The Response to High CO Levels Requires the Neuropeptide Secretion Component HID-1 to Promote Pumping Inhibition

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Carbon dioxide (CO2) is a key molecule in many biological processes. High levels of CO2 in patients with pulmonary diseases are associated with worse outcomes. However, mechanisms by which organisms sense and respond to high CO2 levels remain largely unknown. Using Caenorhabditis elegans as a model system, we found that exposure to high CO2 levels leads to a very rapid cessation in the contraction of the pharynx muscles. Further analysis revealed that the pharynx muscle response is controlled by dense core vesicle secretion from the BAG neurons in a hid-1-mediated pathway. This novel hid-1 pathway sheds new light on the physiological effects of high CO2 levels on animals at the organism-wide level.

Vyšlo v časopise: The Response to High CO Levels Requires the Neuropeptide Secretion Component HID-1 to Promote Pumping Inhibition. PLoS Genet 10(8): e32767. doi:10.1371/journal.pgen.1004529
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004529

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