A Transposable Element Insertion Confers Xenobiotic Resistance in Drosophila

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Given the predictions of future environmental fluctuations, it is crucial to understand how organisms adapt to changing environments. The fruit fly Drosophila melanogaster is an ideal model organism to study environmental adaptation because of our deep understanding of developmental, physiological, and metabolic networks, as well as the ease of experimental manipulation. In this study, we showed that a previously identified putatively adaptive mutation, the insertion of the transposable element FBti0019627, mediates resistance to both natural and synthetic xenobiotics in Drosophila melanogaster. By combining experimental and computational approaches, we further elucidated the molecular and the biochemical mechanisms underlying this natural adaptive mutation. Our results should be relevant for other organisms as well since there are many similarities between species in the way cells respond to stress.

Vyšlo v časopise: A Transposable Element Insertion Confers Xenobiotic Resistance in Drosophila. PLoS Genet 10(8): e32767. doi:10.1371/journal.pgen.1004560
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004560

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