One important innate immune response to viral infection is apoptosis, also called programmed cell death, whereby the infected cells commit suicide rather than serve as factories for virus production. As a result, many viruses have developed strategies to inhibit apoptosis. Here, we demonstrate that five of the Epstein-Barr virus (EBV) miR-BART microRNAs that are expressed in EBV-transformed epithelial cell tumors display anti-apoptotic activity. We have identified ten cellular mRNAs that are bound and downregulated by one of these five anti-apoptotic microRNAs and show that this downregulation can explain the observed reduction in apoptosis in miR-BART-expressing cells. Together, these data demonstrate that the EBV miR-BARTs can help sustain latently EBV-infected cells in the face of pro-apoptotic innate immune signals and this may explain the resistance to DNA damaging agents, including chemotherapeutics and radiation, seen in a subset of EBV-induced epithelial tumors.
Vyšlo v časopise: EBV BART MicroRNAs Target Multiple Pro-apoptotic Cellular Genes to Promote Epithelial Cell Survival. PLoS Pathog 11(6): e32767. doi:10.1371/journal.ppat.1004979 Kategorie: Research Article prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004979
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