Functional Specialization Among Members Of Knickkopf Family Of Proteins In Insect Cuticle Organization

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We have identified two additional members of the family of Knickkopf (Knk)-like proteins in the genome of the red flour beetle as well as in all insect species with completely sequenced genomes. The previously characterized member of this family, TcKnk, protects chitin in the newly forming cuticle (exoskeleton) from degradation by the chitinase enzyme present in the molting fluid. Knk is also required for the laminar organization of the chitin polymer in the cuticle. The two newly identified members of this family, TcKnk2 and TcKnk3, have distinctly different but related functions. They are essential for adult morphogenesis including specialized “Velcro-like” cuticular denticles found in the lateral body wall, as well as the proper development of the tracheal lining. The TcKnk3 gene gives rise to multiple transcripts as a result of alternative polyadenylation and/or splicing, but only one of these transcripts is essential for adult development.

Vyšlo v časopise: Functional Specialization Among Members Of Knickkopf Family Of Proteins In Insect Cuticle Organization. PLoS Genet 10(8): e32767. doi:10.1371/journal.pgen.1004537
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004537

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