Netrins and Wnts Function Redundantly to Regulate Antero-Posterior and Dorso-Ventral Guidance in

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While ample information was gathered in past decades on identifying guidance cues and their downstream mediators, very little is known about how the information from multiple extracellular cues is integrated within the cell to generate normal patterning. Netrin and Wnt signaling pathways are both critical to multiple developmental processes and play key roles in normal development as well as in malignancies. The UNC-6/Netrin guidance cue has a conserved role in guiding cell and growth cone migrations along the dorso-ventral axis, whereas Wnts are critical for determining polarity and guidance along the antero-posterior axis. In this study we show that these two signaling pathways function redundantly in both antero-posterior and dorso-ventral guidance as well as in processes essential for viability. Furthermore, we demonstrate that a fine balance between Wnt and Netrin signaling pathways is critical for proper polarity establishment and identify Wnt signaling as one of the long sought mechanisms that signal in parallel to Netrin to promote dorso-ventral guidance of cells and axons in Caenorhabditis elegans. These findings pave the way to unraveling the broader roles of Wnt and Netrin signaling pathways and provide a conceptually novel view of how antero-posterior and dorso-ventral guidance mechanisms are orchestrated.

Vyšlo v časopise: Netrins and Wnts Function Redundantly to Regulate Antero-Posterior and Dorso-Ventral Guidance in. PLoS Genet 10(6): e32767. doi:10.1371/journal.pgen.1004381
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004381

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