1. Newall AT, Scuttham PA, Hodgkinson B (2007) Economic Report into the cost of influenza to the Australian Health System. http://www.influenzaspecialistgrouporgau/images/stories/docs/isg_cost_influenza_report_30_2007pdf.
2. La GrutaNL, KedzierskaK, StambasJ, DohertyPC (2007) A question of self-preservation: immunopathology in influenza virus infection. Immunol Cell Biol 85: 85–92.
3. ArankalleVA, LoleKS, AryaRP, TripathyAS, RamdasiAY, et al. (2010) Role of host immune response and viral load in the differential outcome of pandemic H1N1 (2009) influenza virus infection in Indian patients. PLoS One 5: e13099.
4. ThomasP, KeatingR, Hulse-PostD, DohertyP (2006) Cell-mediated protection in influenza infection. Emerg Infect Dis 12: 48–54.
5. AlexanderWS (2002) Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol 2: 410–416.
6. HiltonDJ, RichardsonRT, AlexanderWS, VineyEM, WillsonTA, et al. (1998) Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci U S A 95: 114–119.
7. FengZP, ChandrashekaranIR, LowA, SpeedTP, NicholsonSE, et al. (2012) The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5. Proteins 80: 946–957.
8. ZhangJG, FarleyA, NicholsonSE, WillsonTA, ZugaroLM, et al. (1999) The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A 96: 2071–2076.
9. LinossiEM, NicholsonSE (2012) The SOCS box-adapting proteins for ubiquitination and proteasomal degradation. IUBMB Life 64: 316–323.
10. KershawNJ, MurphyJM, LiauNP, VargheseLN, LaktyushinA, et al. (2013) SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat Struct Mol Biol 20: 469–476.
11. BabonJJ, KershawNJ, MurphyJM, VargheseLN, LaktyushinA, et al. (2012) Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity. Immunity 36: 239–250.
12. GreenhalghCJ, Rico-BautistaE, LorentzonM, ThausAL, MorganPO, et al. (2005) SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest 115: 397–406.
13. EndoT, SasakiA, MinoguchiM, JooA, YoshimuraA (2003) CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation. J Biochem 133: 109–113.
14. LavensD, MontoyeT, PiessevauxJ, ZabeauL, VandekerckhoveJ, et al. (2006) A complex interaction pattern of CIS and SOCS2 with the leptin receptor. J Cell Sci 119: 2214–2224.
15. AlexanderWS, StarrR, FennerJE, ScottCL, HandmanE, et al. (1999) SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98: 597–608.
16. MetcalfD, GreenhalghCJ, VineyE, WillsonTA, StarrR, et al. (2000) Gigantism in mice lacking suppressor of cytokine signalling-2. Nature 405: 1069–1073.
17. CrokerBA, MetcalfD, RobbL, WeiW, MifsudS, et al. (2004) SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 20: 153–165.
18. CrokerBA, KrebsDL, ZhangJG, WormaldS, WillsonTA, et al. (2003) SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 4: 540–545.
19. KarioE, MarmorMD, AdamskyK, CitriA, AmitI, et al. (2005) Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. J Biol Chem 280: 7038–7048.
20. BullockAN, RodriguezMC, DebreczeniJE, SongyangZ, KnappS (2007) Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. Structure 15: 1493–1504.
21. HuG, ZhouR, LiuJ, GongAY, ChenXM (2010) MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection. J Infect Dis 202: 125–135.
22. SasiW, JiangWG, SharmaA, MokbelK (2010) Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer. BMC Cancer 10: 178.
23. SutherlandJM, KeightleyRA, NixonB, RomanSD, RobkerRL, et al. (2012) Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation. J Cell Physiol 227: 1188–1198.
24. AugustinM, SedlmeierR, PetersT, HuffstadtU, KochmannE, et al. (2005) Efficient and fast targeted production of murine models based on ENU mutagenesis. Mamm Genome 16: 405–413.
25. BenderBS, CroghanT, ZhangL, SmallPAJr (1992) Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med 175: 1143–1145.
26. DentonAE, DohertyPC, TurnerSJ, La GrutaNL (2007) IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cells. Eur J Immunol 37: 368–375.
27. ImaiY, KubaK, NeelyGG, Yaghubian-MalhamiR, PerkmannT, et al. (2008) Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133: 235–249.
28. PeirisJS, HuiKP, YenHL (2010) Host response to influenza virus: protection versus immunopathology. Curr Opin Immunol 22: 475–481.
29. LawrenceCW, BracialeTJ (2004) Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infection. J Immunol 173: 1209–1218.
30. LawrenceCW, ReamRM, BracialeTJ (2005) Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection. J Immunol 174: 5332–5340.
31. SekiY, HayashiK, MatsumotoA, SekiN, TsukadaJ, et al. (2002) Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci U S A 99: 13003–13008.
32. PothlichetJ, ChignardM, Si-TaharM (2008) Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway. J Immunol 180: 2034–2038.
33. WeiH, WangS, ChenQ, ChenY, ChiX, et al. (2014) Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection. PLoS Pathog 10: e1003845.
34. Ramirez-MartinezG, Cruz-LagunasA, Jimenez-AlvarezL, EspinosaE, Ortiz-QuinteroB, et al. (2013) Seasonal and pandemic influenza H1N1 viruses induce differential expression of SOCS-1 and RIG-I genes and cytokine/chemokine production in macrophages. Cytokine 62: 151–159.
35. PauliEK, SchmolkeM, WolffT, ViemannD, RothJ, et al. (2008) Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. PLoS Pathog 4: e1000196.
36. HuangY, ZaasAK, RaoA, DobigeonN, WoolfPJ, et al. (2011) Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza A infection. PLoS Genet 7: e1002234.
37. ChanMC, CheungCY, ChuiWH, TsaoSW, NichollsJM, et al. (2005) Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir Res 6: 135.
38. JulkunenI, SarenevaT, PirhonenJ, RonniT, MelenK, et al. (2001) Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression. Cytokine Growth Factor Rev 12: 171–180.
39. PaquetteSG, BannerD, ZhaoZ, FangY, HuangSS, et al. (2012) Interleukin-6 is a potential biomarker for severe pandemic H1N1 influenza A infection. PLoS One 7: e38214.
40. JanewayCJr, MedzhitovR (2000) Viral interference with IL-1 and toll signaling. Proc Natl Acad Sci U S A 97: 10682–10683.
41. SchmitzN, KurrerM, BachmannMF, KopfM (2005) Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol 79: 6441–6448.
42. LeJM, FredricksonG, ReisLF, DiamantsteinT, HiranoT, et al. (1988) Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6. Proc Natl Acad Sci U S A 85: 8643–8647.
43. CheungCY, PoonLL, LauAS, LukW, LauYL, et al. (2002) Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet 360: 1831–1837.
44. MikolsCL, YanL, NorrisJY, RussellTD, KhalifahAP, et al. (2006) IL-12 p80 is an innate epithelial cell effector that mediates chronic allograft dysfunction. Am J Respir Crit Care Med 174: 461–470.
45. CooperAM, KhaderSA (2007) IL-12p40: an inherently agonistic cytokine. Trends Immunol 28: 33–38.
46. EverittAR, ClareS, PertelT, JohnSP, WashRS, et al. (2012) IFITM3 restricts the morbidity and mortality associated with influenza. Nature 484: 519–523.
47. ZhangYH, ZhaoY, LiN, PengYC, GiannoulatouE, et al. (2013) Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun 4: 1418.
48. Murali-KrishnaK, AltmanJD, SureshM, SourdiveDJ, ZajacAJ, et al. (1998) Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8: 177–187.
49. ToughDF, BorrowP, SprentJ (1996) Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272: 1947–1950.
50. Di GenovaG, SavelyevaN, SuchackiA, ThirdboroughSM, StevensonFK (2010) Bystander stimulation of activated CD4+ T cells of unrelated specificity following a booster vaccination with tetanus toxoid. Eur J Immunol 40: 976–985.
51. TajimaM, WakitaD, NoguchiD, ChamotoK, YueZ, et al. (2008) IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells. J Exp Med 205: 1019–1027.
52. GeginatJ, SallustoF, LanzavecchiaA (2001) Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells. J Exp Med 194: 1711–1719.
53. UnutmazD, PileriP, AbrignaniS (1994) Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 180: 1159–1164.
54. CoseS, BrammerC, KhannaKM, MasopustD, LefrancoisL (2006) Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. Eur J Immunol 36: 1423–1433.
55. MarzioR, MauelJ, Betz-CorradinS (1999) CD69 and regulation of the immune function. Immunopharmacol Immunotoxicol 21: 565–582.
56. TestiR, D'AmbrosioD, De MariaR, SantoniA (1994) The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol Today 15: 479–483.
57. Smith-GarvinJE, BurnsJC, GohilM, ZouT, KimJS, et al. (2010) T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool. Blood 116: 5548–5559.
58. HanJ, ShuiJW, ZhangX, ZhengB, HanS, et al. (2005) HIP-55 is important for T-cell proliferation, cytokine production, and immune responses. Mol Cell Biol 25: 6869–6878.
59. D'SouzaWN, ChangCF, FischerAM, LiM, HedrickSM (2008) The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol 181: 7617–7629.
60. RainerTH (2002) L-selectin in health and disease. Resuscitation 52: 127–141.
61. JenkinsMR, KedzierskaK, DohertyPC, TurnerSJ (2007) Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL. J Immunol 179: 64–70.
62. BettsMR, BrenchleyJM, PriceDA, De RosaSC, DouekDC, et al. (2003) Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 281: 65–78.
63. LeeC, KolesnikTB, CaminschiI, ChakravortyA, CarterW, et al. (2009) Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response. Clin Exp Allergy 39: 897–907.