Successes and Challenges on the Road to Cure Hepatitis C

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15. Flamm SL, Everson GT, Charlton M, Denning JM, Arterburn S, et al. Ledipasvir/sofosbuvir with ribavirin for the treatment of HCV in patients with decompensated cirrhosis: preliminary results of a prospective, multicenter study. 65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). November 1–5, 2014; Boston, MA.

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22. . Kwo P, Gitlin N, Nahass R, Bernstein D, Rojter S, et al. A phase 3, randomized, open-label study to evaluate the efficacy and safety of 12 and 8 weeks of simeprevir (SMV) plus sofosbuvir (SOF) in treatment-naïve and—experienced patients with chornic HCV genotype 1 infection without cirrhosis: OPTIMIST-1. EASL April 2015, Vienna Austria. Abstract LP14.

23. Lawitz E, Matusow G, DeJesus E, Yoshida E, Felizarta F, et al. A phase 3, open-label, single-arm study to evaluate the efficacy and safety of 12 weeks of simeprevir (SMV) plus sofosbuvir (SOF) in treatment-naïve and—experienced patients with chronic HCV genotype 1 infection and cirrhosis: OPTIMIST-2. EASL April 2015, Vienna Austria. Abstract LP04.

24. Svarovskaia ES, Dvory-Sobol H, Doehle B, Gane E, Jacobson IM, et al. L159F and V321A Sofosbuvir Treatment-Emergent HCV NS5B Substitutions. 65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). November 7–11, 2014; Boston, MA.

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26. Nelson DR, Cooper JN, Lalezari JP, Lawitz E, Pockros P, et al. All-Oral 12-Week Combination Treatment With Daclatasvir and Sofosbuvir in Patients Infected with HCV Genotype 3: ALLY-3 Phase 3 Study. 24th Conference of the Asian Pacific Association for the Study of Liver Disease (APASL). March 12–15, 2015; Istanbul, Turkey.

27. Lawitz E, Flamm S, Yang JC, Pang PS, Zhu Y, et al. Retreatment of Patients who failed 8 or 12 weeks of ledipasvir/sofosbuvir-based regimens with ledipasvir/sofosbuvir for 24 weeks. EASL April 2015, Vienna Austria. Abstract O005.

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30. Dvory-Sobol H, Wyles D, Ouyang W, Chodavarapu K, McNally J, et al. Long-Term Persistence of HCV NS5A Variants After Treatment with NS5A Inhibitor Ledipasvir. EASL April 2015, Vienna Austria. Abstract O059.

31. Fried MW, Forns X, Reau N, Wedemeyer H, Shiffman ML, et al. TURQUIOSE-II: Regimens of ABT-450/r/ombitasvir and Dasabuvir with Ribavirin Achieve High SVR12 Rates in HCV Genotype 1-Infected Patients with Cirrhosis, Regardless of Baseline Characteristics. [Abstract 81] 65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). November 7–11, 2014; Boston, MA.

32. Naggie S, Cooper C, Saag M, Yang J, Stamm L, et al. Ledipasvir/Sofosbuvir for 12 Weeks in Patients Coinfected with HCV and HIV-1. [Abstract 152LB] Conference on Retroviruses and Opportunistic Infections (CROI). February 23–26; Seattle, WA.