Dynamic Functional Modulation of CD4 T Cell Recall Responses Is Dependent on the Inflammatory Environment of the Secondary Stimulus

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A key to the development of strategies for manipulating immune responses is the identification of the factors that regulate the generation of memory T cells. Many vaccination strategies rely on multiple injections to boost memory cell numbers, yet the factors that regulate the function and survival of memory T cells following multiple challenges are not fully understood. Here, we define key parameters during boosting that regulate the functional capacity and longevity of memory T cells. We report that the boosting of highly functional and long-lived memory T cells is dependent on both the activation environment and duration of the secondary challenge. Our findings demonstrate that T cells have functional plasticity that depends on the inflammatory environment of the secondary T cell activation and have direct bearing on the design of strategies aimed at generating highly functional memory T cells.

Vyšlo v časopise: Dynamic Functional Modulation of CD4 T Cell Recall Responses Is Dependent on the Inflammatory Environment of the Secondary Stimulus. PLoS Pathog 10(5): e32767. doi:10.1371/journal.ppat.1004137
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004137

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