A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes

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Entomopathogenic fungi represent a promising class of bio-insecticides for mosquito control. Detailed knowledge of molecular mechanisms governing anti-fungal immune response in mosquitoes is essential. CLSP2 composed of serine protease and lectin domains functions as a modulator of the mosquito immune system during the anti-fungal response. Transcriptome analysis indicated that the Toll pathway and melanization genes are highly up-regulated in CLSP2 RNA interference depleted mosquitoes infected with the fungus Beauveria bassiana. A thioester-containing protein TEP22, a member of α2-macroglobulin family, is involved in the CLSP2-modulated mosquito antifungal defense. Our study has contributed to the understanding of immune-modulating mechanisms in mosquitoes.

Vyšlo v časopise: A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes. PLoS Pathog 11(6): e32767. doi:10.1371/journal.ppat.1004931
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004931

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