiation of primary equine bronchial epithelial cells co-cultured under air-liquid interface
- Investigating cooperation with robotic peers
- Synthesis, purification and crystallization of a putative critical bulge of HAR1 RNA
- Prosthetic push-off power in trans-tibial amputee level ground walking: A systematic review
- A case study of the use of verbal reports for talent identification purposes in soccer: A Messi affair!
- Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
- Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation
- Periodontal disease: Repercussions in pregnant woman and newborn health—A cohort study
- Origins of Chinese reindeer (Rangifer tarandus) based on mitochondrial DNA analyses
- Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis
- How effective are films in inducing positive and negative emotional states? A meta-analysis
- 3D nanostructural characterisation of grain boundaries in atom probe data utilising machine learning methods
- An outbreak of tuberculosis in a middle school in Henan, China: Epidemiology and risk factors
- Initial clinical radiological findings and staging to predict prognosis of primary hepatic angiosarcoma: A retrospective analysis
- A new early Eocene deperetellid tapiroid illuminates the origin of Deperetellidae and the pattern of premolar molarization in Perissodactyla
- Longevity and marginal bone loss of narrow-diameter implants supporting single crowns: A systematic review
- Impact of UVC-sustained recirculating air filtration on airborne bacteria and dust in a pig facility
- Cold-related Florida manatee mortality in relation to air and water temperatures
- Conceptual fluency in inductive reasoning
- Clinical outcomes and treatment patterns among Medicare patients with nonvalvular atrial fibrillation (NVAF) and chronic kidney disease
- Improvements in the learnability of smartphone haptic interfaces for visually impaired users
- Role of the malic enzyme in metabolism of the halotolerant methanotroph Methylotuvimicrobium alcaliphilum 20Z
- Cyclic loading test study on a new cast-in-situ insulated sandwich concrete wall
- Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies
- Analysis of virulence potential of Escherichia coli O145 isolated from cattle feces and hide samples based on whole genome sequencing
- Pre-clinical medical student reflections on implicit bias: Implications for learning and teaching
- Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients
- Determinants of preterm birth among mothers who gave birth at public hospitals in the Amhara region, Ethiopia: A case-control study
- Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain
- Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
- Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice
- Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth
- Achievement of weight loss in patients with overweight during dietetic treatment in primary health care
- Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation
- The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study
- Reorganization of spatial configurations in visual working memory: A matter of set size?
- Unravelling travellers’ route choice behaviour at full-scale urban network by focusing on representative OD pairs in computer experiments
- Evaluating the higher-order structure of the Profile of Emotional Competence (PEC): Confirmatory factor analysis and Bayesian structural equation modeling
- HIV prevalence and correlated factors among male clients of female sex workers in a border region of China
- Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis
- Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population
- Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians
- Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project
- Friends with benefits: The effects of vegetative shading on plant survival in a green roof environment
- Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis
- Identifying candidate diagnostic markers for early stage of non-small cell lung cancer
- Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
- Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
- Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood
- Enhanced fibrinolysis detection in a natural occurring canine model with intracavitary effusions: Comparison and degree of agreement between thromboelastometry and FDPs, D-dimer and fibrinogen concentrations
- Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants
- Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses
- Autonomous drone hunter operating by deep learning and all-onboard computations in GPS-denied environments
- Heterogeneity Diffusion Imaging of gliomas: Initial experience and validation
- Frequency cluster formation and slow oscillations in neural populations with plasticity
- DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy
- Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
- Analytical solution to swing equations in power grids
- Pathways to conspiracy: The social and linguistic precursors of involvement in Reddit’s conspiracy theory forum
- Spatiotemporally random and diverse grid cell spike patterns contribute to the transformation of grid cell to place cell in a neural network model
- Empathic concern and personal distress depend on situational but not dispositional factors
- Who is more susceptible to job stressors and resources? Sensory-processing sensitivity as a personal resource and vulnerability factor
- Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa
- A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
- One step at a time: Physical activity is linked to positive interpretations of ambiguity
- Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells
- Evaluation of various methods of selection of B. subtilis strains capable of secreting surface-active compounds
- Association between US Pharmacopeia (USP) monograph standards, generic entry and prescription drug costs
- Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects
- On sorption hysteresis in wood: Separating hysteresis in cell wall water and capillary water in the full moisture range
- Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction
- Reliability and construct validity of the stepping-forward affordance perception test for fall risk assessment in community-dwelling older adults
- Socioeconomic determinants of nutritional status among ‘Baiga’ tribal children In Balaghat district of Madhya Pradesh: A qualitative study
- Study on characteristics of fire plume in building facade window under lateral blow
- ‘When you talk to someone in a bad way or always put her under pressure, it is actually worse than beating her’: Conceptions and experiences of emotional intimate partner violence in Rwanda and South Africa
- Effects of 6-mercaptopurine in pressure overload induced right heart failure
- The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes
- Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study
- Factors associated with persistently high-cost health care utilization for musculoskeletal pain
- Nitrogen and chlorophyll status determination in durum wheat as influenced by fertilization and soil management: Preliminary results
- Effect of repeated in vivo microCT imaging on the properties of the mouse tibia
- Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia
- Hematology and plasma biochemistries in the Blanding’s turtle (Emydoidea blandingii) in Lake County, Illinois
- CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
- Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors
- Antidepressant prescriptions, discontinuation, depression and perinatal outcomes, including breastfeeding: A population cohort analysis
- Why men with a low-risk prostate cancer select and stay on active surveillance: A qualitative study
- Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis
- Combined treatment (image-guided thrombectomy and endovascular therapy with open femoral access) for acute lower limb ischemia: Clinical efficacy and outcomes
- Low-latency single channel real-time neural spike sorting system based on template matching
- Quantifying the scale effect in geospatial big data using semi-variograms
- Paper-and-pencil versus computerized administration mode: Comparison of data quality and risk behavior prevalence estimates in the European school Survey Project on Alcohol and other Drugs (ESPAD)
- Regression adjusted colocalisation colour mapping (RACC): A novel biological visual analysis method for qualitative colocalisation analysis of 3D fluorescence micrographs
- Ostrich eggshell bead diameter in the Holocene: Regional variation with the spread of herding in eastern and southern Africa
- Spatial and temporal variations in female size at maturity of a Southern Rock Lobster (Jasus edwardsii) population: A likely response to climate change
- Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
- Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies
- Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity
- Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study
- Effectiveness of telerehabilitation in the management of adults with stroke: A systematic review
- Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
- Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
- Retraction: Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization
- Evaluation of neutral oral contrast agents for assessment of the small bowel at abdominal staging CT
- Blood type and breed-associated differences in cell marker expression on equine bone marrow-derived mesenchymal stem cells including major histocompatibility complex class II antigen expression
- Induced abortion and future use of IVF treatment; A nationwide register study
- Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan
- Measurement of finger joint angle using stretchable carbon nanotube strain sensor
- Determinants of mortality among patients with drug-resistant tuberculosis in northern Nigeria
- Drugs modulating stochastic gene expression affect the erythroid differentiation process
- Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study
- Prognostic value of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma treated with transarterial chemotherapy: A systematic review and meta-analysis
- Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis
- Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment
- Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits
- Correction: Good and Bad in the Hands of Politicians: Spontaneous Gestures during Positive and Negative Speech
- Adolescents with worse levels of oral health literacy have more cavitated carious lesions
- Effective methods for the inactivation of Francisella tularensis
- Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients
- Correlation between internal pudendal artery stenosis and erectile dysfunction in patients with suspected coronary artery disease
- Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
- Population productivity of shovelnose rays: Inferring the potential for recovery
- Correction: Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era
- Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis
- Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression
- Changes in weight and body composition across five years at university: A prospective observational study
- Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning
- Effects of insulin signaling on mouse taste cell proliferation
- Patient-level cost of home- and facility-based child pneumonia treatment in Suba Sub County, Kenya
- TAP: A static analysis model for PHP vulnerabilities based on token and deep learning technology
- Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil
- Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: Results of a cluster randomized controlled trial
- Changes over time in creatinine clearance and comparison of emergent adverse events for HIV-positive adults receiving standard doses (300 mg/day) of lamivudine-containing antiretroviral therapy with baseline creatinine clearance of 30–49 vs ≥50 mL/min
- Population dynamics of foxes during restricted-area culling in Britain: Advancing understanding through state-space modelling of culling records
- Impacts of experimental advisory exit speed sign on traffic speeds for freeway exit ramp
- In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium
- Monitoring quality indicators for the Xpert MTB/RIF molecular assay in Ethiopia
- Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
- Correction: Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia
- Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes
- Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma
- Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
- Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
- Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
- Comparison of two experimental ARDS models in pigs using electrical impedance tomography
- Are primary school children attending full-day school still engaged in sports clubs?
- Stroke risks in women with dysmenorrhea by age and stroke subtype
- Changes in patterns of mortality rates and years of life lost due to firearms in the United States, 1999 to 2016: A joinpoint analysis
- In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin
- Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients
- Correction: Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods
- Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica)
- Time trends between 2002 and 2017 in correlates of self-reported sitting time in European adults
- Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis
- Changes in HbA1c during the first six years after the diagnosis of Type 2 diabetes mellitus predict long-term microvascular outcomes
- Correction: Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
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- Correction: Identifying performance benchmarks and determinants for reproductive performance and calf survival using a longitudinal field study of cow-calf herds in western Canada
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- Correction: Interspecific Phylogenic Relationships within Genus Melilotus Based on Nuclear and Chloroplast DNA
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- Correction: KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
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- Complete Chloroplast Genomes of Vachellia nilotica and Senegalia senegal: Comparative Genomics and Phylogenomic Placement in a New Generic System
- Retraction: Over-Expression of Superoxide Dismutase Ameliorates Cr(VI) Induced Adverse Effects via Modulating Cellular Immune System of Drosophila melanogaster
- Effect of pre-season training phase on anthropometric, hormonal and fitness parameters in young soccer players
- Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis
- Outcome of patients with heart failure after transcatheter aortic valve implantation
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- Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding
- Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium
- Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis
- Correction: Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- Correction: Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
- Retraction: Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage
- Correction: Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
- Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study
- Correction: Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
- Discovering novel disease comorbidities using electronic medical records
- Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome
- Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics
- Social information use in adolescents: The impact of adults, peers and household composition
- Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members
- Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial
- Comparative studies of two generations of NanoString nCounter System
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- A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma
- A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE
- Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
- Seasonal alternation of the ontogenetic development of the moon jellyfish Aurelia coerulea in Maizuru Bay, Japan
- Reliability of measurement of active trunk movement in wheelchair basketball players
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- Correction: Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
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- Improved chemotherapy modeling with RAG-based immune deficient mice
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- Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass
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- Correction: A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
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- Correction: Population-based dementia prediction model using Korean public health examination data: A cohort study
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- Correction: ISED: Constructing a high-resolution elevation road dataset from massive, low-quality in-situ observations derived from geosocial fitness tracking data
- Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies
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- Correction: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing
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