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Interdisciplinary stratified care for low back pain: A qualitative study on the acceptability, potential facilitators and barriers to implementation
Authors: Carmen Caeiro aff001; Helena Canhão aff002; Sofia Paiva aff001; Luís A. Gomes aff001; Rita Fernandes aff001; Ana Maria Rodrigues aff002; Rute Sousa aff002; Fernando Pimentel-Santos aff002; Jaime Branco aff002; Ana Cristina Fryxell aff003; Lília Vicente aff003; Eduardo B. Cruz aff001
Authors place of work: Physiotherapy Department, Setúbal Polytechnic Institute, Setúbal, Portugal aff001; EpiDoC Unit, CEDOC, NOVA Medical School, Lisbon, Portugal aff002; ACES Arrábida, The Regional Health Administration of Lisbon and Tagus Valley, Setúbal, Portugal aff003
Published in the journal: PLoS ONE 14(11)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0225336Summary
Background and objective
The SPLIT project aims to introduce an interdisciplinary stratified model of care for patients with low back pain. This study aimed to explore the acceptability and identify potential barriers and facilitators regarding the upcoming implementation of this project, based on the general practitioners' and physiotherapists' perceptions.
Methods
A qualitative study was carried out supported by two focus groups, which were conducted by two researchers. A focus group was carried out with each professional group. One focus group included six general practitioners and the other included six physiotherapists. The focus groups were based on a semi-structured interview schedule, audio-recorded and transcribed verbatim. A thematic analysis was conducted.
Results
The participants explored aspects related to the acceptability of the SPLIT project, emphasising the satisfactory amount of effort that is expected to be required for its implementation. Potential facilitators to the implementation of the model were identified, such as the participants`motivation. Potential barriers were also explored, with particular emphasis on the challenges related to the change of routine care. Lastly, the need for particular adjustments in the health services was also highlighted.
Conclusions
This study`s participants highlighted the feasibility and acceptability of the SPLIT project. The identification of potential barriers and facilitators to its implementation also attained major relevance to better prepare the upcoming implementation of this project. The generalizability of findings to the larger population of relevant practitioners is limited, since only two focus groups were carried out. Therefore, this study`s findings should be considered in terms of transferability to contexts that may have some similarities to the context where the study was carried out.
Keywords:
Patients – Lower back pain – Qualitative studies – Health services administration and management – Primary care – Physiotherapy – Health services research – Treatment guidelines
Introduction
Low back pain (LBP) has prevailed worldwide as one of the three leading causes of non-fatal health loss for almost three decades [1]. It has been identified as a leading cause of years lived with disability and its burden has steadily increased, despite the extended research and health care resources that have been developed in this area [2–4]. In Portugal, LBP is the most prevalent musculoskeletal condition, with a significant proportion of patients reporting disability as well as a high level consumption of health services [5–7].
It has been suggested that the current clinical practice has not followed clinical guideline recommendations and may not be delivering the best treatment to Portuguese patients with LBP [8]. In particular, the advice to rest, analgesic, anti-inflammatories and medical imaging prescriptions as well as sickness certifications were amongst the most common approaches to Portuguese patients with LBP in primary care [8]. These findings were consistent with those from worldwide studies, which have called attention to the poor outcomes of this approach on pain, disability and sense of well-being in patients with LBP [9–13].
Research has recommended a greater use of biopsychosocial model in the management of patients with LBP [3,14,15]. Stratified care for LBP has tried to reassure the aforementioned model in clinical practice, by targeting treatment to subgroups of patients based on their key characteristics such as prognostic factors, likely response to treatment and underlying mechanisms [16]. The STarT Back—Subgroups for Targeted Treatment is a stratified model of care that has been developed and tested by researchers from Keele University over the last 15 years [17]. According to this model, patients with LBP are assessed with the Keele STarT Back Tool (KSBT) that categorizes them into three subgroups based on their risk (low, medium or high) of developing persistent disabling pain. Based on this categorization, patients are provided with matched treatments [18]. Research focused on the STarT Back has demonstrated better clinical outcomes at 4 and 12 months, as well as lower health costs when compared with current best practice [19]. Further research on the STarT Back has strengthened its clinical and cost effectiveness and demonstrated its feasibility in primary care in the UK [20,21]. Additionally, one study has reported positive results in Ireland [22]. However, further research is needed to determine if these benefits are still evident when compared to current practice in other countries, and six studies are in progress [17].
Considering previous findings from research on the STarT Back, the SPLIT project aimed to introduce a similar approach, involving General Practitioners (GPs) and Physiotherapists (PTs) in the triage and targeted treatment for patients with LBP, in a Group of Portuguese Health Centres (ACES Arrábida), in primary care. The KSBT was translated into Portuguese and validated in Portuguese population [23], and then funding was obtained for the SPLIT Project in 2018.
Since previous qualitative research has called attention for potential barriers that may prevent the successful implementation of the STarT Back in the UK as well as in other countries [24–27], the SPLIT research team has introduced several adjustments to the original model since its early conception. For example, rheumatologists and PTs from the research team delivered a training program, which was tailored to each professional group. GPs attended two 2-hours workshops focused on the triage process as well as on the model of care proposed for patients with LBP, inspired on the STarT Back. PTs also attended the latter workshop, as well as to a 4-days course focused on the assessment and treatment of patients classified, by the KSBT, with low, medium and high risk of developing persistent disabling pain. A book in Portuguese including detailed information about the contents of the course was also developed in order to support the PTs while attending the course and afterwards in their clinical settings.
In order to promote the successful implementation of the SPLIT project, the exploration of the perceptions of the GPs and PTs, who had attended the aforementioned training, regarding its upcoming implementation was considered fundamental. In particular, the knowledge about acceptability as well as potential facilitators and barriers prior to its implementation was considered essential to better prepare researchers and health professionals.
Materials and methods
Study design
In order to gain insights into the GPs and PTs perceptions regarding the upcoming implementation of the SPLIT project, a qualitative study was considered most suitable. The criteria for reporting qualitative research (COREQ) provided important guidelines for this study design as well as data analysis [28]. In particular, a Thematic Analysis (TA) was carried out to identify, analyse and report common themes and sub-themes within and across data [29]. Some authors have characterized TA as a tool to use across different methods, however, others argued that it might be seen as a method in its own right [29,30]. In this study, TA was used as a methodological approach, particularly focused on a rich description of data, with less emphasis on producing an in-depth interpretation that would be expected from other methodological approaches, such as grounded theory or interpretative phenomenological analysis [31,32].
Ethical approval was granted by the Specialized Ethics Committee from the School of Health Care, Setúbal Polytechnic Institute (36/LN/2018).
Context
The Portuguese health care system is organized around an NHS model, whose planning and regulation is developed by the Ministry of Health, with some increasing responsibilities delegated to regional bodies [33]. All residents have access to the health care provided by the NHS and participate in health care financing via co-payments and co-insurance [34–37]. The primary care follows the organization of the NHS, including regional administration bodies that manage groups of primary care centres. The SPLIT project was planned in partnership with one of the aforementioned administration bodies (ARS Lisbon and Tagus Valley) to be implemented in 1 Group of Health Centers (ACES Arrábida). This group of health centers provides health services to a population of 233.516 individuals, living in the municipalities of Palmela, Setúbal and Sesimbra [38]. From the 22 health units included in this group of health centers, 7 were selected for piloting the project, based on the proportion of geographical area covered by ACES Arrábida (1 health unit from Palmela, 2 health units from Sesimbra and 4 health units in Setúbal). A total of 52 GPs and 3 PTs works in these 7 health units [38].
Information on the typical journey of a patient with LBP in primary care in Portugal is quite scarce. Recent literature has highlighted the patients`multiple journeys in the Portuguese NHS [39]. The vast majority of individuals start by attending an appointment with their GP, who make the decision about the need for referral to another health professional [40]. Patients consider the access to health care and the process of diagnosing and referring as difficult and prolonged [40] and tend to go to NHS and private practice interchangeably [39].
Despite the limited information on the specific waiting time of patients with LBP in the health units where the SPLIT project was going to be implemented, it was known that the process was lengthy, as there were no physiotherapy services available for these patients and they needed referral for outsourced physiotherapy services.
Participants
Since the SPLIT project was routed in an interdisciplinary work involving GPs and PTs, the collection of data regarding the perceptions of both professionals groups was considered fundamental. Accordingly, twelve participants (six GPs and six PTs) were recruited from those who had completed the training program that had been delivered. As there were only 3 PTs working in the health units where the SPLIT project was going to be implemented, the participation of more PTs from similar units was considered. The attendance to all sessions of the program was the only inclusion criteria for the participation in this study. The potential participants were randomly selected and invited to participate by e-mail, two weeks prior to the focus group. The e-mail included an invitation with a detailed explanation of the study, a consent form as well as the interview schedule. The potential participants were given the opportunity to consider if they wished to participate and, in case of a positive decision, were asked to reply to the e-mail in one week. All participants, who were invited to participate, accepted to take part.
Data collection
Two focus groups (one with GPs and one with PTs) were carried out in order to collect data. The focus group is defined as a discussion-based interview that produces data and insights via group interaction, which would be less accessible without the interaction founded in a group [41,42]. The focus groups were selected as a method for data collection since the aim of this study was focused on understanding the combined local perspectives of each professional group participating in the implementation of the SPLIT project. The research team aimed to explore potential agreements or disagreements as the discussion progressed and to grasp each professional group perceptions regarding the future implementation of the SPLIT project. The focus group sessions had a 60-minute duration and were held by the first author (CC), while SP took notes in order to summarize the main topics discussed during the session. CC had previous experience in facilitating focus group discussions and SP had experience as a research assistant in focus groups.
Both focus groups were carried out immediately after the end of the previously mentioned training program. The five stages for moderating focus groups suggested by Finch et al (2014) were followed: scene setting and ground rules; individual introduction; the opening topic; discussion; and, ending the discussion [42]. The discussion was based on a semi-structured interview schedule based on exploratory open-ended questions. Particularly, open, transitional, key questions and probes were used, following Krueger and Casey`s recommendations [43]. The questions were grouped into two sections, as outlined in Table 1. The first section included generic questions, designed to explore the participants`perceptions regarding the acceptability of the SPLIT project; the second section contained specific questions designed to explore the potential facilitators and barriers to the upcoming implementation of this project. Since questions on the first section were generic, they were asked to both professional groups. The second section was tailored to each professional group, according to the expected role on the SPLIT project.
Tab. 1. Interview schedule. The focus group sessions were audio-recorded and transcribed verbatim by SP. The participants`names were replaced by the pseudonymous they had selected prior the focus group session.
Data analysis
Data analysis followed the six-phase process suggested by Braun and Clarke (2006). The first phase involved the researchers`familiarization with data by reading and re-reading the transcripts and listening to the recordings, while taking initial notes about the data and potential topics for further exploration. The following phase included a systematic coding of the data. The codification was guided by this study`s aims, meaning that the researchers were looking for information related to the acceptability, facilitators and barriers to the upcoming implementation of the SPLIT project. Nevertheless, it was agreed that the codification should remain opened in order to allow the inclusion of any other relevant topics that emerged from the data. Two researchers (CC and SP) independently coded the transcripts and produced a list of codes and the relevant excerpts to each code. Each excerpt was identified by a sequence of words and numbers (professional group, pseudonymous, page number of the transcript, line number) in order to allow an easy identification in the transcript. The researchers discussed the codes and examined their scope and relevance. This discussion prompted the beginning of the third phase of analysis, which was focused on the development of initial themes. At this phase, the codes were examined in more depth in order to identify similarities and differences and then were clustered to form the first sub-themes. The connections among the sub-themes were discussed in order to develop potential themes. A “thematic map” of the analysis was developed as an outcome of this discussion. In the following phase, CC reviewed the previously identified themes and sub-themes against the data in order to check that the themes together addressed the study`s aims in a meaningful way, the most relevant data were captured and no relevant information was discharged. Themes and sub-themes were refined and brought to discussion with SP and EBC, who agreed with the proposed themes and sub-themes. This prompted the beginning of the fifth and sixth phases that were focused on naming the final themes and sub-themes and writing-up, respectively. In fact, both phases overlapped since writing-up involved further analysis and subsequent reorganization of themes, sub-themes and relevant excerpts [29,30].
Results
Twelve participants (9 female, 3 male) were included. Five of the participants were 30–39, four were 40–49, and three were 20–29, 50–59 and 60–69, respectively. The GPs`group had an average of 13.17 years of professional experience, from which 10.17 years were based in primary care. The PTs`had an average of 21 years of professional experience, from which 13.87 years were based in primary care.
Four themes and twelve sub-themes emerged from data analysis, as outlined in Table 2. These themes explored the aspects that this study`s participants considered relevant to promote the effective and successful implementation of the SPLIT project in the context of primary care. Excerpts from the focus groups are presented to support the analysis.
Tab. 2. Main themes and sub-themes emerged from data analysis. Theme 1: Acceptability of the SPLIT project
In the first theme, the participants`perceptions regarding the acceptability of the SPLIT project were examined. This theme included three sub-themes that explored the main factors that justify the participants`perception of acceptability: the feasibility; the potential increase of the quality of health care provided; and, the potential value creation and innovation.
Sub-theme 1.1. The SPLIT project feasibility
From the GPs`point of view the acceptability was mainly related to the reduced time required from their appointments, since they considered being very restricted in what concerns to the time available to attend patients. The referral to physiotherapy in the context of this project was perceived as both acceptable and advantageous for two main reasons: quickness, as GPs do not need to fulfil the KSBT prior to referral; and, lowered costs since it allows the referral for physiotherapy in the health unit, as opposed to the referral to outsourced physiotherapy service that happened previously.
" … the GPs won`t have extra work (…) We`ll consider the need for referral to physiotherapy… But, we won`t have to do anything extra in the few minutes we have to pay attention to each patient.” (GP Maria, 15, 673)
"If this tool [KSBT] were introduced in the appointments with GPs it wouldn`t be possibly used. So, it is very important to keep it with the PTs, as this facilitates the referral.” (GP João, 5, 208)
“On the other hand, we should consider the potential costs reduction. The costs associated to the referral to physiotherapy inside the health unit will be lower than those from the outsourced physiotherapy services. So, this is an important factor for the acceptability and adherence to this project.” (GP João, 2, 49)
Both professional groups valued the use of the KSBT and considered it as an important instrument for triage and stratification of patients according to their risk of developing persistent disabling low back pain. In particular, the PTs, who were expected to use this tool to assess patients, emphasised the importance of its easy usage as well as the usefulness of the information obtained from it for their clinical reasoning.
“This tool is feasible in our context, because it includes only nine questions, which are easy to answer (…). The outcome helps us on stratifying the patient and identifying treatment priorities.” (PT Eunice, 5, 198)
"So, this tool is going to be very useful because it`s going to guide our practice, by stratifying patients… This is going to help us in clinical reasoning and in the decisions regarding treatment.” (PT Sofia, 4, 154)
Sub-theme 1.2. The potential increase of the quality of health care provided
Both professional groups emphasised the potential increase of the quality of health care provided, when they compared the SPLIT project to the care that was being provided at the time of the focus groups. This potential improvement was justified by three factors: firstly, the expected reduction of waiting time to start physiotherapy; secondly, the expected provision of care that is both evidence-based and personalised according to the patient`s risk of developing persistent disabling pain; and, thirdly, the expected reduction of the number of sessions needed for discharge.
"Ok, currently I assess a patient and identify that he needs physiotherapy. But, when does he start doing physiotherapy? In a month? Two months? He waits for another appointment with a physician in the outsourced physiotherapy service and then he waits again to start doing physiotherapy sessions… It`s too much time (…) I think this is meaningful for the patient…” (GP Lita, 7, 300)
“This model helps us personalizing treatment according to the patient`s sub-group (…) and, thus, providing a more effective and evidence-based response." (PT Cristina, 3, 104)
"We [GPs] are aware some patients do physiotherapy in an outsourced service and have some outcomes after a number of sessions, but other patients in another service need much more sessions to obtain those outcomes." (GP Sophie, 7, 325)
Sub-theme 1.3. The potential value creation and innovation
While considering the acceptability of the SPLIT project, this study`s participants also emphasised the potential innovation and value added to the services provided by health units from primary care. The aforementioned innovation and value added were explained by the implementation of an interdisciplinary stratified model of care that responds to LBP patients`needs and by a more effective management of time and human resources.
"It [the SPLIT project] will add a new offer to the list of health services provided by this group of health centres… Something that it`s new and different… And, taking into account the scientific evidence presented by the research team, it seems better than the current clinical practice…” (GP João, 1, 46)
"To be able to better manage human resources is an added value to our employee… PTs are scarce in primary care (…) So, this may help moving PTs from practices that are not evidence-based towards new and more effective treatments.” (PT Guilherme, 3, 83)
Theme 2. Facilitators to the implementation of the SPLIT project
In the second theme, the potential facilitators to the implementation of this project were identified. Three main facilitators were explored: the participants`motivation to improve the health care provided; the coherence between this project and the aims and mission of health units from primary care where it was going to be implemented; and, the promotion of interdisciplinary work as well as the centralization of care in each unit.
Sub-theme 2.1. The motivation to improve the health care provided
Both groups considered their motivation to implement the SPLIT as an important facilitator. This motivation was grounded on the expectation of increasing the quality of health care provided. Nevertheless, the PTs called attention to the expected challenges and difficulties associated with the need to change their practice. Additionally, the GPs highlighted the importance of having regular contact with elements from the research team in order to maintain their motivation.
“… this is a facilitator… having the guarantee that I`m doing evidence-based treatment and I`m contributing to improve patients' health condition.” (PT Maria, 4, 146)
“This is going to be the biggest challenge: to change what we used to do and then assess the outcomes from an approach that is more focused on patient education and exercise” (PT Sofia, 5, 192)
Sub-theme 2.2. The coherence between the SPLIT project and the aims and mission of primary care
According to this study`s participants the alignment between the SPLIT project and the mission of health units from primary care was considered one of the main facilitators to its implementation. On the one hand, the SPLIT project was expected to implement a model of care that may help to reduce the substantial impact of LBP on both patients and the NHS. On the other hand, it may contribute to achieve the goals planned by the health units from primary care. More specifically, the GPs and PTs called attention to the potential improvement on health indicators for medical prescription, with a potential reduction on medical prescription of medication and medical exams, such as X-rays.
"Without this stratification we would probably use the same treatment for everyone. Some would become better, some wouldn`t. We would have more costs because we would probably prescribe more unnecessary medical exams …" (GP Sophie, 6, 268)
“In LBP, the prescription of anti-inflammatory and medical exams needs to be reduced. This [the SPLIT project] may help patients but also health units, which have health indicators to achieve… So, for me, this is one of the major facilitators.” (PT Guilherme, 17, 665)
Sub-theme 2.3. Interdisciplinary work and centralization of care in the health units
The SPLIT project alignment with the multidisciplinary nature of services provided by the health units from primary care and the simultaneous maintenance of the autonomy of each professional group are considered key facilitators. The GPs considered the SPLIT project might promote interdisciplinary health care, since it would possibly contribute to the increase of knowledge of the specific contribution of each professional group in the approach to LBP patients. Additionally, the centralization of care in the health units from primary care, without the need for referral to outsourced physiotherapy services, was also identified as an important facilitator, since it was expected to facilitate the patients' access to health care.
" (…) So. we`ll have physios working directly with us… (…) So, we know what they have to offer, what may be the advantageous for patients. And, this makes us feel more confident to recommend physiotherapy” (GP Sophie, 7, 329)
"… I think this [the SPLIT project] may prompt and be a good example of interdisciplinary care… even for projects in other health problems (…) it puts patients in the centre, may increase efficacy and reduce costs." (GP João, 7, 316)
Theme 3: Barriers to the implementation of the SPLIT project
In the third theme, the barriers were discussed, with particular emphasis on three potential issues: the change of routine care; the patients' resistance to a different treatment approach; and, the management of rooms in health units.
Sub-theme 3.1. The change of routine care
Although the personal motivation to implement the SPLIT project was considered as a facilitator, the participants also stressed that the change of routine care might be a barrier. The GPs identified two main problems related to the referral to physiotherapy: “reduced” referrals—due to reduced time of appointments, GPs were afraid of not referring patients who would benefit from physiotherapy; and, “incorrect” referrals—GPs anticipated the possibility of referring patients with exclusion criteria.
“… some days are chaotic… sometimes our levels of stress are at the top… we don`t have time even for the basic procedures … let alone the new procedures that constitute an extra, of course it`s a nice extra, but they will require extra time since we`re not used to them…” (GP Diana, 18, 821)
" … the reduced referral may be an issue, and also an incorrect referral, I mean we may not consider the inclusion and exclusion criteria for patients to be included in the SPLIT project” (GP João, 10, 433)
The PTs also emphasised the need to change their clinical practice, mainly with patients classified with high risk, as a potential issue. This professional group anticipated difficulty in implementing hands-off treatments focused on patient education about pain, as this would be very different from what they were used to do.
“Well I can learn the neurophysiology of pain… it`s all about reading the references… But, the cognitive-behavioural model for patient education… For me, this is definitely the most difficult.” (PT Guilherme, 18, 702)
Sub-theme 3.2. The patients' resistance to a different treatment approach
Both groups anticipated the potential resistance from patients to a different clinical approach as a potential barrier. However, they had different perceptions regarding the group of patients that might be more resistant–the GPs considered the patients classified with low risk, while the PTs indicated the patients classified with high risk.
" … just one session? We know patients and we know how difficult it is… Are they going to be ok with this idea? I ask myself. I`m not sure." (GP Lita, 5, 190)
" (…) I don`t think the low risk group is going to feel the need for more sessions because the prognosis is quite positive (…) But, the patients classified with high risk… we`ll need to manage this approach with caution because it`s a completely different treatment [from what they were used to]…” (PT Sofia, 5, 183)
Despite the aforementioned resistance, the GPs emphasised patients' lack of satisfaction with the outcomes they have achieved with previous health care and considered this could reduce resistance to new treatments.
" (…) they [patients with LBP] want new solutions. They want different treatments… And, it`s important to explain that having an X-ray won`t release pain… (…) they need a specialized treatment…” (GP Alex, 5, 196)
Sub-theme 3.3. The management of rooms in health units
The management of material resources was also identified as a potential barrier for the implementation of the SPLIT project. In particular, the participants identified the lack of rooms with adequate dimensions to carry out physiotherapy group sessions. Nevertheless, both groups seemed to be motivated to look for solutions for this problem.
"We are very limited in what concerns rooms… (…) Of course, with good will we`ll find a suitable place, but it`s very difficult to manage this issue." (GP Lita, 9, 378)
"For example, we just have one room for group sessions in the health unit where I`m working… (…) This room is used for different purposes, by several health professionals, so we have to manage this very carefully and book our sessions on the available time schedule” (PT Ana, 14, 572)
Theme 4 –Tailored planning and specific adaptation to the context
In the fourth theme, the need for a tailored planning and specific adaptation to the contexts where the SPLIT project was going to be implemented was emphasised. Three main aspects were explored: the health professionals`need for specific training; the reorganization of the services; and, the development of new strategies to facilitate communication between GPs and PTs.
Sub-theme 4.1. The health professionals`need for specific training
Both professional groups emphasised the importance of specific training included in the context of the implementation of the SPLIT project. The PTs explored the role of this training in more depth and considered it as fundamental for what they called “a paradigm shift”. This shift seemed to be related to the focus on promoting patients' self-management, rather than on the identification and treatment of the body structure in the origin of pain. According to the PTs the training provided was considered adequate for starting the implementation of this project. However, they identified two areas (patient education and exercise) in which they perceived to be less competent and highlighted them as learning needs for future.
"In my opinion the training covered all important aspects (…) It has been a good starting point…” (PT Guilherme, 3, 93)
“I need to learn more about patient education, mainly how to use strategies from the cognitive-behavioural model in order to carry out education about the neurophysiology of pain” (PT Guilherme, 17, 678).
"Also, from our graduation… We have little knowledge about exercise prescription…” (PT Sofia, 18, 696)
Sub-theme 4.2. The reorganization of the health services
Both groups identified the need to reorganize health services in each unit in order to promote the successful implementation of the SPLIT project. The need for creating a specific period in the PTs`agendas focused on treating patients with LBP was highlighted. This was identified as a priority, since PTs working in the health units where the SPLIT project was going to be implemented did not use to treat patients with LBP (these patients used to be referred to outsourced physiotherapy services).
"To have a physiotherapist available twice a week to receive the patients that we assessed is fundamental… Also, the administrative assistants should be involved, they should know the schedule and inform patients… And we [GPs] should be able to inform patients: on that day, at that time, you [the patient] can come to the health unit and speak with the physiotherapist. I think this is very important” (GP Diana, 13, 602)
" … we need to create a specific period on our schedules to treat these patients” (PT Ana, 10, 409)
Sub-theme 4.3. The development of new strategies to facilitate communication between GPs and PTs
Finally, the need for new strategies that may facilitate communication between GPs and PTs was highlighted. This sub-theme was explored in more depth by the GPs. Since the referral had been previously identified as a potential barrier, the GPs suggested some strategies to promote the integration of referral of patients with LBP to physiotherapy into their routine care.
"We have so much work to do each day… frequently, our IT has problems and this steals time from the appointment… We have just 20 minutes to that patient… if we don`t have a reminder we will forget to do this referral…” (GP Maria, 16, 721)
" … I suggest something simple, for example a stick with the word SPLIT… Something that we can put in our desk, on our computer… This is enough to remind us" (GP João, 17, 754)
Additionally, they emphasised the need for feedback from PTs regarding two aspects: the referral, in what concerns to its agreement with the inclusion and exclusion criteria for the SPLIT project, particularly, in the first months of implementation; and, the outcomes achieved with each patient referred. In order to facilitate this process, regular meetings with both professionals groups were proposed.
"This feedback may happen on a monthly basis, or each three months, whatever… But, it should be incorporated into the GPs meetings… (…) Feedback about the referrals themselves, and also about the outcomes achieved with patients… this is quite important.” (GP João, 19, 852)
"The physiotherapist is there so… we could increase our communication… We [GPs] have regular meetings, and it may be possible for her [PT] to come… (…) Or, she may think about the adequate frequency…” (GP Lita, 17, 787)
Discussion
The SPLIT project aims to improve clinical outcomes and cost-efficiency of services delivered to patients with LBP as well as improve their experiences in the NHS. Given the GPs and PTs involvement in all changes proposed to care delivery, it became important to explore their perceptions regarding the acceptability, potential facilitators and barriers before the implementation of the aforementioned project. Qualitative research methods have been considered useful for the development, evaluation and implementation of complex interventions in health care [44]. Previous qualitative studies have already been published on the perceptions of GPs as well as PTs about this topic [24–27], however, data from both groups have been explored separately. To the authors`knowledge, this is the first study encompassing and combining the perceptions of both professional groups, which were expected to implement an interdisciplinary approach. The exploration of the potential barriers and facilitators to the implementation of an intervention, rather than simply focusing on observations before and after its implementation may provide an opportunity for future triangulation of data. This could increase the understanding of both the outcomes of the project as well as the implementation process and how the latter influences the health care delivery and its outcomes [45].
This study`s participants highlighted the feasibility of the SPLIT project. On the one hand, the GPs valued the possibility of referring patients with LBP for physiotherapy in the health unit without adding extra work and consuming time from their appointments. On the other hand, the PTs emphasised the easy usage of KSBT as well as the usefulness of the information obtained from it for their clinical reasoning. The use of KSBT by PTs, rather than by GPs was introduced in the SPLIT project, since previous research carried out in the UK has suggested GPs`reluctance in using the tool due to time constraints and pressures inherent to a busy practice [24]. On the other hand, the study by Karstens and colleagues (2015) has called attention to the lack of agreement among German GPs regarding the most appropriate KSBT administering health professional. Findings from the current study as well as the latter two studies called attention to differences in the organization of health care services and health professionals’ perceptions regarding the use of KSBT across different countries. Despite the demonstration of STarT Back clinical and cost effectiveness in the UK [19], further evidence for the adaptations required to test and implement it in other countries is still needed [17]. In the current study, both professional groups anticipated a potential increase of the quality of health care provided, following the introduction of the SPLIT project in their health units. This was related to a potential reduction of waiting time to start physiotherapy as well as to the provision of evidence-based and patient-centred care. The future implementation of the SPLIT project was viewed as an important step to improve the experiences of patients with LBP, by providing a new service designed to enable a better management of time and human resources and, simultaneously, respond to patients' needs. This study`s participants`perceptions regarding the potential impact of the SPLIT project were aligned with the advantages associated with the implementation of models of care that have been reported in previous research [46,47]. Moreover, both professionals`groups demonstrated awareness of some inconsistencies between their current clinical practice and the international guidelines for treating patients with LBP. This awareness seemed to promote the acceptability of the SPLIT project. Acceptability is a multi-faceted construct that reveals the extent to which people delivering or receiving a health care intervention consider it to be appropriate, taking into account anticipated or experiential cognitive and emotional responses to the intervention [48]. It has been considered a key element in the design, evaluation and implementation of health care interventions [48]. Although the interview schedule used in this study was not designed to explore all dimensions comprised in acceptability, the participants discussed several of them such as their affective attitude about the project, the perceived amount of work required, the extent to which the intervention was perceived as likely achieve its purpose, as well as the extent to which they understood the project and how it would work [48]. The acceptability demonstrated by this study`s participants could be viewed as an important indicator that the implementation of the SPLIT project will be possibly delivered as intended by the research team [49].
GPs and PTs, who participated in this study, perceived their motivation to take part in the implementation of the SPLIT project as a facilitator. The importance of health professionals`engagement in the operating of workforce changes had already been stressed in previous research [45]. Furthermore, this study`s participants also considered the promotion of interdisciplinary work as an important facilitator. This finding is coherent with previous studies that had already called attention to the need to improve inter-professional collaboration to successfully implement the STarT Back [27]. While in previous research GPs`limited levels of trust in PTs`work and education was identified as a significant challenge [27], in the current study GPs were the professional group who stressed this cooperation the most and emphasised the importance of knowing in more depth the work of PTs. Additionally, the centralization of care in each unit without the need for referral to outsourced physiotherapy services was considered one of the most important facilitators, since this is expected to increase patients' accessibility to health services and reduce the costs for the NHS.
This study`s participants also identified potential barriers to the implementation of the SPLIT project. The change of routine care was stressed by both professionals groups and had already been identified in previous research [24,25,45]. The GPs`anticipated struggle to remember identifying patients who might benefit from the project had already been reported by GPs, who had participated in the STarT Back Trial, in the UK. Similarly, the PTs, who participated in this study, highlighted the challenges inherent to the change of their treatment from a biomechanical perspective to a biopsychosocial model, as PTs in the UK had identified before [25]. Furthermore, patients`resistance to a different treatment approach was also identified as a potential barrier, although GPs and PTs were not in agreement regarding the group of patients that might be the most reluctant. Patients' resistance was not particularly emphasised in former studies [24,26,27], with the exception of the study by Sanders and colleagues (2013) that mentioned the PTs`anticipation of patients' resistance regarding the discussion of psychosocial dimension of LBP. Previous research has focused the resistance to new health care interventions on health professionals, due to the perceived threat to their autonomy [24]. The difference found in the current study may be related to the aforementioned GPs and PTs`awareness of some inconsistencies between their current clinical practice and the international guidelines for treating patients with LBP. Nevertheless, it is important to take into consideration the potential impact of social desirability on the participants`interventions in the focus groups, which were conducted by two members of the research team implementing the SPLIT project. Moreover, the lack of available appropriate rooms was also identified as a potential barrier. This seemed to be a contextual issue, which might be related to the recent financial crisis that has affected the quality of health care provided in Portugal [50]. In spite of this potential problem, both professionals groups seemed to be committed to find solutions.
Finally, both GPs and PTs that participated in this study stressed the need for a tailored planning and specific adaptation of the project to the context where it was going to be implemented. Both professionals groups valued the training delivered and considered it adequate to prompt the implementation of the SPLIT project. Indeed, this training program integrated specific adaptations to the Portuguese context. For example, workshops were used for answering questions from GPs and PTs about their role on this process and two dates were offered for each workshop in order to facilitate adherence. A specific program was designed for PTs, including seminars, practical sessions, role-plays and mentoring sessions in the PTs`clinical settings were also planned to be operating on a monthly basis in the first six months of implementation. Additionally, two members from the research team were also available to provide assistance by telephone during this initial stage of implementation. Feedback about referrals and clinical outcomes was also planned to be delivered to GPs and PTs on a regular basis, in the first six months of implementation. Although the practicalities of conducting the SPLIT trial had already been considered by the research team, the GPs and PTs emphasised new aspects in the focus groups that deserved further attention. For instance, the need for reorganizing the health services was stressed by this study`s participants. This seemed to demonstrate their willingness regarding the implementation of a model of care for patients with LBP in primary care. Additionally, both professional groups, in particular GPs, emphasised the need for new strategies to facilitate inter-professional communication and work team. These findings indicated that there might be a good adherence from GPs and PTs to this project, although it is known that the adoption rates for complex interventions tend to be low, which is partially explained by poor or ineffective implementation [51]. Further research on GPs and PTs perceptions after an initial period of implementation is recommended and may provide important knowledge, especially if combined with the analysis of clinical outcomes and cost-efficacy. Furthermore, it is important to assess acceptability and clinical outcomes from the perspective of patients with LBP, since it may offer a deep understanding of the adhesion to the interventions proposed [48,52].
Some limitations should be considered. Respondent validation, that is participants`revision of data collection and/or analysis [53], could have been used to increase the credibility of findings. However, this procedure was not carried out as it might burden the participants, who were expected to be focused on the initial stage of implementation of the SPLIT project. Additionally, the number of participants included may be seen as a potential limitation, particularly if this study`s findings are considered in terms of empirical generalizability. It is important to take into account that the 7 seven health units, where the SPLIT project was going to be piloted, had at least one practitioner participating in the focus groups. Thus, the participants could be considered representative of the practitioners that would be involved in the future implementation of the project. However, they cannot be considered representative of all GPs and PTs`perceptions regarding interdisciplinary stratified care for patients with LBP. These findings should be considered in terms of transferability, which is described as the ability to transfer the study`s findings to individuals in contexts that may have some similarities to the context where the study was carried out [54]. Thus, some procedures were undertaken in order to enable the aforementioned transferability. For example, attention was given to describing the Portuguese context as well as the participants`characteristics and verbatim transcriptions from focus groups were presented to support the researchers`interpretations.
Conclusions
This study provided the first insights into the perceptions of both GPs and PTs regarding the upcoming implementation of an interdisciplinary stratified model of care for patients with LBP. The use of qualitative research methods provided useful knowledge for the development and upcoming implementation of the SPLIT Project. The exploration of the acceptability, potential barriers and facilitators to the implementation of this project may provide an opportunity for future triangulation of data and, thus, for developing a deep understanding about the clinical outcomes and cost-efficacy as well as about the process of implementation and how they impact on each other. Further research focused on patients' perceptions regarding the interdisciplinary stratified model of care integrated into the SPLIT project is recommended.
Zdroje
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- Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
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- From waste to food: Optimising the breakdown of oil palm waste to provide substrate for insects farmed as animal feed
- Quantitative assessment of interstitial lung disease in Sjögren’s syndrome
- Comparative efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naive chronic hepatitis B: A systematic review and meta-analysis
- Reference ranges for ultrasonographic renal dimensions as functions of age and body indices: A retrospective observational study in Taiwan
- Finding phrases: On the role of co-verbal facial information in learning word order in infancy
- Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization
- Effects of forest management and roe deer impact on a mountain forest development in the Italian Apennines: A modelling approach using LANDIS-II
- Evaluation of comprehensive improvement for mild and moderate soil salinization in arid zone
- Efficacy, acceptability and feasibility of daily text-messaging in promoting glycaemic control and other clinical outcomes in a low-resource setting of South Africa: A randomised controlled trial
- Magnitude and associated factors of postpartum depression among women in Nekemte town, East Wollega zone, west Ethiopia, 2019: A community-based study
- Comparison of continuous wave and cold lateral condensation filling techniques in 3D printed simulated C-shape canals instrumented with Reciproc Blue or Hyflex EDM
- Effect of caffeine on neuromuscular function following eccentric-based exercise
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- Selection of reference genes for normalization of cranberry (Vaccinium macrocarpon Ait.) gene expression under different experimental conditions
- The household economic costs associated with depression symptoms: A cross-sectional household study conducted in the North West province of South Africa
- Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping
- Acute low- compared to high-load resistance training to failure results in greater energy expenditure during exercise in healthy young men
- Impact of body mass index and metabolically unhealthy status on mortality in the Japanese general population: The JMS cohort study
- Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis
- Ecohydrology of urban trees under passive and active irrigation in a semiarid city
- Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model
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- Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models
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- Yeasts affect tolerance of Drosophila melanogaster to food substrate with high NaCl concentration
- The effect of climate change on cholera disease: The road ahead using artificial neural network
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- Improving the antimicrobial efficacy against resistant Staphylococcus aureus by a combined use of conjugated oligoelectrolytes
- Kin discrimination and outer membrane exchange in Myxococcus xanthus: Experimental analysis of a natural population
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- Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson's disease: A systematic review
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- Association between housing tenure and self-rated health in Japan: Findings from a nationwide cross-sectional survey
- Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China
- One-year follow-up of changes in refraction and aberrations induced by corneal incision
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- Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania
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- Ion torrent high throughput mitochondrial genome sequencing (HTMGS)
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- Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination
- Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon
- Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures
- CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say
- Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
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- Comparative distribution of extended-spectrum beta-lactamase–producing Escherichia coli from urine infections and environmental waters
- Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters
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- Intolerance of uncertainty fuels depressive symptoms through rumination: Cross-sectional and longitudinal studies
- Monitoring exercise-induced muscle damage indicators and myoelectric activity during two weeks of knee extensor exercise training in young and old men
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- The association between self-efficacy and self-management behaviors among Chinese patients with type 2 diabetes
- Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat
- Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study
- Evaluation of forearm vascular resistance during orthostatic stress: Velocity is proportional to flow and size doesn’t matter
- Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size
- Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring
- Aspartate aminotransferase-to-platelet ratio index (APRI): A potential marker for diagnosis in patients at risk of severe malaria caused by Plasmodium vivax
- Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology
- Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal
- Clinical characteristics of neonatal fulminant necrotizing enterocolitis in a tertiary Children's hospital in the last 10 years
- Effects of neuromuscular electrical stimulation training on muscle size in collegiate track and field athletes
- Adaptive fuzzy flow rate control considering multifractal traffic modeling and 5G communications
- Evaluation of four commercial tests for detecting ceftiofur in waste milk bulk tank samples
- A smart tele-cytology point-of-care platform for oral cancer screening
- Vasopressin SNP pain factors and stress in sickle cell disease
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- Microbial metabolisms in an abyssal ferromanganese crust from the Takuyo-Daigo Seamount as revealed by metagenomics
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- The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death
- Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS)
- Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012
- The effects of prolonged single night session of videogaming on sleep and declarative memory
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- Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane
- Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
- Correction: Effect of corruption on perceived difficulties in healthcare access in sub-Saharan Africa
- Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters
- Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects
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- Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis
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- Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults
- Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
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- The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice
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- Effect of feeding patterns on growth and nutritional status of children aged 0-24 months: A Chinese cohort study
- A fecal sequel: Testing the limits of a genetic assay for bat species identification
- Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study
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- Correction: Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
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- Cold-related Florida manatee mortality in relation to air and water temperatures
- Conceptual fluency in inductive reasoning
- Clinical outcomes and treatment patterns among Medicare patients with nonvalvular atrial fibrillation (NVAF) and chronic kidney disease
- Improvements in the learnability of smartphone haptic interfaces for visually impaired users
- Role of the malic enzyme in metabolism of the halotolerant methanotroph Methylotuvimicrobium alcaliphilum 20Z
- Cyclic loading test study on a new cast-in-situ insulated sandwich concrete wall
- Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies
- Analysis of virulence potential of Escherichia coli O145 isolated from cattle feces and hide samples based on whole genome sequencing
- Pre-clinical medical student reflections on implicit bias: Implications for learning and teaching
- Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients
- Determinants of preterm birth among mothers who gave birth at public hospitals in the Amhara region, Ethiopia: A case-control study
- Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain
- Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
- Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice
- Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth
- Achievement of weight loss in patients with overweight during dietetic treatment in primary health care
- Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation
- The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study
- Reorganization of spatial configurations in visual working memory: A matter of set size?
- Unravelling travellers’ route choice behaviour at full-scale urban network by focusing on representative OD pairs in computer experiments
- Evaluating the higher-order structure of the Profile of Emotional Competence (PEC): Confirmatory factor analysis and Bayesian structural equation modeling
- HIV prevalence and correlated factors among male clients of female sex workers in a border region of China
- Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis
- Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population
- Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians
- Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project
- Friends with benefits: The effects of vegetative shading on plant survival in a green roof environment
- Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis
- Identifying candidate diagnostic markers for early stage of non-small cell lung cancer
- Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
- Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
- Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood
- Enhanced fibrinolysis detection in a natural occurring canine model with intracavitary effusions: Comparison and degree of agreement between thromboelastometry and FDPs, D-dimer and fibrinogen concentrations
- Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants
- Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses
- Autonomous drone hunter operating by deep learning and all-onboard computations in GPS-denied environments
- Heterogeneity Diffusion Imaging of gliomas: Initial experience and validation
- Frequency cluster formation and slow oscillations in neural populations with plasticity
- DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy
- Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
- Analytical solution to swing equations in power grids
- Pathways to conspiracy: The social and linguistic precursors of involvement in Reddit’s conspiracy theory forum
- Spatiotemporally random and diverse grid cell spike patterns contribute to the transformation of grid cell to place cell in a neural network model
- Empathic concern and personal distress depend on situational but not dispositional factors
- Who is more susceptible to job stressors and resources? Sensory-processing sensitivity as a personal resource and vulnerability factor
- Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa
- A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
- One step at a time: Physical activity is linked to positive interpretations of ambiguity
- Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells
- Evaluation of various methods of selection of B. subtilis strains capable of secreting surface-active compounds
- Association between US Pharmacopeia (USP) monograph standards, generic entry and prescription drug costs
- Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects
- On sorption hysteresis in wood: Separating hysteresis in cell wall water and capillary water in the full moisture range
- Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction
- Reliability and construct validity of the stepping-forward affordance perception test for fall risk assessment in community-dwelling older adults
- Socioeconomic determinants of nutritional status among ‘Baiga’ tribal children In Balaghat district of Madhya Pradesh: A qualitative study
- Study on characteristics of fire plume in building facade window under lateral blow
- ‘When you talk to someone in a bad way or always put her under pressure, it is actually worse than beating her’: Conceptions and experiences of emotional intimate partner violence in Rwanda and South Africa
- Effects of 6-mercaptopurine in pressure overload induced right heart failure
- The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes
- Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study
- Factors associated with persistently high-cost health care utilization for musculoskeletal pain
- Nitrogen and chlorophyll status determination in durum wheat as influenced by fertilization and soil management: Preliminary results
- Effect of repeated in vivo microCT imaging on the properties of the mouse tibia
- Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia
- Hematology and plasma biochemistries in the Blanding’s turtle (Emydoidea blandingii) in Lake County, Illinois
- CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
- Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors
- Antidepressant prescriptions, discontinuation, depression and perinatal outcomes, including breastfeeding: A population cohort analysis
- Why men with a low-risk prostate cancer select and stay on active surveillance: A qualitative study
- Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis
- Combined treatment (image-guided thrombectomy and endovascular therapy with open femoral access) for acute lower limb ischemia: Clinical efficacy and outcomes
- Low-latency single channel real-time neural spike sorting system based on template matching
- Quantifying the scale effect in geospatial big data using semi-variograms
- Paper-and-pencil versus computerized administration mode: Comparison of data quality and risk behavior prevalence estimates in the European school Survey Project on Alcohol and other Drugs (ESPAD)
- Regression adjusted colocalisation colour mapping (RACC): A novel biological visual analysis method for qualitative colocalisation analysis of 3D fluorescence micrographs
- Ostrich eggshell bead diameter in the Holocene: Regional variation with the spread of herding in eastern and southern Africa
- Spatial and temporal variations in female size at maturity of a Southern Rock Lobster (Jasus edwardsii) population: A likely response to climate change
- Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
- Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies
- Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity
- Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study
- Effectiveness of telerehabilitation in the management of adults with stroke: A systematic review
- Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
- Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
- Retraction: Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization
- Evaluation of neutral oral contrast agents for assessment of the small bowel at abdominal staging CT
- Blood type and breed-associated differences in cell marker expression on equine bone marrow-derived mesenchymal stem cells including major histocompatibility complex class II antigen expression
- Induced abortion and future use of IVF treatment; A nationwide register study
- Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan
- Measurement of finger joint angle using stretchable carbon nanotube strain sensor
- Determinants of mortality among patients with drug-resistant tuberculosis in northern Nigeria
- Drugs modulating stochastic gene expression affect the erythroid differentiation process
- Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study
- Prognostic value of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma treated with transarterial chemotherapy: A systematic review and meta-analysis
- Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis
- Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment
- Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits
- Correction: Good and Bad in the Hands of Politicians: Spontaneous Gestures during Positive and Negative Speech
- Adolescents with worse levels of oral health literacy have more cavitated carious lesions
- Effective methods for the inactivation of Francisella tularensis
- Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients
- Correlation between internal pudendal artery stenosis and erectile dysfunction in patients with suspected coronary artery disease
- Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
- Population productivity of shovelnose rays: Inferring the potential for recovery
- Correction: Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era
- Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis
- Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression
- Changes in weight and body composition across five years at university: A prospective observational study
- Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning
- Effects of insulin signaling on mouse taste cell proliferation
- Patient-level cost of home- and facility-based child pneumonia treatment in Suba Sub County, Kenya
- TAP: A static analysis model for PHP vulnerabilities based on token and deep learning technology
- Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil
- Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: Results of a cluster randomized controlled trial
- Changes over time in creatinine clearance and comparison of emergent adverse events for HIV-positive adults receiving standard doses (300 mg/day) of lamivudine-containing antiretroviral therapy with baseline creatinine clearance of 30–49 vs ≥50 mL/min
- Population dynamics of foxes during restricted-area culling in Britain: Advancing understanding through state-space modelling of culling records
- Impacts of experimental advisory exit speed sign on traffic speeds for freeway exit ramp
- In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium
- Monitoring quality indicators for the Xpert MTB/RIF molecular assay in Ethiopia
- Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
- Correction: Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia
- Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes
- Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma
- Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
- Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
- Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
- Comparison of two experimental ARDS models in pigs using electrical impedance tomography
- Are primary school children attending full-day school still engaged in sports clubs?
- Stroke risks in women with dysmenorrhea by age and stroke subtype
- Changes in patterns of mortality rates and years of life lost due to firearms in the United States, 1999 to 2016: A joinpoint analysis
- In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin
- Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients
- Correction: Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods
- Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica)
- Time trends between 2002 and 2017 in correlates of self-reported sitting time in European adults
- Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis
- Changes in HbA1c during the first six years after the diagnosis of Type 2 diabetes mellitus predict long-term microvascular outcomes
- Correction: Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
- Correction: Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Establishing an infrastructure for collaboration in primate cognition research
- Correction: The impact of public health insurance on health care utilisation, financial protection and health status in low- and middle-income countries: A systematic review
- Health provider and service-user experiences of sensory modulation rooms in an acute inpatient psychiatry setting
- Comparison of potential drug-drug interactions with metabolic syndrome medications detected by two databases
- The Polish version of the Cultural Intelligence Scale: Assessment of its reliability and validity among healthcare professionals and medical faculty students
- Selection of optimal reference genes for qRT-PCR analysis of shoot development and graviresponse in prostrate and erect chrysanthemums
- Metastasis risk prediction model in osteosarcoma using metabolic imaging phenotypes: A multivariable radiomics model
- Defining hospital community benefit activities using Delphi technique: A comparison between China and the United States
- Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
- A robust multi-objective optimization framework to capture both cellular and intercellular properties in cardiac cellular model tuning: Analyzing different regions of membrane resistance profile in parameter fitting
- Sea star wasting disease demography and etiology in the brooding sea star Leptasterias spp.
- Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass
- Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola
- I’ve been robbed! – Can changes in floral traits discourage bee pollination?
- Visualising statistical models using dynamic nomograms
- Assessing the capacity of Malawi’s district and central hospitals to manage traumatic diaphyseal femoral fractures in adults
- Diagnostic performance of basal cortisol level at 0900-1300h in adrenal insufficiency
- The Mastery Rubric for Bioinformatics: A tool to support design and evaluation of career-spanning education and training
- Microdissection and whole chromosome painting confirm karyotype transformation in cryptic species of the Lariophagus distinguendus (Förster, 1841) complex (Hymenoptera: Pteromalidae)
- Quality of Kangaroo Mother Care services in Ethiopia: Implications for policy and practice
- Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer
- iTRAQ-based high-throughput proteomics analysis reveals alterations of plasma proteins in patients infected with human bocavirus
- The detection of a non-anemophilous plant species using airborne eDNA
- Perception and control of low cable operation forces in voluntary closing body-powered upper-limb prostheses
- Neoadjuvant chemotherapy plus surgery versus concurrent chemoradiotherapy in stage IB2-IIB cervical cancer: A systematic review and meta-analysis
- Randomized methods to characterize large-scale vortical flow networks
- Disentangling the coexistence strategies of mud-daubing wasp species through trophic analysis in oases of Baja California peninsula
- Front-of-pack nutritional labels: Understanding by low- and middle-income Mexican consumers
- Distress in patients with end-stage renal disease: Staff perceptions of barriers to the identification of mild-moderate distress and the provision of emotional support
- Pathways to antibiotics in Bangladesh: A qualitative study investigating how and when households access medicine including antibiotics for humans or animals when they are ill
- DOC export is exceeded by C fixation in May Creek: A late-successional watershed of the Copper River Basin, Alaska
- Behavioral observation of prosocial behavior and social initiative is related to preschoolers’ psychopathological symptoms
- Evaluating the impact of citations of articles based on knowledge flow patterns hidden in the citations
- Correction: Economic sanctions and academia: Overlooked impact and long-term consequences
- Correction: A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization
- Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
- Price dispersion of generic medications
- Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice
- The emotion regulation effect of cognitive control is related to depressive state through the mediation of rumination: An ERP study
- Comparison of SMS-EPI and 3D-EPI at 7T in an fMRI localizer study with matched spatiotemporal resolution and homogenized excitation profiles
- Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method
- Correction: Combining biophysical parameters, spectral indices and multivariate hyperspectral models for estimating yield and water productivity of spring wheat across different agronomic practices
- Correction: Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- 'Small small quarrels bring about happiness or love in the relationships’: Exploring community perceptions and gendered norms contributing to male perpetrated intimate partner violence in the Central Region of Ghana
- The performance of practitioners conducting facial comparisons on images of children across age
- Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide
- Patients with limitation or withdrawal of life supporting care admitted in a medico-surgical intermediate care unit: Prevalence, description and outcome over a six-month period
- Correction: Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster
- Predicting the performance of TV series through textual and network analysis: The case of Big Bang Theory
- Risk of temperature, humidity and concentrations of air pollutants on the hospitalization of AECOPD
- Mixed methods grant applications in the health sciences: An analysis of reviewer comments
- Renal abnormalities among children with sickle cell conditions in highly resource-limited setting in Ghana
- Size matters: How reaching and vergence movements are influenced by the familiar size of stereoscopically presented objects
- Willingness to receive institutional and community-based eldercare among the rural elderly in China
- An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences
- Beyond executive functions, creativity skills benefit academic outcomes: Insights from Montessori education
- A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions
- Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease
- Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma
- The fight against polio through the NO-DO newsreels during the Francoism period in Spain
- Ocean sound levels in the northeast Pacific recorded from an autonomous underwater glider
- Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study
- The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis
- How medical professional students view older people with dementia: Implications for education and practice
- An enhanced nonparametric EWMA sign control chart using sequential mechanism
- Land use change, carbon stocks and tree species diversity in green spaces of a secondary city in Myanmar, Pyin Oo Lwin
- Is there a difference in women’s experiences of care with medication vs. manual vacuum aspiration abortions? Determinants of person-centered care for abortion services
- Maternal complications in pregnancy and childbirth for women with epilepsy: Time trends in a nationwide cohort
- Adsorption of oxytetracycline on kaolinite
- Interdisciplinary stratified care for low back pain: A qualitative study on the acceptability, potential facilitators and barriers to implementation
- The role of resource transfer in positive, non-additive litter decomposition
- The impact of language on the interpretation of resuscitation clinical care plans by doctors. A mixed methods study
- Quantum dots reveal heterogeneous membrane diffusivity and dynamic surface density polarization of dopamine transporter
- Genomic analysis of Shiga toxin-producing Escherichia coli from patients and asymptomatic food handlers in Japan
- The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress
- Anatomical, taxonomic, and phylogenetic reappraisal of a poorly known ghost knifefish, Tembeassu marauna (Ostariophysi: Gymnotiformes), using X-ray microcomputed tomography
- Matrix-assisted laser desorption/ionization time of flight mass spectrometry identification of Vibrio (Listonella) anguillarum isolated from sea bass and sea bream
- Recommendations of older adults on how to use the PROM ‘TOPICS-MDS’ in healthcare conversations: A Delphi study
- The winner takes it all—Competitiveness of single nodes in globalized supply networks
- Hamsters in the city: A study on the behaviour of a population of common hamsters (Cricetus cricetus) in urban environment
- Correction: Liquid biopsies for omics-based analysis in sentinel mussels
- Size matters! Association between journal size and longitudinal variability of the Journal Impact Factor
- Drug resistance and epidemiology characteristics of multidrug-resistant tuberculosis patients in 17 provinces of China
- A model-based framework for chronic hepatitis C prevalence estimation
- Adding rewards to regulation: The impacts of watershed conservation on land cover and household wellbeing in Moyobamba, Peru
- Clinical determinants of social media use in individuals with schizophrenia
- Arsenic and nutrient absorption characteristics and antioxidant response in different leaves of two ryegrass (Lolium perenne) species under arsenic stress
- An evolution of socioeconomic related inequality in teenage pregnancy and childbearing in Malawi
- A single plasmid based CRISPR interference in Synechocystis 6803 – A proof of concept
- Structural vulnerability to narcotics-driven firearm violence: An ethnographic and epidemiological study of Philadelphia’s Puerto Rican inner-city
- Temporal trends in intracerebral hemorrhage: Evidence from the Austrian Stroke Unit Registry
- Prevalence and risk factors for multi-drug resistant Escherichia coli among poultry workers in the Federal Capital Territory, Abuja, Nigeria
- Prediction of disease-related metabolites using bi-random walks
- Clinical use, efficacy, and durability of maraviroc for antiretroviral therapy in routine care: A European survey
- Biomarker discovery in inflammatory bowel diseases using network-based feature selection
- The Cinderella Complex: Word embeddings reveal gender stereotypes in movies and books
- Exoproteome profiling of Trypanosoma cruzi during amastigogenesis early stages
- Reproducible phenotype alteration due to prolonged cooling of the pupae of Polyommatus icarus butterflies
- Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats
- Pharmacy-based predictors of non-adherence, non-persistence and reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands
- Systematic review of the accuracy of plasma preparation tubes for HIV viral load testing
- Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex
- “Anybody can make kids; it takes a real man to look after your kids”: Aboriginal men’s discourse on parenting
- Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions
- Maternal interpregnancy weight change and premature birth: Findings from an English population-based cohort study
- Correction: Identifying performance benchmarks and determinants for reproductive performance and calf survival using a longitudinal field study of cow-calf herds in western Canada
- Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease
- Treatment of Urethral Pain Syndrome (UPS) in Sweden
- Migration and political polarization in the U.S.: An analysis of the county-level migration network
- Epidemiology and complications of late-onset sepsis: an Italian area-based study
- The relationship between women’s experience of intimate partner violence and other socio-demographic factors, and under-5 children’s health in South Africa
- Association between trunk and gluteus muscle size and long jump performance
- Multimorbidity and complex multimorbidity in Brazilian rural workers
- Correction: Interspecific Phylogenic Relationships within Genus Melilotus Based on Nuclear and Chloroplast DNA
- Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
- Wolf diet and prey selection in the South-Eastern Carpathian Mountains, Romania
- In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms
- Sample size issues in multilevel logistic regression models
- Seed germination ecology of Ageratum houstonianum: A major invasive weed in Nepal
- Experiences of lifestyle change among women with gestational diabetes mellitus (GDM): A behavioural diagnosis using the COM-B model in a low-income setting
- Pharmacologic management of HCV treatment in patients with HCV monoinfection vs. HIV/HCV coinfection: Does coinfection really matter?
- The association between cigarette smoking and serum thyroid stimulating hormone, thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents: A cross-sectional study in 10 cities
- Mouse movement measures enhance the stop-signal task in adult ADHD assessment
- Ecosystem functioning in urban grasslands: The role of biodiversity, plant invasions and urbanization
- Correction: KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
- Does craniofacial morphology affect third molars impaction? Results from a population-based study in northeastern Germany
- Hyperconnectivity during screen-based stories listening is associated with lower narrative comprehension in preschool children exposed to screens vs dialogic reading: An EEG study
- Weight loss is associated with improved quality of life among rural women completers of a web-based lifestyle intervention
- Long-term high-grain diet altered the ruminal pH, fermentation, and composition and functions of the rumen bacterial community, leading to enhanced lactic acid production in Japanese Black beef cattle during fattening
- Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile
- Golgi reassembly and stacking protein 65 downregulation is required for the anti-cancer effect of dihydromyricetin on human ovarian cancer cells
- SSR marker development in Clerodendrum trichotomum using transcriptome sequencing
- Risk factors for the carriage of Streptococcus infantarius subspecies infantarius isolated from African fermented dairy products
- Development of an intervention tool for precision oral self-care: Personalized and evidence-based practice for patients with periodontal disease
- Personal values in adolescence and psychological distress in adults: A cross-sectional study based on a retrospective recall
- Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren’s syndrome patients: A nationwide population-based study
- Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: A retrospective review from a single center
- Hip stress distribution - Predictor of dislocation in hip arthroplasties. A retrospective study of 149 arthroplasties
- Mortality, morbidity, and cardiac surgery in Injection Drug Use (IDU)-associated versus non-IDU infective endocarditis: The need to expand substance use disorder treatment and harm reduction services
- Pup mortality in New Zealand sea lions (Phocarctos hookeri) at Enderby Island, Auckland Islands, 2013-18
- In vitro endothelial cell migration from limbal edge-modified Quarter-DMEK grafts
- Liquid Chromatography/Mass Spectrometry based serum metabolomics study on recurrent abortion women with antiphospholipid syndrome
- Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors
- Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty
- Reliability of the Swedish version of the Evidence-Based Practice Attitude Scale assessing physiotherapist’s attitudes to implementation of evidence-based practice
- Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS
- Complete Chloroplast Genomes of Vachellia nilotica and Senegalia senegal: Comparative Genomics and Phylogenomic Placement in a New Generic System
- Retraction: Over-Expression of Superoxide Dismutase Ameliorates Cr(VI) Induced Adverse Effects via Modulating Cellular Immune System of Drosophila melanogaster
- Effect of pre-season training phase on anthropometric, hormonal and fitness parameters in young soccer players
- Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis
- Outcome of patients with heart failure after transcatheter aortic valve implantation
- Fatty acid profile of Romanian’s common bean (Phaseolus vulgaris L.) lipid fractions and their complexation ability by β-cyclodextrin
- Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding
- Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium
- Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis
- Correction: Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- Correction: Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
- Retraction: Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage
- Correction: Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
- Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study
- Correction: Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
- Discovering novel disease comorbidities using electronic medical records
- Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome
- Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics
- Social information use in adolescents: The impact of adults, peers and household composition
- Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members
- Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial
- Comparative studies of two generations of NanoString nCounter System
- General practitioners’ perceptions of delayed antibiotic prescription for respiratory tract infections: A phenomenographic study
- Can altered magnetic field affect the foraging behaviour of ants?
- Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011–2018
- A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma
- A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE
- Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
- Seasonal alternation of the ontogenetic development of the moon jellyfish Aurelia coerulea in Maizuru Bay, Japan
- Reliability of measurement of active trunk movement in wheelchair basketball players
- Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus
- Does source credibility matter for point-of-decision prompts? A quasi-experimental field study to increase stair use
- Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study
- Quality and utilization patterns of maternity waiting homes at referral facilities in rural Zambia: A mixed-methods multiple case analysis of intervention and standard of care sites
- Determining an optimal pool size for testing beef herds for Johne’s disease in Australia
- Correction: Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
- APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix
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- Correction: Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T
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- Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP
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- Research ethics in inter- and multi-disciplinary teams: Differences in disciplinary interpretations
- Correction: Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
- Correction: People making deontological judgments in the Trapdoor dilemma are perceived to be more prosocial in economic games than they actually are
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- Topical estrogen application to wounds promotes delayed cutaneous wound healing in 80-week-old female mice
- Correction: An international randomised placebo-controlled trial of a four-component combination pill (“polypill”) in people with raised cardiovascular risk
- Correction: Evaluation of lung toxicity risk with computed tomography ventilation image for thoracic cancer patients
- Retraction: Pathological Roles of Interleukin-22 in the Development of Recurrent Hepatitis C after Liver Transplantation
- Correction: Elevational Distribution and Ecology of Small Mammals on Tanzania's Second Highest Mountain
- Correction: Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer
- Correction: Fecal microbiota dysbiosis in macaques and humans within a shared environment
- Correction: The center of pressure and ankle muscle co-contraction in response to anterior-posterior perturbations
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