1. FuchsY, StellerH (2011) Programmed cell death in animal development and disease. Cell 147: 742–758.
2. BaehreckeEH (2002) How death shapes life during development. Nat Rev Mol Cell Biol 3: 779–787.
3. LettreG, HengartnerMO (2006) Developmental apoptosis in C. elegans: a complex CEDnario. Nat Rev Mol Cell Biol 7: 97–108.
4. PottsMB, CameronS (2011) Cell lineage and cell death: Caenorhabditis elegans and cancer research. Nat Rev Cancer 11: 50–58.
5. SulstonJE, HorvitzHR (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 56: 110–156.
6. SulstonJE, SchierenbergE, WhiteJG, ThomsonJN (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100: 64–119.
7. ConradtB, HorvitzHR (1998) The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93: 519–529.
8. HengartnerMO, HorvitzHR (1994) C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76: 665–676.
9. YuanJ, ShahamS, LedouxS, EllisHM, HorvitzHR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75: 641–652.
10. ZouH, HenzelWJ, LiuX, LutschgA, WangX (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405–413.
11. EllisHM, HorvitzHR (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44: 817–829.
12. HengartnerMO, EllisRE, HorvitzHR (1992) Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356: 494–499.
13. ChenF, HershBM, ConradtB, ZhouZ, RiemerD, et al. (2000) Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science 287: 1485–1489.
14. YanN, GuL, KokelD, ChaiJ, LiW, et al. (2004) Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4. Mol Cell 15: 999–1006.
15. YangX, ChangHY, BaltimoreD (1998) Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281: 1355–1357.
16. PourkarimiE, GreissS, GartnerA (2012) Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction. Cell Death Differ 19: 406–415.
17. NehmeR, ConradtB (2008) egl-1: a key activator of apoptotic cell death in C. elegans. Oncogene 27 Suppl 1: S30–40.
18. PedenE, KillianDJ, XueD (2008) Cell death specification in C. elegans. Cell Cycle 7: 2479–2484.
19. ThellmannM, HatzoldJ, ConradtB (2003) The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins. Development 130: 4057–4071.
20. GrantS, QiaoL, DentP (2002) Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival. Front Biosci 7: d376–389.
21. DanielsenAJ, MaihleNJ (2002) The EGF/ErbB receptor family and apoptosis. Growth Factors 20: 1–15.
22. WieduwiltMJ, MoasserMM (2008) The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol Life Sci 65: 1566–1584.
23. XianCJ, ZhouXF (2004) EGF family of growth factors: essential roles and functional redundancy in the nerve system. Front Biosci 9: 85–92.
24. BergmannA, TugentmanM, ShiloBZ, StellerH (2002) Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling. Dev Cell 2: 159–170.
25. HensonES, GibsonEM, VillanuevaJ, BristowNA, HaneyN, et al. (2003) Increased expression of Mcl-1 is responsible for the blockage of TRAIL-induced apoptosis mediated by EGF/ErbB1 signaling pathway. J Cell Biochem 89: 1177–1192.
26. JostM, HuggettTM, KariC, BoiseLH, RodeckU (2001) Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway. J Biol Chem 276: 6320–6326.
27. LeuCM, ChangC, HuC (2000) Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway. Oncogene 19: 1665–1675.
28. AllanLA, MorriceN, BradyS, MageeG, PathakS, et al. (2003) Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol 5: 647–654.
29. FangX, YuS, EderA, MaoM, BastRCJr, et al. (1999) Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene 18: 6635–6640.
30. GulliLF, PalmerKC, ChenYQ, ReddyKB (1996) Epidermal growth factor-induced apoptosis in A431 cells can be reversed by reducing the tyrosine kinase activity. Cell Growth Differ 7: 173–178.
31. ArmstrongDK, KaufmannSH, OttavianoYL, FuruyaY, BuckleyJA, et al. (1994) Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells. Cancer Res 54: 5280–5283.
32. GarciaR, FranklinRA, McCubreyJA (2006) Cell death of MCF-7 human breast cancer cells induced by EGFR activation in the absence of other growth factors. Cell Cycle 5: 1840–1846.
33. HillRJ, SternbergPW (1992) The gene lin-3 encodes an inductive signal for vulval development in C. elegans. Nature 358: 470–476.
34. AroianRV, KogaM, MendelJE, OhshimaY, SternbergPW (1990) The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 348: 693–699.
35. ChamberlinHM, SternbergPW (1994) The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans. Development 120: 2713–2721.
36. ClandininTR, DeModenaJA, SternbergPW (1998) Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. Cell 92: 523–533.
37. JiangLI, SternbergPW (1998) Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans. Development 125: 2337–2347.
38. Van BuskirkC, SternbergPW (2007) Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nat Neurosci 10: 1300–1307.
39. HanM, SternbergPW (1990) let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein. Cell 63: 921–931.
40. ClarkSG, SternMJ, HorvitzHR (1992) C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature 356: 340–344.
41. HanM, GoldenA, HanY, SternbergPW (1993) C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Nature 363: 133–140.
42. WuY, HanM, GuanKL (1995) MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events. Genes Dev 9: 742–755.
43. KornfeldK, GuanKL, HorvitzHR (1995) The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes & Development 9: 756–768.
44. LacknerMR, KornfeldK, MillerLM, HorvitzHR, KimSK (1994) A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. Genes & development 8: 160–173.
45. WuY, HanM (1994) Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation. Genes Dev 8: 147–159.
46. TanPB, LacknerMR, KimSK (1998) MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. Cell 93: 569–580.
47. HopperNA (2006) The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans. Genetics 173: 163–175.
48. GumiennyTL, LambieE, HartwiegE, HorvitzHR, HengartnerMO (1999) Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. Development 126: 1011–1022.
49. PerrinAJ, GundaM, YuB, YenK, ItoS, et al. (2013) Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways. Cell Death Differ 20: 97–107.
50. RutkowskiR, DickinsonR, StewartG, CraigA, SchimplM, et al. (2011) Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling. PLoS Genet 7: e1002238.
51. QuevedoC, KaplanDR, DerryWB (2007) AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Curr Biol 17: 286–292.
52. FergusonEL, HorvitzHR (1985) Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics 110: 17–72.
53. HoeppnerDJ, HengartnerMO, SchnabelR (2001) Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature 412: 202–206.
54. EllisRE, JacobsonDM, HorvitzHR (1991) Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics 129: 79–94.
55. Hunt-NewburyR, ViveirosR, JohnsenR, MahA, AnastasD, et al. (2007) High-throughput in vivo analysis of gene expression in Caenorhabditis elegans. PLoS Biol 5: e237.
56. ChangC, NewmanAP, SternbergPW (1999) Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia. Curr Biol 9: 237–246.
57. LiuJ, TzouP, HillRJ, SternbergPW (1999) Structural requirements for the tissue-specific and tissue-general functions of the Caenorhabditis elegans epidermal growth factor LIN-3. Genetics 153: 1257–1269.
58. KatzWS, HillRJ, ClandininTR, SternbergPW (1995) Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates. Cell 82: 297–307.
59. SternbergPW, HorvitzHR (1986) Pattern formation during vulval development in C. elegans. Cell 44: 761–772.
60. HwangBJ, SternbergPW (2004) A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development. Development 131: 143–151.
61. FukushigeT, HawkinsMG, McGheeJD (1998) The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine. Dev Biol 198: 286–302.
62. ConradtB, HorvitzHR (1999) The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene. Cell 98: 317–327.
63. MillerLM, GallegosME, MorisseauBA, KimSK (1993) lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development. Genes Dev 7: 933–947.
64. BeitelGJ, TuckS, GreenwaldI, HorvitzHR (1995) The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Genes Dev 9: 3149–3162.
65. MileyGR, FantzD, GlossipD, LuX, SaitoRM, et al. (2004) Identification of residues of the Caenorhabditis elegans LIN-1 ETS domain that are necessary for DNA binding and regulation of vulval cell fates. Genetics 167: 1697–1709.
66. TiensuuT, LarsenMK, VernerssonE, TuckS (2005) lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans. Dev Biol 286: 338–351.
67. ChiuB, MirkinB, MadonnaMB (2006) Mitogenic and apoptotic actions of epidermal growth factor on neuroblastoma cells are concentration-dependent. J Surg Res 135: 209–212.
68. WangH, GuoD, YeF, XiG, WangB, et al. (2006) Effect and mechanism of epidermal growth factor on proliferation of GL15 gliomas cell line. J Huazhong Univ Sci Technolog Med Sci 26: 604–606.
69. KileySC, ChevalierRL (2007) Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF. Am J Physiol Renal Physiol 293: F895–903.
70. SugimotoA, KusanoA, HozakRR, DerryWB, ZhuJ, et al. (2001) Many genomic regions are required for normal embryonic programmed cell death in Caenorhabditis elegans. Genetics 158: 237–252.
71. BooyEP, HensonES, GibsonSB (2011) Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer. Oncogene 30: 2367–2378.
72. BernsJS, FordPA (1997) Renal toxicities of antineoplastic drugs and bone marrow transplantation. Semin Nephrol 17: 54–66.
73. PricePM, SafirsteinRL, MegyesiJ (2004) Protection of renal cells from cisplatin toxicity by cell cycle inhibitors. Am J Physiol Renal Physiol 286: F378–384.
74. AranyI, MegyesiJK, KanetoH, PricePM, SafirsteinRL (2004) Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells. Am J Physiol Renal Physiol 287: F543–549.
75. Frusic-ZlotkinM, RaichenbergD, WangX, DavidM, MichelB, et al. (2006) Apoptotic mechanism in pemphigus autoimmunoglobulins-induced acantholysis–possible involvement of the EGF receptor. Autoimmunity 39: 563–575.
76. BotellaJA, KretzschmarD, KiermayerC, FeldmannP, HughesDA, et al. (2003) Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap. Mol Biol Cell 14: 241–250.
77. PaoW, ChmieleckiJ (2010) Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer. Nat Rev Cancer 10: 760–774.
78. BrennerS (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71–94.
79. TimmonsL, CourtDL, FireA (2001) Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 263: 103–112.
80. SimmerF, TijstermanM, ParrishS, KoushikaSP, NonetML, et al. (2002) Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr Biol 12: 1317–1319.
81. KamathRS, FraserAG, DongY, PoulinG, DurbinR, et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231–237.
82. MelloC, FireA (1995) DNA transformation. Methods Cell Biol 48: 451–482.
83. MaduroM, PilgrimD (1995) Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141: 977–988.
84. SchnabelR, HutterH, MoermanD, SchnabelH (1997) Assessing normal embryogenesis in Caenorhabditis elegans using a 4D microscope: variability of development and regional specification. Dev Biol 184: 234–265.
85. LivakKJ, SchmittgenTD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402–408.
86. GuT, OritaS, HanM (1998) Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. Mol Cell Biol 18: 4556–4564.