An Otx/Nodal Regulatory Signature for Posterior Neural Development in Ascidians

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The Chordate phylum groups vertebrates, tunicates (including ascidians) and cephalochordates (amphioxus). These animals share a typical body plan characterized by the presence during embryonic life of a notochord and a dorsal neural tube. Ascidians, however, took a significantly different evolutionary path from other chordates resulting in divergent morphological, embryological and genomic features. Their development is fast and stereotyped with very few cells and ascidian genomes have undergone compaction and extensive rearrangements when compared to vertebrates, but also between ascidian species. This raises the question of whether developmental mechanisms controlling typical chordate structure formation are conserved between ascidians and vertebrates. Here, we have studied the set of ascidian genes which control the formation of the posterior part of the nervous system. We uncovered original usages of the signaling molecule Nodal and the transcription factor Otx. For example, Otx, which is a specific determinant of anterior identity in most metazoans, has been co-opted for the formation of the ascidian posterior nervous system. These two factors define a regulatory signature found in enhancers of posterior neural genes in two genomically divergent ascidian species.

Vyšlo v časopise: An Otx/Nodal Regulatory Signature for Posterior Neural Development in Ascidians. PLoS Genet 10(8): e32767. doi:10.1371/journal.pgen.1004548
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004548

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