First evidence of hepatitis E virus infection in a small mammal (yellow-necked mouse) from Croatia
Autoři:
Jelena Prpić aff001; Tomislav Keros aff001; Marko Vucelja aff002; Linda Bjedov aff002; Oktavija Đaković Rode aff003; Josip Margaletić aff002; Boris Habrun aff001; Lorena Jemeršić aff001
Působiště autorů:
Croatian Veterinary Institute, Zagreb, Croatia
aff001; Forestry Faculty University of Zagreb, Zagreb, Croatia
aff002; University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, Zagreb, Croatia
aff003; University of Zagreb School of Dental Medicine, Zagreb, Croatia
aff004
Vyšlo v časopise:
PLoS ONE 14(11)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0225583
Souhrn
Since the role of wild rodents/small mammals in hepatitis E virus (HEV) epidemiology has been a subject of considerable debate, this study was conducted to investigate the potential presence of HEV RNA in small rodents collected within their natural habitats and to detect if they can be potential reservoirs of the virus. A total of 483 small rodents were captured using snap traps placed at 11 regions in Croatia. Sampling was undertaken in 2008 and repeated from 2010 to 2014. Liver samples were tested for the presence of HEV RNA. HEV RNA was detected in only one liver sample (0.21%) originated from Apodemus flavicollis from the location Medvednica, nearby Zagreb collected in 2014. According to the sequence analysis, the isolate has shown to be a member of Orthohepevirus A species, genotype HEV-3. The genotyping results confirmed grouping into subtype 3a, general cluster 3abchij.The detected HEV strain showed to be genetically highly related to strains found in humans and/or domestic pigs and wild boars from Croatia. Our finding indicates that wild small mammals could play a role in the epidemiology of HEV-3 infection and therefore should be taken under consideration as potential reservoirs or/and transmitters of the disease. However, further investigation is needed to recognize their potential for maintaining the infection in natural conditions.
Klíčová slova:
Sequence analysis – Mammals – Rodents – Livestock – Swine – Hepatitis E virus – Croatia – Genetic epidemiology
Zdroje
1. Smith DB, Simmonds P, Jameel S, Emerson EU, Harrison TJ, Meng XJ, et al. Consensus proposals for classification of the family Hepeviridae. J Gen Virol. 2014;95: 2223–2232. doi: 10.1099/vir.0.068429-0 24989172
2. Smith DB, Simmonds P, Izopet J, Oliveira-Filho EF, Ulrich RG, Johne R, et al. Proposed reference sequences for hepatitis E virus subtypes. J Gen Virol. 2016;97: 537–542. doi: 10.1099/jgv.0.000393 26743685
3. Li TC, Chijiwa K, Sera N, Ishibashi T, Etoh Y, Shinohara Y, et al. Hepatitis E virus transmission from wild boar meat. Emerg Infect Dis. 2005;11: 1958–1960. doi: 10.3201/eid1112.051041 16485490
4. Purcell RH, Emerson SU. HepatitisE: an emerging awareness of an old disease. J Hepatol. 2008;48(3): 494–503. doi: 10.1016/j.jhep.2007.12.008 18192058
5. Aggarwal R, Naik S. Epidemiology of hepatitis e: Current status. J Gastroenterol Hepatol. 2009;24: 1484–1493. doi: 10.1111/j.1440-1746.2009.05933.x 19686410
6. Jemeršić L, Prpić J, Brnić D, Keros T, Pandak N, Đaković-Rode O. Genetic diversity of hepatitis E virus (HEV) strains derived from humans, swine and wild boars in Croatia from 2010 to 2017. BMC Infect Dis. 2019;19: 269. doi: 10.1186/s12879-019-3906-6 30890143
7. Prpić J, Černi S, Škorić D, Keros T, Brnić D, Cvetnić Ž, et al. Distribution and molecular characterization of Hepatitis E virus in domestic animals and wildlife in Croatia. Food Environ Virol. 2015;7: 195–205. doi: 10.1007/s12560-015-9193-5 25820413
8. Lipej Z, Novosel D, Vojta L, Roić B, Šimpraga M, Vojta A. Detection and characterisation of hepatitis E virus in naturally infected swine in Croatia. Acta Vet Hung. 2013;61:517–28. doi: 10.1556/AVet.2013.031 23974940
9. Balayan MS, Usmanov RK, Zamyatina NA, Djumalieva DI, Karas FR. 1990. Brief report: experimental hepatitis E infection in domestic pigs. J Med Virol. 1990;32: 58–59. doi: 10.1002/jmv.1890320110 2122999
10. Usmanov RK, Blayan MS, Dvoinikova OV, Alymbaeva DB, Zamiatina NA, Kazachkov IUA, et al. An experimental infection in lambs by hepatitis E virus. VoprVirusol. 1994;39: 165–168.
11. Favorov MO, Nazarova OK, Yashina TL, McCaustland K, Fields HA, Margolis HS. Cattle as a possible reservoir of hepatitis E virus infection. Ninth Triennial International Symposium on Viral Hepatitis and Liver Disease (Rome), 21–25 April, 1996 (A140).
12. Meng XJ, Purcell RH, Halbur PG, Lehman JR, Webb DM, Tsareva TSet al. 1997. A novel virus in swine is closely related to the human hepatitis E virus. Proc Natl Acad Sci U S A. 1997;94: 9860–9865. doi: 10.1073/pnas.94.18.9860 9275216
13. Meng XJ, Halbur PG, Shapiro MS. Genetic and experimental evidence for cross-species infection by swine hepatitis E virus. J Virol. 1998;72: 9714–9721. 9811705
14. Favorov MO, Kosoy MY, Tsarev SA, Childs JE, Margolis HS. Prevalence of antibody to hepatitis E virus among rodents in the United States. J Infect Dis. 2000;181: 449–455. doi: 10.1086/315273 10669325
15. Kabrane-Lazizi Y, Fine JB, Elm J, Glass GE, Higa H, Diwan A, et al. Evidence for widespread infection of wild rats with hepatitis E virus in the United States. Am J Trop Med Hyg. 1999;61: 331–335. doi: 10.4269/ajtmh.1999.61.331 10463689
16. Arankalle VA, Joshi MV, Kulkarni AM, Gandhe SS, Chobe LP, Rautmare SS, et al. Prevalence of anti-hepatitis E virus antibodies in different Indian animal species. J Viral Hepat. 2001;8: 223–227. doi: 10.1046/j.1365-2893.2001.00290.x 11380801
17. Hirano M, Ding X, Li TC, Takeda N, Kawabata H, Koizumi N, et al. Evidence for widespread infection of hepatitis E virus among wild rats in Japan. Hepatol Res. 2003;27: 1–5. doi: 10.1016/s1386-6346(03)00192-x 12957199
18. Easterbrook JD, Kaplan JB, Vanasco NB, Reeves WK, Purcell RH, Kosoy MY, et al. A survey of zoonotic pathogens carried by Norway rats in Baltimore, Maryland, USA. Epidemiol Infect. 2007;135: 1192–1199. doi: 10.1017/S0950268806007746 17224086
19. Obana S, Shimizu K, Yoshimatsu K, Hasebe F, Hotta K, Isozumi R, et al.Epizootiological study of rodent-borne hepatitis E virus HEV-C1 in small mammals in Hanoi, Vietnam.J Vet Med Sci. 2017;79(1): 76–81. doi: 10.1292/jvms.16-0355 27795461
20. He W, Wen Y, Xiong Y, Zhang M, Cheng M, Chen Q. The prevalence and genomic characteristics of hepatitis E virus in murine rodents and house shrews from several regions in China. BMC Vet Res. 2018;14(1): 414. doi: 10.1186/s12917-018-1746-z 30577796
21. Kurucz K, Hederics D, Bali D, Kemenesi G, Horváth G, Jakab F. Hepatitis E virus in Common voles (Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae-specific genotype of Orthohepevirus C. Zoonoses Public Health. 2019;66(2):259–263. doi: 10.1111/zph.12543 30499180
22. Simanavicius M, Juskaite K, Verbickaite A, Jasiulionis M, Tamosiunas PL, Petraityte-Burneikiene R, et al. Detection of rat hepatitis E virus, but not human pathogenic hepatitis E virus genotype 1–4 infections in wild rats from Lithuania. Vet Microbiol. 2018;221: 129–133. doi: 10.1016/j.vetmic.2018.06.014 29981698
23. Sayed IM, Verhoye L, Cocquerel L, Abravanel F, Foquet L, Montpellier C, et al. Study of hepatitis E virus infection of genotype1 and 3 in mice with humanised liver. Gut. 2017;66: 920–929. doi: 10.1136/gutjnl-2015-311109 27006186
24. Shukla P, Nguyen HT, Torian U, Engle RE, Faulk K, Dalton HR, et al. Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant. Proc Natl Acad Sci U S A. 2011;108: 2438–43. doi: 10.1073/pnas.1018878108 21262830
25. Tadin A, Tokarz R, Markotić A, Margaletić J, Turk N, Habuš J, et al. Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia. Am J Trop Med Hyg. 2016;94: 466–473. doi: 10.4269/ajtmh.15-0517 26711522
26. Sikes RS, Gannon WL. Guidelines of the American Society of Mammalogists for the use of wild mammals in research. J Mammal. 2011;92: 235–253.
27. Jothikumar N, Cromeans TL, Robertson BH, Meng XJ, Hill VR. A broadly reactive one-step real-time RT-PCR assay for rapid and sensitive detection of hepatitis E virus. J Virol Methods. 2006;131: 65–71. doi: 10.1016/j.jviromet.2005.07.004 16125257
28. Van der Poel WH, Verschoor F, van der Heide R, Herrera MI, Vivo A, Kooreman M, et al. Hepatitis E virus sequences in swine related to sequences in humans, The Netherlands. EmergInfecti Dis. 2001;7: 970–976.
29. Kumar S, Stecher G, Tamura K. MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Mol BiolEvol. 2016; 33(7): 1870–4.
30. Tadin A, Turk N, Korva M, Margaletić J, Beck R, Vucelja M, et al.Multiple co-infections of rodents with hantaviruses, Leptospira, and Babesia in Croatia.Vector Borne Zoonotic Dis. 2012;12(5): 388–92. doi: 10.1089/vbz.2011.0632 22217170
31. Tadin A, Tokarz R, Markotić A, Margaletić J, Turk N, Habuš J, et al.Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia.Am J Trop Med Hyg. 2016;94(2): 466–73 doi: 10.4269/ajtmh.15-0517 26711522
32. Schmidt S, Essbauer SS, Mayer-Scholl A, Poppert S, Schmidt-Chanasit J, Klempa B, et al.Multiple infections of rodents with zoonotic pathogens in Austria.Vector Borne Zoonotic Dis. 2014;14(7): 467–75. doi: 10.1089/vbz.2013.1504 24915446
33. Lack JB, Volk K, Van den Bussche RA. Hepatitis E virus genotype 3 in wild rats, United States. Emerg Infect Dis. 2012;18: 1268–1273. doi: 10.3201/eid1808.120070 22840202
34. Đaković Rode O, Jemeršić L, Brnić D, Pandak N, Mikulić R, Begovac J, et al. Hepatitis E in patients with hepatic disorders and HIV-infected patients in Croatia: is one diagnostic method enough for hepatitis E diagnosis?Eur J Clin Microbiol Infect Dis. 2014;33: 2231–2236. doi: 10.1007/s10096-014-2187-7 25005459
35. Vilibić-Čavlek T, Vilibić M, Kolarić B, Jemeršić L, Kučinar J, BarbićLj, et al. Seroepidemiology of hepatitis E in selected population groups in Croatia: a prospective pilot study. Zoonoses Public Health. 2016;63: 494–502. doi: 10.1111/zph.12254 26776465
36. Jemeršić L, Keros T, Maltar Lj, Barbić Lj, Vilibić-Čavlek T, Jeličić P, et al. Differences in hepatitis E virus (HEV) presence in naturally infected seropositive domestic pigs and wild boars–an indication of wild boars having an important role in HEV epidemiology.Vet arhiv. 2017;87: 651–663.
37. Fischer C, Hofmann M, Danzer M, Hofer K, Kaar J, Gabriel C. Seroprevalence and Incidence of hepatitis E in Blood Donors in Upper Austria. PLoS One. 2015;10(3): e0119576. doi: 10.1371/journal.pone.0119576 25751574
38. Debing Y, Moradpour D, Neyts J, Gouttenoire J. Update on hepatitis E virology: Implications for clinical practice. J Hepatol. 2016;65(1): 200–212. doi: 10.1016/j.jhep.2016.02.045 26966047
39. Williams TP, Kasorndorkbua C, Halbur PG, Haqshenas G, Guenette DK, Toth TE, et al. Evidence of extrahepatic sites of replication of the hepatitis E virus in a swine model. J Clin Microbiol. 2001;39: 3040–3046. doi: 10.1128/JCM.39.9.3040-3046.2001 11526125
40. Geng Y, Zhao C, Huang W, Harrison TJ, Zhang H, Geng K, et al. Detection and assessment of infectivity of hepatitis E virus in urine. J Hepatol. 2016;64: 37–43. doi: 10.1016/j.jhep.2015.08.034 26362822
41. Maneerat Y, Clayson ET, Myint KS, Young GD, Innis BL. Experimental infection of the laboratory rat with the hepatitis E virus. J Med Virol. 1996;48: 121–8. doi: 10.1002/(SICI)1096-9071(199602)48:2<121::AID-JMV1>3.0.CO;2-B 8835343
42. Purcell RH, Engle RE, Rood MP, Kabrane-Lazizi Y, Nguyen HT, Govindarajan S, et al. Hepatitis E virus in rats, Los Angeles, California, USA. Emerg Infect Dis. 2011;17: 2216–22. doi: 10.3201/eid1712.110482 22172320
43. Johne R, Plenge-Bonig A, Hess M, Ulrich RG, Reetz J, Schielke A. Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR. J Gen Virol. 2010;91: 750–758. doi: 10.1099/vir.0.016584-0 19889929
Článok vyšiel v časopise
PLOS One
2019 Číslo 11
- Metamizol jako analgetikum první volby: kdy, pro koho, jak a proč?
- Nejasný stín na plicích – kazuistika
- Ne každé mimoděložní těhotenství musí končit salpingektomií
- Masturbační chování žen v ČR − dotazníková studie
- Těžké menstruační krvácení může značit poruchu krevní srážlivosti. Jaký management vyšetření a léčby je v takovém případě vhodný?
Najčítanejšie v tomto čísle
- A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
- Molecular validation of clinical Pantoea isolates identified by MALDI-TOF
- Pathways to conspiracy: The social and linguistic precursors of involvement in Reddit’s conspiracy theory forum
- Urticating setae of tarantulas (Araneae: Theraphosidae): Morphology, revision of typology and terminology and implications for taxonomy
Zvýšte si kvalifikáciu online z pohodlia domova
Všetky kurzy